CN209917925U - Micro-fluidic chip anchor clamps and anchor clamps system - Google Patents
Micro-fluidic chip anchor clamps and anchor clamps system Download PDFInfo
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- CN209917925U CN209917925U CN201920509841.3U CN201920509841U CN209917925U CN 209917925 U CN209917925 U CN 209917925U CN 201920509841 U CN201920509841 U CN 201920509841U CN 209917925 U CN209917925 U CN 209917925U
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Abstract
The utility model discloses a micro-fluidic chip anchor clamps and anchor clamps system, its equipment is convenient, uses in a flexible way. The microfluidic chip clamp comprises an upper base plate, a liquid inlet arranged on the upper base plate, a lower base plate and a liquid outlet arranged on the lower base plate; one part of the upper bottom plate and the lower bottom plate is provided with a plurality of positioning columns, and the other part is provided with a plurality of positioning holes matched with the positioning columns; the microfluidic chip clamp has a first state and a second state, and when the microfluidic chip clamp is in the first state, the upper base plate and the lower base plate are separated from each other; when the microfluidic chip clamp is in the second state, the positioning columns are inserted into the corresponding positioning holes so as to enable the upper base plate and the lower base plate to be connected with each other, a detection pool for placing a microfluidic chip is formed between the upper base plate and the lower base plate, and the detection pool is communicated with the liquid inlet and the liquid outlet.
Description
Technical Field
The utility model relates to a micro-fluidic chip detection and analysis field, concretely relates to micro-fluidic chip anchor clamps and anchor clamps system.
Background
Micro-fluidic chip systems are receiving more and more attention in the fields of chemical industry, energy, environment, medical treatment and the like. The micro-fluidic chip can realize functions of micro-analysis, mixing or separation and the like through controlling the fluid. E.g., enrichment chips, are commonly used to capture and enrich for biomolecules or cells, such as circulating tumor cells.
The micro-fluidic chip needs to be installed in a micro-fluidic chip clamp and then connected with an external pump valve system and a pipeline, the existing micro-fluidic chip clamp has the mode of screw connection, gluing and the like, the clamp for fixing the micro-fluidic chip has more accessories, the assembly is inconvenient, the operation is troublesome, the combination process is easy to block, the chip is often unstable due to the weight of the guide pipe, and the position is easy to deviate or even overturn due to the influence of the guide pipe.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing a micro-fluidic chip anchor clamps and anchor clamps system, its equipment is convenient, uses in a flexible way.
In order to achieve the above purpose, the utility model adopts the technical scheme that:
a micro-fluidic chip clamp comprises an upper base plate, a liquid inlet arranged on the upper base plate, a lower base plate and a liquid outlet arranged on the lower base plate; one part of the upper bottom plate and the lower bottom plate is provided with a plurality of positioning columns, and the other part is provided with a plurality of positioning holes matched with the positioning columns; the microfluidic chip clamp has a first state and a second state, and when the microfluidic chip clamp is in the first state, the upper base plate and the lower base plate are separated from each other; when the microfluidic chip clamp is in the second state, the positioning columns are inserted into the corresponding positioning holes so as to enable the upper base plate and the lower base plate to be connected with each other, a detection pool for placing a microfluidic chip is formed between the upper base plate and the lower base plate, and the detection pool is communicated with the liquid inlet and the liquid outlet.
Preferably, the positioning columns are arranged in a polygonal shape, and the positioning holes are arranged in a polygonal shape.
More preferably, the number of the positioning columns and the number of the positioning holes are four respectively and are arranged in a rectangular shape.
Preferably, the lower base plate is provided with a plurality of positioning columns, and the positioning holes are through holes penetrating through the upper base plate.
Preferably, the microfluidic chip clamp further comprises a rubber gasket, and when the microfluidic chip clamp is in the second state, the rubber gasket is located between the microfluidic chip and the lower base plate.
More preferably, a gasket groove for placing the rubber gasket is formed in the upper surface of the lower base plate, and the rubber gasket is arranged in the gasket groove.
The utility model discloses still adopt following technical scheme:
the micro-fluidic chip clamp system comprises a clamping device, wherein the clamping device is provided with a clamping cavity used for tightly pressing the micro-fluidic chip clamp, the micro-fluidic chip clamp system further comprises the micro-fluidic chip clamp, and the micro-fluidic chip clamp is placed in the clamping cavity.
