CN210095776U

CN210095776U - Alimentary canal liquid biopsy sampling device

Info

Publication number: CN210095776U
Application number: CN201920158812.7U
Authority: CN
Inventors: 段晓东; 刘雷
Original assignee: Ankon Medical Technologies Shanghai Ltd
Current assignee: Ankon Medical Technologies Shanghai Ltd
Priority date: 2019-01-29
Filing date: 2019-01-29
Publication date: 2020-02-21
Anticipated expiration: 2029-01-29

Abstract

The utility model provides a alimentary canal liquid biopsy sampling device, including casing and expanded material, be provided with the inside and outside through-hole of intercommunication casing on the casing, it dissolves the membrane to cover the target that dissolves at the target position on the through-hole, expanded material's position with the position of through-hole suits, expanded material absorbs liquid and takes place the inflation and block up the through-hole. The digestive tract liquid biopsy sampling device can accurately absorb the liquid at the target part under the condition of no external power source, and can prevent the liquid at other parts from polluting the sampled liquid.

Description

Alimentary canal liquid biopsy sampling device

Technical Field

The utility model belongs to the technical field of the medical treatment and specifically relates to a alimentary canal liquid biopsy sampling device.

Background

The biopsy technique of the digestive tract has important significance for diagnosing digestive tract diseases. The traditional digestive tract biopsy technology adopts surgical instruments such as a tissue clamp, an electric knife and a puncture needle to obtain biopsy liquid or diseased tissues under the assistance of an endoscope, for example, the tissue clamp under the endoscope directly obtains the diseased tissues, the submucosal resection under the endoscope/mucosa dissection under the endoscope (EMR/ESD) and the fine needle puncture aspiration under the guidance of an ultrasonic endoscope (EUS-FNA) and the like.

With the development of micromachining technology, micro-electromechanical technology (MEMS) represented by capsule endoscopy opens up a new way for minimally invasive/comfortable biopsy sampling of the digestive tract. However, the techniques are still costly, complicated in energy supply equipment, and insufficient in positioning accuracy when actually applied to the biopsy procedure of the digestive tract.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a alimentary canal liquid biopsy sampling device, this alimentary canal liquid biopsy sampling device can be under the condition of no external power source, accurately absorb the liquid at target position, and can prevent that the liquid at other positions from causing the pollution to the sample liquid.

The utility model provides a alimentary canal liquid biopsy sampling device, including casing and expanded material, be provided with the inside and outside through-hole of intercommunication casing on the casing, it dissolves the membrane to cover the target that dissolves at the target position on the through-hole, expanded material's position with the position of through-hole suits, expanded material absorbs liquid and takes place the inflation and makes the through-hole seals.

Further, the shell is in a capsule shape.

Further, a water absorption material for absorbing liquid is arranged in the shell.

Further, the swelling material absorbs liquid to swell and then blocks the through hole, thereby closing the through hole.

Further, the alimentary canal liquid biopsy sampling device still includes the piston ring, be formed with the runner that supplies liquid to pass through on the piston ring, the lateral wall of piston ring supports and leans on the inside wall of casing, the expanding material sets up in the piston ring is kept away from one side of through-hole, the expanding material absorbs liquid and takes place the inflation, promotes the piston ring then makes the piston ring block up the through-hole.

Further, the expansion material is granular, and the granular expansion material is arranged on the water absorption material or the inner side wall of the shell.

Further, the swelling material is the material that absorbs water, alimentary canal liquid biopsy sampling device still includes the piston ring, be formed with the runner that supplies liquid to pass through on the piston ring, the lateral wall of piston ring support lean on in the inside wall of casing on, the material that absorbs water set up in the piston ring is kept away from one side of through-hole, the material that absorbs water takes place the inflation after absorbing liquid, promotes the piston ring, then makes the piston ring block up the through-hole.

Further, a balancing weight is further arranged in the shell.

Further, the shell is a capsule-shaped shell and comprises a body and end parts positioned on two sides of the body, and the through holes are positioned on the body and/or the end parts.

Furthermore, the shell is internally provided with tracing particles which display the position of the alimentary canal liquid biopsy sampling device in the human digestive system through the medical imaging technology.

