CN209712872U - A kind of coaxial endoscope and image processing device of optoacoustic and the coaxial endoscope system of optoacoustic - Google Patents
A kind of coaxial endoscope and image processing device of optoacoustic and the coaxial endoscope system of optoacoustic Download PDFInfo
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- CN209712872U CN209712872U CN201822126601.3U CN201822126601U CN209712872U CN 209712872 U CN209712872 U CN 209712872U CN 201822126601 U CN201822126601 U CN 201822126601U CN 209712872 U CN209712872 U CN 209712872U
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Abstract
The utility model is suitable for Biologic Medical Image equipment technical field, discloses a kind of coaxial endoscope and image processing device of optoacoustic and the coaxial endoscope system of optoacoustic.The coaxial endoscope and image processing device of optoacoustic includes the optoacoustic conduit for making tissue generate optoacoustic effect, the optoacoustic conduit includes tube body, for generating irradiation light or guiding the irradiation light of irradiation light to provide component, the ultrasonic components for emitting ultrasonic wave and receivable ultrasonic wave and photoacoustic signal, the irradiation light provides component and is set to or is inserted into the tube body, and the ultrasonic components are set to the tube body；The optoacoustic conduit further includes the microscope group for focusing to the ultrasonic components central axes after irradiation light is reflected or reflected respectively, the outside of the microscope group setting.The coaxial endoscope system of optoacoustic includes above-mentioned endoscope and image processing device.A kind of coaxial endoscope and image processing device of optoacoustic provided by the utility model and the coaxial endoscope system of optoacoustic, optoacoustic is coaxial, optoacoustic is overlapped that area is big, imaging effect is good.
Description
Technical field
The utility model belong to Biologic Medical Image equipment technical field more particularly to a kind of coaxial endoscope and image processing device of optoacoustic and
The coaxial endoscope system of optoacoustic.
Background technique
China's tumor in digestive tract disease incidence persistently increases in recent years, and early detection and treatment can largely improve patient's
Five year survival rate, endoscopic diagnosis is method common at present, wherein it is very necessary for exploring new endoscope diagnosis and treatment technology.Optoacoustic
A kind of biomedical imaging method as non-invasive is imaged, the technology and digestive endoscopy, which are combined into, realizes that tumor in digestive tract is high
Sensitive early diagnosis provides new Diagnosis-treat Model, shows its huge applications potentiality.
Photoacoustic imaging technology not only makes up the low disadvantage of conventional ultrasound imaging technique resolution ratio, and improve pure optics at
As the disadvantage small because of imaging depth caused by organizing the scattering to light, at the same it is important using difference realization of the biological tissue to light absorption
Functional imaging, as blood oxygen saturation test.Current existing research trial uses photoacoustic imaging technology in conjunction with digestive endoscopy
In alimentary canal based endoscopic imaging, possibility is provided for the diagnosis of alimentary canal infantile tumour.But since traditional optoacoustic endoscopy is led
The region of the photon-phonon coupling of pipe is small, and photoacoustic signal detection efficient is low, while that structure is complicated is changeable for alimentary canal, and stomach wall and intestinal wall exist
Cavity wall bending and mucous membrane buckling phenomena, complicated structural environment reduce the signal-to-noise ratio of system, swell so this is unfavorable for alimentary canal
Tumor early detection and Accurate Diagnosis.
Optoacoustic endoscopy imaging technology (Photoacoustic Endoscopy) be it is a kind of photoacoustic imaging system is integrated into it is micro-
It, can be in human body alimentary canal, intravascular intervention imaging technique of the realization based on photoacoustic principle in small imaging catheter.Because application
Scene is different, peeps optoacoustic conduit in alimentary canal and the size of intravascular intervention optoacoustic two kinds of conduits of conduit has differences.But two
Person is all based on photoacoustic imaging principle, and ps pulsed laser and ns pulsed laser excites tissue, and release thermal energy leads to absorber office after tissue resorption light
Portion's temperature increases, and temperature change causes tissue to expand with heat and contract with cold and generates pressure wave, i.e. photoacoustic signal；The optoacoustic that Tissue reflectance is returned
Signal is received by ultrasonic transducer, is rebuild by later image and is realized optoacoustic endoscopy imaging.
