CN210109125U - Full-automatic streamline chemiluminescence analyzer - Google Patents

Abstract

The utility model relates to a full-automatic streamlined chemiluminescence analysis appearance relates to chemiluminescence immunoassay technical field for solve the technical problem that chemiluminescence analysis appearance's that exists among the prior art detection efficiency is low. The utility model discloses a full-automatic streamlined chemiluminescence analyzer, including host computer unit, temporary storage unit and track conveying mechanism, through setting up the temporary storage unit in the right side of host computer unit, make every host computer can share a track conveying mechanism, therefore just shift to next host computer through the track conveying mechanism and carry out next item and detect after accomplishing an item and detect, thus reduced the time of shifting between the different host computers, improved the efficiency that detects; meanwhile, the track conveying mechanism can selectively convey the sample rack on the track conveying mechanism to the sample detection position of the corresponding host machine for detection by receiving different instructions, so that the detection efficiency is improved.

Description

Full-automatic streamline chemiluminescence analyzer

Cross Reference to Related Applications

This application claims priority to chinese patent application CN201821422937.8 entitled "full-automatic chemiluminescence analyzer" filed on 31/08/2018, the entire contents of which are incorporated herein by reference.

Technical Field

The utility model relates to a chemiluminescence immunoassay technical field especially relates to a full-automatic streamlined chemiluminescence analysis appearance.

Background

Chemiluminescence immunoassay is a non-radioactive immunoassay which is developed rapidly in recent years, and the principle is that a chemiluminescence substance is used for amplifying signals and an immunological binding process is directly measured by virtue of the luminous intensity, and the method is one of important directions of immunological detection. In the existing chemiluminescence analyzer, a sample sending module can only convey a sample to one host, so each host needs to be provided with an independent sample sending module and an independent sample storage unit, and a sample rack needs to be transferred to the next host after one detection is finished, so that a large amount of time is wasted, and the detection efficiency is low.

SUMMERY OF THE UTILITY MODEL

The utility model provides a full-automatic streamlined chemiluminescence analysis appearance for solve the technical problem that the detection efficiency of the chemiluminescence analysis appearance that exists among the prior art is low.

The utility model provides a full-automatic streamlined chemiluminescence analyzer, include:

the host unit comprises a plurality of hosts which are sequentially arranged, wherein the hosts are used for acquiring samples positioned at the sample detection positions and detecting the samples;

the temporary storage unit is used for storing a sample frame for bearing a sample, the temporary storage unit is positioned on one side of the host unit, and comprises a waiting area and a turnover area which are sequentially arranged

The track conveying mechanism is used for connecting the host unit with the temporary storage unit, the sample frame in the area to be detected is conveyed to the sample detection position of each host in sequence by the track conveying mechanism, and the sample frame in each sample detection position after each host completes corresponding operation is conveyed to the turnover area by the track conveying mechanism.

In one embodiment, the main machines are sequentially arranged along the direction from the first end to the second end of the track conveying mechanism.

In one embodiment, the number of hosts is at least two.

In one embodiment, the number of hosts is at least three.

In one embodiment, the buffer unit further comprises a inspected area, and the inspected area is located between the area to be inspected and the transferring area.

In one embodiment, the sample rack in the transfer area is transported to the waiting area or the examined area respectively, and when the detection result of the sample on the sample rack in the transfer area meets the requirement, the sample rack is transported to the examined area; when the detection result of the sample on the sample rack in the turnover area does not meet the requirement, the sample rack is conveyed to the waiting area.

In one embodiment, the turnaround area is provided with a push-back track for transporting the sample racks, by which the turnaround area transports the sample racks to the staging area or the inspected area.

In one embodiment, the track conveying mechanism comprises a detection track and a return pushing track, the detection track is used for connecting the temporary storage unit and each sample detection position, the sample frames in the to-be-detected area are conveyed to the sample detection position by the detection track, and the return pushing track is used for conveying the sample frames in the sample detection position back to the turnover area.

In one embodiment, the detection track and the push-back track are arranged in parallel.

In one embodiment, the detection track and the push-back track are transported in opposite directions.

In one embodiment, the conveying direction of the detection track is from right to left, and the conveying direction of the retreat track is from left to right.

In one embodiment, an orbit transferring mechanism is arranged between the detection track and the retreating and pushing track, and the orbit transferring mechanism is used for pushing the sample rack on the detection track onto the retreating and pushing track.

In one embodiment, the inspection area is provided with a sample rack pushing mechanism for pushing a sample rack on the inspection area onto the detection track.

In one embodiment, the turnaround area is provided with a retrieval pusher for pushing a sample rack on the retraction track to the turnaround area.

In one embodiment, the track transport mechanism further comprises an emergency track for transporting the sample rack of the area to be inspected to an emergency sample testing position of the host computer.

In one embodiment, the emergency track and the detection track are arranged in parallel.

In one embodiment, the direction of transport of the emergency track and the detection track is the same.

In one embodiment, the sample rack is provided with an electronic tag for marking the sample.

In one embodiment, the host comprises a sample feeding arm module and a reagent arm module, wherein the sample feeding arm module transfers the sample at the sample detection position into the reaction cup, and the reagent arm module transfers the reagent into the reaction cup and mixes and incubates with the sample in the reaction cup.

In one embodiment, the sample application arm module comprises a support and an arm assembly, wherein the arm assembly is arranged at the upper part of the support.

In one embodiment, the host comprises a cup-arranging module disposed behind the sample-adding arm module and a cup-loading module disposed between the cup-arranging module and the incubation module.

In one embodiment, the host comprises a detection module disposed above the incubation module, and the detection module performs optical excitation on the sample in the reaction cup after the incubation is finished and detects a luminescence signal generated after the excitation.