To sum up, the utility model discloses a set up the through-hole on the casing to cover the target dissolving film that dissolves at the target position on the through-hole, after ingesting alimentary canal liquid biopsy sampling device human, along human digestive system, reach the target position, like behind positions such as stomach, duodenum, jejunum or colon, according to the special environment of target position, like pH value, special fungus crowd and/or specific enzyme etc. dissolve the target material, make the inside of casing pass through-hole and external intercommunication, the liquid at target position can get into in the casing through the through-hole. Therefore, the utility model provides a alimentary canal liquid biopsy sampling device is under the condition of no external power source, accurately absorbs the liquid at target position. Further, when liquid at the target position enters the shell through the through hole, a part of the liquid can be absorbed by the expansion material, the expansion material absorbs the liquid to expand, then the through hole is sealed, the communication between the inside of the shell and the outside is cut off, and the outside liquid can not enter the shell again. Therefore, the utility model provides a alimentary canal liquid biopsy sampling device can prevent that the liquid at other positions from causing the pollution to the sample liquid. Furthermore, the utility model can absorb liquid smoothly by the arrangement of the water absorption material; the position of the sampling device in the human body can be displayed through the arrangement of the tracer particles; through the setting of balancing weight, can be convenient for the sampling device submergence wait in the absorptive liquid.

The foregoing description is only an overview of the technical solutions of the present invention, and in order to make the technical means of the present invention more clearly understood, the present invention may be implemented according to the content of the description, and in order to make the above and other objects, features, and advantages of the present invention more obvious and understandable, the following preferred embodiments are described in detail with reference to the accompanying drawings.

Drawings

Fig. 1 is a schematic structural diagram of a biopsy sampling device for digestive tract liquid according to a first embodiment of the present invention.

FIG. 2 is a schematic structural diagram of the digestive tract liquid biopsy sampling device shown in FIG. 1 after dissolution of the targeting lysis membrane.

FIG. 3 is a schematic structural view of the biopsy sampling device for digestive tract liquid in FIG. 1 after sampling.

Fig. 4 is a schematic structural diagram of a biopsy sampling device for digestive tract liquid according to a second embodiment of the present invention.

FIG. 5 is a schematic structural diagram of the digestive tract liquid biopsy sampling device after dissolution of the targeting dissolution membrane in FIG. 4.

FIG. 6 is a schematic structural view of the biopsy sampling device for digestive tract liquid in FIG. 4 after sampling.

Fig. 7 is a schematic structural diagram of a biopsy sampling device for digestive tract liquid according to a third embodiment of the present invention.

Fig. 8 is a schematic view of a piston ring structure.

FIG. 9 is a schematic structural view of the biopsy sampling device for digestive tract liquid in FIG. 7 after sampling.

Fig. 10 is a schematic structural view of a biopsy sampling device for digestive tract liquid according to a fourth embodiment of the present invention.

FIG. 11 is a schematic view of the biopsy sampling device for digestive tract fluid shown in FIG. 10 after sampling.

Detailed Description

To further illustrate the technical means and effects of the present invention adopted to achieve the intended purpose of the present invention, the present invention will be described in detail with reference to the accompanying drawings and preferred embodiments.

Fig. 1 is a schematic structural view of a sampling device for liquid biopsy in digestive tract according to a first embodiment of the present invention, fig. 2 is a schematic structural view of the sampling device for liquid biopsy in digestive tract after dissolution of a target dissolution film in fig. 1, and fig. 3 is a schematic structural view of the sampling device for liquid biopsy in digestive tract in fig. 1 after completion of sampling. As shown in fig. 1 to 3, the device for sampling a liquid biopsy in digestive tract according to the first embodiment of the present invention includes a housing 10, a through hole 21 communicating the inside and the outside of the housing 10 is formed in the housing 10, a target dissolving film 22 dissolving at a target site is covered on the through hole 21, the device for sampling a liquid biopsy in digestive tract further includes an expanding material 23 expanding by absorbing liquid, the position of the expanding material 23 is adapted to the position of the through hole 21, and the expanding material 23 absorbs the liquid to expand so as to close the through hole 21.