In the design of existing optoacoustic endoscopy conduit, be divided into optoacoustic it is coaxial with not coaxial two kinds of optoacoustic.Optoacoustic is coaxial to be protected
The search coverage of the irradiation area and sound of demonstrate,proving light is same axle center always, but is generally required in the crystal detection of ultrasonic transducer
Light source is placed in centre by heart aperture, is reached with sacrificing the detection performance of ultrasonic transducer；Or with the light of transmitted light reflected sound
Learning component, optoacoustic is coaxial reaching, but complicated optical module reduces the efficiency of transmission of light in conduit.The not coaxial design of optoacoustic,
It ensure that the complete of ultrasonic transducer, emergent light or ultrasonic transducer tilted to certain angle, so that light area harmony
Search coverage has certain overlapping, but optoacoustic is not coaxial to limit system imaging range and high s/n ratio.
To sum up, optoacoustic endoscopy imaging equipment is primarily present following disadvantage in the prior art:
(1) currently with laser by the ultrasonic transducer of center opening, through reflector to tissue, finally by ultrasound
Although the alimentary canal optoacoustic endoscopy catheter design that energy converter receives photoacoustic signal realizes the coaxial purpose of optoacoustic, but due in
The ultrasonic transducer piezo-electric crystal receiving area of hollow structure is small, reduces the receiving efficiency of photoacoustic signal, is unfavorable for the high noise of system
The realization of ratio.
(2) it is coaxial to realize optoacoustic for the optical module that transmitted light reflected sound is utilized in some optoacoustic endoscopy conduits, improves system
The purpose of system signal-to-noise ratio.But the optical element of multiple groups conjunction reduces the efficiency of transmission of light, finally limits system signal noise ratio.
(3) other than the coaxial catheter design of optoacoustic, catheter design currently not coaxial there is also optoacoustic, it makes use of
Light beam is centainly overlapped area with beamforming, realizes image reconstruction to the photoacoustic signal of acquisition.Although the design avoids in conduit
The disadvantage that light transmissioning efficiency is low, ultrasonic transducer acceptance rate is low, but its optoacoustic is not coaxial, optoacoustic is overlapped Qu little Er causes to be imaged
The shortcomings that depth as shallow the restraining factors as system high s/n ratio.
Utility model content
The utility model aims to solve at least one of above-mentioned technical problem, provides a kind of coaxial endoscope and image processing device of optoacoustic and light
The coaxial endoscope system of sound, optoacoustic is coaxial, optoacoustic coincidence area is big, imaging effect is good.
The technical solution of the utility model is: a kind of coaxial endoscope and image processing device of optoacoustic, including making tissue generate optoacoustic effect
Optoacoustic conduit, the optoacoustic conduit include tube body, the irradiation light offer component for generating irradiation light or guidance irradiation light, are used for
Emit ultrasonic wave and can receive the ultrasonic components of ultrasonic wave and photoacoustic signal, the irradiation light provides component and is set to or protrudes into
In in the tube body, the ultrasonic components are set to the tube body；The optoacoustic conduit further includes anti-for distinguishing irradiation light
The microscope group of the ultrasonic components central axes is penetrated or focuses to after reflecting, the microscope group is set in the tube body and is located at described super
The outside of part part.
Optionally, the microscope group includes the first reflector and the second reflector for being set to the ultrasonic components two sides；Institute
Stating irradiation light and providing component is to be connected to generating device of laser and the intracorporal optical fiber of the pipe is protruded into front end, is also set in the tube body
The laser for projecting the optical fiber is equipped with to distribute to the refractor of the first reflector and the second reflector, the optical fiber
Front end is toward the refractor.
Optionally, the first angle is formed between the mirror surface of first reflector and the optical axis of irradiation light, described second is anti-
Form the second angle between the mirror surface of emitter and the optical axis of irradiation light, first angle, the second angle complementary angle each other.
Optionally, first reflector is located at the ultrasonic components close to the side of the refractor, and described second
Reflector is located at side of the ultrasonic components far from the refractor, and the reflecting surface of first reflector is not higher than described
The working face of ultrasonic components, the reflecting surface of second reflector are higher than the working face of the ultrasonic components.