In one embodiment, the detection module comprises an excitation portion for emitting excitation light and exciting the object to be detected and a detection portion for receiving and detecting a luminescence signal generated by the object to be detected.

In one embodiment, the excitation portion and the detection portion do not operate simultaneously.

In one embodiment, the excitation part comprises an exciter capable of emitting red excitation light of 600-700 nm; the detection part comprises a detector which is a single photon counter, a photomultiplier, a silicon photocell or a photometric integrating sphere.

In one embodiment, the excitation portion includes an excitation light path, and the detection portion includes a signal light path, the excitation light path being on and off at different times from the signal light path.

In one embodiment, a first switch for controlling the excitation light path to be turned on or off is disposed on the excitation light path, a second switch for controlling the signal light path to be turned on or off is disposed on the signal light path, and the first switch and the second switch are linked in reverse.

Compared with the prior art, the utility model has the advantages of: the temporary storage unit is arranged on the right side of the host unit, so that each host can share one rail conveying mechanism, and the host is transferred to the next host for the next detection through the rail conveying mechanism after one detection is finished, thereby reducing the time for transferring different hosts and improving the detection efficiency; meanwhile, the track conveying mechanism can selectively convey the sample rack on the track conveying mechanism to the sample detection position of the corresponding host machine for detection by receiving different instructions, so that the detection efficiency is improved.

Drawings

The present invention will be described in more detail hereinafter based on embodiments and with reference to the accompanying drawings.

Fig. 1 is a top view of a fully automatic streamlined chemiluminescent analyzer in an embodiment of the present invention;

FIG. 2 is a top view of the sample holder shown in FIG. 1;

fig. 3 is a top view of the host shown in fig. 1.

In the drawings, like components are denoted by like reference numerals. The figures are not drawn to scale.

Reference numerals:

a host unit 10;

1-a host;

11-a sample application arm module;

12-a reagent arm module;

13-a detection module;

14-reaction cup; 15-a reagent module; 151-first reagent disk; 152-a second reagent tray;

16-a cup loading module;

17-cup arranging module;

18-a cup moving and discarding module; 19-an incubation module; 191-first incubation tray; 192-a second incubation tray;

2-temporary storage unit, 21 turnover area, 22 to-be-detected area and 23 detected area;

3-a rail conveying mechanism;

31 detecting the track; 32 retreat pushing track, 33 emergency treatment track;

34-test tube bar code scanner, 35-test tube type discriminator and 36-sampling pusher;

4-pushing back the orbit, 41-the first cycle pushing hands, 42-the second cycle pushing hands;

5-a track changing mechanism, 6-a recovery pushing handle and 7-a sample frame propelling mechanism;

8-sample rack, 81-test tube rack, 82-test tube.

Detailed Description

The present invention will be further explained with reference to the accompanying drawings.

As shown in fig. 1, the utility model provides a full-automatic streamlined chemiluminescence analyzer, it includes host computer unit 10, temporary storage unit 2 and track conveying mechanism 3. The host unit 10 comprises a plurality of hosts 1 which are sequentially arranged, wherein the hosts 1 are used for obtaining samples located at sample detection positions and detecting the samples; the temporary storage unit 2 is used for storing a sample rack 8 for bearing samples; and the rail conveying mechanism 3 is positioned between the host machine 1 and the temporary storage unit 2 and is used for connecting the host machine 1 and the temporary storage unit 2, and after each host machine 3 completes corresponding operation, the sample rack 8 of each sample detection position is conveyed to the turnover area 21 of the temporary storage unit 2 by the rail conveying mechanism 3, namely the rail conveying mechanism 3 is a channel for conveying the sample rack 8 between the temporary storage unit 2 and the host machine 1. As shown in fig. 1, the buffer unit 2 is disposed at one side of the main unit 10, and the main units 1 are sequentially disposed along a direction from a first end to a second end (from left to right) of the track conveying mechanism 3. The number of hosts 1 is at least 3, and the embodiment shown in fig. 1 is a host unit 10 having 3 hosts 1.

It should be noted that the operations performed by the host 1 of the present invention include absorbing a sample, adding a reagent, incubating, and detecting, and the specific operations will be described below.

The temporary storage unit 2 comprises a to-be-detected area 22 and a turnover area 21 which are sequentially arranged, a sample frame of the to-be-detected area 22 is conveyed to a sample detection position by the rail conveying mechanism 3, and a sample frame 8 of the sample detection position is conveyed to the turnover area 21 by the return pushing rail 32 after the operation of the host 1.

Through setting up turnover area 21, make track conveying mechanism 3 transport the sample to sample detection position (A department) after, as long as can transport it back turnover area 21 after the corresponding operation of host computer 1 is accomplished and wait for the testing result, and need not to wait for the testing result at sample detection position, consequently can make the transport efficiency of sample improve greatly to improve the efficiency that detects.

In one embodiment, the sample rack 8 of the sample testing position after the host 1 completes the operation of adding the reagent is transported to the turnaround area 21 by the back-push track 32.

Further, the buffer unit 2 further comprises a inspected zone 23, and the inspected zone 23 is located between the waiting zone 22 and the turnaround zone 21. The sample rack 8 in the turnaround area 21 is transported to the waiting area 22 or the inspected area 23, respectively, and the sample rack 8 waits for the inspection result in the turnaround area 21. When the sample detection result on the sample rack 8 in the turnover area 21 meets the requirement, the sample rack 8 is transported to the detected area 23; when the result of the sample detection on the sample rack 8 in the turnaround area 21 is not satisfactory, the sample rack 8 is transported to the waiting area 22 for the second detection.