Preferably, the clamping device comprises a substrate, a pressing plate, a pressing head rotatably arranged on the substrate through a first pivot, and a handle rotatably arranged on the substrate through a second pivot, the handle rotatably connected to the pressing head through a third pivot, the clamping cavity arranged on the substrate, the clamping device having a clamping state, and when the clamping device is in the clamping state, the pressing plate is pressed on the substrate by the pressing head. The handle and the pressure head are controlled to press through the rotating fit, the consistency of the pressing pressure at every time can be basically achieved, the influence of human factors on the experimental result is reduced, the clamping force is consistent, and the sample leakage problem when the fluid enters the chip is reduced. The clamping device has the advantages of simple structure, strong applicability, low manufacturing cost and flexible movement.
Preferably, the third pivot is located between the first pivot and the second pivot.
Preferably, the axes of the first pivot, the second pivot and the third pivot are parallel to each other.
More preferably, the axes of the first pivot, the second pivot and the third pivot extend horizontally.
Preferably, the base plate is provided with an elbow clamp, the pressure head is rotatably arranged on the elbow clamp through the first pivot, and the handle is rotatably arranged on the elbow clamp through the second pivot.
More preferably, the lower end of the ram forms a rubber crimp. The base plate and the pressing plate are compressed tightly through the pressing head, so that the chip can be conveniently mounted and dismounted, the movement of the rubber pressing part is effectively adjusted through the pressing handle, the clamping force does not need to be adjusted, and the accurate positioning and the stability of the chip are guaranteed.
More preferably, one end portion of the pressing plate is rotatably connected to the base plate. Further, one end portion of the pressing plate is rotatably connected to the base plate by a hinge.
The utility model adopts the above scheme, compare prior art and have following advantage:
the utility model discloses a micro-fluidic chip anchor clamps can realize the quick location of upper plate and lower plate and connect through reference column and locating hole, and the equipment is convenient, uses in a flexible way; the rubber gasket is matched with the microfluidic chip for use, so that a better buffer protection effect is achieved on the microfluidic chip; the micro-fluidic chip clamp matched with the clamping device can completely realize the fixation and the compaction of the chip, and is convenient to use. The utility model discloses a micro-fluidic chip anchor clamps system, micro-fluidic chip simple to operate can conveniently cooperate clamping device to be fixed completely and compress tightly convenient to use.
Drawings
In order to more clearly illustrate the technical solution of the present invention, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.
Fig. 1 is a schematic view of a microfluidic chip holder according to the present invention in a first state;
FIG. 2 is a schematic view of the microfluidic chip holder of FIG. 1 in a second state;
fig. 3 is a schematic structural diagram of a microfluidic chip clamping system according to the present invention.
In the above-described figures of the drawings,
1. a substrate; 10. a clamping cavity; 11. an elbow clip; 2. pressing a plate; 21. a hinge; 3. a pressure head; 30. a rubber crimping part; 4. a handle; 5. a hexagonal positioning post; 6. a base plate; 61. a rubber foot pad; 7. a microfluidic chip clamp;
71. a liquid inlet pipe; 711. a liquid inlet; 72. an upper base plate; 720. positioning holes; 73. a microfluidic chip; 74. a rubber gasket; 75. a lower base plate; 750. a positioning column; 751. a gasket groove; 76. a liquid outlet pipe; 761. and a liquid outlet.
Detailed Description
The following detailed description of the preferred embodiments of the invention, taken in conjunction with the accompanying drawings, enables the advantages and features of the invention to be more readily understood by those skilled in the art. It should be noted that the description of the embodiments is provided to help understanding of the present invention, but the present invention is not limited thereto.