Optionally, the refractor is that will be used for the equal part of laser emitted by the optical fiber front end to described first instead
The gradient-index lens of emitter and second reflector.
Optionally, it is provided in the tube body for the first matching tube for optical fiber insertion and is placed on described first
Second matching tube of piping and the refractor, second matching tube are also arranged with positioned at the intracorporal metal of the pipe outside
Pipe.
Optionally, ultrasonic coupling medium is filled in the tube body.
Optionally, the optical fiber is provided with one, two or two or more, and the microscope group is provided with one group, two groups or two
It is more than group.
Optionally, the ultrasonic components are connected with high-frequency signal line, and the high-frequency signal line is from the outside of the metal tube
It is pierced by the tube body.
The utility model additionally provides a kind of coaxial endoscope system of optoacoustic, including a kind of above-mentioned optoacoustic it is coaxial in peep dress
It sets, further includes:
As the main trigger source of pulse signal computer and data collecting card,
For return pulse signal and issue synchronization signal single-chip microcontroller,
For receive synchronization signal and issue time delayed signal to ultrasound transmitting-receiving instrument laser and driver,
The data collecting card is connected to the computer and the single-chip microcontroller, the single-chip microcontroller be connected to the laser,
Driver and the ultrasound transmitting-receiving instrument, the laser are connected with optical module and photoelectricity slip ring, and photoelectricity slip ring, which is connected to, to be protruded into
Intracorporal optical fiber is managed, the photoelectricity slip ring is also respectively connected in the driver and the ultrasound transmitting-receiving instrument, the ultrasound transmitting-receiving
Instrument is also attached to the data collecting card.
A kind of coaxial endoscope and image processing device of optoacoustic provided by the utility model and the coaxial endoscope system of optoacoustic, in optoacoustic is coaxial
Endoscope devices, endoscope system utilize fiber optic conduction pulse laser, optical fiber combination metal matching tube (the first matching tube) and gradient refractive index
Rate lens reach the matched purpose of size, recycle plastics matching tube (the second matching tube) to fix three, and be assemblied in metal
In outer tube (metal tube).The application of gradient-index lens improves collimation efficiency in optoacoustic conduit, improves achromatism in imaging
Effect, for laser after gradient-index lens focus, the light of half is radiated at the reflecting surface of the first reflector, the other half illumination
Penetrate the reflecting surface in the second reflector, the angle of the first reflector, the second reflector and horizontal plane complementary angle each other realizes two-way
Light beam is in the purpose of the same space zone focusing.Ultrasonic transducer is placed in the centre of the first reflector, the second reflector, receives
From tissue return photoacoustic signal, both realized in this way optoacoustic it is coaxial, increase optoacoustic be overlapped area the characteristics of, in turn avoid laser because
The optical element group of traditional anti-sound of light transmission and the low disadvantage of coupling efficiency, are conducive to the signal-to-noise ratio of raising system, imaging effect is good.
Detailed description of the invention
In order to illustrate more clearly of the technical scheme in the embodiment of the utility model, will make below to required in embodiment
Attached drawing is briefly described, it should be apparent that, the drawings in the following description are merely some embodiments of the present invention,
For those of ordinary skill in the art, without creative efforts, it can also be obtained according to these attached drawings
Other attached drawings.
Fig. 1 is a kind of diagrammatic cross-section of the coaxial endoscope and image processing device of optoacoustic provided by the embodiment of the utility model；
Fig. 2 is a kind of plane partial schematic diagram of the coaxial endoscope system of optoacoustic provided by the embodiment of the utility model；
Fig. 3 is the signal timing diagram of single-chip microcontroller in the coaxial endoscope system of a kind of optoacoustic provided by the embodiment of the utility model；
Fig. 4 is that a kind of optical software Zemax of the coaxial endoscope and image processing device of optoacoustic provided by the embodiment of the utility model is simulated
Light path schematic diagram；
Fig. 5 is the light path schematic diagram that the hot spot intersection that optical path is formed in Fig. 4 is simulated in optical software Zemax；
Fig. 6 is that the quasi- coaxial interior optoacoustic for peeping conduit of traditional optoacoustic is overlapped area's schematic diagram in the prior art；
Fig. 7 is that a kind of optoacoustic of the coaxial endoscope and image processing device of optoacoustic provided by the embodiment of the utility model is overlapped area's schematic diagram.
