CN209727966U - A kind of protein sequencing analyzer - Google Patents
A kind of protein sequencing analyzer Download PDFInfo
- Publication number
- CN209727966U CN209727966U CN201920445821.4U CN201920445821U CN209727966U CN 209727966 U CN209727966 U CN 209727966U CN 201920445821 U CN201920445821 U CN 201920445821U CN 209727966 U CN209727966 U CN 209727966U
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- China
- Prior art keywords
- reagent
- box body
- partition
- protein sequencing
- elevating mechanism
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- 238000000734 protein sequencing Methods 0.000 title claims abstract description 30
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 80
- 238000005192 partition Methods 0.000 claims abstract description 35
- 230000003028 elevating effect Effects 0.000 claims abstract description 22
- 238000003149 assay kit Methods 0.000 claims abstract description 14
- 230000005540 biological transmission Effects 0.000 claims description 12
- 238000004458 analytical method Methods 0.000 claims description 5
- 238000012163 sequencing technique Methods 0.000 abstract description 13
- 238000005070 sampling Methods 0.000 abstract description 2
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The utility model discloses a kind of protein sequencing analyzers, including analyzer ontology and the assay kit being arranged on the analyzer ontology, the assay kit includes reagent box body, it is arranged in the intrinsic rotating mechanism of the kit, elevating mechanism on the rotating mechanism is set, multiple Reagent Tubes for installed reagents for being placed on the elevating mechanism and it is rotatably installed in the intrinsic partition of the kit, the rotating mechanism can drive the elevating mechanism, multiple Reagent Tubes and the partition rotate synchronously, when the elevating mechanism drives the Reagent Tube to rise, multiple Reagent Tubes may pass through the partition.Corresponding sequencing reagent can be sent to sampling station automatically by the protein sequencing analyzer of the utility model, improve the efficiency of sequencing, in addition the spatial design of this assay kit opposing seal can reduce reagent and contact and pollute with the external world, to propose the accuracy of high protein sequencing to a certain extent.
Description
Technical field
The utility model relates to protein sequencing field more particularly to a kind of protein sequencing analyzers.
Background technique
Currently, so-called protein sequencing generally refers to the measurement of the primary structure of protein.The primary structure of protein
Polypeptide chain number including constitutive protein matter.Many occasion peptide and proteins, which can be equal, to be used.The amino acid of polypeptide chain is suitable
Sequence, it is the basis of protein bio function.
Scientific development can be sequenced protein sequencing to today by protein sequencing analysis instrument, number
According to two kinds of common methods for constituting the analysis of proteomic image data when library searching and de novo sequencing, existing protein sequencing analysis
The analyzer of instrument and analytical reagent take be it is separated, cannot achieve the automation of entire sequencing procedure, greatly reduce survey
The efficiency of sequence, the protein sequencing analyzer of the utility model are focused on needle assay kit and are accordingly designed, and are reached with cooperation
Realize that automation takes reagent and automates the purpose of sequencing.
Utility model content
The purpose of this utility model is that: it cannot achieve analytical reagent to solve existing protein sequencing analyzer and take
The drawbacks of sample and sequencing procedure integrally automate progress, and a kind of protein sequencing analyzer proposed.
To achieve the goals above, the utility model adopts the technical scheme that a kind of protein sequencing analyzer, packet
The assay kit for including analyzer ontology and being arranged on the analyzer ontology, the assay kit include kit sheet
Body, be arranged in the intrinsic rotating mechanism of the kit, the elevating mechanism being arranged on the rotating mechanism, be placed on it is described
Multiple Reagent Tubes for installed reagents on elevating mechanism and it is rotatably installed in the intrinsic partition of the kit, the rotation
Mechanism can drive the elevating mechanism, multiple Reagent Tubes and the partition to rotate synchronously, when the elevating mechanism drives institute
When stating Reagent Tube rising, multiple Reagent Tubes may pass through the partition.
It is as above-mentioned technical proposal to further describe:
The reagent box body include box body and with the box cover that is screwed at the top of the box body.
It is as above-mentioned technical proposal to further describe:
The rotating mechanism includes the stepper motor being fixedly mounted on the reagent box body inner sidewall, is rotatably installed in
The supporting plate being fixedly connected at the top of the transmission shaft of box body inner face center and bottom centre and the transmission shaft, the step
Output end into motor is equipped with drive bevel gear, and the transmission shaft is equipped with the slave mantle tooth engaged with the drive bevel gear
Wheel.