The turnaround area 21 is provided with a return track 4 for transporting the sample racks 8, and the turnaround area 21 transports the sample racks 8 to the inspection area 22 or the inspected area 23 through the return track 4, i.e. the return track 4 is a passage for transporting the sample racks 8 between the turnaround area 21 and the inspection area 22 and between the turnaround area 21 and the inspected area 23. And the push-back track 4 is respectively provided with a first circulation pushing hand 41 and a second circulation pushing hand 42, wherein the first circulation pushing hand 41 pushes the sample rack 8 of which the detection structure on the push-back track 4 meets the requirement into the detected area 23, and the second circulation pushing hand 42 pushes the sample rack 8 of which the detection structure on the push-back track 4 does not meet the requirement into the to-be-detected area 22 for further detection.

The track conveying mechanism 3 comprises a detection track 31 and a back-pushing track 32, the detection track 31 is used for connecting the temporary storage unit 2 with the sample detection position, the detection track 31 is used for conveying the sample rack 8 of the to-be-detected area 22 to the sample detection position, the back-pushing track 32 is used for conveying the sample rack 8 of the sample detection position back to the turnover area 21, namely, the detection track 31 is a channel for conveying the sample rack from the to-be-detected area 22 to the sample detection position, and the back-pushing track 32 is a channel for conveying the sample rack from the sample detection position to the turnover area 21. The conveying efficiency of the samples can be improved by conveying the undetected samples and the detected samples through different tracks.

Specifically, the detection rail 31 and the retreat rail 32 are both belt conveying mechanisms. And the detection track 31 and the retreat pushing track 32 are both provided with a baffle plate for preventing the sample rack 8 from shaking in the transportation process.

Wherein the detection track 31 and the backward pushing track 32 are arranged in parallel. The detection rail 31 and the retreat rail 32 are transported in opposite directions. As shown in fig. 1, the direction indicated by an arrow in the figure is the conveying direction of the rail conveying mechanism 3, the conveying direction of the detection rail 31 is from right to left, and the conveying direction of the retreat rail 32 is from left to right. The advantage of this arrangement is that a plurality of main machines 1 can be connected in parallel, thereby improving the capability of the whole machine for processing samples.

Further, a test tube position sensing device for sensing the position of the sample rack 8 is arranged on the sample rack 8, and when the test tube position sensing device senses that the sample rack 8 reaches the sample detection position, the sample adding arm module 11 receives a sample sucking instruction, so that the sample in the sample rack 8 is transferred to the reaction cup.

Further, an electronic tag for marking the sample is provided on the sample rack 8. Specifically, as shown in fig. 2, each sample rack 8 includes a test tube rack 81 and test tubes 82 arranged in the test tube rack 81, each test tube rack 81 is provided with one test tube 82 for placing a sample, for example, as shown in fig. 1, each sample rack 8 carries 10 test tubes 82, and each test tube 82 is provided with an electronic tag at a corresponding position for representing a sample in the test tube 82.

The test tube barcode scanner 34 is arranged between the detection track 31 and the to-be-detected area 22, and the sample rack 8 passes through the test tube barcode scanner 34 before entering the detection track 31, so as to obtain the property and type of the reagent in the test tube 82.

In one embodiment, the first sensor and the second sensor are respectively disposed on the test tube type discriminator 35, the first sensor is located above the second sensor, the first sensor and the second sensor are respectively disposed with a detecting rod facing the direction of the test tube rack, and the length of the detecting rod of the first sensor is longer than that of the detecting rod of the second sensor. The test tube 82 on the sample rack 8 comprises two specifications of 13mm in diameter and 16mm in diameter, and because the length of the detection rod of the first sensor is longer than that of the detection rod of the second sensor, when the 16mm test tube passes through the test tube type discriminator 35, the detection rod of the first sensor and the detection rod of the second sensor can both touch the test tube 82, and signals of the two sensors are sensed at the moment; and when 13 mm's test tube process test tube type discriminator 35, because the probe rod of second sensor, shorter probe rod touches test tube 82 promptly, can only sense longer probe rod this moment, the sensor signal that first sensor detected promptly, from this, judge the test tube type of process through the sensor signal of sensing different quantity, judge that test tube 82 is the test tube of diameter 13mm, still 16 mm's test tube.

A sampling push handle 36 is arranged at the sample detection position, as shown in fig. 1, the sampling push handle 36 is located at the leftmost side of the detection track 31, in the operation process of the detection track 31, the leftmost sample rack 8 firstly touches the sampling push handle 36, then the sample rack 8 is blocked and cannot advance continuously, at this time, the position of the leftmost test tube 82 on the sample rack 8 is the sample detection position, the sample arm module 11 samples at the position, and then the sampling of the first test tube 82 is finished; after finishing sampling, the sampling pushing handle 36 moves a distance leftwards and then stops, the sample rack 8 also continues to move leftwards for the same distance along with the detection track 31 due to the loss of obstruction, at this time, the second test tube 82 from left to right on the sample rack 8 moves to the detection position, at this time, the sampling arm module 11 samples at the position, the second test tube 82 samples, and so on, and all samples on the sample rack 8 enter the backward pushing track after finishing sampling.

Further, the sampling push handle 36 moves leftward by a distance between two test tubes 82, for example, 20mm, so as to ensure that the subsequent test tube 82 just reaches the position where the previous test tube 82 is located, i.e., the sample detection position, after each movement of the sample rack 8.

Specifically, the sampling push handle 36 is a push plate.

In an embodiment, whether there is a test tube on the sample rack 8 and whether to add sample to the reagent in the test tube is determined, if there is a test tube and the reagent in the test tube needs to be added, then the sample adding arm module 11 absorbs the sample therein to add sample, so as to quickly and accurately add sample to the target test tube.

In addition, a track changing mechanism 5 is provided between the detection track 31 and the retreat pushing track 32, and the track changing mechanism 5 is used for pushing the sample rack 8 on the detection track 31 to the retreat pushing track 32. The detection track 31 conveys the sample rack 8 to the sample detection position and then waits for the host 1 to operate, after the host 1 finishes operating, the sample rack 8 on the detection track 31 is pushed to the return pushing track 32 through the track changing mechanism 5, and is conveyed to the turnover area 21 through the return pushing track 32.

