CN209789891U - Alimentary canal multiposition liquid biopsy sampling device - Google Patents
Alimentary canal multiposition liquid biopsy sampling device Download PDFInfo
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- CN209789891U CN209789891U CN201920158392.2U CN201920158392U CN209789891U CN 209789891 U CN209789891 U CN 209789891U CN 201920158392 U CN201920158392 U CN 201920158392U CN 209789891 U CN209789891 U CN 209789891U
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Abstract
The utility model provides a alimentary canal multiposition liquid biopsy sampling device, including the casing be formed with a plurality of sample chambeies in the casing, each all set up the inside and outside through-hole of this sample intracavity of intercommunication on the casing in sample chamber, be different the through-hole in sample chamber coats and is stamped the target dissolved film that dissolves at the target position of difference the sample intracavity still is provided with absorption liquid and expanded material, expanded material's position with the position of through-hole suits, expanded material absorbs the liquid inflation and makes the through-hole seals. The multi-position liquid biopsy sampling device for the alimentary canal can accurately absorb liquid of a plurality of target positions under the condition of no external power source, and can prevent the liquid of other positions from polluting the sampled liquid.
Description
Technical Field
The utility model belongs to the technical field of the medical treatment and specifically relates to a alimentary canal multiposition liquid biopsy sampling device.
Background
The biopsy technique of the digestive tract has important significance for diagnosing digestive tract diseases. The traditional digestive tract biopsy technology adopts surgical instruments such as a tissue clamp, an electric knife and a puncture needle to obtain biopsy liquid or diseased tissues under the assistance of an endoscope, for example, the tissue clamp under the endoscope directly obtains the diseased tissues, the submucosal resection under the endoscope/mucosa dissection under the endoscope (EMR/ESD) and the fine needle puncture aspiration under the guidance of an ultrasonic endoscope (EUS-FNA) and the like.
With the development of micromachining technology, micro-electromechanical technology (MEMS) represented by capsule endoscopy opens up a new way for minimally invasive/comfortable biopsy sampling of the digestive tract. However, the techniques are still costly, complicated in energy supply equipment, and insufficient in positioning accuracy when actually applied to the biopsy procedure of the digestive tract.
In addition, the existing biopsy technique of the digestive tract can only sample one part of the digestive tract at a time, which can prolong the diagnosis time of diseases and increase the pain of patients.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a alimentary canal multiposition liquid biopsy sampling device, this alimentary canal multiposition liquid biopsy sampling device can accurately absorb the liquid at a plurality of target positions under the condition that does not have external power source, and can prevent that the liquid at other positions from causing the pollution to the sample liquid.
The utility model provides a alimentary canal multiposition liquid biopsy sampling device, including the casing be formed with a plurality of sample chambeies in the casing, each all set up the inside and outside through-hole of this sample intracavity of intercommunication on the casing in sample chamber, be different the through-hole in sample chamber coats and is stamped the target dissolved film that dissolves at the target position of difference the sample intracavity still is provided with absorption liquid and expanded material, expanded material's position with the position of through-hole suits, expanded material absorbs the liquid inflation and makes the through-hole seals.
Further, the shell is in a capsule shape.
Further, a water absorption material is arranged in the sampling cavity.
Further, the expansion material is a polymer formed by mixing a rubber polymer and a water-absorbent resin, and the expansion material of the polymer formed by mixing the rubber polymer and the water-absorbent resin blocks the through hole after absorbing liquid expansion, so that the through hole is closed.
Further, the expansion material is a polymer formed by mixing a rubber polymer and a water-absorbent resin, the digestive tract multi-position liquid biopsy sampling device further comprises a piston ring, the piston ring is arranged in the sampling cavity, a flow channel for liquid to pass through is formed in the piston ring, the outer side wall of the piston ring abuts against the inner side wall of the shell, the expansion material of the polymer formed by mixing the rubber polymer and the water-absorbent resin is arranged on one side, away from the through hole, of the piston ring, and the expansion material of the polymer formed by mixing the rubber polymer and the water-absorbent resin absorbs the liquid to expand so as to push the piston ring to further seal the through hole.
Further, the swelling material of the polymer obtained by mixing the rubber-based polymer with the water-absorbent resin is in the form of particles, and the swelling material of the polymer obtained by mixing the rubber-based polymer with the water-absorbent resin in the form of particles is provided on the water-absorbent material or on the inner wall of the housing.
