CN210079266U

CN210079266U - Lateral blood filter

Info

Publication number: CN210079266U
Application number: CN201920596599.8U
Authority: CN
Inventors: 邬鹏程; 周孝祥; 汤刚
Original assignee: Hunan Lok Zhixin Bio Technology Co Ltd
Current assignee: Hunan Lok Zhixin Bio Technology Co Ltd
Priority date: 2019-04-28
Filing date: 2019-04-28
Publication date: 2020-02-18
Anticipated expiration: 2029-04-28

Abstract

The utility model discloses a side direction blood filtration device. The lateral blood filtering device comprises a substrate, a first assembly cavity and a second assembly cavity which are arranged in the substrate, and a sample adding port and a collecting cavity which are formed by extending downwards from the top surface of the substrate; the first assembly cavity is used for placing a first filter element, and the second assembly cavity is used for placing a second filter element; the sample adding port, the first assembly cavity and the second assembly cavity are communicated with the collection cavity in series; the second filter elements are arranged vertically to form lateral filter elements. The utility model discloses a side direction blood filter device strains blood efficiently, and easy productization.

Description

Lateral blood filter

Technical Field

The utility model relates to a side direction blood filter belongs to biochip detection area.

Background

In biochip assays or clinically, it is often desirable to determine the concentration or presence of certain substances in blood. Since whole blood contains a large number of red blood cells, which makes the blood red or deep red, it is difficult or impossible to directly determine the accurate result of the test if whole blood is used in the test. For this purpose, it is necessary to separate plasma from whole blood and measure the plasma.

For example, patent CN207520722U discloses a plasma extraction device in the prior art blood filtration technical scheme, which represents most of the prior art. Wherein strain the blood structure and all adopt the mode of straining blood perpendicularly, specifically include the shell, be equipped with the filtration membrane that the level was placed in the shell, the shell top is equipped with the first cavity of opening up, is equipped with the second cavity that is located under the first cavity in the shell, through filtration membrane intercommunication between first cavity and the second cavity. When filtering blood, firstly adding whole blood into the first cavity, then pressurizing the first cavity in a closed manner, enabling plasma with small molecules to pass through the filtering membrane below the first cavity and enter the second cavity, and enabling red blood cells with large molecules to be retained in the first cavity, thereby achieving the purpose of filtering blood. Such disadvantages are:

1. the vertical blood filtering structure is adopted, and a pre-filtering membrane is not arranged, so that red blood cells are easy to block a filtering membrane, the whole blood filtering efficiency is low, and the risk of crushing the red blood cells is increased, so that the sample is ineffective.

2. In order to achieve the filtering effect of whole blood, the prior technical scheme needs to seal the membrane to prevent red blood cells from permeating into a plasma cavity from a whole blood cavity from an edge gap. The prior art needs to achieve the purpose and is complex to manufacture.

3. The defects of the existing device that the sample adding mode and the quantification cannot be realized determine that the existing device cannot be realized or is difficult to realize automation and cannot be integrated into a biochip.

4. In the existing vertical blood filtration structure, because red blood cells are retained in the first cavity and can be deposited on the filtering membrane at the bottom of the first cavity, along with the progress of blood filtration, the concentration of the red blood cells in the first cavity is higher and higher, so that the filtering membrane is easy to block, the blood filtration is insufficient, the time required for filtering a unit amount of sample is prolonged, the efficiency is reduced, and even the red blood cells can be crushed, and the sample is invalid.

5. The existing blood filtering device only considers the blood filtering membrane to realize blood filtering, but the blood filtering efficiency is low, and the whole blood volume which can be filtered by the membrane per unit area is small.

6. After the existing partial blood filtering device solves the problems, the production and the assembly are complex.

SUMMERY OF THE UTILITY MODEL

The utility model aims at providing a blood device is strained to side direction, this blood device is strained to side direction is strained blood efficiently, and easy productization.

In order to realize the purpose, the utility model discloses the technical scheme who adopts is:

a lateral blood filter device is structurally characterized by comprising a substrate, a first assembly cavity and a second assembly cavity which are arranged in the substrate, and a sample adding port and a collecting cavity which are formed by extending downwards from the top surface of the substrate;

the first assembly cavity is used for placing a first filter element, and the second assembly cavity is used for placing a second filter element; the sample adding port, the first assembly cavity and the second assembly cavity are communicated with the collection cavity in series;

the second filter elements are arranged vertically to form lateral filter elements.

Therefore, the substance to be filtered (whole blood) is injected through the sample injection port, and flows into the collection cavity after being pre-filtered by the first filter element and laterally filtered by the second filter element in sequence, so that the substance to be filtered (whole blood) can be used for the next detection.