In the present embodiment, since the through hole 21 is formed in the housing 10, and the through hole 21 is covered with the target dissolving film 22 dissolved at the target portion, after the biopsy sampling device for digestive tract fluid is taken into the human body, the biopsy sampling device reaches the target portion, such as the stomach, duodenum, jejunum or colon, along the digestive system of the human body, and the target material is dissolved (as shown in fig. 2) according to the specific environment of the target portion, such as PH, specific flora and/or specific enzyme, so that the inside of the housing 10 communicates with the outside through the through hole 21, and the fluid at the target portion can enter the housing 10 through the through hole 21. Therefore, the utility model provides a alimentary canal liquid biopsy sampling device is under the condition of no external power source, accurately absorbs the liquid at target position. Further, when the liquid at the target site enters the housing 10 through the through hole 21, a part of the liquid is absorbed by the swelling material 23, and the swelling material 23 absorbs the liquid to swell (see fig. 3), so that the through hole 21 is closed, the communication between the inside of the housing 10 and the outside is blocked, and the liquid outside cannot enter the housing 10. After the liquid is absorbed, the sampling device can be discharged out of the body in the digestive system, and the obtained liquid can be detected. Therefore, the utility model provides a alimentary canal liquid biopsy sampling device can prevent that the liquid at other positions from causing the pollution to the sample liquid.

In this embodiment, the housing 10 may be made of medical grade polycarbonate, polyurethane, polyacrylate, polymethyl methacrylate, polyether ether ketone, polystyrene or polyethylene, etc. In this embodiment, the housing 10 may be capsule-shaped to facilitate movement of the sampling device within the digestive system of the human body. The capsule-shaped housing 10 includes a body 11 and end portions 12 at both sides of the body 11, and in this embodiment, through holes 21 may be provided on the end portions 12 of the housing 10.

Further, in the present embodiment, in order to better sample the liquid, in the present embodiment, a water absorbing material 13 is further disposed in the housing 10, and the water absorbing material 13 may be a medical PVA sponge, PU sponge, cotton fiber sponge, lignocellulose sponge, chitosan sponge, and/or the like.

In this embodiment, the swelling material 23 may be in the form of particles, and the particles of the swelling material 23 are fixed to the water absorbent material 13 or the inner wall of the casing 10 and are positioned to fit the through holes 21, so that when the particles of the swelling material 23 swell by absorbing liquid, they themselves block the through holes 21. The rate of expansion of the intumescent material 23 may be sized to ensure that sufficient liquid enters the sampling device at the target site and that the intumescent material 23 is able to close the through-hole 21 before the sampling device leaves the target site.

The swelling material 23 may be sodium polyacrylate modified wood cellulose, chitosan modified wood cellulose, or a polymer obtained by mixing a rubber polymer with a water-absorbent resin.

In the present embodiment, the targeted dissolution film 22 may cover the through hole 21 from the outside of the casing 10 or the inside of the casing 10 to insulate the communication between the inside and the outside of the casing 10 in an undissolved state. The material of the target dissolving film 22 that dissolves at the target site may be determined depending on the target site. For example, for a targeted dissolution membrane 21 targeting the stomach, EUDRAGITE100 may be used as the targeted dissolution membrane 21. When duodenum is required to be the target site, the targeting dissolution membrane 22 can be a mixture of EUDRAGIT L100-55 and EUDRAGIT Plastoid B targeting dissolution membrane 22; the membrane resists the erosion of acidic gastric fluids and utilizes the high pH characteristics of the duodenum to dissolve the targeted dissolution membrane 22, which in turn releases the drug. When the colon is taken as a target part, the target dissolving membrane 22 can also be the target dissolving membrane 22 of pectin and/or guar gum, and glycosidase and glycanase produced by special flora in the colon part are utilized to dissolve the target dissolving membrane 22, so that the drug is released. In another embodiment, the targeted dissolution membrane 22 may be a mixture of EUDRAGIT S100 and EUDRAGIT Plastoid B targeted dissolution membrane 22 that may utilize the pH characteristics of the colon site to dissolve the targeted dissolution membrane 22 and subsequently release the drug. More specifically, in order to ensure that the target dissolving film 22 for biopsy sampling of the digestive tract fluid can be dissolved at the target site, in the present embodiment, the thickness of the target dissolving film 22 may be 100nm-100 μm.

