CN209996303U

CN209996303U - Non-confocal adaptive optical imaging system

Info

Publication number: CN209996303U
Application number: CN201822255475.1U
Authority: CN
Inventors: 秦嘉; 林盛豪; 安林; 贺潇; 高儒将
Original assignee: Foshan University
Current assignee: GUANGDONG WEIREN MEDICAL TECHNOLOGY Co.,Ltd.
Priority date: 2018-12-29
Filing date: 2018-12-29
Publication date: 2020-01-31
Anticipated expiration: 2028-12-29

Abstract

The utility model provides an kind of non-confocal adaptive optics imaging system, receive imaging system including light source, adaptive optics system, reverberation, the light that the light source sent is scanned through adaptive optics system guide sample, and the light that reflects back receives the formation of image through reverberation receiving system, reverberation reception imaging system includes 2 at least receivers the utility model discloses an optimize reverberation receiving system, to receiving the diversion of reflection light path for the system can accept the light of non-confocal, and will distinguish with it the most important many confocal light of contrast with it, let the system can accept this have the light of testee morphological structure, and can come to image the morphological structure of testee according to these light, thereby obtain the organizational structure of more clear testee.

Description

Non-confocal adaptive optical imaging system

Technical Field

The utility model belongs to the technical field of the optical detection, specifically speaking relates to non-confocal adaptive optics imaging system.

Background

The Adaptive Optics (AO) has good aberration correction capability, so that the resolution of the system can be improved extremely high by combining the AO with a laser scanning inspection mirror (SLO) and Optical Coherence Tomography (OCT). The AO mainly checks wavefront aberration by the wavefront sensor, and corrects the light beam by adjusting the variable mirror to deform the mirror surface according to the checked wavefront aberration. At present, the imaging technology of AO applied to ophthalmology has become the key research content of the research of the imaging technology of ophthalmology at home and abroad.

With regard to morphological imaging of photoreceptor cell inner and outer layers or other human tissues, which is helpful for the research of medical science on the principle of eye diseases, OCT is currently applied in general to the examination of ophthalmic diseases, for example, to the examination of age-related macular degeneration of human eyes, whether diseases such as age-related macular degeneration occur can be judged by imaging the structure of the eye fundus of human eyes, and the determination of treatment plan can be guided by images.

At present, AO-SLO and AO-OCT combined by AO, SLO and OCT can image human tissues such as photoreceptor cells of retina of living human eye, but because of optical characteristics of photoreceptor cells or other human tissues, optical phenomena such as refraction and scattering of light can occur in an imaging sample, so that a traditional confocal adaptive optical tomography system can not present a clear morphological structure image. However, the reflected light in the non-confocal part has structural information of the imaged sample, and clear information is difficult to obtain because the reflected light is in the edge range of light receiving during imaging and the light intensity of the part is weak, so that the reflected light is easily covered by the focused light.

The non-confocal adaptive optical coherence tomography scanner images the non-confocal image and obtains a clearer morphological structure of a sample, which has great significance for the research of ophthalmic diseases (such as age-related macular degeneration). The application of unfocused imaging to AO-OCT for three-dimensional structural imaging of tissue structures is not known at present.

Disclosure of Invention

In order to solve the above problems, obtain the morphological structure image of comparatively clear testee, the utility model provides an non-confocal adaptive optics imaging systems.

kinds of non-confocal adaptive optics imaging system, including light source, adaptive optics system, reverberation receiving imaging system, the light that the light source sent is scanned through the sample of adaptive optics system guide, and the light of reverberation receives the formation of image through reverberation receiving system, reverberation receiving imaging system includes 2 at least receivers.

Further , the reflected light receiving imaging system includes 3 receivers.

, the receiver comprises a collimating lens, a transmission grating, a lens and a CMOS camera, and the light passes through the collimating lens, the transmission grating and the lens in sequence and then reaches the CMOS camera for imaging.

, the adaptive optics system includes fiber coupler, sample arm, reference arm, the fiber coupler includes coupler and second coupler, the reference arm includes 4F system and plane mirror, the sample arm includes 4F system, wave front sensor and wave front corrector;

the method comprises the steps of dividing light emitted by a light source into two parts after passing through a coupler, enabling part to enter a reference arm after passing through a second coupler, focusing the light to a reflector through a 4F system, returning the light to a second optical fiber coupler after being reflected, enabling the light to enter a reflected light receiving imaging system, enabling part to enter a sample arm, enabling the sample arm to pass through a plurality of 4F systems, enabling the sample arm to strike a wavefront corrector, enabling the sample arm to strike 4F systems after being reflected, enabling the sample arm to be focused to a detection target, enabling the light to return through an original path, dividing the light into two parts through , enabling the part to enter a wavefront sensor through a path to detect wavefront aberration of return light to calibrate the wavefront corrector, enabling the part to enter the reflected light receiving imaging system through a path, enabling the light reflected by the sample arm and the light reflected by the reference arm to interfere in the.