Specific embodiment
In order to make the purpose of the utility model, technical solutions and advantages more clearly understood, below in conjunction with attached drawing and implementation
Example, the present invention will be further described in detail.It should be appreciated that specific embodiment described herein is only used to explain
The utility model is not used to limit the utility model.
It should be noted that term " setting ", " connection " shall be understood in a broad sense, for example, it may be directly setting, connection,
It can also be arranged indirectly by component placed in the middle, center configuration, be connected.
If in addition, have in the utility model embodiment " longitudinal direction ", " transverse direction ", " length ", " width ", " thickness ", "upper",
The orientation of the instructions such as "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom" "inner", "outside" or position are closed
The term of system, to be based on the orientation or positional relationship shown in the drawings or conventional placement status or use state, merely to
Convenient for describing the utility model and simplifying description, rather than structure, feature, device or the element of indication or suggestion meaning must have
There is specific orientation or positional relationship, nor is it necessary that and be constructed and operated in a specific orientation, therefore should not be understood as to this reality
With novel limitation.In the description of the present invention, unless otherwise indicated, the meaning of " plurality " is two or more.
Described each particular technique feature and each embodiment in a specific embodiment, in the case of no contradiction,
It can be combined in any appropriate way, such as can be with shape by different particular technique feature/embodiment combinations
At different embodiments, in order to avoid unnecessary repetition, each particular technique feature/embodiment is each in the utility model
No further explanation will be given for the possible combination of kind.
As shown in Figure 1 to Figure 3, the coaxial endoscope and image processing device of a kind of optoacoustic provided by the embodiment of the utility model, including make tissue
The optoacoustic conduit 10 of optoacoustic effect is generated, the optoacoustic conduit 10 includes tube body 1, for generating irradiation light or guiding irradiation light
Irradiation light provides component, the ultrasonic components 2 for emitting ultrasonic wave and receivable ultrasonic wave and photoacoustic signal, ultrasonic components 2
It can be ultrasonic transducer.The irradiation light provides component and is set to or is inserted into the tube body 1, and the ultrasonic components 2 are arranged
In in the tube body 1；The optoacoustic conduit 10 further includes for focusing to the ultrasound after irradiation light is reflected or reflected respectively
The microscope group of 2 central axes of component, the microscope group are set in the tube body 1 and are located at the outside of the ultrasonic components 2.In this way, nothing
The ultrasonic transducer of hollow structure need to be set, and the piezo-electric crystal receiving area of ultrasonic transducer is big, and photoacoustic signal can be improved
Receiving efficiency, conducive to the realization of system high s/n ratio, and the efficiency of transmission of light is high, conducive to system signal noise ratio is further increased, and
Irradiation light focuses to the central axes of the ultrasonic components 2 after being reflected or reflected respectively, realize that optoacoustic is coaxial, be conducive to increase
Optoacoustic is overlapped area, and imaging depth is good, is conducive to the realization of system high s/n ratio.
In concrete application, the side of tube body 1 is provided with imaging window, and the working faces of ultrasonic components 2 is toward imaging window
Setting.Imaging window can be close to the front end of tube body 1.
Specifically, the microscope group include be set to 2 two sides of ultrasonic components and it is first anti-for reflected illumination light
Emitter 31 and the second reflector 32；First reflector 31 and the second reflector 32 can be optical mirror, such as prism etc..Irradiation
Light can be laser or infrared light etc., and irradiation light can be divided into equal two parts, the first reflector 31 of 2 opposite sides of ultrasonic components
The equal light of two parts can be reflexed on 2 central axes of ultrasonic components respectively with the second reflector 32 and focused, realize that ultrasound is changed
Maximization of the energy device to photoacoustic signal acceptance rate, realizes that optoacoustic is coaxial, increases photon-phonon coupling area, be conducive to mentioning for system signal noise ratio
Height, and imaging depth can be increased.As shown in figure 1, the light beam 901 of the first reflector 31 reflection, the light of the second reflector 32 reflection
Beam 902, the wave beam 903 that ultrasonic components 2 are formed, light beam 901, light beam 902 focus on the central axes of wave beam 903, wave beam 903
Central axes be also ultrasonic components 2 central axes.
