CN209286715U - A kind of automatic control low-temperature circulating leaching device - Google Patents
A kind of automatic control low-temperature circulating leaching device Download PDFInfo
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- CN209286715U CN209286715U CN201821971393.0U CN201821971393U CN209286715U CN 209286715 U CN209286715 U CN 209286715U CN 201821971393 U CN201821971393 U CN 201821971393U CN 209286715 U CN209286715 U CN 209286715U
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- extraction
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- Extraction Or Liquid Replacement (AREA)
Abstract
The utility model provides a kind of automatic control low-temperature circulating leaching device, including cooler, one end piping connection of cooler is to reservoir, the other end is through solution feed pump, connecting tube is connected to extraction column, connecting tube protrudes into extraction column, the top of extraction column is installed by extraction column controller, bottom is equipped with shut-off valve, shaft is equipped with cooling medium inlet adjustment valve and cooling medium outlet valve, AI temperature detection display and cooler controller are installed at the material liquid outlet of cooler, two sides are equipped with refrigerant outlet and refrigerant inlet, the outside of refrigerant inlet passes through motor valve piping connection to refrigerant.Automatic control low-temperature circulating leaching device described in the utility model, according to the first diffusion law of Fick, it joined cooling pump, cooler and extraction column, and realize on-line checking and the automatic control of temperature, intensive incorporates each process equipment element of low-temperature circulating extraction, substantially increases extraction accuracy and extraction efficiency.
Description
Technical field
The utility model belongs to Chinese medicine leaching device field, extracts and fills more particularly, to a kind of automatic control low-temperature circulating
It sets.
Background technique
The extraction of Chinese medicine, which refers to, leaches effective component or active component contained by Chinese medicine using solvent appropriate and method
Operation.Extraction is the important composition link of most of Chinese patent drug manufacturing process, and modern with industrial technology development and Chinese medicine
Change and contacts most close sport technique segment.Efficiently, targetedly extracting technology can significantly improve the effective component of Chinese patent drug
Content, to enhance the therapeutic effect of Chinese patent drug.Prepare the Chinese medicine liquids such as vina, decoction, mixture, syrup, liquid extract, tincture
When body preparation, Chinese Pharmacopoeia has the quality requirement of clarity to final products, that is, requires appearance clear.But it is most of
Often because room temperature is placed for a long time, complexity contained therein is natural to be produced alcohol-containing liquid preparation of Chinese medicine (vina, tincture, a small number of mixture kinds)
Object ingredient becomes turbid because of ageing.The effective means for solving the problems, such as this includes long-term natural subsidence, centrifugation, ultrafiltration etc., but is needed
Large-scale settling tank, supercentrifuge, ultrafilter etc. are wanted, the operating procedure time is long, cannot completely remove dregs, and scavenging solution is placed
A period of time still will appear research of chaotic phenomenon.Therefore it still only is apparent not enough, is needed from extraction work from the aspect of leaching liquor isolation of purified
Skill addresses ageing problem.
Summary of the invention
In view of this, the utility model is directed to a kind of automatic control low-temperature circulating leaching device, to solve in Chinese medicine
Material extracts in extraction process, when being reduced to room temperature with extracting solution or extracting solution being concentrated, since the temperature difference or removal solvent cause
The supersaturation of natural component concentration, and there is ageing research of chaotic phenomenon in long-term place.
In order to achieve the above objectives, the technical solution of the utility model is achieved in that
A kind of automatic control low-temperature circulating leaching device, including extraction column, connecting tube, solution feed pump, cooler, reservoir,
The reservoir piping connection is to one end of the cooler, the cooler other end piping connection to the solution feed pump, institute
It states solution feed pump and is connected to the extraction column by the connecting tube, and protrude into the extraction column, the top peace of the extraction column
Extraction column controller is filled, bottom is equipped with shut-off valve, and the two sides of shaft are respectively equipped with cooling medium inlet adjustment valve and cooling medium
Outlet valve, the extraction column controller signals are connected to the cooling medium inlet adjustment valve and the cooling medium outlet valve
, the installation of TC inside the extraction column controller is inside extraction column；AI is installed at the material liquid outlet of the cooler
Temperature detection display and cooler controller, two sides are respectively equipped with refrigerant outlet and refrigerant inlet, and the refrigerant enters
The outside of mouth passes through motor valve piping connection to refrigerant；The cooler controller signal is connected to the AI temperature
Degree detection display, the motor valve.