Fig. 1-2 show a microfluidic chip holder 7 of the present embodiment. Referring to fig. 1-2, the microfluidic chip clamp 7 includes an upper plate 72, a liquid inlet 711 disposed on the upper plate 72, a lower plate 75, and a liquid outlet 761 disposed on the lower plate 75. Specifically, the upper bottom plate 72 has an upper cavity therein, and the upper cavity extends upward from the lower surface of the upper bottom plate 72; the upper plate 72 is provided with a liquid inlet pipe 71, the liquid inlet pipe 71 is integrally formed with the upper plate 72, and a liquid inlet 711 is formed at the upper end of the liquid inlet pipe 71. The lower plate 75 is provided with a liquid outlet pipe 76, the liquid outlet pipe 76 and the lower plate 75 are integrally formed, and a liquid outlet 761 is formed at the lower end of the liquid outlet pipe 76. One of the upper plate 72 and the lower plate 75 has a plurality of positioning posts 750, and the other has a plurality of positioning holes 720 matching with the positioning posts 750. Specifically, the positioning column 750 is disposed on the lower bottom plate 75, and the positioning column 750 extends upward from the upper surface of the lower bottom plate 75; the positioning hole 720 is a through hole 720 formed through the upper plate 72. The positioning posts 750 are arranged in a polygon, and the positioning holes 720 are correspondingly arranged in a polygon. Specifically, in the present embodiment, the number of the positioning columns 750 and the number of the positioning holes 720 are four respectively and are arranged in a rectangle.
The microfluidic chip holder 7 has a first state as shown in fig. 1 and a second state as shown in fig. 2. Referring to fig. 1, when the microfluidic chip holder 7 is in the first state, the upper plate 72 and the lower plate 75 are separated from each other. The microfluidic chip 73 is placed in the upper cavity of the upper plate 72, and after the upper plate 72 and the lower plate 75 are aligned and connected, the microfluidic chip holder 7 is switched to its second state. Referring to fig. 2, when the microfluidic chip holder 7 is in the second state, the positioning posts 750 are respectively inserted into the corresponding positioning holes 720, so that the upper plate 72 and the lower plate 75 are positioned and connected with each other, a detection cell for placing the microfluidic chip 73 is formed between the upper plate 72 and the lower plate 75, the detection cell is communicated with the liquid inlet 711 and the liquid outlet 761, and the microfluidic chip 73 is installed in the detection cell.
Referring to fig. 1, the microfluidic chip holder 7 further comprises a rubber gasket 74, and when the microfluidic chip holder 7 is in the second state, the rubber gasket 74 is located between the microfluidic chip 73 and the lower base plate 75. Wherein, the upper surface of the lower plate 75 is provided with a gasket groove 751 for placing the rubber gasket 74, the rubber gasket 74 is arranged in the gasket groove 751, and the gasket groove 751 is arranged around the drain pipe 75. The micro-fluidic chip 73 is protected by buffering through the rubber gasket 74, and the rubber gasket 74 and the micro-fluidic chip 73 have smaller contact surfaces and can play a better protection role compared with a rubber gasket.
Fig. 3 shows a microfluidic chip holder system of the present embodiment, which is used by combining the above-mentioned microfluidic chip holder 7 shown in fig. 1 and 2 with a holding device. Referring to fig. 3, the microfluidic chip clamp system includes a clamping device and a microfluidic chip clamp 7, the clamping device has a clamping cavity 10 for fixing and compressing the microfluidic chip clamp 7, after a microfluidic chip 73 is mounted in the microfluidic chip clamp 7, the microfluidic chip clamp 7 is placed in the clamping cavity 10, and the microfluidic chip clamp 7 is compressed and fixed by the clamping device so as to be connected with an external liquid inlet pipeline and an external liquid outlet pipeline for detection.
The clamping device comprises a substrate 1 and a pressing plate 2 which are matched with each other, and a clamping cavity 10 is arranged on the substrate 1. The holding device further comprises a pressing head 3 rotatably arranged on the base plate 1 through a first pivot and a handle 4 rotatably arranged on the base plate 1 through a second pivot, wherein the handle 4 is rotatably connected to the pressing head 3 through a third pivot. The clamping device has a clamping state, when the clamping device is in the clamping state, the pressure head 3 presses the pressure plate 2 on the substrate 1, and the microfluidic chip clamp 7 is pressed between the pressure plate 2 and the substrate 1.
Specifically, the base plate 1 has an elbow clip 11 thereon, the indenter 3 is rotatably provided on a front end portion of the elbow clip 11 by a first pivot, and the handle 4 is rotatably provided on a rear end portion of the elbow clip 11 by a second pivot. The third pivot is located between the first pivot and the second pivot. The axes of the first pivot, the second pivot and the third pivot are parallel to each other and extend horizontally.
The end of the ram 3 forms a rubber crimp 30, the rubber crimp 30 being generally frustoconical, the smaller bottom surface of the rubber crimp 30 mating with the upper surface of the platen 2. When the clamping device is in the clamped state, the smaller bottom surface of the rubber crimping portion 30 and the upper surface of the pressure plate 2 are in contact, thereby pressing the pressure plate 2.