Specifically, it is to be connected to generating device of laser and front end is protruded into the tube body 1 that the irradiation light, which provides component,
Optical fiber 41, the laser being additionally provided with for projecting the optical fiber 41 in the tube body 1 are distributed to the first reflector 31 and second
The refractor 33 of reflector 32, the front end of the optical fiber 41 is toward the refractor 33.The front end face of optical fiber 41 can be with
It is in contact with the plane of incidence of refractor 33.Refractor 33 is distributed to the laser of the first reflector 31 and the second reflector 32
Can be equal, in the present embodiment, refractor 33 distributes the laser of half to the first reflector 31, the other half laser is distributed
To the second reflector 32.
Specifically, the first angle is formed between the mirror surface of first reflector 31 and the optical axis of irradiation light, described second
Form the second angle between the mirror surface of reflector 32 and the optical axis of irradiation light, first angle, the second angle complementary angle each other.Light
The part that fibre 41 protrudes into tube body 1 is defined as the front end portion of optical fiber 41, and the central axes of the front end portion of optical fiber 41 are to irradiate
The optical axis of light.In the present embodiment, the front end portion of optical fiber 41 is arranged along the central axes of tube body 1, i.e. the optical axis Yu tube body 1 of irradiation light
Central axes it is coaxial, when tube body 1 is horizontally arranged, the angle of the first reflector 31 and the second reflector 32 and horizontal plane is each other
Complementary angle.In this way, being conducive to realize that optoacoustic is coaxial.
Specifically, first reflector 31 is located at the ultrasonic components 2 close to the side of the refractor 33, described
Second reflector 32 is located at side of the ultrasonic components 2 far from the refractor 33, the reflecting surface of first reflector
Not higher than the working face of the ultrasonic components 2, the reflecting surface of second reflector is higher than the working face of the ultrasonic components 2,
Laser directly can be passed through refraction distribution to the first reflector 31 and the second reflector 32, laser utilization by refractor 33
It is high.
Specifically, the refractor 33 is that will be used for the equal part of laser emitted by 41 front end of optical fiber to described
The gradient-index lens of one reflector 31 and second reflector 32.Gradient-index lens are located at optical fiber 41 and first instead
Between emitter 31, ultrasonic components 2 are between the first reflector 31 and the second reflector 32.The central axes of optical fiber 41 and gradient are rolled over
The central axes for penetrating rate lens are overlapped, and the central axes of ultrasonic components 2 can be vertical with the central axes of optical fiber 41, the axis of ultrasonic components 2
Line is also vertical with the central axes of gradient-index lens.
Specifically, it is provided with for the first matching tube 11 for the optical fiber 41 insertion and is placed on described in the tube body 1
Second matching tube 12 of the first matching tube 11 and the refractor 33, second matching tube 12 are also arranged with positioned at institute outside
The shielded-plate tube (metal tube 13) in tube body 1 is stated, the second matching tube 12 can be plastic pipe, and assembling structure is simple and reliable.
Specifically, ultrasonic coupling medium can be filled in the tube body 1.
In concrete application, the optical fiber 41 may be provided with one, two or two or more.
In concrete application, the microscope group (the first reflector 31 and the second reflector 32) may be provided with one group, two groups or two
It is more than group.
Specifically, the ultrasonic components 2 are connected with high-frequency signal line 21, and the high-frequency signal line 21 is from the metal tube
Outside is pierced by the tube body 1.
A kind of coaxial endoscope and image processing device of optoacoustic provided by the present embodiment, by the way that at least one set of horizontal sextant angle complementary angle each other is arranged
The first reflector 31 and the second reflector 32, realize the coaxial optoacoustic conduit 10 of optoacoustic, utilize the first reflector 31 and second
Reflector 32 can increase optoacoustic and be overlapped area, improve the utilization rate of light, and optical module only has graded index in acousto-optic conduit
Lens and the first reflector 31 and the second reflector 32, structure is simple, improves the optical coupling rate of conduit, it is coaxial both to have realized optoacoustic
Purpose, while the shortcomings that avoid complicated optical module from reducing the efficiency of transmission of light in conduit, moreover, its optoacoustic is overlapped area's ratio
Quasi-optical sound coaxial design conduit it is bigger, more fully utilize the energy of light.Analog result also turns out, peeps dress in the optoacoustic is coaxial
The coaxial purpose of optoacoustic may be implemented in the design set, and also avoids reducing the efficiency of transmission of light in conduit because of complicated optical module
The shortcomings that, in concrete application, the overall dimensions of acousto-optic conduit can reduce, to be suitable for the intervention light of intravascular or smaller cavity
The corresponding multiple reflecting mirrors of multifiber 41 can be set moreover, not only limiting an optical fiber 41 and two reflecting mirrors in acoustic imaging,
It can avoid the ultrasonic transducer purpose coaxial to the obstruction of optical path, realization optoacoustic.In concrete application, it can use other optics members
Part substitutes reflector, avoids ultrasonic transducer to the obstruction of optical path, realizes the coaxial purpose of optoacoustic.