Further, lower part is equipped with porous ceramics baffle in the extraction column.
Further, the extraction column liner collet, cooling medium be ethylene glycol, polyethylene glycol, isopropanol, propylene glycol and
Its aqueous solution.
Further, the solution feed pump is constant flow peristaltic pump.
Further, the reservoir is that drawer type moves container.
Further, the cooler is the tubular heat exchanger of stainless steel material, and feed liquid walks shell, and refrigerant is walked
Tube layer, cooling medium are ethylene glycol, polyethylene glycol, isopropanol, propylene glycol and its aqueous solution.
Further, the stainless steel material is made of metal coiled pipe or tubulation.
Further, the extraction column controller is AI artificial intelligence temperature controller TIC.
Further, the cooler controller is AI artificial intelligence temperature controller TIC.
Compared with the existing technology, automatic control low-temperature circulating leaching device described in the utility model has the advantage that
(1) automatic control low-temperature circulating leaching device described in the utility model can realize column chromatography, diacolation, low respectively
Three kinds of extraction different Chinese medicine extraction and purification processes of temperature circulation, especially low-temperature circulating extraction function can be realized lower than room temperature
High efficiency extraction can improve Chinese patent drug, especially alcohol-containing liquid Chinese patent medicine preparation to effectively improve the clarity of leaching liquor
Presentation quality.
(2) automatic control low-temperature circulating leaching device described in the utility model is added according to the first diffusion law of Fick
Constant flow peristaltic pump, cooler and extraction column, and on-line checking and the automatic control of temperature are realized, intensive incorporate
Each process equipment element of low-temperature circulating extraction.
(3) automatic control low-temperature circulating leaching device described in the utility model, static by extraction vessel extract improvement
For Dynamic Extraction, so that the extraction efficiency for compensating for low temperature is lost and is lost.
(4) automatic control low-temperature circulating leaching device described in the utility model, using automatic temperature-adjusting detecting and controlling system
Temperature control is carried out to leaching process, to guarantee the efficient operation of leaching process.
Detailed description of the invention
The attached drawing for constituting a part of the utility model is used to provide a further understanding of the present invention, this is practical new
The illustrative embodiments and their description of type are not constituteed improper limits to the present invention for explaining the utility model.?
In attached drawing:
Fig. 1 is the structural schematic diagram that low-temperature circulating leaching device is automatically controlled described in the utility model embodiment.
Description of symbols:
1- extraction column；11- cooling medium inlet adjustment valve；12- cooling medium outlet valve；13- shut-off valve；2- connection
Pipe；3- solution feed pump；4- cooler；5- reservoir；6- cooler controller；7- extraction column controller；8- motor valve；
9- refrigerant inlet；10- refrigerant outlet.
Specific embodiment
It should be noted that in the absence of conflict, the feature in the embodiments of the present invention and embodiment can
To be combined with each other.
In the description of the present invention, it should be understood that term " center ", " longitudinal direction ", " transverse direction ", "upper", "lower",
The orientation or positional relationship of the instructions such as "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outside" is
It is based on the orientation or positional relationship shown in the drawings, is merely for convenience of describing the present invention and simplifying the description, rather than indicate
Or imply that signified device or element must have a particular orientation, be constructed and operated in a specific orientation, therefore cannot understand
For limitations of the present invention.In addition, term " first ", " second " etc. are used for description purposes only, and should not be understood as indicating
Or it implies relative importance or implicitly indicates the quantity of indicated technical characteristic." first ", " second " etc. are defined as a result,
Feature can explicitly or implicitly include one or more of the features.It is in the description of the present invention, unless another
It is described, the meaning of " plurality " is two or more.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " is pacified
Dress ", " connected ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or integrally
Connection；It can be mechanical connection, be also possible to be electrically connected；Can be directly connected, can also indirectly connected through an intermediary,
It can be the connection inside two elements.For the ordinary skill in the art, on being understood by concrete condition
State the concrete meaning of term in the present invention.
