CN209322899U - Bio-analysis system - Google Patents

Abstract

A kind of bio-analysis system includes shell, chassis, block assembly and transmission device.Chassis is arranged in shell.Block assembly is installed to chassis, and is configured to receive multiple samples and multiple cycles samples is made to pass through series of temperature.The transmission device includes guiding piece, which is configured to move block assembly reversibly relative to chassis between open and closed positions according to the manual force on block assembly.User can access multiple sample in open position.

Description

Bio-analysis system

Technical field

The utility model is widely but not exclusively to bio-analysis system, including polymerase chain reaction (PCR) system System, such as real-time PCR (qPCR) system.

Background technique

The bio-analysis system of such as PCR system is for being diagnosed and being studied in biology or biochemical samples Useful tool.PCR system usually has thermal cycler, heats in several cycles and cooling sample is one or more to realize The required multiplication of target molecule.QPCR system, which allows to monitor PCR during each thermal cycle of the process, to be measured.

Can get complicated qPCR instrument and system at present, permission automatically process a large amount of measurements once start-up course and Without user intervention.However, there is a situation where such: where need less complicated system, provide ease for use and intuitive behaviour Make, without damaging the basic demand to accurate and reliable qPCR result.

Accordingly, it is desired to provide a kind of qPCR system for being able to solve at least one of above problem.

Utility model content

According to one aspect of the disclosure, a kind of bio-analysis system, including shell are provided；It is arranged at the intracorporal bottom of shell Disk；It is installed to the block assembly on chassis, which is configured to receive multiple samples and to pass through multiple cycles samples a series of Temperature；Transmission device including guiding piece, the guiding piece are configured to make block assembly relative to institute according to the manual force on block assembly It states chassis reversibly to move between open and closed positions, wherein multiple samples can be visited by user at open position It asks.

The system may include the lock for being installed to chassis, wherein lock is configured to that block assembly is releasedly maintained at closing Position.Lock may include double ball locks.

The system may further include sensor, which is configured as detection block assembly and is in the close stance It sets.The sensor may include proximity sensor.

The system may further include the The lid component for being attached to block assembly, and covers and can be configured to be in when block assembly It is flushed when closed position with shell.The lid component may include recess portion or handle, and the recess portion or handle construction are at permission user's application hand Power is to be moved to open position from closed position for block assembly.

Block assembly can include: at least one sample blocks, for receiving multiple samples；At least one thermoelectric device, has With a main surface of at least one sample blocks thermal communication；Heat exchanger, another master at least one thermoelectric device Surface thermal communication；And sealing element, it is configured to that air is prevented to be recycled at least one sample blocks from heat exchanger.

The system can also include multiple hawsers of control panel and connection at least one thermoelectric device and control panel, multiple Hawser passes through the corresponding multiple holes of setting on the heat exchanger, and sealing element may be positioned such that the multiple holes of covering.

The guiding piece may include sliding equipment, which is configured to make block assembly phase according to the manual force on block assembly The chassis is reversibly slided between open and closed positions.

Detailed description of the invention

According to following written description, only as an example, and in conjunction with attached drawing, the embodiments of the present invention will be general by this field Logical technical staff better understands, and is readily apparent for those of ordinary skills, in which:

Figure 1A shows the front perspective view of bio-analysis system according to example embodiment.Figure 1B shows the biology of Figure 1A The illustrative system block diagram of analysis system.

Fig. 2A shows the perspective view of the block assembly of the bio-analysis system of Fig. 1 in an open position.Fig. 2 B is shown The perspective view of the block assembly of Fig. 2A in the closed position.

Fig. 3 shows the schematic plan view of the lock for block assembly to be releasably held in closed position.

Fig. 4 shows the perspective schematic view of the sensor for detecting block assembly in the closed position.

Fig. 5 shows the exploded view of a part of the block assembly of Fig. 2A.

Fig. 6 shows the sample blocks of the block assembly of Fig. 2A.

Specific embodiment

Figure 1A shows the front perspective view of bio-analysis system 100 according to example embodiment.Figure 1B shows Figure 1A's The illustrative system block diagram of bio-analysis system 100.

Bio-analysis system 100 includes thermal cycler 102, optical system 104 and user interface 106, and each all connects It is connected to control system 108.As shown in Figure 1A, the user interface 106 in example embodiment may include that can receive from user Touch input and provide a user color output or feedback touch screen 110.Thermal cycler 102 and optical system 104 include In shell 112, shell 112 has the opening for installing touch screen 110.System 100 further includes drawer or transmission device 114, allow user to access at least some components of thermal cycler 102 manually, it is as described in more detail below.