Fig. 4 is a kind of optical path analogous diagram of the coaxial endoscope and image processing device of optoacoustic in the present embodiment.When the light source that diameter is 105 μm
After the gradient-index lens (refractor 33) that diameter is 500 μm and length is 2.6mm, the optical path half of focusing is shone
It penetrates and reflects to form light beam 901 on the first reflector 31, the other half is radiated on the second reflector 32 and reflects to form light beam 902.
31 Distance gradient index lens distance of the first reflector herein is 200 μm, and the size of 31 right-angle side of the first reflector is 450
μm * 450 μm.The angle of the reflecting surface of first reflector 31 and horizontal plane is 47.45 °, the reflecting surface of the second reflector 32 with
The angle of horizontal plane is 42.55 °, the two complementary angle each other.It is such to design region and ultrasonic transducer so that two-beam intersection
Center be in same axis, realize the coaxial purpose of optoacoustic, two beams that the first reflector 31 and the second reflector 32 are reflected
The focal zone minimum of light is overlapped section (i.e. hot spot intersection) apart from ultrasonic transducer 3.09mm.Fig. 5 is hot spot intersection
Analogous diagram, the visual field that 200 μm * 200 μm of Fang Tuwei.The transmitting light focal zone of two reflectors is overlapped together at this time, which is
Semicircle, maximal side are about 33 μm.
In Fig. 6, the colored areas in box is that the quasi- coaxial interior optoacoustic for peeping conduit of traditional optoacoustic is overlapped area, by the coincidence area
Area is as 1 arbitrary unit.The reflecting surface of reflector and horizontal angle are 50 °.
In Fig. 7, the colored areas in box is that the optoacoustic of the coaxial endoscope and image processing device of optoacoustic in the present embodiment is overlapped area, the coincidence
Area's area is 2.8 arbitrary units compared with Fig. 6.So can be verified in the present embodiment under both Fig. 6 and attached drawing 7 comparison
The optoacoustic coincidence area of the coaxial endoscope and image processing device of optoacoustic is bigger than quasi-optical sound coaxial design conduit, effectively improves the utilization of luminous energy
Rate.
The utility model embodiment additionally provides a kind of coaxial endoscope system of optoacoustic, coaxial interior including a kind of above-mentioned optoacoustic
Endoscope devices, further includes:
As the main trigger source of pulse signal computer and data collecting card,
For return pulse signal and issue synchronization signal single-chip microcontroller,
For receive synchronization signal and issue time delayed signal to ultrasound transmitting-receiving instrument laser and driver,
The data collecting card is connected to the computer and the single-chip microcontroller, the single-chip microcontroller be connected to the laser,
Driver and the ultrasound transmitting-receiving instrument, the laser are connected with optical module and photoelectricity slip ring, and photoelectricity slip ring is connected to optical fiber
41 rear end, the front end of optical fiber 41 are protruded into tube body 1, and the photoelectricity slip ring is also respectively connected in the driver and the ultrasound
Instrument is received and dispatched, the ultrasound transmitting-receiving instrument is also attached to the data collecting card and ultrasonic components.