Further, the swelling material is the material that absorbs water, alimentary canal multiposition liquid biopsy sampling device still includes the piston ring, the piston ring set up in sample intracavity, be formed with the runner that supplies liquid to pass through on the piston ring, the lateral wall of piston ring support lean on in the inside wall of casing, the material that absorbs water set up in the piston ring is kept away from the one side of through-hole, the material that absorbs water takes place the inflation after absorbing liquid, promotes the piston ring then makes the through-hole seals.
Further, when the water absorbent material does not absorb liquid, the water absorbent material is a compressed water absorbent material.
Further, the shell is internally provided with tracing particles which display the position of the alimentary canal multi-position liquid biopsy sampling device in the human digestive system through medical imaging technology.
Further, a balancing weight is further arranged in the shell.
In conclusion, through forming a plurality of sampling chambers that communicate with the external world through the through-hole in the casing to the through-hole in the sampling chamber of difference coats and is stamped the target dissolving film that dissolves at the target position of difference, sets up the inflation material that absorbs liquid and take place the inflation simultaneously in the casing, can be under the condition of no external power source, accurately absorb the liquid at a plurality of target positions, and can block up the through-hole through the inflation material behind the absorption liquid, consequently can prevent again that the liquid at other positions from causing the pollution to the sampling liquid.
The foregoing description is only an overview of the technical solutions of the present invention, and in order to make the technical means of the present invention more clearly understood, the present invention may be implemented according to the content of the description, and in order to make the above and other objects, features, and advantages of the present invention more obvious and understandable, the following preferred embodiments are described in detail with reference to the accompanying drawings.
Drawings
Fig. 1 is a schematic structural diagram of a multi-position biopsy sampling device for digestive tract fluid according to a first embodiment of the present invention.
Fig. 2 is a schematic structural diagram of the multi-position fluid biopsy sampling device for digestive tract after dissolution of the first targeting dissolution membrane in fig. 1.
Fig. 3 is a schematic structural diagram of the multi-position liquid biopsy sampling device for digestive tract after the dissolution of the second targeting dissolution film in fig. 1.
FIG. 4 is a schematic view of the multi-position biopsy sampling device of the digestive tract shown in FIG. 1 after sampling.
Fig. 5 is a schematic structural view of a multiple position liquid biopsy sampling device for digestive tract according to a second embodiment of the present invention.
Fig. 6 is a schematic view of the piston ring of fig. 5.
FIG. 7 is a schematic view of the multi-position biopsy sampling device of the digestive tract shown in FIG. 5 after sampling.
Fig. 8 is a schematic structural view of a multi-position biopsy sampling device for digestive tract fluid according to a third embodiment of the present invention.
FIG. 9 is a schematic view of the multi-position biopsy sampling device of the digestive tract shown in FIG. 8 after sampling.
Detailed Description
To further illustrate the technical means and effects of the present invention adopted to achieve the intended purpose of the present invention, the present invention will be described in detail with reference to the accompanying drawings and preferred embodiments.
An object of the utility model is to provide a alimentary canal multiposition liquid biopsy sampling device, this alimentary canal multiposition liquid biopsy sampling device can accurately absorb the liquid at a plurality of target positions under the condition that does not have external power source, and can prevent that the liquid at other positions from causing the pollution to the sample liquid.
Fig. 1 is a schematic structural view of a multi-position liquid biopsy sampling device for digestive tract according to a first embodiment of the present invention, fig. 2 is a schematic structural view of the multi-position liquid biopsy sampling device for digestive tract after a first target dissolution film is dissolved in fig. 1, fig. 3 is a schematic structural view of the multi-position liquid biopsy sampling device for digestive tract after a second target dissolution film is dissolved in fig. 1, and fig. 4 is a schematic structural view of the multi-position liquid biopsy sampling device for digestive tract after sampling is completed in fig. 1. As shown in fig. 1 to 4, the multi-position liquid biopsy sampling device for digestive tract according to the first embodiment of the present invention includes a housing 10, a plurality of partition plates 11 are disposed in the housing 10, a plurality of sampling cavities 12 are formed in the housing 10, through holes 13 communicating the inside and the outside of the sampling cavities 12 are disposed on the housing 10 of each sampling cavity 12, the through holes 13 of different sampling cavities 12 are covered with target dissolving films 21 dissolved at different target positions, the target dissolving films 21 on each sampling cavity 12 cover the through holes 13 on the sampling cavity 12, each sampling cavity 12 is provided with an expansion material 22 for absorbing liquid and expanding, the position of the expansion material 22 is adapted to the position of the through hole 13, and the expansion material 22 absorbs liquid and expands to close the through hole 13.
