CN210340448U - Device for continuously supplying sterile water - Google Patents
Device for continuously supplying sterile water Download PDFInfo
- Publication number
- CN210340448U CN210340448U CN201822032323.5U CN201822032323U CN210340448U CN 210340448 U CN210340448 U CN 210340448U CN 201822032323 U CN201822032323 U CN 201822032323U CN 210340448 U CN210340448 U CN 210340448U
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- Prior art keywords
- purified water
- pipeline
- filter
- sterilized
- centrifuge
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 138
- 239000008223 sterile water Substances 0.000 title claims abstract description 20
- 239000008213 purified water Substances 0.000 claims abstract description 76
- 238000001816 cooling Methods 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 9
- 229960000074 biopharmaceutical Drugs 0.000 claims description 5
- 238000011031 large-scale manufacturing process Methods 0.000 claims description 5
- 238000000926 separation method Methods 0.000 claims description 4
- 230000036512 infertility Effects 0.000 claims description 2
- 239000000498 cooling water Substances 0.000 abstract 1
- 210000001503 joint Anatomy 0.000 description 7
- 238000003860 storage Methods 0.000 description 4
- 239000011521 glass Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- 239000010935 stainless steel Substances 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 230000004071 biological effect Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 238000012432 intermediate storage Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
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- Centrifugal Separators (AREA)
Abstract
The utility model provides a device for continuously supplying sterile water. Specifically, the device comprises a purified water source, a high-leg filter, an intermediate tank and a centrifuge, wherein a purified water outlet of the purified water source is connected with a purified water inlet of the high-leg filter through a first pipeline, a sterilized and purified water outlet of the high-leg filter is connected with a sterilized and purified water inlet of the intermediate tank through a second pipeline, and a sterilized and purified water outlet of the intermediate tank is connected with a sterilized and purified water inlet of the centrifuge through a third pipeline; valves are arranged on the first pipeline, the second pipeline and the third pipeline; and the height of the shelf of the high foot filter is the same or nearly the same as the height of the first and second conduits. The device for continuously supplying the sterile water of the utility model can supply cooling water and continuously supply the sterile water, thereby saving time and cost.
Description
Technical Field
The utility model relates to a bio-pharmaceuticals equipment field, concretely relates to device of aseptic water of continuous supply.
Background
In the industrial and large-scale production of biopharmaceuticals, a continuous flow separator is often used as an effective device for solid-liquid separation in the feed liquid of the purification primary stage.
Because the continuous flow disk centrifuge needs to continuously supply sealing water during the use process, in the process with strict pharmaceutical requirements, the water supplied by the disk centrifuge needs to be sterile water in order to prevent pollution. Such sterile water may be injection water, or filtered purified water, or sterilized purified water.
However, the injection water temperature is too high, which affects the biological activity and is not suitable; the demand of sterilized purified water or filtered purified water is small and can be considered, but a large-volume (2000L) pure water storage tank is required for large-scale production and large demand, so that the occupied area is large, the sterilization, cooling and the like are required in advance, and the time and the cost are high, so that the method is not suitable.
Therefore, there is a strong need in the art to develop a low cost, time saving device that can continuously supply sterile water.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing a low-cost, save time's device that can supply sterile water in succession.
In the present invention, there is provided a device for continuously supplying sterilized water, the device comprising:
a purified water source (1) for providing purified water to be sterilized;
a high-foot filter (2) for filter-sterilizing purified water to be sterilized, and placed on the stand (11);
an intermediate tank (3) for storing sterilized purified water to supply the sterilized purified water to the centrifuge if necessary;
a centrifuge (6) for purifying solid-liquid separation equipment in feed liquid in the primary stage in the large-scale production of biopharmaceuticals;
wherein a purified water outlet of the purified water source (1) is connected with a purified water inlet of the high-foot filter (2) through a first pipeline, a sterilized purified water outlet of the high-foot filter (2) is connected with a sterilized purified water inlet of the intermediate tank (3) through a second pipeline, and a sterilized purified water outlet of the intermediate tank (3) is connected with a sterilized purified water inlet of the centrifuge (6) through a third pipeline;
a valve (7) is arranged on the first pipeline, a valve (8) is arranged on the second pipeline, and a valve (9) is arranged on the third pipeline;
and the height of the shelf (11) of the high-foot filter is the same or nearly the same as the height of the first and second ducts.