According to the utility model discloses an embodiment, can also be right the utility model discloses do further optimization, following for optimizing the technical scheme who forms afterwards:

the utility model relates to an in the preferred scheme, collect the chamber setting in one side of application of sample mouth, just through the through-hole intercommunication between second assembly chamber and the collection chamber. The plasma thus filtered laterally through the second filter element flows through the communication openings into the collection chamber.

In order to realize coarse filtration (primary filtration) by utilizing the gravity of the object to be filtered, the first filter element is vertically arranged at one side below the sample adding port to form a lateral filter element.

In order to facilitate the filtration of whole blood, the first mounting chamber is a pre-filtering membrane mounting chamber in which a pre-filtering membrane is mounted as a first filter element. Thus, the pre-filtration membrane achieves primary filtration.

In order to facilitate the filtration of whole blood, the second mounting chamber is a blood filter membrane mounting chamber in which a blood filter membrane as a second filter element is mounted. Thus, the blood filtration membrane realizes secondary filtration.

In order to ensure the effect of secondary filtration, a plunger capable of doing vertical motion is installed in the sample adding port. Thus, by depressing the plunger, the plunger pushes air against the whole blood, further improving blood filtration efficiency.

And an air vent is arranged at the inlet of the sample adding port. Further, the vent hole extends downwards to the middle position of the sample adding opening along the side wall of the sample adding opening. Therefore, the utility model discloses a design air vent, whole blood specimen can lean on the dead weight to flow down like this. Furthermore, a section of air can be formed in the plunger and the whole blood sample, and when the plunger is pressed down, non-contact filtration driven by air is realized, so that the filtration efficiency is higher.

In order to facilitate the assembly and replacement of the filter element, the substrate is provided with a side opening, the first assembly cavity and the second assembly cavity are both positioned in the side opening, and a cover plate is arranged on the side opening. This makes the lateral filter device easy to produce. Meanwhile, the assembly production process is simple, and the blood filtering device can be integrated into a biochip and also can be used independently.

The utility model discloses an adopt side direction blood filtration structure, prefiltration membrane and the cooperation of blood filtration membrane, adopt air non-contact drive mode to realize high efficiency ration and strain blood.

The utility model discloses a blood filtering membrane and cover plate are through the degree of depth of control blood filtering membrane chamber, when realizing the quantitative module cover plate of bonding, have realized the gas tightness of blood filtering membrane again for assembly process is simple, easy volume production.

The utility model discloses design solitary collection chamber after straining blood, this device can be used for automatic absorption quantitative sample or manual absorption quantitative sample.

Compared with the prior art, the beneficial effects of the utility model are that:

1. the utility model has the advantages of the utility model discloses a design has the air vent, strains blood structural design and the configuration of membrane through air vent and side direction and realizes whole blood filtration, strains blood efficiently.

2. The lateral blood filtering device of the utility model can be integrated on a biochip to realize semi-automatic quantitative sampling.

3. The lateral blood filtering device of the utility model has simple assembly process and easy realization of automatic production.

4. The utility model discloses a blood device is strained to side direction has and prefilters the membrane structure, and the cooperation through prefiltration membrane and blood filtering membrane realizes that the high efficiency strains the blood.

Drawings

FIG. 1 is a schematic diagram of the structure of an embodiment of the present invention;

FIG. 2 is an exploded view of FIG. 1;

FIG. 3 is a top view of FIG. 1;

fig. 4 is a sectional view a-a of fig. 3.

In the figure

1-a substrate; 2-pre-filtering the membrane; 3-a blood filtration membrane; 4-cover plate; 5-a plunger; 6-air vent; 7-whole blood sample port; 8-a hemofiltration membrane assembly chamber; 9-pre-filtering membrane assembling cavity; 10-a through-via; 11-collection chamber.

Detailed Description

The present invention will be described in detail below with reference to the accompanying drawings in conjunction with embodiments. It should be noted that, in the present invention, the embodiments and features of the embodiments may be combined with each other without conflict. For convenience of description, the words "upper", "lower", "left" and "right" in the following description are used only to indicate the correspondence between the upper, lower, left and right directions of the drawings themselves, and do not limit the structure.

A lateral blood filtration device, as shown in FIGS. 1 and 2, comprises a base sheet 1, a pre-filter membrane mounting chamber 9 and a blood filtration membrane mounting chamber 8 provided in the base sheet 1, and a sample addition port 7 and a collection chamber 11 for collecting plasma formed extending downward from the top surface of the base sheet 1. The pre-filtering membrane assembly cavity 9 is used for placing the pre-filtering membrane 2, and the blood filtering membrane assembly cavity 8 is used for placing the blood filtering membrane 3.