Specifically, the track transfer mechanism 5 is a mechanical pushing hand, and pushes the sample rack 8 on the detection track 31 in the Y-axis direction (perpendicular to the running direction thereof), and since the detection track 31 and the retreating track 32 are arranged in parallel, the sample rack 8 on the detection track 31 can be pushed onto the retreating track 32 without affecting the running thereof.

The inspection area 22 is provided with a sample rack pushing mechanism 7, and the sample rack 8 pushing mechanism 7 is used for pushing the sample rack 8 on the inspection area 22 onto the detection track 31. Wherein the sample rack pushing mechanism 7 is a mechanical pushing handle.

The turnover area 21 is provided with a recovery pushing handle 6, and the recovery pushing handle 6 is used for pushing the sample rack 8 on the back pushing track 32 to the turnover area 21. As shown in fig. 1, the recovery pushing hand 6 first pushes the sample rack 8 closest to the transferring area 21 on the backward pushing track 32 into the transferring portion of the transferring area 21, and then sequentially pushes the sample racks 8 on the backward pushing track 32 into the transferring portion of the transferring area 21, and the recovery pushing hand 6 pushes one sample rack 8 into the transferring area 21 at a time, and the sample rack 8 that enters the transferring area 21 later pushes the sample rack 8 that enters the transferring area 21 first to move upward until the sample rack 8 that enters the transferring area 21 first reaches the top end of the transferring area 21.

When the detection result of the sample rack 8 reaching the top end of the turnover area 21 meets the requirement, the first circulating pushing handle 41 receives the pushing instruction, and the first circulating pushing handle 41 pushes the sample rack 8 into the detected area 23; similarly, when the non-detection result of the sample rack 8 reaching the top end of the turnaround area 21 meets the requirement, the second circulation pushing handle 42 receives the pushing instruction, and the second circulation pushing handle 42 pushes the sample rack 8 into the waiting area 22.

Additionally, the utility model discloses still provide sample detection's emergency call passageway. Specifically, the rail transport mechanism 3 further includes an emergency rail 33 for transporting the sample rack 8 of the waiting area 22 to an emergency sample inspection position of the main machine 1. Wherein the emergency track 33 and the detection track 31 are arranged in parallel, and the running directions of the emergency track 33 and the detection track 31 are the same.

The priority level of the emergency track 33 is higher than that of the inspection track 31, i.e. the specimen racks 8 on the emergency track 33 have the authority to perform the inspection preferentially. When the sample rack 8 on the emergency track 33 is transported to the emergency sample detection position, the detection track 31 will stop running, and the sample-adding arm module 11 receives the instruction of sucking the sample from the emergency detection position, and then stops sucking the sample from the sample rack 8 on the detection track 31, and sucks the sample from the sample rack 8 on the emergency track 33.

In addition, the emergency track 33 has a function, when the previous sample rack 8 on the detection track 31 needs to enter the rightmost main machine 1 for detection, and the subsequent sample rack 8 needs to enter the leftmost main machine 1 for detection, at this time, the subsequent sample rack 8 does not need to wait for the previous sample rack 8 to enter the rightmost main machine 1, but can directly enter the leftmost main machine 1 for detection through the emergency track 33, so that the emergency channel can improve the detection efficiency and the conveying capacity of the system.

As shown in fig. 3, one of the hosts 1 will be described as an example.

As shown in fig. 3, the host 1 includes a sample feeding arm module 11, a reagent arm module 12, and a detection module 13 disposed above an incubation module 19, wherein the sample feeding arm module 11 transfers a sample at a sample detection position into a reaction cup 14, the reagent arm module 12 transfers a reagent in a reagent module 15 into the reaction cup 14 and mixes with the sample in the reaction cup 14, then the reaction cup 14 is incubated in the incubation module 19, and after the incubation is finished, the detection module 13 performs optical excitation on the sample in the reaction cup and detects a luminescent signal generated after the excitation.

Incubation module 19 includes that first incubation dish 191 and first incubation dish 192 are hatched, and reagent module 15 includes first reagent dish 151 and second reagent dish 152, and it drives the rotation through the motor to hatch the dish, is equipped with between first incubation dish 191 and first incubation dish 192 and moves cup and abandons a cup module 18, moves cup and abandons a cup module 18 and includes pushing away a cup track and abandoning a cup track, pushes away and abandons through the electronic track transform of going on of straight line between a cup track and the abandoning a cup track. When the incubation time of the cuvettes on the first incubation tray 191 is over, the cuvettes 14 rotate to the cuvette removing position of the first incubation tray 191 and the cuvettes of the first incubation tray 192 also rotate to the cuvette removing position, at this time, the cup moving and discarding module 18 is started, the track is moved to the cup discarding track, and the cuvettes of the first incubation tray 192 are discarded; then the cup removing and discarding module 18 switches to the cup moving track to push the detection reaction cups of the first incubation plate 191 to the first incubation plate 192.

In one embodiment, the sample-adding arm module 11 comprises a support and an arm assembly, wherein the arm assembly is arranged at the upper part of the support, the support is further provided with an up-and-down movement assembly and a rotation movement assembly, the up-and-down movement assembly enables the arm assembly to move up and down relative to the support, and the rotation movement assembly enables the arm assembly to rotate relative to the support.

The arm component comprises a connecting arm, one end of the connecting arm is vertically and fixedly connected with a sample needle, the other end of the connecting arm is vertically and fixedly connected with a spline shaft, and the spline shaft can transmit motion in a linear direction and can also transmit torque in a circumferential direction. The sample needle is fixedly connected with the spline shaft through the connecting arm, so that the sample needle can move along with the up-and-down movement or the rotating movement of the spline shaft.