One end part of the pressure plate 2 is rotatably connected to the substrate 1 through a hinge 21, and the middle part of the pressure plate 2 is provided with a through hole for a liquid inlet pipe 71 of the microfluidic chip clamp 7 to pass through. Correspondingly, the substrate 1 is also provided with a through hole for the liquid outlet pipe 76 of the microfluidic chip clamp 7 to pass through.
The clamping device further comprises a bottom plate 6, and the base plate 1 is connected to the bottom plate 6 through an upright post. The stand is specifically hexagonal stand 5, connects respectively on the four corners of base plate 1. The bottom plate 6 can be matched with other instruments for use, and the height of the hexagonal upright post 5 can be adjusted. The bottom of the bottom plate 6 is provided with a plurality of rubber feet 61. The number of the rubber foot pads 61 is four, and the rubber foot pads are respectively fixedly arranged on four corners of the bottom surface of the bottom plate 6.
When in use, the microfluidic chip 73 is placed in the upper cavity of the upper base plate 72 of the microfluidic chip clamp 7, the rubber gasket 74 is installed in the gasket groove 751 on the lower base plate 75, the upper base plate 72 and the lower base plate 75 are aligned to enable the positioning column 750 to penetrate into the corresponding positioning hole 720, positioning connection of the upper base plate 72 and the lower base plate 75 is realized, and the microfluidic chip 73 is installed and fixed in the detection cell between the upper base plate 72 and the lower base plate 75; then, the positioned and connected microfluidic chip clamp 7 is placed in the clamping cavity 10 of the clamping device, the liquid outlet pipe 76 should pass through a through hole on the substrate 1, the pressing plate 2 is turned over, the pressing plate 2 falls on the upper bottom plate 72 of the microfluidic chip 73, the pressing plate 2 is combined on the substrate 1, and the liquid inlet pipe 71 should pass through the through hole on the pressing plate; downwards pulling the handle 4, and enabling the rubber crimping part 30 to fall under the matching of the three pivots, so that the pressing plate 2 is folded and pressed, and the microfluidic chip clamp 7 is fixedly pressed in the clamping cavity 10, thereby achieving the purpose of pressing the microfluidic chip 73 in the detection cell; then, the liquid inlet pipe 71 is connected to an external liquid inlet pipeline, the liquid outlet pipe 76 is connected to an external liquid outlet pipeline, the liquid inlet pipeline starts to sample, the sample enters the detection cell from the liquid inlet 711, passes through the microfluidic chip 73, and is discharged to the external liquid outlet pipeline from the liquid outlet 761.
The microfluidic chip clamp 7 of the utility model can realize the quick positioning connection between the upper base plate 72 and the lower base plate 75 through the positioning column 750 and the positioning hole 720, and has convenient assembly and flexible use; moreover, the rubber gasket 74 is used in cooperation with the microfluidic chip 73, so that the better sealing effect is kept, the higher capturing efficiency is obtained, meanwhile, the better buffer protection effect is realized on the microfluidic chip 73, and the large-area deformation of the microfluidic chip caused by sealing is avoided; the microfluidic chip clamp 7 can be matched with a clamping device to completely realize the fixation and compaction of a chip, and is convenient to use.
The utility model discloses a micro-fluidic chip anchor clamps system, micro-fluidic chip 73 simple to operate can conveniently cooperate clamping device to be fixed completely and compress tightly convenient to use. And press through the control of normal running fit's handle 4 and pressure head 3, accomplish the unanimity of every turn pressure power basically, reduce the influence of human factor to the experimental result to make the clamping dynamics unanimous, reduce the sample leakage problem when the fluid advances the chip. Base plate 1 and clamp plate 2 compress tightly through pressure head 3, have made things convenient for the installation and the dismantlement of chip, and through pressing the activity that handle 4 effectively adjusted rubber crimping portion 30, need not to adjust the tight dynamics of clamp moreover, have guaranteed the accurate positioning and the stability of chip. The clamping device is simple in structure, high in applicability, low in manufacturing cost and capable of being flexibly moved, and the working condition of the chip can be checked in real time by arranging the observation port and the gap on the pressing plate 2 and the substrate 1 respectively. The design of hexagonal location post 7505 makes this clamping device can cooperate other instrument height to carry out a series of operations.
