CN209286723U - A kind of chromatographic column with condensation structure - Google Patents
A kind of chromatographic column with condensation structure Download PDFInfo
- Publication number
- CN209286723U CN209286723U CN201821487958.8U CN201821487958U CN209286723U CN 209286723 U CN209286723 U CN 209286723U CN 201821487958 U CN201821487958 U CN 201821487958U CN 209286723 U CN209286723 U CN 209286723U
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- China
- Prior art keywords
- tube
- column
- chromatographic column
- condensation
- fixed plate
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- 238000009833 condensation Methods 0.000 title claims abstract description 37
- 230000005494 condensation Effects 0.000 title claims abstract description 37
- 239000011521 glass Substances 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000007788 liquid Substances 0.000 claims abstract description 7
- 238000003780 insertion Methods 0.000 claims abstract description 4
- 230000037431 insertion Effects 0.000 claims abstract description 4
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 5
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 5
- 229940058401 polytetrafluoroethylene Drugs 0.000 claims 1
- 238000000926 separation method Methods 0.000 abstract description 6
- 239000000463 material Substances 0.000 abstract description 3
- 238000000034 method Methods 0.000 description 8
- 230000008569 process Effects 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 238000004587 chromatography analysis Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000000945 filler Substances 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000003480 eluent Substances 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- -1 polytetrafluoroethylene Polymers 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 230000005526 G1 to G0 transition Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Landscapes
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The utility model discloses a kind of chromatographic columns with condensation structure, the column tube loading external member including column tube, insertion column tube upper end；The column tube lower end is provided with liquid outlet；The column tube is divided into chromatographic column layer inner tube and condensation layer outer tube, and the chromatographic column layer inner tube runs through the condensation layer outer tube；The edge of the top and bottom of the condensation layer outer tube is tightly connected with the outer wall of the chromatographic column layer inner tube respectively；The condensation layer outer tube upper and lower part is respectively equipped with interface and lower interface；The horizontal glass pallet around chromatographic column layer inner tube is provided at the lower edge of the condensation layer outer tube, the glass tray offers water outlet, and the water outlet is connected with conduit；Chromatographic column provided by the utility model provides a low temperature atmosphere for the column separation process of chromatographic column, and setting horizontal glass pallet can accept the droplet under drippage, avoid it from flowing into separated material, ensure that the accuracy and reproducibility of experimental result.
Description
Technical field
The utility model relates to the separation technology fields of mixed chemical component, and in particular to a kind of layer with condensation structure
Analyse column.
Background technique
Column chromatography is biology, most common a kind of process for separation and purification in chemical laboratory, is obtained in recent decades
It is widely applied and constantly develops, it has also become the too busy to get away important technology of all trades and professions.Chromatography is using each in mixture
The difference of the physicochemical properties of component keeps distributed degrees of each component in two-phase different, make each component in stationary phase with
Different speed migrations are to realize the purpose of separation.During separating-purifying, in addition to gel, adsorbent, solvent, solute
Etc. outside factors, chromatography rod structure itself also will affect separating-purifying efficiency.
Chromatographic column traditional at present usually has the defect of following several respects；(1) chromatographic column loading and plus when eluant, eluent,
Sample solution usually flows directly into cylinder in the middle part of chromatography top end, be easy to cause the top packing layer surface irregularity, shadow
Ring chromatographic effect.(2) when isolating and purifying easy deactivated substance under separating the high temperature such as the protein of some high temperature easy in inactivation,
Chromatographic column realizes this purpose with having condensing mechanism, and in the case where needing to chromatographic column cooling, outer glass tube wall
A large amount of droplet can be generated, droplet accumulation is flowed into along outer glass tube wall in separated material, influences the accurate of experimental result
Property.
Utility model content
In order to overcome the above technical problems, the utility model provides a kind of chromatographic column with condensation structure, feature
It is: the column tube loading external member including column tube, insertion column tube upper end；The column tube lower end is provided with liquid outlet；
The column tube is divided into chromatographic column layer inner tube and condensation layer outer tube, and the chromatographic column layer inner tube is through described cold
Condensate layer outer tube；The edge of the top and bottom of the condensation layer outer tube is sealed with the outer wall of the chromatographic column layer inner tube respectively
Connection；The condensation layer outer tube upper and lower part is respectively equipped with interface and lower interface；
The horizontal glass pallet around chromatographic column layer inner tube is provided at the lower edge of the condensation layer outer tube, it is described
Glass tray offers water outlet, and the water outlet is connected with conduit.
