CN210252321U

CN210252321U - Array structure for microfluidic chip preset layer

Info

Publication number: CN210252321U
Application number: CN201920669331.2U
Authority: CN
Inventors: 孔令豹; 徐珍珍
Original assignee: Fudan University
Current assignee: Fudan University
Priority date: 2019-05-11
Filing date: 2019-05-11
Publication date: 2020-04-07
Anticipated expiration: 2029-05-11

Abstract

The utility model belongs to the technical field of it is micro-fluidic, specifically be an array structure that is used for micro-fluidic chip to predetermine layer. The array structure is formed by linearly arranging and spreading micro-structure units in the horizontal direction and the vertical direction; the microstructure unit is a hexahedron consisting of six surfaces, namely a front surface, a rear surface, an upper surface, a lower surface, a left surface and a right surface; the front surface is a concave surface, and the back surface is a convex surface; a certain inclination angle is formed between the first surface and the upper surface; the columns of the array structure are provided with ridge-shaped separation, the width of the ridge-shaped separation does not exceed the width of the microstructure unit, and the distance between the rows of the array structure is larger than the length of the microstructure unit. The inclination angle of the front surface of the micro-structure unit enables liquid to be transported by utilizing a capillary phenomenon, and the arc-shaped edge of the front surface can effectively block the reverse flow of the liquid by utilizing a liquid blocking effect, so that the problem of liquid directional distribution when the micro-fluidic chip is used for analyzing and detecting medicines is solved, and the medicine reaction efficiency of the micro-fluidic chip is improved.

Description

Array structure for microfluidic chip preset layer

Technical Field

The utility model belongs to the technical field of the micro-fluidic, concretely relates to micro-fluidic chip predetermines array structure on layer.

Background

In recent years, the development of microfluidics, including chemical synthesis, drug diagnosis, single cell analysis, micro-nano fabrication, etc., has triggered a technological revolution, wherein microfluidics is one of the fastest branches of the last decade. Microfluidic technology generally refers to the science and technology related to the intersection of systems for manipulating or processing nano-liter-scale micro-fluids by using micro-channels with dimensions of hundreds of microns, and relates to the intersection of the fields of biology, medicine, chemistry, fluid physics, materials, microelectronics, and the like. In biochemical experiments, basic operation processes such as sample preparation, separation and detection, cell culture and the like are generally integrated on a chip with a centimeter-scale dimension for operation, so that the microfluidic device is also called a microfluidic chip, a lab-on-a-chip and a micro total analysis system.

Although the microfluidic chip has great advantages, such as low cost, fast reaction speed, small dosage of medicament consumption, integrated miniaturization and automation, etc., the microfluidic chip is not really taken out of a laboratory, is widely applied and highly industrialized, and one of the key problems is that the control problem of the microfluidic chip cannot be effectively solved, which is particularly prominent in the field of biological detection. When the microfluidic chip is used for realizing the simultaneous detection of a plurality of sample reactions or a plurality of indexes under a plurality of reaction units, the centrifugal force is generally used for distributing liquid, the rotary chip is used for generating the centrifugal force, and the liquid is distributed to each unit under the driving of the centrifugal force, but the technologies of medicine sample introduction, microchannel inner wall modification and the like in the process are still to be perfected.

In conclusion, how to effectively control the sample injection of the drug and directionally distribute the liquid in the microfluidic chip to improve the reliability of the drug reaction is a problem to be solved in the field of drug detection of the existing microfluidic chip.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to design one kind can advance the appearance and directional micro-fluidic chip who distributes liquid predetermines the array structure on layer at the inside effective control medicine of micro-fluidic chip to solve the medicine control problem among the micro-fluidic chip.

The utility model discloses a micro-structure array for the processing on layer is predetermine to the micro-fluidic chip, formulates the position at the chip with this micro-structure according to the demand and spreads, and processes and decorates the surface, realizes transporting and distributing at the orientation of the inside medicine of micro-fluidic chip.

The array structure designed by the utility model is formed by the micro-structure units which are linearly arranged and spread in the horizontal direction (horizontal direction) and the vertical direction (longitudinal direction); the microstructure unit is a hexahedron consisting of six surfaces, namely a front surface, a rear surface, an upper surface, a lower surface, a left surface and a right surface, and is similar to a horseshoe shape; the front surface (also called as a first surface) is a concave surface, the surface shape of the front surface can be any kind of curved surfaces such as a cylindrical surface, a paraboloid or a saddle surface, the rear surface (also called as a second surface) is a convex surface, and the surface shape of the rear surface is any kind of curved surfaces such as a cylindrical surface, a paraboloid or a saddle surface; the upper surface, the lower surface, the left surface and the right surface are planes; the first surface and the upper surface form a certain inclination angle therebetween, the inclination angle is in the range of 20 degrees to 90 degrees (preferably 40 degrees to 55 degrees), and the second surface and the upper surface form a certain inclination angle therebetween, and the inclination angle range is not limited, and is generally 10 degrees to 90 degrees. See fig. 1 and 2.