As shown in fig. 1 to 4, in the present embodiment, four sampling chambers 12 may be provided, and the target site of each sampling chamber 12 may be a stomach, a duodenum, a jejunum, and a colon in this order. It is understood that in other embodiments, the number of sampling cavities 12 and the corresponding target sites may be selected according to practical situations, and is not limited thereto. For example, the number of sampling chambers 12 may be 2, 3, or 5, etc.
In the present embodiment, a plurality of sampling chambers 12 communicating with the outside through holes 13 are formed in the housing 10, and the through holes 13 of different sampling chambers 12 are covered with target dissolving films 21 dissolving at different target sites, and an expanding material 22 absorbing liquid and expanding is provided in the housing 10. When the sampling device reaches the stomach, the target dissolving membrane 21 dissolved in the stomach is dissolved, and other dissolving membranes are not changed, and at this time, the through hole 13 on the sampling cavity 12 opposite to the stomach (see the sampling cavity 12 at the left end in fig. 2) is communicated with the stomach, and the stomach liquid enters the sampling cavity 12 opposite to the stomach. As the liquid enters, the swelling material 22 absorbs the liquid to swell, and then the through hole 13 is closed, so that the external liquid can not enter the sampling cavity 12 any more. When the sampling device reaches the next target site, such as duodenum, the dissolved target dissolving film 21 in the duodenum is dissolved, and the other undissolved target dissolving films 21 are not changed, at this time, the through hole 13 on the sampling cavity 12 (the second sampling cavity 12 at the left end in fig. 2) opposite to the duodenum is communicated with the duodenum, the liquid in the duodenum enters the sampling cavity 12 opposite to the duodenum, and then the swelling material 22 in the sampling cavity 12 corresponding to the duodenum absorbs the liquid to swell, so that the through hole 13 is closed; along with the sampling device passes through the jejunum part and the colon part in sequence, the liquid in the jejunum part and the colon part enters the sampling device, and thus the sampling of a plurality of parts is completed. Therefore, the utility model provides a alimentary canal multiposition liquid biopsy sampling device can be under the condition of no external power source, accurately absorb the liquid at a plurality of target positions, and can make through-hole 13 closed through expanded material 22 after absorbing liquid, consequently can prevent again that the liquid at other positions from causing the pollution to the sample liquid.
In this embodiment, the housing 10 may be made of medical grade polycarbonate, polyurethane, polyacrylate, polymethyl methacrylate, polyether ether ketone, polystyrene or polyethylene, etc. In this embodiment, the housing 10 may be capsule-shaped to facilitate movement of the sampling device within the digestive system of the human body.
Further, in this embodiment, in order to better sample the liquid, in this embodiment, a water absorbing material 23 is further disposed in the sampling cavity 12, and the water absorbing material 23 may be a water absorbing sponge such as a medical PVA sponge, PU sponge, cotton fiber sponge, lignocellulose sponge and/or chitosan sponge. In other embodiments, the water absorbing material 23 may also be sodium polyacrylate modified wood cellulose or chitosan modified wood cellulose, etc.
In this embodiment, the expansion material 22 may be a mixture of a rubber polymer and a water-absorbent resin, such as polyether-modified polyurethane rubber, sodium polyacrylate-modified styrene-butadiene rubber, polytetrahydrofuran-modified butadiene rubber, and acrylamide-modified ethylene-propylene-diene monomer rubber, and the expansion material 22 may be in the form of particles, and the particles of the expansion material 22 are fixed on the water-absorbent material 23 or on the inner sidewall of the housing 10 and are located in the through holes 13. When the swelling material 22 swells by absorbing liquid, it swells to close the through-hole 13, and then the through-hole 13 is closed. The rate of expansion of the intumescent material 22 may be sized to ensure that sufficient liquid enters the sampling cavity 12 at the target site and that the intumescent material 22 is able to close the through-hole 13 before the sampling device leaves the target site.
In the present embodiment, the targeted dissolution membrane 21 may cover each through hole 13 from the outside of the housing 10 or the inside of the housing 10 to block the communication inside and outside the sampling chamber 12 in an undissolved state. The material of the target dissolving film 21 that dissolves at the target site may be determined depending on the target site. For example, for a targeted dissolution membrane 21 targeting the stomach, EUDRAGIT E100 may be used as the targeted dissolution membrane 21, and for the duodenum, the targeted dissolution membrane 21 may be a mixture of EUDRAGIT L100-55 and EUDRAGIT Plastoid B targeted dissolution membrane 21; the membrane resists the erosion of acidic gastric fluids and utilizes the high pH characteristics of the duodenum to dissolve the targeted dissolution membrane 21, which in turn releases the drug. When the colon is taken as a target part, the targeted dissolving membrane 21 can also be the targeted dissolving membrane 21 of pectin and/or guar gum, and glycosidase and glycanase produced by special flora in the colon part are utilized to dissolve the targeted dissolving membrane 21, so that the drug is released. In another embodiment, the targeted dissolution membrane 21 may be a mixture of EUDRAGIT S100 and EUDRAGIT Plastoid B targeted dissolution membrane 21 that may utilize the pH characteristics of the colon site to dissolve the targeted dissolution membrane 21 and subsequently release the drug. More specifically, in order to ensure that the target dissolving film 21 of the multi-position liquid biopsy sampling device in the digestive tract can be dissolved at the target position, in the embodiment, the thickness of the target dissolving film 21 can be 100nm-100 μm.