The shell 10 is further internally provided with tracing particles 31, the tracing particles 31 can display the position of the sampling device in the digestive system of a human body under the action of medical imaging technologies such as X-ray or magnetic field scanning, the tracing particles 31 can be barium sulfate particles or metal particles with magnetism, and the tracing particles 31 are further coated with a corrosion-resistant layer such as a medical polyurethane coating or a parylene coating to prevent liquid in the digestive system from corroding the tracing particles 31. To facilitate the immobilization of the tracer particles 31, in this embodiment, the tracer particles 31 may be immobilized within the water absorbent material 13.

Fig. 4 is a schematic structural diagram of a sampling device for liquid biopsy in digestive tract according to a second embodiment of the present invention, fig. 5 is a schematic structural diagram of the sampling device for liquid biopsy in digestive tract after the dissolution of the target dissolution film 22 in fig. 4, and fig. 6 is a schematic structural diagram of the sampling device for liquid biopsy in digestive tract after completion of sampling in fig. 4. As shown in fig. 4 to 6, the digestive tract liquid biopsy sampling device provided by the second embodiment of the present invention is substantially the same as the digestive tract liquid biopsy sampling device provided by the first embodiment, except that in the present embodiment, the through hole 21 is located at the middle of the casing 10, i.e. on the body 11 of the capsule casing 10. In other embodiments, the capsule-type casing 10 may be provided with through-holes 21 on both the body 11 and the end 12.

Further, in order to immerse the sampling device in the liquid of the digestive tract and facilitate the absorption of the liquid, in this embodiment, the sampling device for liquid biopsy of the digestive tract further comprises a weight 32, the weight 32 may be a metal block such as an iron block, and the weight 32 is also coated with an anti-corrosion layer such as a medical polyurethane coating or a parylene coating. The weight 32 may be disposed in the end 12 as shown in fig. 4, 5 or 6; or may be provided in the body 11 as shown in fig. 7 or 9.

Fig. 7 is a schematic structural view of a sampling device for liquid biopsy in digestive tract according to a third embodiment of the present invention, fig. 8 is a schematic structural view of a piston ring, and fig. 9 is a schematic structural view of the sampling device for liquid biopsy in digestive tract in fig. 7 after sampling is completed. As shown in fig. 7 to 9, the biopsy sampling device provided by the third embodiment of the present invention is substantially the same as the second embodiment, except that in this embodiment, a piston ring 24 is further disposed in the biopsy sampling device, a flow channel 241 for passing liquid is formed in the middle of the piston ring 24, the piston ring 24 abuts against the inner side wall of the housing 10, the expansion material 23 is disposed on one side of the piston ring 24 away from the through hole 21, and when the expansion material 23 absorbs the liquid to expand, the piston ring 24 is pushed to move, so that the piston ring 24 closes the through hole 21.

Fig. 10 is a schematic structural view of a sampling device for liquid biopsy in digestive tract according to a fourth embodiment of the present invention, and fig. 11 is a schematic structural view of the sampling device for liquid biopsy in digestive tract in fig. 10 after sampling is completed. As shown in fig. 10 to 11, the biopsy sampling device for digestive tract fluid provided by the fourth embodiment of the present invention is substantially the same as the third embodiment, except that in this embodiment, the granular swelling material 23 is not provided, the water absorbing material 13 is provided on the side of the piston ring 24 away from the through hole 21, and the water absorbing material 13 swells after absorbing water, pushing the piston ring 24 to move, and then making the piston ring 24 close the through hole 21. That is, in this embodiment, the water-absorbing material 13 is the swelling material 23, and the water-absorbing material 13 plays two roles of retaining liquid and pushing the piston ring 24 to move. Preferably, in the present embodiment, when the water absorbent material 13 does not absorb liquid, the water absorbent material 13 may be in a compressed state.