The utility model discloses in, typically, among the micro-structure unit, two surfaces on a left side, right side are parallel, and two upper and lower surfaces are also parallel.

In the present invention, in particular, in the microstructure unit, the upper surface and the second surface are smoothly transited to form a curved surface, which is still called as the upper surface, so that the microstructure unit is a special structure of a pentahedron.

In the array structure of the utility model, the micro-structure units are spread according to the vertical direction (namely, spread according to the front and back surface directions of the micro-structure units) to form the longitudinal columns of the array structure, and the micro-structure units are spread according to the horizontal direction (namely, spread according to the left and right surface directions of the micro-structure units) to form the transverse rows of the array structure; the columns of the array structure have ridge-like separations between them, the ridge-like separations having a width not exceeding the width of the microstructure unit (i.e., the spacing between the left and right surfaces), and the rows of the array structure having a spacing between them greater than the length of the microstructure unit (i.e., the spacing between the front and back surfaces), as shown in fig. 3 and 6.

The utility model discloses in, the size of a dimension of micro-structure unit can enlarge or reduce according to the actual demand, and its scope of enlargement is usually at micron magnitude, and otherwise this structure can receive the influence of certain degree when micron magnitude liquid orientation transports.

The utility model discloses in, the processing mode of micro-structure unit can be for photoetching, impression or 3D print etc. any kind of current processing mode.

The utility model discloses an operating principle does, and the inclination of micro-structure unit first surface makes liquid can utilize capillary phenomenon to transport, and the arc edge of first surface can utilize the liquid retarding effect effectively to hinder the reverse flow of liquid simultaneously.

Compared with the prior art, the beneficial effects of the utility model are that:

utilize micro-fluidic chip processing technology such as current photoetching, etching, preset layer at micro-fluidic chip forms the utility model structure, can effectual realization liquid folk prescription transport, need not to make the chip mould in advance or utilize transporting of external energy control liquid. Will the utility model discloses the structure processing can realize directional control medicine folk prescription to advancing the appearance in the introduction port department of different reaction units, has avoided containing the random flow of medicine liquid in the chip inside to solved the liquid directional distribution problem that micro-fluidic chip was used for medicine analysis to examine time measuring, realized the accurate control of liquid flow direction, improved the efficiency of micro-fluidic chip drug reaction, simplified the flow of drug reaction, need not to recycle methods such as centrifugal force and carry out the distribution of liquid.

Drawings

Fig. 1 is a schematic model diagram of a microstructure unit according to a second embodiment of the present invention.

Fig. 2 is a schematic view of a cross section of a microstructure unit according to a second embodiment of the present invention.

Fig. 3 is a schematic diagram of an array structure according to a second embodiment of the present invention.

Fig. 4 is a schematic model diagram of a microstructure unit according to a second embodiment of the present invention.

Fig. 5 is a schematic view of a cross section of a model of a structural unit according to a second embodiment of the present invention.

Fig. 6 is a schematic diagram of an array structure according to a second embodiment of the present invention.

Reference numbers in the figures: 1 is a model of the microstructure unit of example 1, 2 is a first surface of the microstructure unit of example 1, 3 is a second surface of the microstructure unit of example 1, 4 is an upper surface of the microstructure unit of example 1, 5 is a lower surface of the microstructure unit of example 1, 6 is a left surface of the microstructure unit of example 1, 7 is a right surface of the microstructure unit of example 1, 8 is an arc-shaped contour line of the first surface of the microstructure unit of example 1, 9 is a tangent-plane inclined contour line of the microstructure unit of example 1, 10 is a ridge-like contour line between the microstructure units in the array structure of example 1, and 11 is the array structure of example 1. 12 is a model of the microstructure unit of example 2, 13 is a first surface of the microstructure unit of example 2, 14 is a second surface of the microstructure unit of example 2, 15 is an arc-shaped contour of the first surface of the microstructure unit of example 2, 16 is a tangent-inclined contour of the microstructure unit of example 2, 17 is a ridge-like contour between the microstructure units in the array structure of example 2, and 18 is the array structure of example 2.

Detailed Description

The present invention will be further explained with reference to the accompanying drawings.