Preferably, the column tube loading external member include feed pipe, hollow rotary screw, fixture nut part, fixed plate and
Feed cavity；The fixed plate and the fixture nut part above fixed plate are arranged on the rotary screw, it is described
Fixed plate is placed in the flange of column tube upper end along upper, and the fixed plate circumference is equipped with mounting hole, the mounting hole and column tube flange
It is corresponded along upper bolt hole, mounting hole and column tube flange of the fastener in fixed plate are realized solid along upper bolt hole
The connection of fixed board and column tube, rotary screw lower end are connected with feed cavity；The lower end of the feed pipe passes through in the rotary screw
Portion is communicated with feed cavity, and feed cavity bottom, which is circumferentially opened, is equipped with several round flow-out holes.
The loading external member is conducive to control the uniformity and speed that sample and eluent enter filler at the top of cylinder, favorably
In keeping the smooth of filler layer surface, guarantee feed separation purification effect.
This is practical in operation, and loading external member is arranged on column tube top, when passing through feed pipe loading, feed cavity is rotated
To filler surface top, sample enters packing layer top by flow-out hole, and feed cavity is slowly rotated down during loading,
So that feed cavity lower surface is remained at 0.5-1cm above sample surfaces, ensure that the accuracy and reproducibility of experimental result.
Preferably, the rotary screw upper end is equipped with handwheel.
Preferably, there are four the bolts hole.
Preferably, tongs are set on the conduit, the water flowed into glass tray can be discharged.
Preferably, the column tube is equipped with scale.
Preferably, piston is equipped at the liquid outlet.
Preferably, the piston is made of polytetrafluoroethylene (PTFE).
The beneficial effects of the utility model are as follows: the utility model is arranged outside condensation layer outside chromatographic column layer inner tube
Pipe, provides a low temperature atmosphere for the column separation process of chromatographic column；When cooling down to chromatographic column, altitude temperature difference effect is led
A large amount of droplet can be assembled by causing the outer glass tube wall of chromatographic column, and the horizontal glass pallet that chromatographic column bottom is arranged in can accept drippage
Under droplet, avoid it from flowing into separated material, ensure that the accuracy and reproducibility of experimental result.
Detailed description of the invention
Fig. 1 is the chromatographic column structural schematic diagram that one of the utility model has condensation structure；
Fig. 2 is the structural schematic diagram for the chromatographic column feed cavity bottom surface that one of the utility model has condensation structure；
In figure, 1- column tube, 2- column tube loading external member, 3- glass tray, 4- fastener, 11- chromatographic column layer inner tube, 12- are cold
Condensate layer outer tube, 13- piston, the upper interface of 121-, 122- lower interface, 21- feed pipe, 22- hollow rotary screw, 23- are fixed
Nut piece, 24- fixed plate, 25- feed cavity, 250- flow-out hole, 26- handwheel, 31- conduit, 32- tongs.
Specific embodiment
Below with reference to the accompanying drawings illustrate the embodiments of the present invention, so as to be easier the advantages of the utility model with feature
It is understood by the person skilled in the art.
Fig. 1 shows a kind of chromatographic column with condensation structure of the utility model, including column tube 1, insertion column tube upper end
Column tube loading external member 2；1 lower end of column tube is provided with liquid outlet；
The column tube 1 divides for chromatographic column layer inner tube 11 and condensation layer outer tube 12, and the chromatographic column layer inner tube 11 runs through
The condensation layer outer tube 12；The edge of the top and bottom of the condensation layer outer tube 12 is respectively and in the chromatographic column layer
The outer wall of pipe 11 is tightly connected；12 upper and lower part of condensation layer outer tube is respectively equipped with interface 121 and lower interface
122；External condensation water enters condensation layer outer tube 12 from lower interface 122, then from the externally discharged environment of upper interface 121.
The horizontal glass pallet around chromatographic column layer inner tube 11 is provided at the lower edge of the condensation layer outer tube 12
3, the glass tray 3 offers water outlet, and the water outlet is connected with conduit 31.
In the above-mentioned technical solutions, the column tube loading external member 2 includes feed pipe 21, hollow rotary screw 22, fixes
Nut piece 23, fixed plate 24 and feed cavity 25；It is arranged with the fixed plate 24 on the rotary screw 22 and is located at fixed plate 24
The fixture nut part 23 of top, the fixed plate 24 are placed in the flange of 1 upper end of column tube along upper, the circle of fixed plate 24
Week is equipped with mounting hole, the mounting hole and 1 flange of column tube and corresponds along upper bolt hole, and fastener 4 passes through in fixed plate 24
Mounting hole and 1 flange of column tube realize the connection of fixed plate 24 and column tube 1 along upper bolt hole, 22 lower end of rotary screw and into
Expect that chamber 25 is connected；The lower end of the feed pipe 21 passes through 22 inside of rotary screw and communicates with feed cavity 25,25 bottom of feed cavity
Portion, which circumferentially opens, is equipped with several round flow-out holes 250.