It is as above-mentioned technical proposal to further describe:
The elevating mechanism include the miniature push rod for being fixedly mounted on the supporting plate top middle portion, be fixedly mounted on it is described micro-
The pallet of type push rod output end and two guide rods for pallet lift guiding, two guide rods are relatively described miniature to be pushed away
Bar is symmetrical, and one end of two guide rods is fixedly connected on the supporting plate, and the other end of two guide rods is equal
It is fixedly connected on the partition.
It is as above-mentioned technical proposal to further describe:
Annular array is distributed four housing sleeves on the pallet, is placed with Reagent Tube in four housing sleeves.
It is as above-mentioned technical proposal to further describe:
The partition, which horizontally rotates, to be mounted in the box body, and the partition is equipped with set corresponding with four housing sleeves
The perforation set, the Reagent Tube may pass through the perforation.
In conclusion by adopting the above-described technical solution, the beneficial effects of the utility model are:
1, in the utility model, the rotating mechanism that is arranged in instant analyzer elevating mechanism Reagent Tube risen expose to every
Reagent Tube can be driven to rotate behind the upper surface of plate, the examination of different reagents will be equipped with by the intermittent rotation of rotating mechanism
Agent pipe is sent to working position, so that cooperating analyzer ontology to be automatically performed takes reagent, reduces the link that sequencing personnel are manually sequenced, from
And improve the efficiency of sequencing.
2, in the utility model, specially setting is equipped with the partition perforated, and only retains on partition and keeps away wearing for a Reagent Tube disengaging
Hole, and box body is constituted into the space of a relative closure, it even opens the lid, has been similarly formed certain barrier, when not
When with reagent, the Reagent Tube equipped with reagent avoids reagent and extraneous excessive contact and is contaminated below partition,
Avoid the accuracy that protein sequencing is influenced because of reagent contamination.
Detailed description of the invention
Fig. 1 is the overall structure diagram of assay kit in the utility model；
Fig. 2 be the utility model proposes protein sequencing analyzer structural schematic diagram；
Fig. 3 be the utility model in assay kit take away box cover and partition when structural schematic diagram.
Marginal data:
1, analyzer ontology；2, assay kit；21, reagent box body；211, box body；212, box cover；22, whirler
Structure；221, stepper motor；2211, drive bevel gear；222, transmission shaft；2221, driven wheel of differential；223, supporting plate；23, elevator
Structure；231, miniature push rod；232, pallet；2321, housing sleeve；233, guide rod；24, Reagent Tube；25, partition；251, it perforates.
Specific embodiment
The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model
Clearly and completely describe, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than whole
Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art are without creative efforts
All other embodiment obtained, fall within the protection scope of the utility model.
Fig. 1-3 is please referred to, the utility model provides a kind of technical solution: a kind of protein sequencing analyzer, including analysis
Device ontology 1 and the assay kit 2 being arranged on analyzer ontology 1, assay kit 2 exist including reagent box body 21, setting
Rotating mechanism 22 in reagent box body 21, is placed on elevating mechanism 23 elevating mechanism 23 being arranged on rotating mechanism 22
Four Reagent Tubes 24 for installed reagents and the partition 25 that is rotatably installed in reagent box body 21, rotating mechanism 22 can drive
23, four Reagent Tubes 24 of elevating mechanism and partition 25 rotate synchronously, when elevating mechanism 23 drives Reagent Tube 24 to rise, four examinations
Agent pipe 24 may pass through partition 25.
Specifically, as shown in Figure 1, reagent box body 21 include box body 211 and with the box cover 212 that is screwed at the top of box body 211.
Simple screw closure structure is easy to open.
Specifically, as shown in Figure 1, rotating mechanism 22 includes the stepping electricity being fixedly mounted on 21 inner sidewall of reagent box body
Machine 221 is rotatably installed at the top of the transmission shaft 222 and bottom centre and transmission shaft 222 of 211 inner face center of box body and fixes
The output end of the supporting plate 223 of connection, stepper motor 221 is equipped with drive bevel gear 2211, and transmission shaft 222 is equipped with and active conical tooth
The driven wheel of differential 2221 of 2211 engagement of wheel.Rotating mechanism 22 is used to corresponding sequencing reagent being sent to working position, facilitates cooperation
The analyzer ontology 1 of automation takes reagent to use automatically.