The utility model will be described in detail below with reference to the accompanying drawings and embodiments.
A kind of automatic control low-temperature circulating leaching device, as shown in Figure 1, include extraction column 1, connecting tube 2, solution feed pump 3,
Cooler 4, reservoir 5,5 piping connection of reservoir to one end of the cooler 4,4 other end pipeline of cooler
It is connected to the solution feed pump 3, the solution feed pump 3 is connected to the extraction column 1 by the connecting tube 2, and protrudes into the extraction
In column 1, so that the liquid in reservoir 5 is pumped into the extraction column 1 by solution feed pump 3 via cooler 4, the leaching device
Fluid path circulation flow direction are as follows: 5 → connecting tube of reservoir → 1 → reservoir of cooler 4 → solution feed pump, 3 → connecting tube, 2 → extraction column 5；
Extraction column controller 7 is installed at the top of the extraction column 1, and bottom is equipped with shut-off valve 13, and the two sides of shaft are respectively equipped with cooling Jie
Matter inlet adjustment valve 11 and cooling medium outlet valve 12,7 signal of extraction column controller are connected to the cooling medium and enter
Mouthful regulating valve 11 and the cooling medium outlet valve 12, the installation of TC inside the extraction column controller 7 is in extraction column 1
It is internal；AI temperature detection display and cooler controller 6 are installed, two sides are respectively equipped at the material liquid outlet of the cooler 4
The outside of refrigerant outlet 10 and refrigerant inlet 9, the refrigerant inlet 9 passes through 8 piping connection of motor valve extremely
Refrigerant；6 signal of cooler controller is connected to the AI temperature detection display, the motor valve 8.
The model of the cooling controller 6 and extraction column controller 7 is AI artificial intelligence temperature controller TIC.AI people
Work intelligent temperature controller has temperature display control panel, and panel size is 96 × 96mm, and main output installation linear current is defeated
Module out, communication interface are equipped with the type photoelectric isolating communication interface of included isolated power supply.On the one hand, the AI artificial intelligence temperature
The linear current that the numerical value that temperature measuring instrument exports can be corresponded to any range by degree controller exports, that is, is used as temperature display
And pick-up instrument, have remote transmission background computer function；On the other hand, the AI artificial intelligence temperature controller uses AI intelligence
Can artificial algorithm, high-precision control has parameter self-tuning function and a variety of alarm modes, i.e., when controlled temperature reach the upper limit,
Lower limit or when there is overgauge, minus deviation, the output of acousto-optic alarm relay.
AI artificial intelligence temperature controller carries out the New Algorithm of PID adjusting using fuzzy rule: when error is big, using
Fuzzy algorithmic approach is adjusted, to eliminate PID integral saturated phenomenon；When error becomes it is small when, adjusted using improved pid algorithm
Section, and can in adjusting automatic learning and memory controlled device Partial Feature so that effect optimization.
The AI temperature detection display has the display panel of 96 × 96mm, and multi-channel thermocouple, thermal resistance input back
Road, alarm relay output and 1 communication interface.Display instrument and arithmetic unit, cooperation are measured using the multichannel side of modular technology
Various input modules, the multi-signals such as energy side amount multi-channel thermocouple, thermal resistance, voltage, electric current have figure adjustment and number filter
Wave energy, each channel can receive different input specifications, can support that multichannel programmable is alarmed and pick-up exports, can be used for the machine
Alarm also can be used as the port switching value I/O by PC control, and can be in DCS computer supervisory control system or PLC control system
Analog Data Acquistion Module or temperature transmitter are done in system.
The cooling medium inlet flow rate automatic regulating valve 8 selects air to close valve (reaction) working method, is calculated using PID
When method is adjusted, when controlled temperature is lower than process set value, controller input signal becomes smaller, and output signal becomes larger, so that adjusting
Valve turns down automatically, until controlled temperature comes back on process set value, conversely, when temperature is higher than process set value, control
Device input signal becomes larger, and output signal becomes smaller, so that regulating valve is opened greatly automatically, until controlled temperature comes back to process set value
On.
Lower part is equipped with porous ceramics baffle in the extraction column 1, which is equipped with tapered liquid outlet, which goes out
At liquid mouth be equipped with shut-off valve 13, the extraction, 1 be complete low-temperature circulating extraction Primary containers, volume have 1L, 2L, 5L, 10L,
The plurality of specifications such as 50L, 100L, and can be according to the customized volume specification of production scale.
The extraction column 1 is stainless steel material jacketed temperature control, and is furnished with AI artificial intelligence temperature controller 7, it is therefore an objective to
Guarantee that leaching process carries out at a temperature of optimal, cooling medium can be ethylene glycol, polyethylene glycol, isopropanol, propylene glycol and
Its aqueous solution sets temperature-control range as room temperature~-25 DEG C.
The solution feed pump 3 provides the Extraction solvent of flowing for the medicinal material in extraction vessel, forms Dynamic Extraction condition, the confession
Liquid pump 3 can regulate and control transfusion speed, preferably constant flow peristaltic pump.
The reservoir 5 is the container for receiving circulation leaching liquor, can be glass or stainless steel drawer type is removable
Container, as the container can be realizing movement in such a way that braked wheel is installed in bottom.
The cooler 4 is the component part of Extraction solvent circulation fluid path, can be the made of metal coiled pipe of stainless steel material
Or tubulation, and it is furnished with AI artificial intelligence temperature controller, AI temperature detection display, cooling medium entrance are equipped at material liquid outlet
Place's setting motor valve 8, AI temperature detection display are used to detect extraction temperature, and the major function of cooler 4 is cold
But Extraction solvent, cooling medium can be ethylene glycol, polyethylene glycol, isopropanol, propylene glycol and its aqueous solution.
The cooler 4 is preferably the tubular heat exchanger of stainless steel material, and feed liquid walks shell, and refrigerant walks pipe
Layer.
A kind of working principle automatically controlling low-temperature circulating leaching device are as follows:
Embodiment 1
The embodiment is experimental example of the utility model as column chromatography device.
120 mesh column chromatography silica gel of 5kg is suspended in chloroform in 1:2 ratio, pours into the extraction column 1 of the present apparatus
In, the shut-off valve 13 of column bottom is opened, it is concordant with silica gel face to liquid level to release extra chloroform.Separately weigh the leaching of turmeric ethanol stream
2 times of amount column chromatography silica gels are added in evaporating dish in cream 50g, and heating water bath dries ethyl alcohol, and residue is uniformly added on to extraction column 1
Silica Surface, starting quantitative liquid feeding pump 3, be pumped by 200ml/min speed into extraction column 1 chloroform-methanol (100:
1) eluent opens the shut-off valve 13 of column bottom, collects eluent to efflux and is no longer presented yellow.Turmeric ethyl alcohol liquid extract
In natural products ingredient by curcumin, a demethoxycurcumin, two demethoxycurcumins sequence successively elute column, make
The separation of effective component in turmeric ethyl alcohol liquid extract can be realized with the device of the utility model.
Embodiment 2
The embodiment is experimental example of the utility model as percolating device.