And the interior of the sampling device is also provided with tracer particles 24, and the tracer particles 24 can display the position of the sampling device in the digestive system of the human body under the action of medical imaging technologies such as X-ray or magnetic field scanning and the like. The trace particles 24 may be barium sulfate particles or magnetic metal particles, and the trace particles 24 are further coated with an anti-corrosion layer such as Parylene coating or Parylene-C coating to prevent the liquid in the digestive system from corroding the trace particles 24. To facilitate the immobilization of the tracer particles 24, in this embodiment, the tracer particles 24 may be immobilized within the water absorbent material 23.
In order to immerse the sampling device in the liquid in the digestive tract and facilitate the absorption of the liquid, in this embodiment, the sampling device for liquid biopsy in multiple positions in the digestive tract further comprises a fitting block 25, the fitting block 25 can be a metal block such as an iron block, and the outside of the fitting block is also coated with an anti-corrosion layer such as Parylene coating or Parylene-C coating. The weight 32 may be disposed on the body 11 of the housing 10 as shown in the figure, or may be disposed in the end of the housing 10.
Fig. 5 is a schematic structural view of a multi-position biopsy sampling device for digestive tract liquid according to a second embodiment of the present invention, fig. 6 is a schematic structural view of a piston ring in fig. 5, and fig. 7 is a schematic structural view of the multi-position biopsy sampling device for digestive tract liquid in fig. 5 after sampling is completed. As shown in fig. 5-7, the multi-position fluid biopsy sampling device for digestive tract provided by the second embodiment of the present invention is substantially the same as the first embodiment. The difference is that in this embodiment, a piston ring 26 is further disposed in the sampling cavity 12, a flow channel 261 for liquid to pass through is formed in the middle of the piston ring 26, the outer side of the piston ring 26 abuts against the inner side wall of the housing 10, and the expansion material 22 is disposed on the side of the piston ring 26 away from the through hole 13, and when the expansion material 22 absorbs the liquid to expand, the piston ring 26 is pushed to move, so that the piston ring 26 closes the through hole 13.
Fig. 8 is a schematic structural view of a multi-position biopsy sampler for digestive tract liquid according to a third embodiment of the present invention, and fig. 9 is a schematic structural view of the multi-position biopsy sampler for digestive tract liquid shown in fig. 8 after sampling. As shown in FIGS. 8 and 9, a third embodiment of the present invention provides a multiple position biopsy sampler for fluids in the alimentary canal substantially similar to the second embodiment. The difference is that in this embodiment, the granular swelling material 22 is not provided, the water-absorbing material 23 is provided on the side of the piston ring 26 away from the through hole 13, and the water-absorbing material 23 swells after absorbing water, pushing the piston ring 26 to move, and then causing the piston ring 26 to close the through hole 13. Preferably, in the present embodiment, the water absorbent material 23 may be a compressed water absorbent sponge when it does not absorb liquid. That is, in this embodiment, the water absorbent material 23 can play both a role of holding liquid and a role of pushing the piston ring 26 to move.
In summary, a plurality of sampling chambers 12 communicated with the outside through the through holes 13 are formed in the housing 10, the through holes 13 of different sampling chambers 12 are covered with the target dissolving films 21 dissolved at different target positions, and the expansion material 22 which absorbs liquid and expands is arranged in the housing 10, so that the liquid at the plurality of target positions can be accurately absorbed without an external power source, and the through holes 13 can be blocked by the expansion material 22 after the liquid is absorbed, and therefore, the liquid at other positions can be prevented from polluting the sampled liquid.
The above description is only a preferred embodiment of the present invention, and the present invention is not limited to the above embodiments, and although the present invention has been disclosed with the preferred embodiments, it is not limited to the present invention, and any skilled person in the art can make some modifications or equivalent changes without departing from the technical scope of the present invention.