As shown in FIG. 4, the pre-filter membrane 2 is vertically arranged on the lower side of the sample addition port 7. The blood filtering membrane 3 is vertically arranged and is perpendicular to the filtering direction. The sample adding port 7, the pre-filtering membrane assembling cavity 9, the blood filtering membrane assembling cavity 8 and the collecting cavity 11 are communicated in series. The hemofiltration membrane assembling cavity 8 is communicated with the collection cavity 11 through a communicating hole 10. Preferably, both the pre-filtration membrane 2 and the blood filtration membrane 3 are arranged vertically to form a lateral filtration element.

In order to improve the blood filtration efficiency, a vent hole 6 is provided at the inlet of the sample addition port 7, and as shown in fig. 4, the vent hole 6 extends downwards to the middle position of the sample addition port 7 along the side wall of the sample addition port 7 (sample addition cavity). . And a plunger 5 capable of moving vertically is arranged in the sample adding port 7.

For convenient assembly, the substrate 1 is provided with an opening on the side surface, the pre-filtering membrane assembly cavity 9 and the blood filtering membrane assembly cavity 8 are both arranged in the opening on the side surface, and the cover plate 4 is arranged on the opening on the side surface. As shown in FIG. 1, before sample detection, the quantitative block substrate 1, the pre-filter membrane 2, the blood filter membrane 3, the quantitative block cover 4, the blood filter plunger 5, etc. are all assembled together. The blood filtering plunger 5 and the pre-filtering membrane 2 are only required to be assembled at corresponding positions, and the blood filtering membrane 3 and the quantitative module cover plate 6 are bonded on the quantitative module substrate 1 through dispensing.

When the sample is detected, as shown in fig. 2 and 4, the whole blood is added from the whole blood sample adding port 7, because the vent hole 6 is formed, the whole blood sample can automatically flow into the prefilter membrane under the gravity, and is sucked away by the prefilter membrane 2, and the blood plasma automatically moves towards the blood filtering direction under the action of capillary force. And forms an air section between the whole blood and the hemofilter plunger 5.

After the whole blood sample is added, the blood filtering plunger 5 is pressed downwards, the whole blood firstly passes through the pre-filtering membrane 2 along with the pressing of the blood filtering plunger 5, most red blood cells in the whole blood are intercepted by the pre-filtering membrane 2 in the process, and the blood plasma continuously moves forwards under the air pressure and passes through the blood filtering membrane 3. After the sample containing a small amount of red blood cells is filtered by the blood filtering membrane 3, the red blood cells are intercepted by the blood filtering membrane 3, and after the plasma permeates the blood filtering membrane 3, the plasma is gathered together and collected in the plasma collecting cavity 11 through the communicating hole 10.

After the blood filtration is completed, plasma is present in the plasma collection chamber 11, and at this time, a quantitative plasma sample can be automatically drawn from the plasma collection chamber 11 or manually drawn for detection.

The above-mentioned embodiments are illustrative and should not be construed as limiting the scope of the invention, which is defined by the appended claims, and all modifications of the equivalent forms of the present invention which are obvious to those skilled in the art after reading the present invention.

Claims

1. A lateral blood filter device is characterized by comprising a substrate (1), a first assembly cavity and a second assembly cavity which are arranged in the substrate (1), and a sample adding port (7) and a collecting cavity (11) which are formed by extending downwards from the top surface of the substrate (1);

the first assembly cavity is used for placing a first filter element, and the second assembly cavity is used for placing a second filter element; the sample adding port (7), the first assembly cavity and the second assembly cavity are communicated with the collection cavity (11) in series;

2. Lateral hemofilter device according to claim 1, characterized in that the collection chamber (11) is arranged on one side of the sample addition opening (7) and the second assembly chamber communicates with the collection chamber (11) via a communication hole (10).

3. Lateral hemofilter device according to claim 1, characterized in that the first filter element is arranged vertically on the side below the sample addition opening (7) forming a lateral filter element.

4. Lateral blood filter device according to claim 1, wherein the first mounting chamber is a pre-filter mounting chamber (9), the pre-filter mounting chamber (9) having a pre-filter membrane (2) as the first filter element mounted therein.

5. Lateral hemofilter device according to claim 1, characterized in that the second assembly chamber is a hemofilter membrane assembly chamber (8), the hemofilter membrane assembly chamber (8) being fitted with a hemofilter membrane (3) as a second filter element.

6. Lateral hemofiltration device according to any of claims 1 to 5, characterized in that a vertically movable plunger (5) is mounted in the sample port (7).

7. Lateral hemofiltration device according to any of claims 1 to 5, characterized in that a vent (6) is provided at the inlet of the sample addition port (7).

8. The lateral blood filtration device of claim 7, wherein the vent hole (6) extends down the side wall of the sample port (7) to a position in the middle of the sample port (7).

9. Lateral hemofilter device according to any of claims 1 to 5, characterized in that the substrate (1) is open at the side, in which the first and second assembly chambers are located, and on which a cover plate (4) is mounted.