CN110052299A - A kind of array structure for presetting layer for micro-fluidic chip - Google Patents
A kind of array structure for presetting layer for micro-fluidic chip Download PDFInfo
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- CN110052299A CN110052299A CN201910390951.7A CN201910390951A CN110052299A CN 110052299 A CN110052299 A CN 110052299A CN 201910390951 A CN201910390951 A CN 201910390951A CN 110052299 A CN110052299 A CN 110052299A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
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Abstract
The invention belongs to microfluidic art, specially a kind of array structure that layer is preset for micro-fluidic chip.Array structure of the present invention is sprawled by horizontally and vertically linear array by microstructure unit and is formed；Microstructure unit is by a hexahedron of front, rear, top, and bottom, left and right six surface compositions；Front surface is concave surface, and rear surface is convex surface；Certain inclination angle is presented between first surface and upper surface；There is carinate separation between the column of array structure, the width of the carinate separation is no more than the width of microstructure unit, and spacing is greater than the length of microstructure unit between the row of array structure.The tilt angle of microstructure unit front surface allows the liquid to be transported using capillary phenomenon, the curved edge of front surface can effectively hinder the reverse flow of liquid using liquid retarding effect, to solve the problems, such as liquid fixed direction allocation of the micro-fluidic chip for Pharmaceutical Analysis detection when, the efficiency of micro-fluidic chip drug response is improved.
Description
Technical field
The invention belongs to microfluidic arts, and in particular to a kind of micro-fluidic chip presets the array structure of layer.
Background technique
In recent years, the development of microfluidic field includes chemical synthesis, pharmacodiagnosis, single cell analysis, micro-nano manufacture etc.
Technological revolution is caused in many subjects, wherein microflow control technique is to develop one of most rapid branch nearly ten years.It is micro-fluidic
Technology is often referred to involved by the system using the minute fluid of microchannel manipulation or processing nanoliter magnitude that scale is hundred micron dimensions
And intersection Science and Technology, be related to the intersection in the fields such as biology, medicine, chemistry, fluid physics, material, microelectronics
Subject.In Biochemistry Experiment, the basic operations process such as sample preparation, separation detection, cell culture is usually concentrated on one
Block scale is to operate on centimetres chip, the micro-fluidic chip, chip lab, complete point micro- so micro fluidic device is otherwise known as
Analysis system.
Although micro-fluidic chip has big advantage, for example low cost, reaction speed are fast, reagent consumption dosage is small, collection
At miniaturization and automation etc., but micro-fluidic chip is there is no real " walking out laboratory ", is widely used and height
Industrialization, one of crucial problem is exactly that the control problem of microfluid not can effectively solve, and this problem is examined in biology
Survey field is especially prominent.While realizing the reaction of multiple samples under more reaction members or multiple indexs using micro-fluidic chip
When detection, liquid is distributed usually using centrifugal force, generates centrifugal force using rotary chip, liquid distributes under the driving of centrifugal force
To each unit, but in this process, there are also to be improved for the technologies such as the sample introduction of drug, microchannel interior walls modification.
In conclusion how effectively in the sample introduction and fixed direction allocation liquid of micro-fluidic chip internal control drug, to mention
The reliability of high drug response is current micro-fluidic chip for drug tests urgent problem to be solved.
Summary of the invention
It is an object of the invention to design one kind can effectively control drug sample introduction and orientation point inside micro-fluidic chip
Micro-fluidic chip with liquid presets the array structure of layer, to solve the drug control problem in micro-fluidic chip.
The micro structure array that the present invention designs presets the processing of layer for micro-fluidic chip, as desired by the micro-structure
Position is formulated in chip to sprawl, and surface is processed and modified, and realizes that the orientation of the drug inside micro-fluidic chip is defeated
Fortune and distribution.
The array structure that the present invention designs, it is linear by horizontal direction (transverse direction) and vertical direction (longitudinal direction) by microstructure unit
Arrangement sprawls to be formed；The microstructure unit be by a hexahedron of front, rear, top, and bottom, left and right six surface compositions, it is similar
The shape of a hoof；Wherein, front surface (also referred to as first surface) is concave surface, and face shape can appoint for cylindrical surface, paraboloid or saddle camber etc.
One kind of anticipating curved surface, rear surface (also referred to as second surface) are convex surface, and face shape is that any types such as cylindrical surface, paraboloid or saddle camber are bent
Face；Four surfaces are plane up and down；Certain inclination angle, tilt angle ranges 20 are presented between first surface and upper surface
~90 degree (preferably 40-55 degree) is spent, certain inclination angle is presented in second surface and upper surface, which does not limit,
Generally 10 degree~90 degree.Referring to shown in Fig. 1, Fig. 2.