In one embodiment, the up-and-down motion assembly comprises a first motor, the first motor is connected with a first driving wheel, the first driving wheel is connected with a first driven wheel through a second synchronous belt, a moving block is fixed on the second synchronous belt, the lower end of the spline shaft penetrates through the moving block, after the first motor is started, the first driving wheel is driven to rotate so as to drive the second synchronous belt to rotate, the moving block moves up and down along with the rotation of the second synchronous belt, and the spline shaft moves up and down along with the moving block so as to drive a sample needle fixedly connected with the spline shaft through a connecting arm.

Preferably, the upper end and the lower end of the moving block are provided with retaining rings to prevent the spline shaft from moving up and down relative to the moving block.

In one embodiment, the rotary motion assembly comprises a second motor, the second motor is connected with a second driving wheel, the second driving wheel is connected with a second driven wheel through a third synchronous belt, a rotary block is arranged at the upper part of the second driven wheel, and the second driven wheel and the rotary block are both sleeved outside the spline shaft. When the second motor is started to drive the third synchronous belt to rotate, the third synchronous belt drives the second driven wheel to rotate. The second is followed the rotation of driving the integral key shaft and is rotated, because the integral key shaft can rotate in rotatory piece inside relatively, thereby the integral key shaft drives the rotary motion of passing through linking arm fixed connection's sample needle with the integral key shaft along with the second from the rotary motion of driving wheel.

Preferably, a flat key is arranged between the second driven wheel and the spline shaft to prevent the spline shaft and the second driven wheel from rotating relatively.

The sample needle of the sample-adding arm module 11 can move along with the up-and-down movement or the rotation movement of the spline shaft. This configuration not only allows the sample needle to be loaded with sample or reagent at different locations; meanwhile, only the spline shaft rotates at the stage, so that the structure is small, the structure is simple, the assembly and the maintenance are convenient, and the cost is low; and the combination of rotation and up-and-down movement is adopted, so that the movement track of the sample needle is determined, the speed is high, the error probability is reduced, and the precision is high.

Cup sorting module 17 is located the back of application of sample arm module 11, and cup sorting module 17 is including the cup portion that is used for holding the reaction cup and the row's of cup device that is located the cup portion bottom. An opening is provided at one side of the cup portion, the opening extending along the top to the bottom of the one side of the cup portion. Wherein, uncovered top to the middle part along dress cup portion one side is the arc transition to make the volume crescent of the top to the middle part of dress cup portion, the inner wall of dress cup portion is smooth setting, under the effect of the smooth inner wall of dress cup portion, can make reaction cup 14 get into fast and arrange in the cup device.

The cup discharging device comprises a tray fixedly connected to the bottom of the cup containing part and a reaction cup rotating disc arranged in the tray, and a cup groove matched with the reaction cup 14 is formed in the circumferential edge of the top of the reaction cup rotating disc (the position, contacting with the reaction cup 14, of the reaction cup rotating disc). A first driving part for driving the reaction cups 14 to be discharged from the cup slots is provided at one side of the reaction cup rotating disk. The reaction cup rotating disk is driven to rotate by the first driving device, the reaction cups 14 at the bottom of the cup containing part can be sequentially placed in the cup grooves under the rotating action of the reaction cup rotating disk, and then the reaction cups 14 are orderly and uniformly discharged out of the cup grooves under the action of the first driving part.

The reaction cup slideway communicated with the cup groove is arranged in the reaction cup slideway base, the longitudinal guide groove is arranged on the reaction cup slideway, the transverse guide groove communicated with the longitudinal guide groove is transversely arranged at the bottom of the longitudinal guide groove, and the second driving device used for driving the reaction cups 14 in the transverse guide groove to sequentially slide to the tail end along the transverse guide groove is arranged on one side of the transverse guide groove.

In one embodiment, the second driving device comprises a driving motor and a friction wheel fixedly connected with an output shaft of the driving motor for controlling the movement of the reaction cup 14, the driving motor drives the friction wheel to rotate, during the rotation of the friction wheel, the circumferential side surface of the friction wheel contacts with the flange of the reaction cup 14, and the reaction cup 14 is driven to move towards the tail end of the reaction cup along the transverse guide groove in an upright posture by the acting force between the friction wheel and the reaction cup 14.

Preferably, an electromagnet guide part for controlling the reaction cups to be discharged out of the lateral guide groove is provided at the end of the lateral guide groove, and a contact sensor is provided at the start end of the electromagnet guide part.

The reaction cup in the transverse guide groove stops moving after contacting the contact sensor of the electromagnet guide part.

The cup arranging module 17 can arrange the disordered reaction cups in order, and sequentially pushes the reaction cups to the first incubation disc 191 through the cup feeding module 16, so that the detection efficiency of the sample is improved. Firstly, the reaction cup 14 is placed in the cup loading part through the opening, the first driving device drives the reaction cup rotating disc to rotate anticlockwise, and the reaction cups 14 in the cup loading part sequentially enter the cup grooves. The reaction cup rotating disc rotates anticlockwise to drive the shifting wheel to rotate anticlockwise periodically, reaction cups 14 in the cup grooves can be sequentially laid down and neatly conveyed to the reaction cup slide ways, and then the reaction cups 14 sequentially enter the longitudinal guide grooves and the transverse guide grooves. When the rotating disc of the reaction cup is blocked, the first motor idles under the action of the friction clutch in the first driving device, and the reaction cup 14 blocked on the rotating disc of the reaction cup can be conveniently taken out. When the position of the reaction cup 14 in the longitudinal guide groove reaches the position of the full cup sensor, the reaction cup rotating disc stops rotating. The second motor drives the friction wheel to move, the friction wheel is ensured to be in contact with the reaction cup 14, and the reaction cup 14 is controlled to move from the starting end of the transverse guide groove to the tail end in sequence and in a right-standing posture in a neat and uniform manner. When the cuvette 14 positioned at the end of the lateral guide groove contacts the touch sensor, the movement of the cuvette 14 is stopped, thereby achieving the purpose of making the messy cuvette 14 clean.