In another preferred example, the purified water outlet of the purified water source (1) is connected with a three-way valve (13).
In another preferred example, the first purified water outlet of the three-way valve (13) is connected with the purified water inlet of the high-leg filter (2) through a first pipeline.
In another preferred example, the centrifuge (6) further comprises a circulating water pipeline (5) outside the rotary drum, and the circulating water pipeline (5) outside the rotary drum of the centrifuge is used for cooling the outside of the rotary drum of the centrifuge by cooling circulating water.
In another preferred example, the purified water inlet of the circulating water pipeline (5) outside the centrifuge drum is connected with the second purified water outlet of the three-way valve (13) of the purified water source (1) through a fourth pipeline, and the fourth pipeline is provided with a valve (10).
In another preferred embodiment, the device further comprises a laminar flow hood (4), wherein the high-foot filter (2), the valve (7), the valve (8), the part of the first pipeline between the high-foot filter (2) and the valve (7), and the part of the second pipeline between the high-foot filter (2) and the valve (8) are all positioned in the laminar flow hood (4), and the laminar flow hood (4) is used for maintaining the sterile state of the high-foot filter and the first pipeline and the second pipeline at two ends of the high-foot filter when the high-foot filter (2) is connected into the device before the device is used.
In another preferred embodiment, the high-foot filter (2) is selected from the group consisting of: 20 inches, 10 inches, or 5 inches, etc.
In another preferred embodiment, the high-foot filter (2) is detachable.
In another preferred example, the first pipeline and the second pipeline are made of sanitary pharmaceutical grade, high temperature resistant (121 ℃) and high pressure resistant (0.3MPa) braids.
In another preferred example, a clamp is welded at one end of the first pipeline and the second pipeline connected with the high-foot filter (2).
In another preferred embodiment, the clamp is a 316L stainless steel clamp.
In another preferred example, the laminar flow hood (4) is a movable laminar flow hood.
In another preferred embodiment, the laminar flow hood (4) is a hundred-stage laminar flow hood, preferably a thousand-stage laminar flow hood.
In another preferred example, a visible mirror (12) is included in the intermediate tank (3), and the visible mirror (12) is used for observing the water level in the intermediate tank (3).
In another preferred embodiment, the capacity of the intermediate tank (3) is 100-.
It is understood that within the scope of the present invention, the above-mentioned technical features of the present invention and those specifically described below (e.g. in the examples) can be combined with each other to constitute new or preferred technical solutions. Not to be reiterated herein, but to the extent of space.
Drawings
Fig. 1 is a schematic view of a preferred embodiment of a device for continuously supplying sterilized water according to the present invention;
in the figure, 1 is a purified water source, 2 is a high-foot filter, 3 is a middle tank, 4 is a laminar flow cover, 5 is a circulating water pipeline outside a rotary drum of the centrifugal machine, 6 is the centrifugal machine, 7, 8, 9 and 10 are all valves on the pipeline, 11 is a support of the high-foot filter, 12 is a visible mirror, and 13 is a three-way valve.
Detailed Description
The present inventors have made extensive and intensive studies to develop a device for continuously supplying sterilized water. Specifically, the present inventors have found that when sterile water is supplied to a centrifuge, a filter and an intermediate tank for storing sterilized purified water are added between a purified water source and the centrifuge, and the filter, a pipe connecting both ends of the filter, and a valve are placed in a laminar flow hood that provides a sterile environment, i.e., the centrifuge can be continuously supplied with sterile water; and the purified water outlet of the purified water source can be connected with a circulating water pipeline outside the rotary drum of the centrifuge through another pipeline, so that the temperature of the outside of the rotary drum of the centrifuge is reduced. The device can continuously supply sterile water to the centrifuge, and has the advantages of time saving, low cost, small occupied area and convenient operation. On this basis, the utility model discloses has been accomplished.