In the present invention, typically, in microstructure unit, left and right two surfaces are parallel, and upper and lower two surfaces are also parallel.
In the present invention, particularly, in microstructure unit, upper surface and second surface seamlessly transit to form a curved surface, still
Referred to as upper surface, then microstructure unit is the special construction of pentahedron.
In array structure of the invention, microstructure unit is sprawled in a vertical direction (i.e. by the front and rear surfaces of microstructure unit
Sprawl in direction), the file of array structure is formed, microstructure unit is sprawled by horizontal direction (i.e. by the left and right table of microstructure unit
Sprawl in face direction), form the row of array structure；There is carinate separation between the file of array structure, the width of the carinate separation
No more than the width of microstructure unit (spacing between i.e. left and right two surfaces), spacing is greater than between the row of array structure
The length (spacing i.e. between former and later two surfaces) of microstructure unit, referring to shown in Fig. 3, Fig. 6.
In the present invention, the size of microstructure unit can zoom in or out, amplification range according to actual needs
Usually in micron dimension, otherwise for the structure in micron dimension liquid directed transport, effect will receive a degree of influence.
In the present invention, the processing method of microstructure unit can be the existing processing methods such as photoetching, coining or 3D printing
It is any.
The operation principle of the present invention is that the tilt angle of microstructure unit first surface allows the liquid to utilize capillary phenomenon
It is transported, while the curved edge of first surface can effectively hinder the reverse flow of liquid using liquid retarding effect.
Compared with prior art, the beneficial effects of the present invention are:
Using the micro-fluidic chips processing technology such as existing photoetching, etching, knot of the present invention is formed in the default layer of micro-fluidic chip
Structure can effectively realize that the one direction of liquid transports, without making Chip mold in advance or controlling liquid using external energy
Transport.Structure of the invention is machined at the injection port of differential responses unit, can be realized oriented control drug one direction into
Sample, avoids the random flowing in drug containing liquid portion in the chip, detects to solve micro-fluidic chip for Pharmaceutical Analysis
When liquid fixed direction allocation problem, realize liquid flow direction accurately control, improve micro-fluidic chip drug response efficiency, letter
The process for having changed drug response no longer needs to the distribution that liquid is carried out using the methods of centrifugal force.
Detailed description of the invention
Fig. 1 is the model schematic of the microstructure unit of second example of the invention.
Fig. 2 is the model section schematic diagram of the microstructure unit of second example of the invention.
Fig. 3 is the array structure schematic diagram of second example of the invention.
Fig. 4 is the model schematic of the microstructure unit of second example of the invention.
Fig. 5 is the model section schematic diagram that second example of the invention is structural unit.
Fig. 6 is the array structure schematic diagram of second example of the invention.
Figure label: 1 is the model of the microstructure unit of example 1, and 2 be the first surface of the microstructure unit of example 1,3
It is the second surface of 1 microstructure unit of example, 4 be the upper surface of 1 microstructure unit of example, and 5 be under 1 microstructure unit of example
Surface, 6 be the left surface of 1 microstructure unit of example, and 7 be the right surface of 1 microstructure unit of example, and 8 be the micro-structure list of example 1
The arc wheel profile of the first surface of member, 9 be the section angle wheel profile of 1 microstructure unit of example, and 10 be 1 array structure of example
In microstructure unit between ridge profile, 11 be the array structure of example 1.12 be the model of the microstructure unit of example 2, and 13 are
The first surface of the microstructure unit of example 2,14 be the second surface of 2 microstructure unit of example, and 15 be the micro-structure list of example 2
The arc wheel profile of the first surface of member, 16 be the section angle wheel profile of 2 microstructure unit of example, and 17 be 2 array junctions of example
Ridge profile between microstructure unit in structure, 18 be the array structure of example 2.
Specific embodiment
Below in conjunction with attached drawing, the present invention is further described.
Embodiment 1
As shown in Figure 1, single secondary building unit is in horse-hof shape, by key surface first surface 2, second surface 3 and 4,5,
6,7 four faces compositions up and down.As shown in Fig. 2, wherein first surface 2 has curved edge 8, it is in structural unit upper surface
45 ° of inclinations angle, 9 be the section angle wheel profile of structural unit.In instances, it is 34 μm that the curved edge of first surface, which is radius,
Circular arc one section of arc length, second surface 3 is one section arc length of the radius equal to 35.4 μm of circle, and first surface is equal with second surface
For cylindrical surface, other four surfaces are plane.