The upper cup module 16 is positioned between the cup arranging module 17 and the incubation module 19 and comprises a sliding rail, a cup clamping device, a transmission device, a sliding rail and a reset device, wherein the cup clamping device is connected with the sliding rail in a sliding manner, the transmission device is positioned above the sliding rail and used for controlling the cup clamping device to move along the sliding rail, the sliding rail 169 is positioned below the cup clamping device, the reaction cup 14 is positioned in the sliding rail 169, and the cup clamping device can control the reaction cup 14 to move in the sliding rail 169; the resetting device is used for resetting the cup clamping device, and preferably, the resetting device is fixed above one end of the sliding rail.

The card cup device includes: the device comprises a sliding block, a reaction cup jaw, an electromagnet and a first photocurrent sensor. The slide block is connected with the slide rail in a sliding fit mode, a reaction cup clamping jaw is arranged on one side of the slide block and vertically slides relative to the slide block, a sliding groove for enabling a limiting screw to pass through is formed in the reaction cup clamping jaw, and the limiting screw connects the reaction cup clamping jaw to the slide block through the sliding groove. An electromagnet used for controlling the reaction cup gripper to vertically slide relative to the sliding block is arranged above the reaction cup gripper, wherein the electromagnet is fixedly connected with the sliding block, the reaction cup gripper leaves the electromagnet to move downwards along the sliding groove when the electromagnet is in a power-on state, and the reaction cup gripper is adsorbed at the lower end of the electromagnet when the electromagnet is not in the power-on state. The first photoelectric sensor is arranged on one side of the reaction cup gripper and used for detecting the position of the reaction cup gripper.

The bottom of the reaction cup 14 is hemispherical, the cup body is cylindrical, a cylindrical protrusion is arranged in the center of the bottom of the cup, an outward protruding cup edge is arranged on the periphery of the cup opening, and the diameter of the cup edge is larger than that of the reaction cup 14. The bottom of the reaction cup gripper is provided with a limiting groove, the limiting groove is used for clamping the reaction cup 14, the length of the limiting groove is the same as the diameter of the cup edge, when the reaction cup 14 is moved, the cup edge of the reaction cup 14 is clamped in the limiting groove, and the reaction cup 14 moves along with the movement of the reaction cup gripper. Because the gripper of the reaction cup moves downwards to the edge of the reaction cup when the electromagnet is electrified, the reaction cup 14 only moves horizontally in the slideway 169 along with the gripper of the reaction cup instead of vertically, so that the phenomenon that the reaction cup falls off cannot occur, and the gripper is simple in structure and convenient to assemble and process.

Preferably, the cup clamping device and the sliding rail are perpendicular to each other, an idler wheel and a synchronous belt wheel are arranged at two ends of the sliding rail above the sliding rail respectively, the idler wheel and the synchronous belt wheel are connected together through a synchronous belt, the cup clamping device is perpendicular to the first synchronous belt, the first synchronous belt is driven to rotate through a stepping motor, and when the first synchronous belt rotates, the cup clamping device is driven to move between the cup module 17 and the incubation disc module along the sliding rail.

Preferably, the slide 169 is located below the reaction cup jaws and arranged parallel to the slide, and the reaction cup jaws are induced by the electromagnet to drive the reaction cup 14 to reach the incubation tray module through the slide 169. The reaction cup 14 arranged by the cup arranging module 17 is located at one end of the sliding rail, the electromagnet is started at the moment, the photoelectric sensor inducts that the electromagnet is started to drive the cup clamping gripper to move downwards, the opening at the bottom of the cup clamping gripper clamps the edge of the reaction cup 14, meanwhile, the stepping motor drives the first synchronous belt to rotate, the reaction cup moving device is driven to move towards the direction of the first incubation disc 5 along the sliding rail, and the reaction cup 14 penetrates through the sliding rail 169 to reach the first incubation disc 5.

Preferably, the resetting device is a second photoelectric sensing sensor and comprises an N-shaped groove through which the cup clamping device can pass, after the electromagnet is powered off, the reaction cup clamping jaw moves upwards until the first photoelectric sensor 14 detects that the reaction cup clamping jaw passes through the U-shaped groove of the first photoelectric sensor, the reaction cup clamping jaw is adsorbed on the electromagnet and leaves the reaction cup 14, at the moment, the stepping motor moves to drive the synchronous belt pulley to rotate in the direction opposite to that in the cup feeding process, the first synchronous belt drives the cup clamping device to move in the direction opposite to that in the cup feeding process until the cup clamping device returns to the N-shaped groove of the second photoelectric sensor resetting device, namely, the other end of the incubation disc is returned, and the process of feeding the cup to the resetting process is completed.

Through going up cup module 16, reaction cup 14 can be in the direct plane removal between cup module 17, slide 169, the first dish 5 of hatching, has avoided the problem that the error rate is high, fall the cup and work efficiency is low that snatchs reaction cup 14 at three-dimensional robotic arm tongs causes, in addition, the motor adopts step motor, makes the band pulley operation more steady when controlling the transmission of belt transmission device.