The utility model embodiment additionally provides a kind of control method of coaxial endoscope system of optoacoustic, using above-mentioned one kind
The coaxial endoscope system of optoacoustic, comprising the following steps:
Computer and data collecting card generate pulse signal；
Single-chip microcontroller, which captures, issues synchronization signal after the pulse signal to laser and driver, and issues time delayed signal extremely
Ultrasound transmitting-receiving instrument；
When triggering after laser reception synchronization signal and outgoing pulse laser, pulse laser are coupled into photoelectricity through optical module
It in slip ring, and is conducted by optical fiber 41 to optoacoustic conduit 10, is finally excited at tissue；
While the laser is triggered, the driver is triggered and photoelectricity slip ring and optoacoustic conduit 10 is driven to revolve
Turn and pulls back；
Time-delayed trigger after the ultrasound transmitting-receiving instrument reception delay signal, the ultrasound transmitting-receiving instrument, which issues electric signal, leads optoacoustic
Ultrasonic components 2 issue mechanical wave in pipe 10；
Ultrasonic components 2 receive the photoacoustic signal that tissue is generated by optoacoustic effect, while also receiving spontaneous ultrasonic signal, most
Signal is reached into data collecting card afterwards and later image processing is done by computer, realizes optoacoustic/ultrasonic double-mode state imaging of tissue.
A kind of coaxial endoscope and image processing device of optoacoustic provided by the utility model embodiment and the coaxial endoscope system of optoacoustic, optoacoustic are total
Axis endoscope and image processing device, endoscope system conduct pulse laser using optical fiber 41, and optical fiber 41 combines metal matching tube (the first matching tube 11)
Reach the matched purpose of size with gradient-index lens, plastics matching tube (the second matching tube 12) recycled to fix three,
And it is assemblied in metal outer pipe (metal tube).Tube body 1 is used as protection pipe, and the effect of protection pipe is to prevent optoacoustic conduit 10 from (inside peeping
Conduit) it is contaminated in imaging process, while ultrasonic coupling medium is filled in protection pipe.Graded index in optoacoustic conduit 10 herein
The application of lens improves collimation efficiency, improves achromatism effect in imaging.Laser is after gradient-index lens focus, half
Light be radiated at the reflecting surface of the first reflector 31, the other half light is radiated at the reflecting surface of the second reflector 32.First reflection
The angle complementary angle each other of device 31, the second reflector 32 and horizontal plane, realizes two-way light beam in the mesh of the same space zone focusing
's.Ultrasonic transducer is placed in the centre of the first reflector 31, the second reflector 32, receives the photoacoustic signal returned from tissue,
The characteristics of optoacoustic is coaxial, increase optoacoustic is overlapped area had both been realized in this way, in turn avoided optics member of the laser because of the anti-sound of traditional light transmission
Part group and the low disadvantage of coupling efficiency, are conducive to the signal-to-noise ratio of raising system.When system works, computer and data collecting card conduct
The main trigger source of signal, after pulse signal is captured by single-chip microcontroller, single-chip microcontroller sending synchronization signal to laser and driver, concurrently
Time delayed signal to ultrasound receives and dispatches instrument, timing diagram such as Fig. 3 out.When pulse laser is triggered, outgoing pulse laser, laser is through light
It learns component to be coupled into photoelectricity slip ring, and is conducted by optical fiber 41 to optoacoustic conduit 10, finally excited at tissue.Laser quilt
While triggering, driver is also triggered, and photoelectricity slip ring is driven to rotate and pull back with optoacoustic conduit 10.And ultrasound transmitting-receiving instrument quilt
After Time-delayed trigger, the autonomous electric signal that issues makes ultrasonic transducer in conduit issue mechanical wave.This process, ultrasonic transducer needs connect
Receive the photoacoustic signal that generates by optoacoustic effect of tissue, while also receiving the ultrasonic signal of idioreflex, finally by photoacoustic signal with
Ultrasonic signal reaches data collecting card and does later image processing by computer, is imaged by computer output optoacoustic/ultrasonic double-mode state, real
The optoacoustic now organized/ultrasonic double-mode state imaging, imaging effect are good.
The above is only the preferred embodiment of the utility model only, is not intended to limit the utility model, all at this
Made any modification, equivalent replacement or improvement etc., should be included in the utility model within the spirit and principle of utility model
Protection scope within.
