CN210364922U - CIK cell activation kit - Google Patents
CIK cell activation kit Download PDFInfo
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- CN210364922U CN210364922U CN201920915579.2U CN201920915579U CN210364922U CN 210364922 U CN210364922 U CN 210364922U CN 201920915579 U CN201920915579 U CN 201920915579U CN 210364922 U CN210364922 U CN 210364922U
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- fixedly connected
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- cell activation
- cik cell
- reagent pipe
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Abstract
The utility model discloses a CIK cell activation kit, which belongs to the field of CIK cell activation, and comprises a kit body, wherein the outer end of the kit body is hinged with a box cover, the outer end of the box cover is fixedly connected with a buckle, a plurality of placing grooves are chiseled in the kit body, reagent tubes are arranged in the placing grooves, the left end wall and the right end wall of each placing groove are fixedly connected with fixed blocks, a buffer cushion is fixedly connected between the two fixed blocks, the outer ends of the fixed blocks are rotatably connected with a rotating shaft, the outer ends of the rotating shaft are fixedly connected with a connecting rod, the outer ends of the connecting rod are close to one end of the reagent tubes and are fixedly connected with a linking plate, and the upper end of the box cover is provided with a plurality of accommodating grooves, on one hand, the reagent tubes can be fastened in the kit body, the, further reducing the possibility of fragmentation of the reagent tube.
Description
Technical Field
The utility model relates to a CIK cell activation field, more specifically say, relate to a CIK cell activation kit.
Background
In the prior art, a lymphocyte separation liquid, a serum-free culture medium, a recombinant human IL-2, a CD3 monoclonal antibody, a recombinant human IFN-gamma and a recombinant human IL-1 α are commonly used for inducing and activating CIK cells, the lymphocyte separation liquid is used for separating and purifying peripheral blood mononuclear cells collected from a patient, the serum-free culture medium is used for providing nutrients required for culturing the CIK cells, the recombinant human IL-2 plays an important role in maintaining the cytotoxic activity of the CIK cells and can stimulate the growth of the CIK cells and stimulate the proliferation of the CD3 monoclonal antibody to simulate the recognition and activation process of an antigen and a TCR/CD3 complex, so that the proliferation and the activation of the T cells are caused and are indispensable stimulating factors in CIK cell culture, the recombinant human IFN-gamma has the function of up-regulating the expression of the peripheral blood lymphocyte to show that the IL-2R can enhance the proliferation reaction and the strength of the T cells on IL-2 proliferation, the use amount of the human IFN-gamma in the CIK cell culture process can be reduced, the sensitivity of the recombinant human IFN-gamma in the research process is found, the sensitivity of the recombinant human IL-2 can be reduced, and the growth of the CIK cells can be used for saving the growth of the CIK cells after the non-2.
With the research on CIK cells, the induction and culture of CIK cells are gradually standardized, and lymphocyte separation liquid, a serum-free culture medium, recombinant human IFN-gamma, recombinant human IL-2 and CD3 monoclonal antibodies required for culturing the CIK cells are required to be placed in the same reagent box according to a standard proportion, and the reagents are not required to be additionally arranged during the culture of the CIK cells, so that the complexity of operation and the risk of pollution of the cells in the culture process are greatly reduced.
SUMMERY OF THE UTILITY MODEL
1. Technical problem to be solved
To the problem that exists among the prior art, the utility model aims to provide a CIK cell activation kit, it can be internal at the kit with the reagent pipe fastening on the one hand, reduces the possibility that reagent pipe and kit body inner wall produced the collision, and on the other hand can cushion the shock attenuation to the reagent pipe, further reduces the possibility that the reagent pipe produces fragmentation.
2. Technical scheme
In order to solve the above problems, the utility model adopts the following technical proposal.
A CIK cell activation kit comprises a kit body, wherein a box cover is hinged to the outer end of the kit body, a buckle is fixedly connected to the outer end of the box cover, a plurality of placing grooves are formed in the kit body in a chiseled mode, reagent tubes are arranged in the placing grooves, fixing blocks are fixedly connected to the left end wall and the right end wall of each placing groove, a cushion pad is fixedly connected between the two fixing blocks, a rotating shaft is rotatably connected to the outer end of each fixing block, a connecting rod is fixedly connected to the outer end of the rotating shaft, a linkage plate is fixedly connected to one end, close to the reagent tubes, of the outer end of the connecting rod, a plurality of accommodating grooves are formed in the upper end of the box cover and correspond to the placing grooves respectively, fastening plates are connected in the accommodating grooves in a sliding mode, compression springs are fixedly connected to the left end and the, the utility model discloses an aspect can be with reagent pipe fastening at the kit originally internally, reduces the possibility that reagent pipe and kit body inner wall produced the collision, and on the other hand can cushion the shock attenuation to reagent pipe, further reduces reagent pipe and produces cracked possibility.
Further, rotation axis outer end fixedly connected with reset spring, when reagent pipe need follow this internal time of taking out of kit, reset spring can assist the rotation axis to circle round, and the staff of being convenient for removes the fixed relation between reagent pipe and the arc piece.
Further, the one end fixedly connected with arc piece that the connecting rod is close to the reagent pipe, the one end that the arc piece is close to the reagent pipe matches each other with the reagent pipe, under the effect of arc piece, can correspondingly increase the area of contact between fixing device and the reagent pipe, has increased fixing device to the fastening degree of reagent pipe to a certain extent.
Further, interlock board upper end fixedly connected with plastic pad, the one end that the plastic pad is close to the reagent pipe matches each other with the reagent pipe, under the effect of plastic pad, can make reagent pipe bottom surface and interlock board laminate more, increases the area of contact between reagent pipe and the interlock board, has increased the cushioning effect to reagent pipe bottom surface to a certain extent.
Further, it has all dug the spout to accomodate the groove left and right sides both ends wall, the equal fixedly connected with slider of both ends wall about the mounting plate, slider and spout sliding connection, under the mating reaction of spout and slider, can be injectd the removal orbit of mounting plate simultaneously with the mounting plate restriction at accomodating the inslot.
Further, mounting plate lower extreme fixedly connected with rubber circle, the rubber circle matches each other with reagent pipe up end, under the effect of rubber circle, can reduce the effort between reagent pipe up end and the mounting plate, makes it play the effect of protection reagent pipe.
3. Advantageous effects
Compared with the prior art, the utility model has the advantages of:
(1) this scheme is compared in prior art to the mode of depositing of reagent pipe, and the kit body is when long-distance transport, the utility model discloses an aspect can be with the fastening of reagent pipe at the kit originally internally, reduces the possibility that reagent pipe and kit body inner wall produced the collision, and on the other hand can cushion the shock attenuation to the reagent pipe, further reduces the reagent pipe and produces cracked possibility.
(2) The outer end of the rotating shaft is fixedly connected with a return spring, when the reagent tube needs to be taken out of the reagent box body, the return spring can assist the rotating shaft to rotate around, and the fixing relation between the reagent tube and the arc-shaped block is conveniently released by a worker.
(3) The one end fixedly connected with arc piece that the connecting rod is close to reagent pipe, and the one end that the arc piece is close to reagent pipe matches each other with reagent pipe, under the effect of arc piece, can correspondingly increase the area of contact between fixing device and the reagent pipe, has increased fixing device to the fastening degree of reagent pipe to a certain extent.
(4) Interlock board upper end fixedly connected with plastic pad, the plastic pad is close to the one end of reagent pipe and is matchd each other with the reagent pipe, under the effect of plastic pad, can make reagent pipe bottom surface and interlock board laminate more, and the area of contact between increase reagent pipe and the interlock board has increased the buffering effect to reagent pipe bottom surface to a certain extent.
(5) The groove is accomodate and the both ends wall is all dug there is the spout, and the equal fixedly connected with slider of both ends wall about the mounting plate, slider and spout sliding connection, under the mating reaction of spout and slider, can be injectd the mounting plate and accomodating the inslot, can inject the removal orbit of mounting plate simultaneously.
(6) The reagent tube lower extreme fixedly connected with rubber circle of mounting plate, rubber circle and reagent tube up end match each other, under the effect of rubber circle, can reduce the effort between reagent tube up end and the mounting plate, make it play the effect of protection reagent tube.
Drawings
Fig. 1 is a schematic external structural view of the present invention;
FIG. 2 is a schematic view of the front cross-sectional structure of the present invention when not in use;
FIG. 3 is a schematic view of the structure at A in FIG. 2;
fig. 4 is a schematic view of a part of the structure of the present invention during use.
The reference numbers in the figures illustrate:
the kit comprises a kit body 1, a kit cover 2, a buckle 3, a fixing block 4, a buffer plate 5, a rotating shaft 6, a return spring 7, a connecting rod 8, an arc-shaped block 9, a linkage plate 10, a plastic pad 11, a containing groove 12, a sliding groove 13, a sliding block 14, a compression spring 15, a fastening plate 16 and a reagent tube 17.
Detailed Description
The technical solution in the embodiment of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiment of the present invention; obviously, the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and all other embodiments obtained by those skilled in the art without any inventive work are within the scope of the present invention based on the embodiments of the present invention.