The full-automatic streamlined chemiluminescence analyzer of the invention is detected by the following processes:

the detection track 31 pushes the sample to be detected to a sample suction position; the cup arranging module 17 arranges the unordered reaction cups 14 orderly and neatly, and pushes the reaction cups 14 to the cup feeding positions of the first incubation plate 191 through the cup feeding module 16; subsequently, the first incubation plate 191 is rotated to transfer the reaction cup 14 from the cup feeding position to the sample feeding position; then, the sample application arm module 11 is controlled to rotate by the flow path system, sucks the sample from the test tube reaching the sample suction position in the detection track 31, then rotates to the sample application position of the first incubation plate 191, and applies the sample to the cuvette 14 at the sample application position; if an emergency sample is encountered, the sample adding arm module 11 firstly absorbs the emergency sample, and continues to absorb the sample in the detection track 31 before the emergency sample is taken; then, the sample is diluted by absorbing the diluent through the sample-adding arm module 11, and then the first incubation disk 191 continues to rotate to transfer the cuvette 14 on the sample-adding position from the sample-adding position to the reagent position, and at the same time, the first reagent disk 151 rotates to transfer the reagent on the first reagent disk 151 to the first reagent-absorbing position; the first reagent arm is controlled by the flow path system, sucks a certain amount of first reagent from the reagent sucking position of the first reagent tray 151, rotates to the reagent position of the first incubation tray 191, and adds the first reagent into the reaction cup 14;

subsequently, the first incubation disk 191 continues to rotate to transfer the cuvette 14 from the first reagent position to the second reagent position, and simultaneously the first reagent disk 151 rotates to transfer the reagent to the second reagent aspirating position; the second reagent arm is controlled by the flow path system, a certain amount of second reagent is sucked from the reagent sucking position of the first reagent disc 152, the second reagent is rotated to the second reagent position of the first incubation disc 191, the reagent is added into the reaction cup 14, and the reaction cup 14 containing the mixed solution is rotated to the mixing position by the first incubation disc 191; then, the blending mechanism will blend the sample in the reaction cup 14; thereafter, the reaction cup 14 will be incubated in the first incubation plate 191 by rotation for a certain period. After the incubation time is up, the cuvette 14 is rotated to the cuvette removal position of the first incubation plate 191; meanwhile, the first incubation disc 192 rotates and is transferred to a reaction cup 14 moving-out position, the cup moving and discarding module 18 is started, the track moves to a cup discarding track, and the reaction cup 14 on the second incubation disc 13 is discarded; then the cup removing and discarding module 18 is switched to the cup removing track, and the reaction cup 14 of the first incubation plate 191 to be tested is pushed to the first incubation plate 192. Reaction cup 14 is transferred to the reagent addition position with first incubation tray 192; simultaneously, the second reagent disk 152 rotates to transfer the reagent to the third reagent suction position of the second reagent disk 152; the third reagent arm rotates to suck the third reagent out of the reagent bottle through the control of the flow path system, and then the third reagent arm rotates to the reagent adding position of the second incubation plate to spit the reagent into the reaction cup 14. Thereafter, the reaction cup 14 rotates with the first incubation disk 192. After the incubation time is up, the reaction cup 14 is transferred to the optical path detection device 18, the optical path detection system 18 optically detects the sample in the reaction cup 14, the excitation light emitted by the excitation unit excites the sample to generate a luminescence signal, the luminescence signal is collected and read for a plurality of times, the chemiluminescence signal is converted into a digital signal to be correspondingly processed (the process of detecting the chemiluminescence signal by the detection component comprises collecting the chemiluminescence signal and reading and correspondingly processing the chemiluminescence signal), and then the chemiluminescence signal is transmitted to the control system, so that the control system can detect and analyze the received information.

Reaction cups 14 are then rotated with first incubation tray 192 to index into and out of the reagent cups of first incubation tray 192. Simultaneously, the cup discarding module 18 is started to the cup discarding track to push out the detected reaction cup 14 for discarding. So far, the whole sample detection process is completed.

The whole operation is automatic, so that the problems of individual difference, artificial error, operation specification and other uncertainties in manual operation can be effectively avoided, and the accuracy of chemiluminescence immunoassay is improved.

Further, the first incubation disc 192 rotates to move the same substance to be detected to the detection position for multiple times, so that the detection module 13 detects the substance to be detected for multiple times, and then determines whether there is a HOOK risk in immunoassay.

In some embodiments, the detection position refers to a position where the detection mechanism is located (i.e., a position where the excitation light is generated). Of course, the detection position can also be the position of the substance to be detected on the first incubation tray 192.

The detection module 13 includes an excitation portion for emitting excitation light and exciting the object to be detected and a detection portion for receiving and detecting a light emission signal generated by the object to be detected, and the excitation portion and the detection portion do not operate simultaneously.

In one embodiment, the excitation section comprises an exciter capable of emitting red excitation light of 600-700 nm.

The exciter is disposed above the substance to be tested, and in the exciting portion, the remaining components of the exciting portion may move periodically with the first incubation tray 192 except that the exciter does not move periodically with the first incubation tray 192, which is not limited in the present invention.

In one embodiment, the detection portion comprises a detector, wherein the detector is a single photon counter, a photomultiplier tube, a silicon photocell, or a photometric integrating sphere.

Wherein the wavelength of the luminescence signal which can be detected by the detection part is 520-620 nm.

Similarly, in the detecting part, the remaining components of the detecting part may move periodically with the first incubation tray 192, except that the detector does not move periodically with the first incubation tray 192, which is not limited in the present invention.

Further, the excitation portion includes an excitation light path, and the detection portion includes a signal light path, and the excitation light path is not simultaneously turned on or off with the signal light path.

The excitation light passage and the signal light passage are both arranged on the shell, and the axis of the excitation light passage is perpendicular to the axis of the signal light passage. The axis L1 of the excitation light path is along the Z-axis direction, and the axis L2 of the signal light path is along the X-axis direction.

The exciting light path is provided with a first switch for controlling the on-off of the exciting light path, the signal light path is provided with a second switch for controlling the on-off of the signal light path, and the first switch and the second switch are linked in a reverse direction. Therefore, the excitation light channel and the signal light channel are driven to be opened and closed at the same time, and the method comprises the following steps: when the exciting light path is opened, the signal light path is closed; when the excitation light path is closed, the signal light path is opened.

Specifically when need the exciting light to arouse the determinand, drive division rotates, and drive division drives first switch and rotates, and the exciting light passageway switches on, and drive division drives the second switch and rotates simultaneously, and the signal light passageway is in the off-state.

Similarly, when the light-emitting signal generated by the object to be detected is received and detected, the driving part rotates again, the driving part drives the first switch to rotate, the first switch blocks the exciting light path, meanwhile, the driving part drives the second switch to rotate, and the signal light path is in an open state. Therefore, the driving part controls the opening and closing of the exciting light channel and the signal light channel simultaneously.

The first switch and the second switch are respectively connected with two ends of the driving part, and the driving part enables the first switch and the second switch to be linked in opposite directions.

Wherein, the driving part is a rotary electromagnet or a motor. Output shafts are respectively arranged at two ends of the driving part, wherein one end of the driving part is connected with the first switch, and the other end of the driving part is connected with the second switch.

While the invention has been described with reference to a preferred embodiment, various modifications may be made and equivalents may be substituted for elements thereof without departing from the scope of the invention. In particular, the technical features mentioned in the embodiments can be combined in any way as long as there is no structural conflict. The present invention is not limited to the particular embodiments disclosed herein, but encompasses all technical solutions falling within the scope of the claims.

Claims (19)

1. A full-automatic streamlined chemiluminescence analyzer, comprising:

the host unit comprises a plurality of hosts which are sequentially arranged, wherein the hosts are used for acquiring samples positioned at the sample detection positions and detecting the samples;

the temporary storage unit is used for storing a sample frame for bearing a sample, the temporary storage unit is positioned on one side of the host unit, and comprises a waiting area and a turnover area which are sequentially arranged

The track conveying mechanism is used for connecting the host unit with the temporary storage unit, the sample frame in the area to be detected is conveyed to the sample detection position of each host in sequence by the track conveying mechanism, and the sample frame in each sample detection position after each host completes corresponding operation is conveyed to the turnover area by the track conveying mechanism.

2. The fully automatic streamlined chemiluminescent analyzer of claim 1 wherein the hosts are sequentially positioned along the track transport mechanism in a direction from the first end to the second end.

3. The fully automated pipelined chemiluminescent analyzer of claim 1 or 2 wherein the number of hosts is at least two.

4. The fully automated pipelined chemiluminescent analyzer of claim 1 or 2 wherein the number of hosts is at least three.

5. The fully automated pipelined chemiluminescent analyzer of claim 3 wherein the staging unit further comprises a inspected zone located between the area to be inspected and the turnaround zone.

6. The fully automatic streamlined chemiluminescent analyzer of claim 5 wherein the sample rack in the transfer area is transported to the waiting area or the examined area, respectively, and when the sample detection result on the sample rack in the transfer area meets the requirement, the sample rack is transported to the examined area; when the detection result of the sample on the sample rack in the turnover area does not meet the requirement, the sample rack is conveyed to the waiting area.

7. The fully automatic streamlined chemiluminescent analyzer of claim 6 wherein the turnaround area is provided with a back-push track for transporting the sample rack, the turnaround area transporting the sample rack to the waiting area or the inspected area through the back-push track.

8. The fully automatic streamlined chemiluminescent analyzer of claim 3 wherein the track transport mechanism comprises a detection track for connecting the buffer unit and each sample detection site and a back-push track, wherein the detection track transports the sample rack in the waiting area to the sample detection site, and the back-push track transports the sample rack in the sample detection site back to the turnover area.

9. The fully automated pipelined chemiluminescent analyzer of claim 8 wherein the detection track and the retreat track are disposed in parallel.

10. The fully automated streamlined chemiluminescent analyzer of claim 8 wherein the detection track and the back-push track are transported in opposite directions.

11. The fully automatic streamlined chemiluminescent analyzer of claim 8 wherein the transporting direction of the detection track is from right to left and the transporting direction of the pushing track is from left to right.

12. The fully-automatic streamlined chemiluminescent analyzer of claim 8, wherein an orbital transfer mechanism is disposed between the detection track and the withdrawing track, and the orbital transfer mechanism is used for pushing the sample rack on the detection track onto the withdrawing track.

13. The fully automatic streamlined chemiluminescent analyzer of claim 8 wherein the area to be examined is provided with a sample rack pushing mechanism for pushing the sample rack on the area to be examined onto the detection track.

14. The fully automatic streamlined chemiluminescent analyzer of claim 8 wherein the turnaround area is provided with a recovery pusher for pushing the sample rack on the back-pushing track to the turnaround area.

15. The fully automated pipelined chemiluminescent analyzer of claim 8 wherein the track transport mechanism further comprises an emergency track for transporting the sample rack of the area to be inspected to an emergency sample testing location of the host computer.

16. The fully automated pipelined chemiluminescent analyzer of claim 15 wherein the emergency track and the detection track are disposed in parallel.

17. The fully automated pipelined chemiluminescent analyzer of claim 15 wherein the emergency track and the detection track are transported in the same direction.

18. The fully-automatic streamlined chemiluminescent analyzer of claim 1 or 2, wherein the host comprises a detection module disposed above the incubation module, and the detection module optically excites the sample in the reaction cup after the incubation is completed and detects the luminescent signal generated after the excitation.

19. The fully-automatic on-line chemiluminescence analyzer of claim 18, wherein the detection module comprises an excitation portion for emitting excitation light and exciting an analyte, and a detection portion for receiving and detecting a luminescence signal generated by the analyte, wherein the excitation portion comprises an exciter capable of emitting 600-700 nm red excitation light; the detection part comprises a detector which is a single photon counter, a photomultiplier, a silicon photocell or a photometric integrating sphere.

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