In the above-mentioned technical solutions, 22 upper end of rotary screw is equipped with handwheel 26.
In the above-mentioned technical solutions, there are four the bolts hole.
In the above-mentioned technical solutions, tongs 32 are set on the conduit 31.
In the above-mentioned technical solutions, the column tube 1 is equipped with scale.
In the above-mentioned technical solutions, piston 13 is equipped at the liquid outlet.
In the above-mentioned technical solutions, the piston 13 is made of polytetrafluoroethylene (PTFE).
Obviously, it is practical without departing from this can to carry out various modification and variations to the utility model by those skilled in the art
Novel spirit and scope.If in this way, these modifications and variations of the present invention belong to the utility model claims and
Within the scope of its equivalent technologies, then the utility model is also intended to include these modifications and variations.
Although the utility model and its advantage has been described in detail it should be appreciated that without departing from by appended right
Various changes, substitution and transformation can be carried out in the case where the spirit and scope of the utility model defined by it is required that.Moreover, this
The range of application is not limited only to the specific embodiment of process, equipment described in specification, means, method and steps.This field
Interior those of ordinary skill from the disclosure of the utility model it will be readily understood that according to the utility model can be used execution with
The essentially identical function of corresponding embodiment described herein or obtain the result essentially identical with it, existing and future will quilt
Process, equipment, means, method or the step of exploitation.Therefore, the attached claims are intended in the range of them include this
Process, equipment, means, method or the step of sample.
Claims (8)
1. a kind of chromatographic column with condensation structure, it is characterised in that: the column tube loading set including column tube, insertion column tube upper end
Part；The column tube lower end is provided with liquid outlet；
The column tube is divided into chromatographic column layer inner tube and condensation layer outer tube, and the chromatographic column layer inner tube runs through the condensed water
Layer outer tube；The edge of the top and bottom of the condensation layer outer tube is sealed with the outer wall of the chromatographic column layer inner tube respectively to be connected
It connects；The condensation layer outer tube upper and lower part is respectively equipped with interface and lower interface；
The horizontal glass pallet around chromatographic column layer inner tube, the glass are provided at the lower edge of the condensation layer outer tube
Pallet offers water outlet, and the water outlet is connected with conduit.
2. a kind of chromatographic column with condensation structure according to claim 1, it is characterised in that: the column tube loading external member
Including feed pipe, hollow rotary screw, fixture nut part, fixed plate and feed cavity；It is arranged on the rotary screw described
Fixed plate and the fixture nut part above fixed plate, the fixed plate are placed in the flange of column tube upper end along upper,
The fixed plate circumference is equipped with mounting hole, the mounting hole and column tube flange and corresponds along upper bolt hole, and fastener passes through
Mounting hole and column tube flange in fixed plate realize the connection of fixed plate and column tube along upper bolt hole, rotary screw lower end with
Feed cavity is connected；The lower end of the feed pipe, which passes through, to be communicated inside the rotary screw with feed cavity, and feed cavity bottom is circumferentially
It opens and is equipped with several round flow-out holes.
3. a kind of chromatographic column with condensation structure according to claim 2, it is characterised in that: the rotary screw upper end
Handwheel is installed.
4. a kind of chromatographic column with condensation structure according to claim 2, it is characterised in that: the bolt hole has four
It is a.
5. a kind of chromatographic column with condensation structure according to claim 1, it is characterised in that: be set on the conduit
There are tongs.
6. a kind of chromatographic column with condensation structure according to claim 1, it is characterised in that: the column tube, which is equipped with, to be carved
Degree.
7. a kind of chromatographic column with condensation structure according to claim 1, it is characterised in that: set at the liquid outlet
There is piston.
8. a kind of chromatographic column with condensation structure according to claim 7, it is characterised in that: the piston is by polytetrafluoro
Ethylene is made.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821487958.8U CN209286723U (en) | 2018-09-12 | 2018-09-12 | A kind of chromatographic column with condensation structure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821487958.8U CN209286723U (en) | 2018-09-12 | 2018-09-12 | A kind of chromatographic column with condensation structure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209286723U true CN209286723U (en) | 2019-08-23 |
Family
ID=67653082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821487958.8U Expired - Fee Related CN209286723U (en) | 2018-09-12 | 2018-09-12 | A kind of chromatographic column with condensation structure |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209286723U (en) |
-
2018
- 2018-09-12 CN CN201821487958.8U patent/CN209286723U/en not_active Expired - Fee Related
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20190823 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |