CN106390510A - Percolation device and percolation method - Google Patents
Percolation device and percolation method Download PDFInfo
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- CN106390510A CN106390510A CN201510500613.6A CN201510500613A CN106390510A CN 106390510 A CN106390510 A CN 106390510A CN 201510500613 A CN201510500613 A CN 201510500613A CN 106390510 A CN106390510 A CN 106390510A
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Abstract
The invention relates to a percolation device and a percolation method. The invention provides a direct-current percolation device. The percolation device comprises a percolation cylinder, a receiving bottle and a liquid storage vessel which is used for storing a percolation solvent, wherein the liquid storage vessel is in sealed connection with the top of the percolation cylinder through a first direct-current connecting pipe, the bottom of the percolation cylinder is connected with the receiving bottle through a second direct-current connecting pipe, the first direct-current connecting pipe and/or the second direct-current connecting pipe are/is provided with liquid flow control switches, and the percolation cylinder is provided with an exhaust valve which is used for adjusting flow velocity of liquid in the first direct-current connecting pipe.
Description
Technical field
The present invention relates to a kind of percolating device and percolation method, it is more particularly to effective components from natural materials
The percolating device being extracted and method.
Background technology
Percolation is to put the natural products such as the medical material of appropriateness pulverizing in percolator, constantly adds solvent by top,
Solvent oozed the method leaching effective ingredient during medicinal material layer flows downward.Percolation method belongs to Dynamic Leaching side
Method, solvent utilization rate is high, and effective ingredient leaches completely, can directly collect leachate.Percolation method is particularly well-suited to
Valuable medicinal, toxicity medical material and high concentrate formulation；Can also be used for the relatively low medicinal material extract of active constituent content.But it is right
Fresh and expansive medical material, the medical material of inorganization structure should not be selected.This method commonly use variable concentrations ethanol or
Chinese liquor makees solvent, therefore should prevent the volatilization loss of solvent.
Percolation, according to the difference of operational approach, can be divided into single percolation, Repercolation method, pressurization percolation, inverse
Stream percolation.Single percolation means the normal pressure percolation method with a percolator, and its operation generally comprises pulverizing medicinal materials
6 steps such as → moistening → fitted tube → aerofluxuss → dipping → percolation.Operating process is：1. pulverize：The granularity of medical material
Should be suitable, meticulous easy blocking, adsorptivity strengthens, and leaching effect is poor；Cross and be slightly difficult to compress, solvent is connect with medical material
Contacting surface is little, is all unfavorable for leaching.General with《Chinese Pharmacopoeia》Medium powder or coarse powder specification are advisable.2. moistening：Medicine
Powder should first use extraction solvent moistening before dress percolator, it is to avoid expand in percolator and result in blockage, impact percolation behaviour
The carrying out making.The solvent of general dosing powder 1 times amount, mixes backsight medical material quality thoroughly, airtight placement 15 minutes to 6
Hour, with medicated powder fully uniform wet and degree of being expanded to.3. fitted tube：Medicated powder loads should uniformly during percolator, pine
Tightly consistent.Fill too loose, solvent flows through medicated powder quickly, leach not exclusively；Conversely, liquid outlet can be made to block again,
Cannot be carried out percolation.4. aerofluxuss：Medicated powder loads and finishes, and should exclude to greatest extent in medicated powder gap when adding solvent
Air, solvent submergence medicated powder surface all the time, otherwise medicated powder dry up cracking, then solubilizer flows through and shadow between crack
Ring and leach.5. impregnate：General dipping placement 24～48 hours, makes the abundant diffusion of solvent, particularly prepares
More seem during high concentrate formulation important.6. percolation：Percolation speed should meet the regulation under every preparation item.If too fast,
Then effective ingredient has little time to ooze out and spreads, and Steep cencentration is low；Too slow then impact utilization rate of equipment and installations and yield.One
As medical material 1000g outflow per minute l～3mL；During a large amount of production, effluent should be equivalent to percolation container per hour
Be utilized 1/48～1/24. effective ingredient of volume whether percolation completely, though can by the color of percolate, taste, smell
Distinguish, the qualitative reaction that also should make known composition when such as having ready conditions is judged.If prepare fluid extract with percolation,
The first liquid of filtering first collecting medication amount 85% preserves in another device, merges with liquid of just filtering, adjustment after continuous liquid cryoconcentration of filtering
To required standard；If being prepared during the relatively low leaching preparation of tincture isoconcentration it is not necessary to another device preserves and just filters with percolation
Liquid, can directly collect the liquid of filtering being equivalent to be intended to preparation amount 3/4, that is, stop percolation, squeeze medicinal residues, pressed liquor
Merge with percolate, add ethanol to normal concentration and capacity, standing, filtration obtains final product.