2kg rheum officinale coarse powder is weighed, adds 1 times of amount ethyl alcohol to mix wet, loaded in extraction column 1, compacting adds ethyl alcohol there be not rheum officinale to rigid
Medicinal material, tapping cylinder exclude the bubble in medicinal material, close the shut-off valve 13 at column bottom, soaking at room temperature is overnight.Next day is on
Quantitative liquid feeding pump 31 is pumped into ethyl alcohol into extraction column by 5ml/min speed, opens the shut-off valve 13 of 1 bottom of extraction column, collect
About 1800ml percolate closes solution feed pump 3, recycles residual ethanol in extraction column 1, percolate is merged with recovered liquid, filters, filter
Liquid adds ethyl alcohol to adjust to 2kg to get Extractum Rhei Liquidum.
Embodiment 3
The embodiment is experimental example of the utility model as low-temperature circulating leaching device.
Ginseng, fingered citron, rhizoma polygonati, fructus lycii, Chinese yam, longan, rhizoma polygonati, raspberry, peach kernel, donkey-hide gelatin fine powder are weighed by formula rate
Total 95g infiltrates 2h with 40% ethyl alcohol of 150mL, is fitted into extraction column 1, add 350mL wine liquid, closes 1 bottom of extraction column
Shut-off valve 13, soaking at room temperature is overnight.Next day opens shut-off valve, collects about 300ml soak, starts the temperature control of AI artificial intelligence
Device 7 processed, the temperature being arranged in extraction column 1 are -15 DEG C, and concrete operations position AI artificial intelligence temperature controller TIC (7) passes through control
But medium inlet is equipped with automatic regulating valve (11) and outlet valve (12) to refrigeration, adjusts refrigerant flow to automatically control extraction
Temperature；The temperature inside cooler 4 is arranged by cooler controller 6 simultaneously, cooler controller 6 is by adjusting refrigerant
Motor valve 8 automatically controls material liquid outlet temperature, thus guarantee the constant temperature of leaching device various pieces,
By solid-liquid ratio 1:10, the extraction of 4h low-temperature circulating is carried out with flow velocity 3ml/min, collects leaching liquor, entirely simultaneously with soak,
Filtering, adds appropriate 40% ethyl alcohol to be diluted to 1kg to get low-temperature circulating leaching liquor.Identical inventory and solid-liquid ratio, use the present apparatus
Percolate is prepared at room temperature by percolation, and with the Determination of Content of Ginsenoside Rg_1 of both high effective liquid chromatography for measuring, sodium nitrite is aobvious
After color ultraviolet-visible spectrophotometry in 507nm measurement both general flavone content, both Fehling test solution colorimetric method for determining it is total
Polyoses content, as a result as shown in the table.
The comparison of low-temperature circulating extraction and room temperature percolation
Low-temperature circulating extraction is relatively more efficient in terms of effective component leaching.By the extracting solution Room-temperature seal of two kinds of leach extraction methods
One week is stood, is obviously become turbid in room temperature percolation solution, and low-temperature circulating leaching liquor appearance still clear.
Chinese medicine is extracted lower than room temperature, and it is temperature-rise period that extracting solution, which reaches room temperature substantially, the solubility of natural products is
It is increased, ageing caused by reversing solubility can be easier to.But unlike that the low temperature of supercritical fluid extracts, common water,
Extraction efficiency of the Extraction solvents such as ethyl alcohol in lower temperature is lower than heating extraction.Therefore the utility model expands according to Fick first
Law is dissipated, static extract of extraction vessel improve as Dynamic Extraction, to compensate for the extraction efficiency thanks to mistake of low temperature.Meanwhile
The utility model also applies automatic temperature-adjusting detecting and controlling system to carry out temperature control to leaching process, to guarantee the height of leaching process
Effect operation.
The above is only the preferred embodiment of the utility model only, is not intended to limit the utility model, all at this
Within the spirit and principle of utility model, any modification, equivalent replacement, improvement and so on should be included in the utility model
Protection scope within.