Claims (10)
1. A multiple position biopsy sampling device for fluid from the alimentary canal, comprising: the sampling device comprises a shell, wherein a plurality of sampling cavities are formed in the shell, through holes communicated with the inside and the outside of the sampling cavities are formed in the shell of each sampling cavity, different targeting dissolving films dissolved at different targeting positions are covered on the through holes of the sampling cavities, an expansion material which absorbs liquid and expands is further arranged in the sampling cavities, the position of the expansion material is matched with that of the through holes, and the expansion material absorbs the liquid to expand so as to seal the through holes.
2. The multiple position liquid biopsy sampling device of the alimentary canal of claim 1, wherein: the shell is in a capsule shape.
3. The multiple position liquid biopsy sampling device of the alimentary canal of claim 1, wherein: and a water absorption material for absorbing liquid is arranged in the sampling cavity.
4. The multiple position biopsy sampling device of the alimentary canal of claim 3, wherein: the expansion material is a polymer formed by mixing a rubber polymer and a water-absorbent resin, and the expansion material of the polymer formed by mixing the rubber polymer and the water-absorbent resin blocks the through hole after absorbing liquid expansion, so that the through hole is closed.
5. The multiple position biopsy sampling device of the alimentary canal of claim 3, wherein: the expansion material is a polymer formed by mixing rubber polymer and water-absorbent resin, the digestive tract multi-position liquid biopsy sampling device further comprises a piston ring, the piston ring is arranged in the sampling cavity, a flow channel for liquid to pass through is formed in the piston ring, the outer side wall of the piston ring abuts against the inner side wall of the shell, the expansion material of the polymer formed by mixing rubber polymer and water-absorbent resin is arranged on one side, away from the through hole, of the piston ring, the expansion material of the polymer formed by mixing rubber polymer and water-absorbent resin absorbs liquid to expand, and the piston ring is pushed to further seal the through hole.
6. The multiple position biopsy sampling device of alimentary canal according to claim 4 or 5, wherein: the expanded material of the polymer formed by mixing the rubber-like polymer and the water-absorbent resin is granular, and the expanded material of the polymer formed by mixing the granular rubber-like polymer and the water-absorbent resin is arranged on the water-absorbent material or the inner side wall of the shell.
7. The multiple position liquid biopsy sampling device of the alimentary canal of claim 1, wherein: the expansion material is a water-absorbing material, the multi-position liquid biopsy sampling device for the alimentary canal further comprises a piston ring, the piston ring is arranged in the sampling cavity, a flow passage for liquid to pass through is formed in the piston ring, the outer side wall of the piston ring is abutted to the inner side wall of the shell, the water-absorbing material is arranged on one side, away from the through hole, of the piston ring, the water-absorbing material expands after absorbing liquid, and the piston ring is pushed to further seal the through hole.
8. The multiple position liquid biopsy sampling device of the alimentary canal of claim 7, wherein: when the absorbent material does not absorb liquid, the absorbent material is a compressed absorbent material.
9. The multiple position liquid biopsy sampling device of the alimentary canal of claim 1, wherein: and the shell is internally provided with trace particles which display the position of the alimentary canal multi-position liquid biopsy sampling device in the human digestive system through a medical imaging technology.
10. The multiple position liquid biopsy sampling device of the alimentary canal of claim 1, wherein: and a balancing weight is also arranged in the shell.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201920158392.2U CN209789891U (en) | 2019-01-29 | 2019-01-29 | Alimentary canal multiposition liquid biopsy sampling device |
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| CN201920158392.2U CN209789891U (en) | 2019-01-29 | 2019-01-29 | Alimentary canal multiposition liquid biopsy sampling device |
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| CN209789891U true CN209789891U (en) | 2019-12-17 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109620299A (en) * | 2019-01-29 | 2019-04-16 | 上海安翰医疗技术有限公司 | A kind of alimentary canal multiposition liquid sampling device for biopsy |
| CN111449688A (en) * | 2020-04-13 | 2020-07-28 | 西安交通大学医学院第一附属医院 | Diagnostic instrument for early gastrointestinal tumor |
-
2019
- 2019-01-29 CN CN201920158392.2U patent/CN209789891U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109620299A (en) * | 2019-01-29 | 2019-04-16 | 上海安翰医疗技术有限公司 | A kind of alimentary canal multiposition liquid sampling device for biopsy |
| CN111449688A (en) * | 2020-04-13 | 2020-07-28 | 西安交通大学医学院第一附属医院 | Diagnostic instrument for early gastrointestinal tumor |
| CN111449688B (en) * | 2020-04-13 | 2022-07-08 | 西安交通大学医学院第一附属医院 | Diagnostic instrument for early gastrointestinal tumor |
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