In the description of the present invention, it should be noted that the terms "upper", "lower", "inner", "outer", "top/bottom", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted", "provided", "sleeved/connected", "connected", and the like are to be understood in a broad sense, such as "connected", which may be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Example 1:
a CIK cell activation kit, please refer to fig. 1, comprising a kit body 1, a box cover 2 is hinged at the outer end of the kit body 1, a buckle 3 is fixedly connected at the outer end of the box cover 2, the kit body 1 and the box cover 2 can be fixed with each other under the action of the buckle 3, please refer to fig. 2-3, a plurality of placing grooves are chiseled in the kit body 1, fixing blocks 4 are fixedly connected at the left and right end walls of the placing grooves, a cushion 5 is fixedly connected between the two fixing blocks 4, the cushion 5 can protect the bottom surfaces of reagent tubes 17, so that the reagent tubes 17 can not contact with the bottom ends in the placing grooves all the time, a rotating shaft 6 is rotatably connected at the outer end of the fixing block 4, a return spring 7 is fixedly connected at the outer end of the rotating shaft 6, when the reagent tubes 17 need to be taken out of the kit body 1, the return spring, the fixed relation between reagent pipe 17 and arc piece 9 is relieved to the staff of being convenient for.
Referring to fig. 2-3, the outer end of the rotating shaft 6 is fixedly connected with a connecting rod 8, one end of the connecting rod 8 close to the reagent tube 17 is fixedly connected with an arc-shaped block 9, one end of the arc-shaped block 9 close to the reagent tube 17 is matched with the reagent tube 17, under the action of the arc-shaped block 9, the contact area between the fixing device and the reagent tube 17 can be correspondingly increased, the fastening degree of the fixing device to the reagent tube 17 is increased to a certain degree, one end of the outer end of the connecting rod 8 close to the reagent tube 17 is fixedly connected with a linkage plate 10, the upper end of the linkage plate 10 is fixedly connected with a plastic pad 11, one end of the plastic pad 11 close to the reagent tube 17 is matched with the reagent tube 17, under the effect of plastic pad 11, can make reagent pipe 17 bottom surface and trace board 10 more laminate, increase the area of contact between reagent pipe 17 and the trace board 10, increased the cushioning effect to reagent pipe 17 bottom surface to a certain extent.
Referring to fig. 4, a plurality of storage grooves 12 are bored at the upper end of the case cover 2, the storage grooves 12 correspond to the plurality of storage grooves, respectively, a fastening plate 16 is slidably connected to the storage grooves 12, sliding grooves 13 are bored at both left and right end walls of the storage grooves 12, sliders 14 are fixedly connected to both left and right end walls of the fastening plate 16, the sliders 14 are slidably connected to the sliding grooves 13, the fastening plate 16 can be limited in the storage grooves 12 under the cooperation of the sliding grooves 13 and the sliders 14, and the moving track of the fastening plate 16 can be limited, a rubber ring is fixedly connected to the lower end of the fastening plate 16, the rubber ring is matched with the upper end surface of the reagent tube 17, under the action of the rubber ring, the acting force between the upper end surface of the reagent tube 17 and the fastening plate 16 can be reduced, so as to protect the reagent tube 17, compression springs 15 are fixedly connected to both left and right ends of the fastening plate 16, the compression springs 15 are fixed to the top end walls of the storage grooves 12, in the closed state of the box cover 2, the fastening plate 16 can always contact with the reagent tube 17 under the elastic force of the compression spring 15, and has downward pressure on the reagent tube, so that the fastening degree of the reagent tube 17 is increased to a certain degree.
When a worker needs to place the reagent tube 17 in the reagent kit body 1 for storage, please refer to fig. 1, the worker firstly opens the buckle and turns the box cover 2 open in a rotating manner, please refer to fig. 4, the worker places the reagent tube 17 between the two connecting rods 8, under the action of the self gravity of the reagent tube 17, the two linkage plates 10 are driven to rotate along the rotating shaft 6 against the elastic force of the reset spring 7, meanwhile, the linkage plates 10 drive the connecting rods 8 to enable the arc-shaped blocks 9 at the left end and the right end to clamp the reagent tube 17, the worker then covers the box cover 2 in a rotating manner, under the action of the fastening plate 16, the reagent tube 17 is vertically pressed downwards, so that the reagent tube 17 is clamped by the two arc-shaped blocks 9 more firmly, and under the action of the compression spring 15, the reagent tube 17 can be buffered in the transportation process of the reagent kit body 1, compare in prior art to the mode of depositing of reagent pipe 17, kit body 1 when long-distance transport, the utility model discloses an aspect can be with reagent pipe 17 fastening in kit body 1, reduces the possibility that reagent pipe 17 and 1 inner wall of kit body produced the collision, and on the other hand can cushion the shock attenuation to reagent pipe 17, further reduces reagent pipe 17 and produces cracked possibility.