Claims (10)
1. a kind of coaxial endoscope and image processing device of optoacoustic, which is characterized in that including making tissue generate the optoacoustic conduit of optoacoustic effect, the light
Acoustic conducting pipe includes tube body, for generating irradiation light or the irradiation light of irradiation light being guided to provide component, for emitting ultrasonic wave and can
The ultrasonic components of ultrasonic wave and photoacoustic signal are received, the irradiation light provides component and is set to or is inserted into the tube body,
The ultrasonic components are set to the tube body；
The optoacoustic conduit further includes for focusing to the ultrasonic components central axes after irradiation light is reflected or reflected respectively
Microscope group, the microscope group are set to the outside in the tube body and being located at the ultrasonic components.
2. a kind of coaxial endoscope and image processing device of optoacoustic as described in claim 1, which is characterized in that
The microscope group includes the first reflector and the second reflector for being set to the ultrasonic components two sides；
It is to be connected to generating device of laser and the intracorporal optical fiber of the pipe, the tube body are protruded into front end that the irradiation light, which provides component,
The laser for projecting the optical fiber is inside additionally provided with to distribute to the refractor of the first reflector and the second reflector, it is described
The front end of optical fiber is toward the refractor.
3. a kind of coaxial endoscope and image processing device of optoacoustic as claimed in claim 2, which is characterized in that the mirror surface of first reflector with
The first angle is formed between the optical axis of irradiation light, and the second folder is formed between the mirror surface of second reflector and the optical axis of irradiation light
Angle, first angle, the second angle complementary angle each other.
4. a kind of coaxial endoscope and image processing device of optoacoustic as claimed in claim 3, which is characterized in that first reflector is located at described
For ultrasonic components close to the side of the refractor, second reflector is located at the ultrasonic components far from the refractor
Side, the reflecting surface of first reflector is not higher than the working face of the ultrasonic components, the reflection of second reflector
Face is higher than the working face of the ultrasonic components.
5. a kind of coaxial endoscope and image processing device of optoacoustic as claimed in claim 4, which is characterized in that the refractor be will be used for by
The equal part of laser emitted by the optical fiber front end to first reflector and second reflector gradient-index lens.
6. the coaxial endoscope and image processing device of a kind of optoacoustic as described in any one of claims 1 to 5, which is characterized in that in the tube body
It is provided with the first matching tube for being inserted into for optical fiber and is placed on the second matching tube of first matching tube and refractor,
It is also arranged with outside second matching tube positioned at the intracorporal metal tube of the pipe.
7. a kind of coaxial endoscope and image processing device of optoacoustic as claimed in claim 6, which is characterized in that filled with ultrasonic coupling in the tube body
Close medium.
8. the coaxial endoscope and image processing device of a kind of optoacoustic the invention according to any one of claims 2 to 5, which is characterized in that the optical fiber is set
Be equipped with one, two or two or more, the microscope group be provided with one group, two groups or more.
9. a kind of coaxial endoscope and image processing device of optoacoustic as claimed in claim 6, which is characterized in that the ultrasonic components are connected with high frequency
Signal wire, the high-frequency signal line are pierced by the tube body on the outside of the metal tube.
10. a kind of coaxial endoscope system of optoacoustic, which is characterized in that including a kind of light as claimed in any one of claims 1-9 wherein
The coaxial endoscope and image processing device of sound, further includes:
As the main trigger source of pulse signal computer and data collecting card,
For return pulse signal and issue synchronization signal single-chip microcontroller,
For receive synchronization signal and issue time delayed signal to ultrasound transmitting-receiving instrument laser and driver,
The data collecting card is connected to the computer and the single-chip microcontroller, and the single-chip microcontroller is connected to the laser, driving
Device and the ultrasound transmitting-receiving instrument, the laser are connected with optical module and photoelectricity slip ring, and photoelectricity slip ring, which is connected to, protrudes into tube body
Interior optical fiber, the photoelectricity slip ring are also respectively connected in the driver and the ultrasound transmitting-receiving instrument, and the ultrasound transmitting-receiving instrument is also
It is connected to the data collecting card.
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| CN113654993A (en) * | 2021-07-14 | 2021-11-16 | 华中科技大学 | Coaxial axial modulation high-resolution photoacoustic microscopic imaging method and imaging system |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113654993A (en) * | 2021-07-14 | 2021-11-16 | 华中科技大学 | Coaxial axial modulation high-resolution photoacoustic microscopic imaging method and imaging system |
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