, the number of the reference arms comprises 1 4F systems, the number of the sample arms comprises 4F systems, and light enters the sample arms, then sequentially passes through the 3 4F systems, reaches the wavefront corrector, and then passes through the 1 4F systems to be focused to a detection target.

, the 4F system of the reference arm is composed of collimating mirror and lens, and the 4F system of the sample arm is composed of curved mirror.

Further , the wavefront corrector is a deformable mirror.

Compared with the prior art, the utility model has the beneficial effects that the utility model discloses an optimize the reverberation receiving system, to receiving the radius of change of reflection light path, make the system can accept the light of non-confocal, and will distinguish with it many confocal lights that contrast will be strong with it, let the system can accept this light that has the measured object morphological structure, and can come to image the morphological structure of measured object according to these light, come to obtain the more clear tissue morphological structure of measured object, this has great meaning to ophthalmic diseases (like age macular degeneration) research, and do not see to use the non-focused imaging to carry out three-dimensional structure formation of image at AO-OCT tissue structure at present yet.

Drawings

The accompanying drawings are included to provide a further understanding of the invention at , and are incorporated in and constitute a part of this specification with embodiment for purposes of explanation of the invention, and are not intended to limit the scope of the invention:

FIG. 1 is a schematic view of light reflected from human tissue;

FIG. 2 is an imaging schematic of a prior art optical imaging system;

FIG. 3 is a schematic diagram of a non-confocal adaptive optical imaging system of the present invention;

fig. 4 is a schematic diagram of a non-confocal adaptive optical imaging system according to an embodiment of the present invention.

Detailed Description

The preferred embodiments of the present invention will be described in conjunction with the accompanying drawings, and it will be understood that they are presented herein only to illustrate and explain the present invention, and not to limit the present invention.

As shown in fig. 1, due to the optical characteristics of human tissue, incident light is refracted or scattered inside the tissue, the obtained reflected light is not and is received as it is, and a part of light with tissue morphology structure cannot return to the focusing region as it is, while the optical imaging system such as AO-OCT performs structural imaging based on the information of the light reflected from the sample under examination.

As shown in fig. 2, 4F systems are currently used between the sample and the reflected light receiver to adjust the light and receive the reflected light at the focal point, which means that portion of the light with structural information cannot be received or is covered by the strong focused light, so that the system image is not clear enough.

In order to make more useful reflection light can be received by the system to can be discerned by the system, the utility model provides an non-confocal adaptive optics imaging system, including light source, adaptive optics system, reverberation receiving imaging system, the light that the light source sent is directed the sample through adaptive optics system and is scanned, and the light that reflects back receives the formation of image through reverberation receiving system, reverberation receiving imaging system includes 2 at least receivers.

The utility model discloses a non-confocal adaptive optics imaging system principle is shown in figure 3, adopts the mode of a plurality of independent receipts, lets it distinguish with its very strong focusing light of contrast light intensity, and does not submerge by strong focusing light, can let the system discern non-confocal light well like this to improve the imaging ability of system.

Referring to fig. 4, in an embodiment of the present invention, non-confocal adaptive optics imaging system includes a light source SLD, an adaptive optics system, a reflected light receiving imaging system, which includes 3 receivers.

The receiver comprises collimating lenses C2, C3 and C4, transmission type gratings DG1, DG2 and DG3, lenses L2, L3, L4 and CMOS camera CMOS1, CMOS2 and COMS3, light rays sequentially pass through the collimating lenses C2, C3 and C4, the transmission type gratings DG1, DG2 and DG3, the lenses L2, L3 and L4 and then reach CMOS camera imaging CMOS1, CMOS2 and COMS 3.

The adaptive optics system comprises an -th coupler CP1, a second coupler CP2, a sample arm and a reference arm, wherein the reference arm comprises 1 4F system consisting of a collimating mirror C1 and a lens L1 and a plane mirror FM1, the sample arm comprises 4F systems consisting of a curved mirror SM1, an SM2, an SM3, an SM4, an SM5, an SM6, an SM7 and an SM8, a wavefront sensor WFS and a wavefront corrector, and the wavefront corrector is a deformable mirror DM.