The above description is only the preferred embodiment of the present invention; the scope of the present invention is not limited thereto. Any person skilled in the art should also be able to cover the technical scope of the present invention by replacing or changing the technical solution and the improvement concept of the present invention with equivalents and modifications within the technical scope of the present invention.
Claims (6)
1. The utility model provides a CIK cell activation kit, includes kit body (1), kit body (1) outer end hinge connection has lid (2), lid (2) outer end fixedly connected with buckle (3), it has a plurality of standing grooves to open the chisel in kit body (1), be equipped with reagent pipe (17) in the standing groove, its characterized in that: equal fixedly connected with fixed block (4) in both ends wall about the standing groove, two fixedly connected with blotter (5) between fixed block (4), fixed block (4) outer end is rotated and is connected with rotation axis (6), rotation axis (6) outer end fixedly connected with connecting rod (8), one end fixedly connected with interlock board (10) that connecting rod (8) outer end is close to reagent pipe (17), open chisel on lid (2) upper end has a plurality of grooves of accomodating (12), and is a plurality of accomodate groove (12) and correspond each other with a plurality of standing grooves respectively, accomodate groove (12) sliding connection have mounting plate (16), the equal fixedly connected with compression spring (15) in both ends about mounting plate (16), compression spring (15) are fixed with accomodating groove (12) top wall mutually.
2. The CIK cell activation kit according to claim 1, wherein: the outer end of the rotating shaft (6) is fixedly connected with a return spring (7).
3. The CIK cell activation kit according to claim 1, wherein: one end fixedly connected with arc piece (9) that connecting rod (8) are close to reagent pipe (17), the one end that arc piece (9) are close to reagent pipe (17) matches each other with reagent pipe (17).
4. The CIK cell activation kit according to claim 1, wherein: the reagent tube detection device is characterized in that a plastic pad (11) is fixedly connected to the upper end of the linkage plate (10), and one end, close to the reagent tube (17), of the plastic pad (11) is matched with the reagent tube (17).
5. The CIK cell activation kit according to claim 1, wherein: it has spout (13) all to cut in both ends wall about groove (12) to accomodate, about mounting plate (16) both ends wall equal fixedly connected with slider (14), slider (14) and spout (13) sliding connection.
6. The CIK cell activation kit according to claim 1, wherein: the lower end of the fastening plate (16) is fixedly connected with a rubber ring, and the rubber ring is matched with the upper end face of the reagent tube (17).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920915579.2U CN210364922U (en) | 2019-06-18 | 2019-06-18 | CIK cell activation kit |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920915579.2U CN210364922U (en) | 2019-06-18 | 2019-06-18 | CIK cell activation kit |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN210364922U true CN210364922U (en) | 2020-04-21 |
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ID=70265375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920915579.2U Active CN210364922U (en) | 2019-06-18 | 2019-06-18 | CIK cell activation kit |
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|---|---|
| CN (1) | CN210364922U (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111762425A (en) * | 2020-07-16 | 2020-10-13 | 宿州市睿鼎信息科技有限公司 | Canned fruit convenient to open |
| CN113025479A (en) * | 2021-02-28 | 2021-06-25 | 南京帝基生物科技有限公司 | Kit for detecting cell activation antigen |
| CN114394316A (en) * | 2021-12-29 | 2022-04-26 | 上海鸣捷生物科技有限公司 | Kit for detecting African swine fever virus |
| CN114394325A (en) * | 2022-02-17 | 2022-04-26 | 华威特（江苏）生物制药有限公司 | Equipment is deposited to bacterin |
-
2019
- 2019-06-18 CN CN201920915579.2U patent/CN210364922U/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111762425A (en) * | 2020-07-16 | 2020-10-13 | 宿州市睿鼎信息科技有限公司 | Canned fruit convenient to open |
| CN113025479A (en) * | 2021-02-28 | 2021-06-25 | 南京帝基生物科技有限公司 | Kit for detecting cell activation antigen |
| CN114394316A (en) * | 2021-12-29 | 2022-04-26 | 上海鸣捷生物科技有限公司 | Kit for detecting African swine fever virus |
| CN114394316B (en) * | 2021-12-29 | 2024-01-02 | 上海鸣捷生物科技有限公司 | Kit for detecting African swine fever virus |
| CN114394325A (en) * | 2022-02-17 | 2022-04-26 | 华威特（江苏）生物制药有限公司 | Equipment is deposited to bacterin |
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Address after: 201100 floor 2, building 23, No. 1188 LIANHANG Road, Minhang District, Shanghai Patentee after: Huaxiayuan Cell Engineering Group Co.,Ltd. Address before: Unit A2, 2 / F, building 23, No. 1188, LIANHANG Road, Minhang District, Shanghai 201100 Patentee before: SINONEURAL (SHANGHAI) CELL AND GENE ENGINEERING HOLDINGS Co.,Ltd. |