Term(s) for
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
As used herein, the terms "comprising," "including," and "containing" are used interchangeably and include not only open-ended definitions, but also semi-closed and closed-ended definitions. In other words, the term includes "consisting of … …", "consisting essentially of … …".
As used herein, the terms "upper", "lower", "top", "bottom", "horizontal", and the like refer to an orientation or positional relationship based on that shown in the drawings, which is merely for convenience in describing the invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore should not be construed as limiting the invention.
As used herein, the term "coupled" is to be construed broadly, as including both fixed and removable couplings or integrally coupled.
As used herein, the terms "device for continuous supply of sterile water" and "device" are used interchangeably.
As used herein, the terms "high-foot filter" and "filter" are used interchangeably.
As used herein, the terms "intermediate tank", "intermediate storage tank" and "sterile water storage tank" are used interchangeably.
For convenience of explanation, the present invention will be further described with reference to fig. 1, in which the present invention is to be understood not to be limited by the accompanying drawings.
Typically, the present invention provides an apparatus for continuously supplying sterile water, the apparatus comprising:
a purified water source 1 for providing purified water to be sterilized;
a high-foot filter 2 for filter-sterilizing purified water to be sterilized, and placed on the stand 11;
an intermediate tank 3 for storing sterilized purified water to supply the sterilized purified water to the centrifuge if necessary;
the centrifuge 6 is used for purifying solid-liquid separation equipment in feed liquid in the primary stage in large-scale production of biopharmaceuticals;
wherein, the purified water outlet of the purified water source 1 is connected with the purified water inlet of the high-foot filter 2 through a first pipeline, the sterilized purified water outlet of the high-foot filter 2 is connected with the sterilized purified water inlet of the intermediate tank 3 through a second pipeline, and the sterilized purified water outlet of the intermediate tank 3 is connected with the sterilized purified water inlet of the centrifuge 6 through a third pipeline; a valve 7 is arranged on the first pipeline, a valve 8 is arranged on the second pipeline, and a valve 9 is arranged on the third pipeline; and the height of the shelf 11 of the high foot filter is the same or nearly the same as the height of the first and second ducts.
Preferably, the purified water outlet of the purified water source 1 is connected with a three-way valve 13, and a first purified water outlet of the three-way valve 13 is connected with the purified water inlet of the high-leg filter 2 through a first pipeline; the centrifuge 6 further comprises a circulating water pipeline 5 outside the drum, and the circulating water pipeline 5 outside the centrifuge drum is used for cooling the outside of the centrifuge drum through cooling circulating water; and a purified water inlet of a circulating water pipeline 5 outside the centrifuge drum is connected with a second purified water outlet of a three-way valve 13 of a purified water source 1 through a fourth pipeline, and the fourth pipeline is provided with a valve 10.
Preferably, the apparatus further comprises a laminar flow hood 4, the high leg filter 2, the valve 7, the valve 8, the portion of the first conduit between the high leg filter 2 and the valve 7, and the portion of the second conduit between the high leg filter 2 and the valve 8, all being located within the laminar flow hood 4, the laminar flow hood 4 being adapted to maintain the sterility of the high leg filter and the first and second conduits at either end thereof when the high leg filter 2 is connected into the apparatus prior to use of the apparatus.
Preferably, the high foot filter 2 is selected from the group consisting of: 20 inches, 10 inches, or 5 inches, etc.
In another preferred example, the first pipeline and the second pipeline are made of sanitary pharmaceutical grade, high temperature resistant (121 ℃) and high pressure resistant (0.3MPa) braids. And the clamp is welded at one end of the first pipeline and the second pipeline connected with the high-foot filter 2. Preferably, the clamp is a 316L stainless steel clamp.
In another preferred example, the laminar flow hood 4 is a movable laminar flow hood. Preferably, the laminar flow hood 4 is a hundred-stage laminar flow hood, preferably a thousand-stage laminar flow hood.