Example 1

As shown in FIG. 1, the single secondary structural unit is horseshoe-shaped and is composed of a first surface 2, a second surface 3, a first surface 4, a second surface 5, a first surface 6, a second surface 7, an upper surface, a lower surface, a left surface and a right surface. As shown in FIG. 2, the first surface 2 has an arc-shaped edge 8, which forms an inclined angle of 45 degrees with the upper surface of the structural unit, and 9 is a section inclined contour line of the structural unit. In the example, the arc-shaped edge of the first surface is the arc length of a circular arc with a radius of 34 μm, the second surface 3 is the arc length of a circle with a radius equal to 35.4 μm, the first and second surfaces are both cylindrical surfaces, and the other four surfaces are both planar surfaces.

The individual elements are laid out in a linear array in the XY directions on the plane, and the ridge structure with a width of about 10 μm is formed between the two structural elements, and in practice, the linear array is machined on the surface of the desired workpiece, and the liquid flows in a direction inclined to the first surface of the structural elements. When liquid contacts the unit structure, the single structural unit can be quickly submerged under the action of capillary force under the capillary phenomenon of the liquid and spread to the next structural unit, and the pinning effect of the liquid can be generated due to the arc-shaped edge of the first surface of the structural unit in the opposite direction of the liquid flow, so that the liquid can be transported only in one direction. Likewise, it is within the scope of this patent to spread the structure over a surface such as a curved surface, a surface of revolution, or the like during practical use.

Example 2

As shown in fig. 4, when the second surface exists, the arc-shaped edge may also be a straight line edge, and the inclination angle of the second surface may also be any angle smaller than that, although the second surface is designed into a slope surface, which can effectively reduce the liquid advancing resistance and increase the liquid transportation speed, but does not determine the core function of the microstructure surface, so that two arc-shaped edges are combined into one, the second surface does not exist any more, and the second surface and the structural upper surface are modified into a slope surface structure, wherein 13 is the first surface of example 2, and 14 is the structural unit upper surface, wherein the arc-shaped edge of the first surface is an arc length of an arc with a radius of 34 μm. As shown in FIG. 5, the first surface 13 has an arcuate edge 15 which is inclined at an angle of 45 degrees to the horizontal plane of the upper surface of the structural unit, and 16 is the tangential inclined profile of the structural unit.

The individual elements are laid out in a linear array in the XY directions on the plane, and the ridge structure with a width of about 10 μm is formed between the two structural elements, and in practice, the linear array is machined on the surface of the desired workpiece, and the liquid flows in a direction inclined to the first surface of the structural elements. When liquid contacts the unit structure, a single structural unit can be quickly submerged under the action of capillary force under the capillary phenomenon of the liquid and can be extended to the next structural unit, in the opposite direction of liquid flow, the structural unit cancels the second surface, the liquid can quickly and reversely climb to the arc-shaped edge of the first surface, and the arc-shaped edge of the first surface of the structural unit can generate the pinning effect of the liquid, so that the liquid can be transported only in one direction. Likewise, it is within the scope of this patent to spread the structure over a surface such as a curved surface, a surface of revolution, or the like during practical use.

Claims

1. An array structure for a preset layer of a microfluidic chip is characterized in that the array structure is formed by linearly arranging and spreading microstructure units in the horizontal direction and the vertical direction; the microstructure unit is a hexahedron consisting of six surfaces, namely a front surface, a rear surface, an upper surface, a lower surface, a left surface and a right surface, and is similar to a horseshoe shape; wherein the front surface is also called the first surface as a concave surface, and the back surface is also called the second surface as a convex surface; the upper surface, the lower surface, the left surface and the right surface are planes; the first surface and the upper surface form a certain inclination angle, the inclination angle range is 20-90 degrees, the second surface and the upper surface form a certain inclination angle, and the inclination angle range is not limited;

the micro-structure units are spread in the vertical direction to form columns of an array structure, and the micro-structure units are spread in the horizontal direction to form rows of the array structure; the columns of the array structure are provided with ridge-shaped separation, the width of the ridge-shaped separation does not exceed the width of the microstructure unit, and the distance between the rows of the array structure is larger than the length of the microstructure unit.

2. The array structure for the preset layer of the microfluidic chip according to claim 1, wherein the left and right surfaces of the microstructure unit are parallel, and the upper and lower surfaces are also parallel.

3. The array structure for the preset layer of the microfluidic chip according to claim 1, wherein the microstructure unit has a special structure of a pentahedron, in which the upper surface and the second surface smoothly transition to form a curved surface, also called as the upper surface.

4. The array structure for the preset layer of the microfluidic chip according to claim 1, wherein the size of the microstructure unit is determined according to actual requirements, and the maximum range of the microstructure unit is micrometer.