Claims (9)
1. a kind of automatic control low-temperature circulating leaching device, it is characterised in that: including extraction column (1), connecting tube (2), solution feed pump
(3), cooler (4), reservoir (5), the one end of reservoir (5) piping connection to the cooler (4), the cooler
(4) other end piping connection to the solution feed pump (3), the solution feed pump (3) are connected to the extraction by the connecting tube (2)
Column (1), and protrude into the extraction column (1), extraction column controller (7) are installed at the top of the extraction column (1), and bottom, which is equipped with, to be cut
Only valve (13), the two sides of shaft are respectively equipped with cooling medium inlet adjustment valve (11) and cooling medium outlet valve (12), described
Extraction column controller (7) signal is connected to the cooling medium inlet adjustment valve (11) and the cooling medium outlet valve
(12), the internal the installation of TC of the extraction column controller (7) is internal in extraction column (1)；The feed liquid of the cooler (4) goes out
AI temperature detection display is installed at mouthful and cooler controller (6), two sides are respectively equipped with refrigerant outlet (10) and refrigerant
The outside of entrance (9), the refrigerant inlet (9) passes through motor valve (8) piping connection to refrigerant；The cooling
Device controller (6) signal is connected to the AI temperature detection display, the motor valve (8).
2. a kind of automatic control low-temperature circulating leaching device according to claim 1, it is characterised in that: the extraction column
(1) interior lower part is equipped with porous ceramics baffle.
3. a kind of automatic control low-temperature circulating leaching device according to claim 1, it is characterised in that: the extraction column
(1) liner collet, cooling medium are ethylene glycol, polyethylene glycol, isopropanol, propylene glycol and its aqueous solution.
4. a kind of automatic control low-temperature circulating leaching device according to claim 1, it is characterised in that: the solution feed pump
It (3) is constant flow peristaltic pump.
5. a kind of automatic control low-temperature circulating leaching device according to claim 1, it is characterised in that: the reservoir
(5) container is moved for drawer type.
6. a kind of automatic control low-temperature circulating leaching device according to claim 1, it is characterised in that: the cooler
It (4) is the tubular heat exchanger of stainless steel material, feed liquid walks shell, and refrigerant walks tube layer, and cooling medium is ethylene glycol, poly- second
Glycol, isopropanol, propylene glycol and its aqueous solution.
7. a kind of automatic control low-temperature circulating leaching device according to claim 6, it is characterised in that: the stainless steel
Matter is made of metal coiled pipe or tubulation.
8. a kind of automatic control low-temperature circulating leaching device according to claim 1, it is characterised in that: the extraction column control
Device (7) processed is AI artificial intelligence temperature controller TIC.
9. a kind of automatic control low-temperature circulating leaching device according to claim 1, it is characterised in that: the cooler control
Device (6) processed is AI artificial intelligence temperature controller TIC.
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| CN201821971393.0U CN209286715U (en) | 2018-11-27 | 2018-11-27 | A kind of automatic control low-temperature circulating leaching device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109224511A (en) * | 2018-11-27 | 2019-01-18 | 天津达仁堂京万红药业有限公司 | A kind of automatic control low-temperature circulating leaching device |
| CN111494982A (en) * | 2020-04-24 | 2020-08-07 | 天津市中环系统工程有限责任公司 | Draw jar intelligent temperature control system |
-
2018
- 2018-11-27 CN CN201821971393.0U patent/CN209286715U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109224511A (en) * | 2018-11-27 | 2019-01-18 | 天津达仁堂京万红药业有限公司 | A kind of automatic control low-temperature circulating leaching device |
| CN111494982A (en) * | 2020-04-24 | 2020-08-07 | 天津市中环系统工程有限责任公司 | Draw jar intelligent temperature control system |
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Address after: 300112 No. 20 Daming Road, Xiqing District, Tianjin Patentee after: Jinyao Darrentang Jingwanhong (Tianjin) Pharmaceutical Co.,Ltd. Country or region after: China Address before: 300112 No. 20 Daming Road, Xiqing District, Tianjin Patentee before: TIANJIN DARENTANG JINGWANHONG PHARMACEUTICAL Co.,Ltd. Country or region before: China |
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