The light source SLD is divided into two beams by a 1X 2 fiber coupler CP1, beam enters a reference arm through a fiber coupler CP2, enters three 2X 1 fiber couplers CP3, CP4 and CP5 through a C1 and L1 after passing through a plane mirror FM1 and is reflected back to the fiber coupler CP2, is divided into three paths by a beam velocity sub-receiver F1, enters three 2X 1 fiber couplers CP3, CP4 and CP5 respectively, and the other beam is reflected by a beam splitter BS1, then is transmitted through a beam splitter BS2, enters a 4F system composed of curved mirrors SM1 and SM2 to a scanning beam splitter, enters a 4F system composed of curved mirrors SM3 and SM4 to enter another scanning beam splitters, passes through a 4F system composed of curved mirrors SM5 and SM6 to a deformable mirror DM, finally passes through the 4F system composed of curved mirrors SM7 and SM 72, passes through a FM 7, passes through a lens 7 and a 4F system composed of SM7, enters a deformable mirror DM, enters a CMOS image-forming light-imaging wavefront sensor 7, the wavefront reflected light is divided into a CMOS image-forming three paths by a CMOS image-forming light beam splitter CP 72, and a CMOS image-forming light-wave-forming-wave-front, and a CMOS image-forming light-wave-forming-wave-front, the CMOS image-forming-wave-splitting device, and a CMOS-forming-splitting device, the CMOS-.

In summary, in the conventional AO-OCT confocal imaging, a reflected signal reflected from a tissue is received, and due to the scattering effect of biological tissues on light, an anisotropic signal (a non-confocal signal) cannot be received by a system due to the fact that the light intensity is weak and the signal is edged (the non-confocal light is in an edge position), so that part of the reflected light with the morphological structure information of the object to be measured is lost, and a clear overall morphological structure image of the object to be measured cannot be obtained.

The utility model discloses an optimize the reverberation receiving system, to the radius of change of receiving reflection light path, make the system can accept the light of non-confocal, and will want to distinguish with it a lot of confocal light that contrast is strong with it, let the system can accept this light that has the measured object morpholoid, and can come to image the morpholoid of measured object according to these light, come to obtain the more clear tissue morpholoid of measured object, this has great meaning to ophthalmology disease (such as the old macular degeneration) research.

Finally, it should be noted that: although the present invention has been described in detail with reference to the embodiments, it will be apparent to those skilled in the art that modifications, equivalents, improvements and the like can be made in the technical solutions of the foregoing embodiments or in some technical features of the foregoing embodiments, but all modifications, equivalents, improvements and the like within the spirit and principle of the present invention are intended to be included in the scope of the present invention.

Claims

The non-confocal adaptive optics imaging system comprises a light source, an adaptive optics system and a reflected light receiving imaging system, wherein light emitted by the light source is guided to a sample by the adaptive optics system for scanning, and reflected light is received by the reflected light receiving imaging system for imaging, and the reflected light receiving imaging system is characterized by comprising at least 2 receivers;

the receiver comprises a collimating lens, a transmission type grating, a lens and a CMOS camera, and light rays sequentially pass through the collimating lens, the transmission type grating and the lens and then reach the CMOS camera for imaging.
2. The non-confocal adaptive optics imaging system of claim 1, wherein the reflected light receiving imaging system comprises 3 receivers.
3. The non-confocal adaptive optics imaging system according to claim 1 or 2, wherein the adaptive optics system comprises a fiber coupler, a sample arm and a reference arm, wherein the fiber coupler comprises an th coupler and a second coupler, the reference arm comprises a 4F system and a plane mirror, and the sample arm comprises a 4F system, a wavefront sensor and a wavefront corrector;

the device comprises a light source, a coupler, a reference arm, a 4F system, a reflector, a reflected light receiving imaging system, a sample arm, a part, a wavefront corrector, a 4F system, a detection target, an original path and a path, wherein light emitted by the light source is divided into two parts after passing through the coupler, the part enters the reference arm after passing through the second coupler, is focused on the reflector after passing through the 4F system, then enters the second fiber coupler and then enters the reflected light receiving imaging system, the part enters the sample arm, passes through the 4F system, is irradiated onto the wavefront corrector, is reflected onto the F system, is focused onto the detection target, then returns through the original path and is divided into two parts, the path enters the wavefront sensor to detect wavefront aberration of return light to calibrate the wavefront corrector, the path enters the reflected light receiving imaging system, and finally the light reflected by the.
4. The non-confocal adaptive optics imaging system of claim 3, wherein the reference arm comprises 1 of a 4F system; the number of the sample arms is 4 including 4F systems, and light rays sequentially pass through the 3 4F systems after entering the sample arms, reach the wavefront corrector, then pass through the 1 4F system, and are focused to a detection target.
5. The non-confocal adaptive optics imaging system of claim 4, wherein the 4F system of the reference arm is comprised of a collimating mirror and a lens; the 4F system of the sample arm consists of a curved mirror.
6. The non-confocal adaptive optics imaging system of claim 5, wherein the wavefront corrector is a deformable mirror.