Specifically, as shown in figures 1 and 3, elevating mechanism 23 includes miniature the pushing away for being fixedly mounted on 223 top middle portion of supporting plate
Bar 231, the pallet 232 for being fixedly mounted on miniature 231 output end of push rod and two guide rods 233 for the lifting guiding of pallet 232,
The relatively miniature push rod 231 of two guide rods 233 is symmetrical, and one end of two guide rods 233 is fixedly connected on supporting plate 223,
The other end of two guide rods 233 is fixedly connected on partition 25.When carrying out protein sequencing, elevating mechanism 23 is by Reagent Tube
24 are sent to the upper surface for exposing partition 25, and after use, elevating mechanism 23 sends Reagent Tube 24 back to partition 25 lower section, in addition lead
Partition 25 and rotating mechanism 22 are also constituted an entirety in addition to using as guiding by bar 233.
Specifically, as shown in figures 1 and 3, annular array is distributed four housing sleeves 2321, four housing sleeves on pallet 232
Reagent Tube 24 is placed in 2321.Reagent Tube 24 is directly placed in housing sleeve 2321 convenient be directly brought into and takes out.
Specifically, partition 25 is equipped with and four placements as shown in Figure 1, partition 25 horizontally rotates is mounted in box body 211
The perforation 251 that set 2321 is correspondingly arranged, Reagent Tube 24 may pass through perforation 251.Only retain on partition 25 and keeps away the disengaging of a Reagent Tube 24
Perforation 251, and box body 211 is constituted into the space of a relative closure, even opens the lid 212, be similarly formed one
Fixed barrier, when not having to reagent, the Reagent Tube 24 equipped with reagent is to be located at 25 lower section of partition, avoids reagent and extraneous mistake
Degree is contacted and is contaminated, and avoids the accuracy that protein sequencing is influenced because of reagent contamination.
It should be noted that the model of the stepper motor 221 and miniature push rod 231 mentioned in the utility model can be
It directly buys in the market, and circuit connecting mode and control mode are understood by those skilled in the art, it will not be described here.
Working principle: it the utility model proposes a kind of protein sequencing analyzer, is set in the analyzer of the utility model
The assay kit 2 set is that the analyzer ontology 1 for taking reagent of cooperation automation uses, in use, box cover 212 is unscrewed,
The miniature push rod 231 of subsequent start-up drives pallet 232 to move straight up along two guide rods 233, to be placed on housing sleeve
Four Reagent Tubes 24 in 2321 and then move upwards, and four Reagent Tubes 24 is made to both pass through wearing for corresponding position on partition 25
Hole 251 and the upper surface for exposing partition 25, facilitate and take reagent, and rotating mechanism 22 can drive Reagent Tube 24 stepping interval to turn
It moves that the analyzer ontology 1 of automation is cooperated to take reagent automatically, stepper motor 221 can intermittently drive Reagent Tube 24 to rotate four
/ mono- circle specifically starts stepper motor 221, and the drive bevel gear 2211 of output end can drive driven wheel of differential
2221, so that transmission shaft 222 be driven to rotate, then supporting plate 223 can be rotated with the rotation of transmission shaft 222, to will drive
Overall structure above supporting plate 223 rotates synchronously, and corresponding Reagent Tube 24 is sent to corresponding survey by rotating mechanism 22
Sequence station facilitates the reagent that takes automated, will be under the Reagent Tube 24 equipped with reagent by elevating mechanism 23 after sequencing
25 lower section of partition is dropped to, and box cover 212 is covered, the use of partition 25 can will be divided into an opposing seal in box body 211
Space, without opening completely, can avoid reagent excessively with extraneous contact stain and cause the accuracy of protein sequencing,
Corresponding sequencing reagent can be sent to sampling station automatically by the protein sequencing analyzer of the utility model, facilitate realization complete certainly
The sequencing of dynamicization improves the efficiency of sequencing, and in addition the spatial design of 2 opposing seal of this assay kit can reduce reagent and outer
Boundary contacts and pollutes, to propose the accuracy of high protein sequencing to a certain extent.