By individual unit on two direction XY linear array paving plane, by width be about 10 μm between two structural units
Ridge-like structure constitute, when practical application, by linear array processing in required workpiece surface, the flow direction of liquid is structure
The inclined direction of unit first surface.When liquid touches cellular construction, by the work of the capillary force under the capillary phenomenon of liquid
With, it will single structure unit is flooded rapidly, is stretched to next structural unit, in the opposite direction that liquid flows due to the structure
The curved edge of the first surface of unit can generate the pinning effect of liquid, therefore can make liquid that can only unidirectionally transport.Together
Sample, which sprawls in the scope of this patent in the type of the faces such as curved surface, surfaces of revolution in practical application.
Embodiment 2
As shown in figure 4, curved edge can also take linear edge in the presence of second surface, the inclination angle of second surface can also be taken
Any angle being less than improves liquid transporting speed although second surface is designed to that slope surface can effectively reduce liquid advance resistance
Degree, but do not determine the core function of the micro-structure surface, therefore two arc side edge are merged into one, second surface is no longer deposited
Second surface and structure upper surface are being improved to slope structure, wherein 13 be the first surface of example 2, and 14 be structural unit
Upper surface, wherein the curved edge of first surface is one section of arc length of the circular arc that radius is 34 μm.As shown in figure 5, first surface
13 have curved edge 15, are in 45 ° of inclinations angle with structural unit upper surface horizontal plane, and 16 be the section slope profile of structural unit
Line.
By individual unit on two direction XY linear array paving plane, by width be about 10 μm between two structural units
Ridge-like structure constitute, when practical application, by linear array processing in required workpiece surface, the flow direction of liquid is structure
The inclined direction of unit first surface.When liquid touches cellular construction, by the work of the capillary force under the capillary phenomenon of liquid
With, it will single structure unit is flooded rapidly, is stretched to next structural unit, in the opposite direction of liquid flowing, due to the knot
Structure unit eliminates second surface, and liquid snap back can climb to first surface curved edge simultaneously, the structural unit
The curved edge of first surface can generate the pinning effect of liquid, therefore can make liquid that can only unidirectionally transport.Likewise, should
Structure is sprawled in the scope of this patent in the type of the faces such as curved surface, surfaces of revolution in practical application.
Claims (4)
1. a kind of array structure for presetting layer for micro-fluidic chip, which is characterized in that by microstructure unit by horizontal direction and
Vertical direction linearly arranges and sprawls to be formed；The microstructure unit be by front, rear, top, and bottom, left and right six surface compositions one
A hexahedron, the similar shape of a hoof；Wherein, it is concave surface that front surface, which is also referred to as first surface, and it is convex surface that rear surface, which is also referred to as second surface,；On
The surface of lower left and right four is plane；It is presented certain inclination angle between first surface and upper surface, tilt angle ranges are 20 degree~
90 degree, certain inclination angle is presented in second surface and upper surface, which does not limit；
Microstructure unit is sprawled in a vertical direction, forms the column of array structure, and microstructure unit is sprawled by horizontal direction, forms battle array
Array structure row；There is carinate separation between the column of array structure, the width of the carinate separation is no more than the width of microstructure unit, battle array
Spacing is greater than the length of microstructure unit between the row of array structure.
2. the array structure according to claim 1 for presetting layer for micro-fluidic chip, which is characterized in that affiliated micro-structure
In unit, left and right two surfaces are parallel, and upper and lower two surfaces are also parallel.
3. the array structure according to claim 1 for presetting layer for micro-fluidic chip, which is characterized in that the micro-structure
In unit, upper surface and second surface seamlessly transit to form a curved surface, still referred to as upper surface, and then microstructure unit is five faces
The special construction of body.
4. the array structure according to claim 1 for presetting layer for micro-fluidic chip, which is characterized in that the micro-structure
The size of unit, determines according to actual needs, and maximum magnitude is micron dimension.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910390951.7A CN110052299A (en) | 2019-05-11 | 2019-05-11 | A kind of array structure for presetting layer for micro-fluidic chip |
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| CN201910390951.7A CN110052299A (en) | 2019-05-11 | 2019-05-11 | A kind of array structure for presetting layer for micro-fluidic chip |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113289700A (en) * | 2021-05-14 | 2021-08-24 | 北京航空航天大学 | Density gradient microstructure, preparation method of density gradient microstructure and magnetic control switch |
| CN113477285A (en) * | 2021-07-21 | 2021-10-08 | 杜林� | Micro-droplet array chip system and method |
| CN114547853A (en) * | 2022-01-12 | 2022-05-27 | 大连理工大学 | Design method and application of three-dimensional porous inclined array structure for liquid directional transportation |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113289700A (en) * | 2021-05-14 | 2021-08-24 | 北京航空航天大学 | Density gradient microstructure, preparation method of density gradient microstructure and magnetic control switch |
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| CN114547853A (en) * | 2022-01-12 | 2022-05-27 | 大连理工大学 | Design method and application of three-dimensional porous inclined array structure for liquid directional transportation |
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