Current percolating device, during percolation, needs the solvent of artificial supplementation leaching at any time, is beneficial to Chinese medicine
Effective ingredient in material fully leaches, and operation is cumbersome.In order to overcome the problems referred to above, CN202212025U is public
Open the percolating device that a kind of single flow prepares medicated wine, it includes percolator, receiving bottle and is used for containing solvent liquid
Liquid storage container, described Liquid storage container is tightly connected by the top of direct current connecting tube and percolator, the bottom of percolator
Portion is connected with receiving bottle by direct current connecting tube, and described DC tube is provided with liquid flow volume adjustment switch.In above-mentioned skill
In art scheme, the solvent in Liquid storage container, according to once-through principle, in inflow percolator that can be quantitative, and makes percolator
Interior solvent keeps a certain amount it is achieved that the purpose of automatic control liquid feeding, solves and manually adds at any time during percolation
The trouble of liquid.But, also there is certain defect in above-mentioned direct current percolating device, such as cannot individually control inflow speed
Degree and the rate of outflow, cause solvent deficiency etc. in percolator；Fluctuation of service etc..
Therefore, it is badly in need of a kind of new percolating device and method in the art, it does not have existing percolation dress
Put and the defect existing for method, such as solvent deficiency, fluctuation of service etc. in percolator.
Content of the invention
It is an object of the invention to provide a kind of new percolating device and method, it does not have existing percolating device
With the defect existing for method, such as solvent deficiency, fluctuation of service etc. in percolator.
One aspect of the present invention provides a kind of single flow percolating device, and described percolating device includes：Percolator, connect
Receive bottle and the Liquid storage container for storing percolation solvent, described Liquid storage container passes through the first direct current connecting tube and percolator
Top be tightly connected, the bottom of percolator is connected with receiving bottle by the second direct current connecting tube, described first direct current
Pipe and/or the second DC tube are provided with liquid flow volume adjustment switch, and described percolator has for adjusting the first direct current
The air bleeding valve of the flow rate of liquid in pipe.
Another aspect of the present invention provides a kind of single flow percolating device, and described percolating device includes：
Percolator, described percolator has holding pad, air bleeding valve and control device, and described control device includes
The sensor of air pressure, logic control element and exhaust valve controller in monitoring percolator；
Receiving bottle, and
For storing the Liquid storage container of percolation solvent, described Liquid storage container has photoscope, air bleeding valve and controls dress
Put, described control device is included for monitoring the sensor of percolation solvent, logic control in Liquid storage container
Unit and the controller of material inlet valve and/or air bleeding valve；
Described Liquid storage container is tightly connected by the top of the first direct current connecting tube and percolator, the bottom of percolator
It is connected with receiving bottle by the second direct current connecting tube, described first DC tube and/or the second DC tube are provided with liquid
Flow control valve；
The position of described Liquid storage container is higher than described percolator, with will be molten for the percolation in Liquid storage container by gravity
Agent is transported in percolator；
Described percolating device also includes control device, and it includes logic control element and controller；When first is straight
When flow velocity in flow tube is not equal to the flow velocity in the second DC tube, it is straight that control device adjusts first by controller
Flow control valve in flow tube and the/the second DC tube, so that the stream in the first DC tube and the second DC tube
Speed is consistent；
Described percolating device also includes the second leaching device, and wherein said second leaching device is soaking container,
For soaking natural materials before or after percolation.
A further aspect of the present invention provides a kind of percolation method, and described percolation method includes：
Percolation solvent is provided；
Natural product for percolation is provided；
Single flow percolating device of the present invention is provided；
With above-mentioned percolation solvent, percolation is carried out to described natural product by described single flow percolating device and obtain percolation
Liquid.
A further aspect of the present invention provides a kind of percolation method, and described percolation method includes：
First percolation solvent and the second percolation solvent are provided；
Natural product for percolation is provided；
With natural product described in the first percolation solvent soaking；
Percolating device described in single flow percolating device is provided to include：
Percolator, described percolator has holding pad and air bleeding valve；
Receiving bottle, and
For storing the Liquid storage container of the second percolation solvent, described Liquid storage container has photoscope and aerofluxuss
Valve；
Described Liquid storage container is tightly connected by the top of the first direct current connecting tube and percolator, percolator
Bottom is connected with receiving bottle by the second direct current connecting tube, on described first DC tube and/or the second DC tube
It is provided with liquid flow volume adjustment switch；
The position of described Liquid storage container is higher than described percolator, with by gravity by oozing in Liquid storage container
Filter solvent delivery in percolator；
Carry out percolation by described single flow percolating device to the natural product after soaking with the second percolation solvent to obtain
Percolate.