The above embodiments are only for illustrating the technical concept and features of the present invention, and are preferred embodiments, which are intended to enable persons skilled in the art to understand the contents of the present invention and to implement the present invention, and thus, the protection scope of the present invention cannot be limited thereby. All equivalent changes or modifications made according to the principles of the present invention are intended to be covered by the scope of the present invention.
Claims (10)
1. A micro-fluidic chip clamp comprises an upper base plate, a liquid inlet arranged on the upper base plate, a lower base plate and a liquid outlet arranged on the lower base plate; the method is characterized in that: one part of the upper bottom plate and the lower bottom plate is provided with a plurality of positioning columns, and the other part is provided with a plurality of positioning holes matched with the positioning columns; the microfluidic chip clamp has a first state and a second state, and when the microfluidic chip clamp is in the first state, the upper base plate and the lower base plate are separated from each other; when the microfluidic chip clamp is in the second state, the positioning columns are inserted into the corresponding positioning holes so as to enable the upper base plate and the lower base plate to be connected with each other, a detection pool for placing a microfluidic chip is formed between the upper base plate and the lower base plate, and the detection pool is communicated with the liquid inlet and the liquid outlet.
2. The microfluidic chip holder of claim 1, wherein: the positioning columns are arranged in a polygonal mode, and the positioning holes are arranged in a polygonal mode.
3. The microfluidic chip holder of claim 2, wherein: the number of the positioning columns and the number of the positioning holes are four respectively and are arranged in a rectangular shape.
4. The microfluidic chip holder of claim 1, wherein: the lower base plate is provided with a plurality of positioning columns, and the positioning holes are through holes penetrating through the upper base plate.
5. The microfluidic chip holder of claim 1, wherein: the microfluidic chip clamp further comprises a rubber gasket, and when the microfluidic chip clamp is in the second state, the rubber gasket is located between the microfluidic chip and the lower base plate.
6. The microfluidic chip holder of claim 5, wherein: and a gasket groove for placing the rubber gasket is formed in the upper surface of the lower base plate, and the rubber gasket is arranged in the gasket groove.
7. A microfluidic chip gripper system comprising a clamping device having a clamping cavity for compressing a microfluidic chip gripper, characterized in that the microfluidic chip gripper system further comprises a microfluidic chip gripper according to any of claims 1-6, the microfluidic chip gripper being placed in the clamping cavity.
8. The microfluidic chip gripper system of claim 7, wherein: clamping device includes base plate, clamp plate, rotationally set up through first pivot in pressure head on the base plate and rotationally set up through the second pivot in handle on the base plate, the handle rotationally connect in through the third pivot in the pressure head, the centre gripping chamber set up in on the base plate, clamping device has the centre gripping state, works as clamping device is when the centre gripping state, the pressure head will the clamp plate compresses tightly on the base plate.
9. The microfluidic chip gripper system of claim 8, wherein: the lower end of the pressure head forms a rubber crimping part.
10. The microfluidic chip gripper system of claim 8, wherein: one end of the pressure plate is rotatably connected to the base plate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920509841.3U CN209917925U (en) | 2019-04-16 | 2019-04-16 | Micro-fluidic chip anchor clamps and anchor clamps system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920509841.3U CN209917925U (en) | 2019-04-16 | 2019-04-16 | Micro-fluidic chip anchor clamps and anchor clamps system |
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| Publication Number | Publication Date |
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| CN209917925U true CN209917925U (en) | 2020-01-10 |
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| CN201920509841.3U Active CN209917925U (en) | 2019-04-16 | 2019-04-16 | Micro-fluidic chip anchor clamps and anchor clamps system |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109954528A (en) * | 2019-04-16 | 2019-07-02 | 上海邦先医疗科技有限公司 | A kind of micro-fluidic chip clamp and chucking appliance system |
| CN109954528B (en) * | 2019-04-16 | 2024-10-29 | 上海邦先医疗科技有限公司 | Micro-fluidic chip fixture and fixture system |
-
2019
- 2019-04-16 CN CN201920509841.3U patent/CN209917925U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109954528A (en) * | 2019-04-16 | 2019-07-02 | 上海邦先医疗科技有限公司 | A kind of micro-fluidic chip clamp and chucking appliance system |
| CN109954528B (en) * | 2019-04-16 | 2024-10-29 | 上海邦先医疗科技有限公司 | Micro-fluidic chip fixture and fixture system |
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