In another preferred example, a visible mirror 12 is included in the intermediate tank 3, and the visible mirror 12 is used for observing the water level in the intermediate tank 3.
In another preferred embodiment, the capacity of the intermediate tank 3 is 100-.
In a preferred embodiment, the first tubing, second tubing and filter are removed together prior to use, autoclaved off-line and the intermediate tank autoclaved separately. After sterilization, the hose is in clamp butt joint with the valve 7 under the protection of opening the movable hundred-level laminar flow cover 4, and the other hose is also in clamp butt joint with the valve 8 under the protection of opening the movable hundred-level laminar flow cover 4. After the butt joint is finished, the valves 7, 8 and 9 can be opened, sterile purified water is continuously and continuously supplied, the pure water level in the tank can be observed at any time through the sight glass, and the valve 8 is timely adjusted to be closed. The water level in the tank is too low, the valve 8 is opened, the water level in the tank is too high, the valve 8 is closed, and the valve 9 is opened if a water source needs to be conveyed. While the machine is running, non-sterile purified water can be supplied by opening the valve 10 for cooling the exterior of the centrifuge bowl.
The utility model has the advantages that:
1. traditional large capacity (2000L) pure water storage tank is bulky, area is big, still need to disinfect in advance, cool down etc. compare and take time, with high costs, and the utility model discloses well middle storage tank area that uses is little, need not to disinfect in advance and cool down, convenient to use.
2. Use the utility model discloses a steerable lower temperature of sterile water that the device provided does not influence biological activity.
3. The utility model discloses a device can provide refrigerated circulating water to centrifuge's rotary drum outside, on the basis that provides sterile water, has the function that makes the outside cooling of centrifuge rotary drum simultaneously.
4. Use the utility model discloses a device can provide sterile water continuously, satisfies incessant large-scale mass production's needs.
The invention will be further described with reference to the following specific examples. It is to be understood that the following description is only illustrative of the present invention and is not intended to limit the scope of the present invention. In view of the full understanding of the present invention, the skilled person can make non-essential changes to the technical solution of the present invention, usually according to the conventional conditions or the conditions suggested by the manufacturer, and such changes should be considered as included in the protection scope of the present invention. The experimental procedures, in which specific conditions are not noted in the following examples, are generally carried out under conventional conditions or conditions recommended by the manufacturers. Unless otherwise indicated, percentages and parts are by weight.
Example 1
The embodiment provides a device for continuously supplying sterile water, which is characterized in that a tee joint is arranged on a purified water 1 pipeline, wherein one water source is directly communicated with the outer part 5 of a rotary drum of a disc centrifuge, and a cavity of the rotary drum is cooled; in the other path of water source, a degerming high-leg filter 2 is arranged on the pipeline, and the height of a filter bracket is parallel or nearly parallel to the purified water pipeline; two ends of the filter are respectively connected with a section of sanitary pharmaceutical grade, high temperature (121 ℃) resistant and high pressure (0.3MPa) reticulated braided tube, and two ends of the hose are welded with 316L stainless steel clamp joints; the rear end of the hose is connected to a smaller intermediate tank 3(500L) with a sight glass.
Before use, the two hoses and the filter are removed together, off-line autoclaving is carried out, and the intermediate tank is sterilized by single high-pressure steam. After sterilization, the hose is in clamp butt joint with the valve 7 under the protection of opening the movable hundred-level laminar flow cover 4, and the other hose is also in clamp butt joint with the valve 8 under the protection of opening the movable hundred-level laminar flow cover 4. After the butt joint is finished, the valves 7, 8 and 9 can be opened to continuously supply sterile purified water.
In the use, can observe the interior pure water liquid level of jar at any time through the sight glass, and then in time adjust valve 8 close. The water level in the tank is too low, the valve 8 is opened, the water level in the tank is too high, the valve 8 is closed, and the valve 9 is opened if a water source needs to be conveyed. While the machine is running, non-sterile purified water can be supplied by opening the valve 10 for cooling the exterior of the centrifuge bowl.