A further aspect of the present invention provides a kind of percolation method, and described percolation method includes：
The ethanol water of 25-45 volume % and the ethanol water of 50-75 volume % are provided；
Natural product for percolation is provided；
Soak described natural product with the ethanol water of 50-75 volume %；
Percolating device described in single flow percolating device is provided to include：
Percolator, described percolator has holding pad and air bleeding valve；
Receiving bottle, and
For storing the Liquid storage container of the second percolation solvent, described Liquid storage container has photoscope and aerofluxuss
Valve；
Described Liquid storage container is tightly connected by the top of the first direct current connecting tube and percolator, percolator
Bottom is connected with receiving bottle by the second direct current connecting tube, on described first DC tube and/or the second DC tube
It is provided with liquid flow volume adjustment switch；
The position of described Liquid storage container is higher than described percolator, with by gravity by oozing in Liquid storage container
Filter solvent delivery in percolator；
With the ethanol water of 25-45 volume % by described single flow percolating device to the natural product after soaking
Carry out percolation and obtain percolate.
Brief description
Fig. 1 describes an embodiment of percolating device of the present invention.
Fig. 2 describes another embodiment of percolating device of the present invention.
Fig. 3 describes an embodiment of fluid present invention flow control valve.
Specific embodiment
In the present invention, illustrate without special, percent (%) or part all refer to respect to combination
The percetage by weight of thing or weight portion.
In the present invention, illustrate without special, involved each component or its preferred ingredient can phases
Mutually combination forms new technical scheme.
In the present invention, illustrate without special, all embodiments mentioned in this article and preferably
Embodiment can be mutually combined and form new technical scheme.
In the present invention, illustrate without special, all technical characteristics mentioned in this article and preferably
Feature can be mutually combined and form new technical scheme.
In the present invention, without contrary explanation, in compositionss, the content sum of each component is 100%.
In the present invention, without contrary explanation, in compositionss, the number sum of each component can be 100
Weight portion.
In the present invention, unless otherwise indicated, numerical range " a-b " represents any between a to b
The breviary of real combinings represents, wherein a and b is real number.For example numerical range " 0-5 " represents herein
In all list whole real numbers between " 0-5 ", " 0-5 " is the breviary of these combinations of values
Represent.
In the present invention, unless otherwise indicated, integer numerical range " a-b " represents between a to b
The breviary of arbitrary integer combination represents, wherein a and b is integer.Such as integer numerical range " 1-N "
Represent 1,2 ... N, wherein N is integer.
In the present invention, unless otherwise indicated, " a combination thereof " represents the multicomponent mixing of described each element
Thing, such as two kinds, three kinds, four kinds and the multicomponent mixture until maximum possible.
Without particularly pointing out, the term " a kind of " used by this specification refers to " at least one ".
Without particularly pointing out, the benchmark of percent (inclusion percetage by weight) of the present invention is all
The gross weight of described compositionss.
" scope " disclosed herein is in the form of lower limit and the upper limit.One or more lower limits can be respectively,
With one or more upper limits.Given range is defined by selecting a lower limit and a upper limit.Choosing
Fixed lower limit and the upper limit define the border of special scope.The all scopes that can be defined by this way are
Comprise and can be combined, that is, any lower limit can combine one scope of formation with any upper limit.For example, for
Special parameter lists the scope of 60-120 and 80-110, is interpreted as the model of 60-110 and 80-120
Enclose is also expect.If additionally, the minimum zone value 1 and 2 listed, and if listing maximum model
Enclose value 3,4 and 5, then following scope can all expect：1-3,1-4,1-5,2-3,2-4,
And 2-5.
Herein, unless otherwise stated, each step is all carried out at normal temperatures and pressures.
Herein, unless otherwise stated, each reactions steps can sequentially carry out it is also possible to out of order
Carry out.For example, other steps can be comprised between each step, and can also reversed order between step.
Preferably, reaction method herein is that order is carried out.
Herein, unless otherwise stated, described equipment or its part can be equipment conventional in the art
Or part, and operated in the way of the routine of this area and/or connect.For example, all parts of equipment it
Between can be connected by pipeline, circuit or a combination thereof, to carry out mass transfer or energy transmission.
Herein, unless otherwise stated, natural product refers to naturally occurring various forms of material, bag
Include but be not limited to dehydration product.For example, described natural product includes Chinese medicinal material.