Thermal cycler 102 includes at least one sample blocks 116, heating/cooling element 118 and heat exchanger or heat block 120. At least one sample blocks 116 can receive multiple samples 122, for example, the form of microtiter plate, including multiple sample wells or Bottle, each sample well or bottle contain one or more samples.Heating/cooling element 118 in use can be according to user Test, measurement or the experiment of selection carry out thermal cycle sample 122, and are usually the form of one or more thermoelectric devices 118, example Such as one or more Peltier devices.At least part of thermal cycler 102 can be set in the come-at-able drawer of user or biography It send in device 114.In certain embodiments, bio-analysis system 100 includes polymerase chain reaction (PCR) system, such as Real-time PCR (qPCR) system.In such embodiments, thermal cycler 102 is configured to execute qPCR measurement, process or reality It tests, so that multiple sample 122 undergoes the assigned temperature curve of the circulation of predetermined quantity.

For brevity, power supply is not shown in Figure 1B, but it is to be understood that power supply is typically included in such as system.This Outside, the component of optical system 104 and function are not described in further detail, but it is generally understood that, optical system 104 can be by electromagnetism On radiation-emitting to sample or in sample, and from sample reception electromagnetic radiation for analyzing.For example, for wherein bioanalysis system System 100 includes the embodiment of qPCR system, and optical system 104 can be configured to generate and/or read by multiple samples 122 The fluorescence signal that one or more generates.

Fig. 2A shows the perspective of the block assembly 200 for the bio-analysis system 100 being arranged in drawer or transmission device 114 Figure, the drawer or transmission device are in an open position.Block assembly 200 movably or is slidably mounted on chassis 202, bottom Disk 202 is fixedly positioned in shell 112 (Figure 1A).For example, the drawer or transmission device 114 in illustrated embodiment have sliding Mechanism or guidance system 205, form is to be connected to a pair of sliders 204 of block assembly 200, with setting on chassis 202 Respective track 206 cooperate.In open position, user can carry out the positioning of sample, filling, replacement and/or inspection.Shown In embodiment, block assembly 200 includes thermal cycler 102.In other embodiments, block assembly 200 includes sample blocks 116, and is added But element 118 and/or heat block 120 are located at the fixation position in chassis 202 to hot/cold.

The open position shown in Fig. 2A, user can be by providing power on drawer or transmission device 114 to push away manually The dynamic The lid component 208 for being connected to block assembly 200, slides into closed position shown in Fig. 2 B for block assembly 200.In close stance It sets, The lid component 208 can be with the external flush (referring to Figure 1A) of shell 112, and user can be selected by user interface 106 The operation (Figure 1B) for the system 100 to be run.As that can see from Fig. 2A and 2B, The lid component 208 includes handle or groove 210, user can from the handle or groove 210 on drawer or transmission device 114 applied force so that block assembly 200 is from close stance It sets movement or slides into open position.Advantageously, The lid component 208 is combined with guidance system 205, allows user with economical but accurate Mode control system 100 operation, without automate hardware, automation hardware can increase system 100 cost and Weight, and reduce global reliability.

System 100 may include lock 212, and block assembly 200 can be releasably held in closed position by lock 212.Such as figure Shown in 2A, lock 212 is mounted on chassis 202, allows it only when block assembly 200 is in the closed position and the block assembly 200 The position of engagement.Fig. 3 shows plan view, wherein lock 212 is engaged with the end 300 of block assembly 200.In this example, it locks Button 212 is double ball locks, wherein each ball is releasedly pushed by the side towards end 300 (for example, by corresponding bullet Spring), and touch feedback is provided when successfully engaging.It will be understood that other kinds of lock can be used in an alternative embodiment.

System 100 further includes sensor 400, whether in the closed position can detecte block assembly 200.Fig. 4 is shown The perspective schematic view of the arrangement of sensor 400.Here, sensor 400 is proximity sensor, is mounted on chassis 202, and And be configured to if flange or component 402 in its vicinity if detect corresponding flange or component 402 on block assembly 200, such as when When block assembly 200 is completely in closed position.Other kinds of sensor can be used in an alternative embodiment, such as optics passes Sensor, pressure sensor etc..

Lock 212 and sensor 400 in exemplary embodiment can provide the instruction of affirmative, i.e. bio-analysis system 100 block assembly 200 is properly in the closed position before thermal cycle operation starts.For example, control system 108 (Figure 1B) can To be configured so that it is based only upon signal activation heating/cooling element 118 from sensor 400, to confirm block assembly 200 It is in the closed position.Lock 212 can prevent the unexpected of block assembly 200 from sliding and being configured to block assembly 200 accurately It is located in bio-analysis system 100, while the manual force applied by user being allowed to discharge block assembly 200 with movable block again Component 200 arrives open position, as shown in Figure 2 A.Optionally, can also provide manual lock (not shown) with by block assembly 200 in addition It is fixed on closed position.