To sum up, the utility model discloses a set up through-hole 21 on casing 10 to cover the target dissolved membrane 22 that dissolves at the target position on through-hole 21, after ingesting alimentary canal liquid biopsy sampling device human body, along human digestive system, reach the target position, like stomach, duodenum, jejunum or position such as colon after, according to the special environment of target position, like pH value, special fungus crowd and/or specific enzyme etc. dissolve the targeting material (like figure 2), make casing 10's inside pass through-hole 21 and external intercommunication, the liquid at target position can get into in casing 10 through-hole 21. Therefore, the utility model provides a alimentary canal liquid biopsy sampling device is under the condition of no external power source, accurately absorbs the liquid at target position. Further, when the liquid at the target site enters the housing 10 through the through hole 21, a part of the liquid is absorbed by the swelling material 23, and the swelling material 23 absorbs the liquid to swell (see fig. 3), so that the through hole 21 is closed, the communication between the inside of the housing 10 and the outside is cut off, and the liquid outside can not enter the housing 10 again. Therefore, the utility model provides a alimentary canal liquid biopsy sampling device can prevent that the liquid at other positions from causing the pollution to the sample liquid. Furthermore, the utility model can absorb liquid smoothly by the arrangement of the water absorption material 13; by the arrangement of the tracer particles 31, the position of the sampling device in the human body can be displayed; by the arrangement of the weight 32, the sampling device can be conveniently immersed into the liquid to be absorbed.

The above description is only a preferred embodiment of the present invention, and the present invention is not limited to the above embodiments, and although the present invention has been disclosed with the preferred embodiments, it is not limited to the present invention, and any skilled person in the art can make some modifications or equivalent changes without departing from the technical scope of the present invention.

Claims

1. A gastrointestinal fluid biopsy sampling device, comprising: the device comprises a shell and an expansion material, wherein a through hole communicated with the inside and the outside of the shell is formed in the shell, a target dissolving film dissolved at a target part is covered on the through hole, the position of the expansion material is matched with that of the through hole, and the expansion material absorbs liquid to expand so as to seal the through hole.

2. The alimentary canal liquid biopsy sampling device of claim 1, wherein: the shell is in a capsule shape.

3. The alimentary canal liquid biopsy sampling device of claim 1, wherein: and a water absorption material for absorbing liquid is arranged in the shell.

4. The digestive tract liquid biopsy sampling device of claim 3, wherein: the swelling material absorbs liquid to swell and then blocks the through hole, so that the through hole is closed.

5. The digestive tract liquid biopsy sampling device of claim 3, wherein: the digestive tract liquid biopsy sampling device further comprises a piston ring, a flow channel for liquid to pass through is formed in the piston ring, the outer side wall of the piston ring is abutted to the inner side wall of the shell, the expansion material is arranged on one side, far away from the through hole, of the piston ring, the expansion material absorbs the liquid to expand, and the piston ring is pushed to plug the through hole.

6. The digestive tract liquid biopsy sampling device of claim 4 or 5, wherein: the expansion material is granular, and the granular expansion material is arranged on the water absorption material or the inner side wall of the shell.

7. The alimentary canal liquid biopsy sampling device of claim 1, wherein: the expansion material is a water-absorbing material, the digestive tract liquid biopsy sampling device further comprises a piston ring, a flow channel for liquid to pass through is formed in the piston ring, the outer side wall of the piston ring abuts against the inner side wall of the shell, the water-absorbing material is arranged on one side, away from the through hole, of the piston ring, the water-absorbing material expands after absorbing liquid, the piston ring is pushed, and then the piston ring is enabled to block the through hole.

8. The alimentary canal liquid biopsy sampling device of claim 1, wherein: and a balancing weight is also arranged in the shell.

9. The alimentary canal liquid biopsy sampling device of claim 1, wherein: the shell is a capsule-shaped shell and comprises a body and end parts positioned on two sides of the body, and the through holes are positioned on the body and/or the end parts.

10. The alimentary canal liquid biopsy sampling device of claim 1, wherein: and the shell is internally provided with trace particles which display the position of the alimentary canal multi-position liquid biopsy sampling device in the human digestive system through a medical imaging technology.