The preferable specific embodiment of the above, only the utility model, but the protection scope of the utility model is not
It is confined to this, anyone skilled in the art is within the technical scope disclosed by the utility model, practical according to this
Novel technical solution and its utility model design are subject to equivalent substitution or change, should all cover the protection model in the utility model
Within enclosing.
Claims (6)
1. a kind of protein sequencing analyzer, including analyzer ontology (1) and the analysis being arranged on the analyzer ontology (1)
Kit (2), which is characterized in that the assay kit (2) includes reagent box body (21), is arranged in the reagent box body
(21) rotating mechanism (22) in, is placed on the elevator at the elevating mechanism (23) being arranged on the rotating mechanism (22)
Multiple Reagent Tubes (24) for installed reagents on structure (23) and the partition that is rotatably installed in the reagent box body (21)
(25), the rotating mechanism (22) can drive the elevating mechanism (23), multiple Reagent Tubes (24) and the partition (25)
It rotates synchronously, when the elevating mechanism (23) drive the Reagent Tube (24) to rise, multiple Reagent Tubes (24) can be worn
Cross the partition (25).
2. a kind of protein sequencing analyzer according to claim 1, which is characterized in that reagent box body (21) packet
The box cover (212) for including box body (211) and being screwed with the box body (211) top.
3. a kind of protein sequencing analyzer according to claim 2, which is characterized in that the rotating mechanism (22) includes
The stepper motor (221) that is fixedly mounted on reagent box body (21) inner sidewall is rotatably installed in the box body (211)
The supporting plate (223) being fixedly connected at the top of the transmission shaft (222) of end face center position and bottom centre and the transmission shaft (222),
The output end of the stepper motor (221) is equipped with drive bevel gear (2211), and the transmission shaft (222) is equipped with and the active
The driven wheel of differential (2221) of bevel gear (2211) engagement.
4. a kind of protein sequencing analyzer according to claim 3, which is characterized in that the elevating mechanism (23) includes
It is fixedly mounted on that the miniature push rod (231) of the supporting plate (223) top middle portion, to be fixedly mounted on the miniature push rod (231) defeated
The pallet (232) of outlet and two guide rods (233) being oriented to for the pallet (232) lifting, two guide rod (233) phases
It is symmetrical to the miniature push rod (231), and one end of two guide rods (233) is fixedly connected in the supporting plate
(223) on, the other end of two guide rods (233) is fixedly connected on the partition (25).
5. a kind of protein sequencing analyzer according to claim 4, which is characterized in that annular on the pallet (232)
Four housing sleeves (2321) of array distribution are placed with Reagent Tube (24) in four housing sleeves (2321).
6. a kind of protein sequencing analyzer according to claim 5, which is characterized in that the partition (25) horizontally rotates
It is mounted in the box body (211), the partition (25) is equipped with the perforation being correspondingly arranged with four housing sleeves (2321)
(251), the Reagent Tube (24) may pass through the perforation (251).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920445821.4U CN209727966U (en) | 2019-04-03 | 2019-04-03 | A kind of protein sequencing analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920445821.4U CN209727966U (en) | 2019-04-03 | 2019-04-03 | A kind of protein sequencing analyzer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209727966U true CN209727966U (en) | 2019-12-03 |
Family
ID=68690142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920445821.4U Expired - Fee Related CN209727966U (en) | 2019-04-03 | 2019-04-03 | A kind of protein sequencing analyzer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209727966U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113148442A (en) * | 2021-04-13 | 2021-07-23 | 陕西中医药大学 | Food hygiene microorganism detect reagent box |
| CN113976201A (en) * | 2021-10-14 | 2022-01-28 | 广州市红十字会医院（暨南大学医学院附属广州红十字会医院） | Nasopharyngeal carcinoma circulating tumor cell detection kit |
-
2019
- 2019-04-03 CN CN201920445821.4U patent/CN209727966U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113148442A (en) * | 2021-04-13 | 2021-07-23 | 陕西中医药大学 | Food hygiene microorganism detect reagent box |
| CN113976201A (en) * | 2021-10-14 | 2022-01-28 | 广州市红十字会医院（暨南大学医学院附属广州红十字会医院） | Nasopharyngeal carcinoma circulating tumor cell detection kit |
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20191203 Termination date: 20200403 |
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| CF01 | Termination of patent right due to non-payment of annual fee |