Fig. 5 shows the exploded view of a part of the block assembly 200 of Fig. 2A.As described above, block assembly 200 includes at least one A sample blocks 116 and at least one thermoelectric device 118.At least one sample blocks 116 include corresponding to multiple reaction vessels Multiple cavities, as can be seen in Figure 6.As non-limiting example, a sample blocks 116 can have 32 cavitys 600 Array is to receive 32 reaction vessels.In the block assembly using three sample blocks 116,96 reactions in total can be provided and held Device.In such an example, three thermoelectric devices 118 corresponding to three sample blocks 116 can be used.It will be appreciated that In alternative embodiment, the quantity of the quantity of sample blocks, the quantity of thermoelectric device and/or reaction vessel can be different.

In block assembly 200, a surface of at least one thermoelectric device 118 is configured as and at least one sample blocks 116 thermal communications are heated or cooled with providing by necessity of at least one received sample of sample blocks 116.At least one thermoelectricity dress Setting 118 another surface can be configured to and 120 thermal communication of heat block.Multiple hawsers 500 connect at least one thermoelectric device 118 With the control panel (Figure 1B) of control system 108.In one embodiment, multiple hawsers 500 are passed through in heat block 120 Corresponding multiple holes 502, and sealing element 504 is positioned to multiple hole 502, and sealing element 504 is allowed to stop hot sky Gas is recycled at least one sample blocks 116 from the heat block 120.In use, sealing element 504 can preferably prevent waste heat dry Disturb the thermal cycle of the sample at least one sample blocks 116.

By using direct hawser between at least one thermoelectric device and control panel, it is possible to reduce the number of control circuit Amount.In addition, motor and its relevant electronic device can be saved by having manual drawer or pallet comprising block assembly. Due to these improvement, the power demand of system reduces and can simplify maintenance.Therefore, which not only has lower initial Cost, and there is lower operating cost.

It will be understood by those skilled in the art that the case where not departing from the spirit or scope of broadly described the utility model Under, a variety of variations and/or modification can be carried out to the utility model shown in specific embodiment.Therefore, the utility model Embodiment is all regarded in an illustrative, rather than a restrictive in all respects.

Claims (10)

1. a kind of bio-analysis system, comprising:

Shell；

It is arranged on the intracorporal chassis of the shell；

It is installed to the block assembly on the chassis, the block assembly is configured to receive multiple samples and keeps the multiple cycles samples logical Cross series of temperature；With

Transmission device including guiding piece, the guiding piece are configured to make the block assembly according to the manual force on the block assembly It is reversibly moved between open and closed positions relative to the chassis, which is characterized in that can be in the open position Set the multiple sample accessible by user.

2. system according to claim 1, which is characterized in that further include the lock for being installed to the chassis, wherein described Lock is configured to the block assembly being releasably held in the closed position.

3. system according to claim 2, which is characterized in that the lock includes double ball locks.

4. system according to claim 1, which is characterized in that further include sensor, the sensor is configured as detecting The block assembly is in the closed position.

5. system according to claim 4, which is characterized in that the sensor includes proximity sensor.

6. system according to claim 1, which is characterized in that further include the The lid component for being attached to the block assembly, wherein The lid is configured to flush when the block assembly is in the closed position with the shell.

7. system according to claim 6, which is characterized in that the The lid component includes recess portion or handle, the recess portion or Handle construction applies manual force at permission user the block assembly is moved to the open position from the closed position.

8. system according to claim 1, which is characterized in that the block assembly includes:

For receiving at least one sample blocks of the multiple sample；

At least one thermoelectric device, at least one described thermoelectric device have one at least one sample blocks thermal communication Main surface, at least one described thermoelectric device are configured to the temperature by recycling the multiple sample to execute qPCR measurement, mistake Journey or experiment；

With the heat exchanger of another main surface thermal communication of at least one thermoelectric device；And

It is configured to the sealing element for preventing air from being recycled at least one sample blocks from the heat exchanger.

9. system according to claim 8, which is characterized in that further include control panel and connection at least one thermoelectricity dress Multiple hawsers with the control panel are set, the multiple hawser passes through the corresponding multiple holes being arranged on the heat exchanger, And wherein, the sealing element is positioned to the multiple hole.

10. system according to claim 1, which is characterized in that the guiding piece includes sliding equipment, the sliding equipment It is configured to be made according to the manual force on the block assembly block assembly relative to the chassis in the open position and described It is reversibly slided between closed position.