All documents mentioned in this application are incorporated by reference into this application as if each were individually incorporated by reference. Furthermore, it should be understood that various changes and modifications of the present invention may be made by those skilled in the art after reading the above teachings of the present invention, and these equivalents also fall within the scope of the appended claims.
Claims (12)
1. An apparatus for continuously supplying sterile water, the apparatus comprising:
a purified water source (1) for providing purified water to be sterilized;
a high-foot filter (2) for filter-sterilizing purified water to be sterilized, and placed on the stand (11);
an intermediate tank (3) for storing sterilized purified water to supply the sterilized purified water to the centrifuge if necessary;
a centrifuge (6) for purifying solid-liquid separation equipment in feed liquid in the primary stage in the large-scale production of biopharmaceuticals;
wherein a purified water outlet of the purified water source (1) is connected with a purified water inlet of the high-foot filter (2) through a first pipeline, a sterilized purified water outlet of the high-foot filter (2) is connected with a sterilized purified water inlet of the intermediate tank (3) through a second pipeline, and a sterilized purified water outlet of the intermediate tank (3) is connected with a sterilized purified water inlet of the centrifuge (6) through a third pipeline;
a valve is arranged on the first pipeline, a valve is arranged on the second pipeline, and a valve is arranged on the third pipeline;
and the height of the shelf (11) of the high-foot filter is the same or nearly the same as the height of the first and second ducts.
2. The device according to claim 1, characterized in that the purified water outlet of the source of purified water (1) is connected to a three-way valve (13).
3. The device according to claim 2, characterized in that the first purified water outlet of the three-way valve (13) is connected to the purified water inlet of the high-foot filter (2) by a first conduit.
4. The device according to claim 1, characterized in that the centrifuge (6) further comprises a water circulation conduit (5) outside the bowl.
5. An apparatus according to claim 4, characterized in that the water circulation conduit (5) outside the bowl is used for cooling down the outside of the centrifuge bowl by cooling the circulating water.
6. The device according to claim 4, characterized in that the purified water inlet of the circulating water pipe (5) outside the drum is connected with the second purified water outlet of the three-way valve (13) of the purified water source (1) through a fourth pipe, and the fourth pipe is equipped with a valve.
7. The device according to claim 1, characterized in that it further comprises a laminar flow hood (4).
8. The device according to claim 7, characterized in that the laminar flow hood (4) is covered by the high-foot filter (2), two valves connected to the high-foot filter (2), and partial sections between the high-foot filter (2) and the two connected valves, which are located in the first and second pipes, respectively,
wherein the laminar flow hood (4) is adapted to maintain the sterility of the high-foot filter and the first and second conduits at either end thereof when the high-foot filter (2) is connected into the device prior to use of the device.
9. The device according to claim 1, characterized in that the high-foot filter (2) is selected from the group consisting of: 20 inches, 10 inches, and 5 inches.
10. An arrangement according to claim 1, characterized in that a visible mirror (12) is included in the intermediate tank (3), which visible mirror (12) is used to observe the water level in the intermediate tank (3).
11. The apparatus according to claim 1, characterized in that the intermediate tank (3) has a capacity of 500L.
12. The device according to claim 7, characterized in that the laminar flow hood (4) is a movable laminar flow hood.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822032323.5U CN210340448U (en) | 2018-12-05 | 2018-12-05 | Device for continuously supplying sterile water |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822032323.5U CN210340448U (en) | 2018-12-05 | 2018-12-05 | Device for continuously supplying sterile water |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN210340448U true CN210340448U (en) | 2020-04-17 |
Family
ID=70172775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201822032323.5U Expired - Fee Related CN210340448U (en) | 2018-12-05 | 2018-12-05 | Device for continuously supplying sterile water |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN210340448U (en) |
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2018
- 2018-12-05 CN CN201822032323.5U patent/CN210340448U/en not_active Expired - Fee Related
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20200417 |