One aspect of the present invention provides a kind of single flow percolating device, and described percolating device includes：Percolator, connect
Receive bottle and the Liquid storage container for storing percolation solvent, described Liquid storage container passes through the first direct current connecting tube and percolator
Top be tightly connected, the bottom of percolator is connected with receiving bottle by the second direct current connecting tube, described first direct current
Pipe and/or the second DC tube are provided with liquid flow volume adjustment switch, and described percolator has for adjusting the first direct current
The air bleeding valve of the flow rate of liquid in pipe.
In the present invention, described Liquid storage container is conventional, its can be any can be used in store liquid
Container, for example, it can be canister, glass container, ceramic vessel etc..Generally, reservoir
Container can be open or airtight.In a preferred embodiment of the present invention, described Liquid storage container can be pacified
Equipped with photoscope, with by content liquid in naked eyes monitoring Liquid storage container, thus controlling the use of solvent.?
In another preferred embodiment of the present invention, described Liquid storage container can have transparent with Liquid storage container fluid connection
Pipe, with by the liquid level in naked eyes monitoring Liquid storage container.In another preferred embodiment of the present invention, described
Liquid storage container has air bleeding valve, for adjusting air pressure in Liquid storage container.If percolation container is airtight, that
With in Liquid storage container percolation solvent liquid level decline, from Liquid storage container flow into percolator percolation solvent just
Can reduce, thus causing the problem of percolation solvent deficiency or the decline of percolation speed in percolator.And,
In the case of percolation solvent is volatile, with the volatilization of percolation solvent, the air pressure in Liquid storage container also can be sent out
Changing, thus cause the change of flow velocity in the first DC tube.In order to keep containing of percolation solvent in percolator
Amount and/or percolation speed, can adjust the pressure in Liquid storage container by air bleeding valve, thus ensureing from storage
The percolation solvent that liquid container flows into percolator will not reduce.Generally, described Liquid storage container has charging
Mouthful.In a preferred embodiment of the present invention, the charging aperture of described Liquid storage container has material inlet valve, is used for
Control the percolation solvent entering Liquid storage container.In a preferred embodiment of the present invention, described Liquid storage container
All parts are dismountable, thus facilitating fixed time cleaning or carrying out when changing different percolation solvent clear
Wash.
In a preferred embodiment of the present invention, described Liquid storage container may also include control device, described control
Device is included for monitoring the sensor of percolation solvent, logic control element and charging in Liquid storage container
Valve and/or the controller of air bleeding valve.When the solvent in Liquid storage container is less than setting value, sensor
Pass the signal to logic control element, logic control element forms according to the signal that sensor sends and controls letter
Number, then logic control element transmits control signals to the controller of material inlet valve and/or air bleeding valve,
Controller adjusts material inlet valve and/or air bleeding valve afterwards, by percolation solvent delivery to Liquid storage container.
In a preferred embodiment of the present invention, the position of described Liquid storage container is higher than described percolator, with logical
Cross gravity by the percolation solvent delivery in Liquid storage container in percolator.
In the present invention, described percolator is conventional, and it can be percolator commonly used in the art.?
In one preferred embodiment of the present invention, described percolator has holding pad.Generally, natural product
Density is smaller, and therefore natural product typically all floats on the surface of percolation solvent, thus can be resulted in blockage
One DC tube and/or percolation are insufficient.In order to solve the above problems, holding pad can be set in percolator,
All of natural product to be maintained at below the liquid level of percolation solvent.
In a preferred embodiment of the present invention, described percolator has air bleeding valve, for adjusting in percolator
Air pressure.With the carrying out of percolation, in percolator, the content of percolation solvent it may happen that change, and is oozed
Solvent of filtering is also possible to volatilize, thus causing the change of air pressure in percolator, and finally affects percolation speed.
Described air bleeding valve can be used for adjusting the air pressure in percolator, thus reaching the purpose preventing percolation velocity variations.
In a preferred embodiment of the present invention, described percolator also can have control device, described control dress
Put including the sensor of air pressure, logic control element and exhaust valve controller in monitoring percolator.When percolation dress
When air pressure in putting is higher than setting value, sensor passes the signal to logic control element, logic control element
Control signal is formed according to the signal that sensor sends, then logic control element transmits control signals to arrange
Air valve controller, last controller adjusts air bleeding valve, and the air pressure in percolator is kept constant.
Herein, described first DC tube and/or the second DC tube are provided with liquid flow volume adjustment switch.At this
In one preferred embodiment of invention, described first DC tube or the second DC tube are provided with liquid flow volume adjustment switch.
In another preferred embodiment of the present invention, described first DC tube and the second DC tube are designed with fluid flow and adjust
Section switch.
Herein, described flow control valve is conventional, and it can be arbitrary Flow-rate adjustment in this area
Switch.In a preferred embodiment of the present invention, described flow control valve has Part I and Part II,
Described Part I is used for controlling flow in DC tube, described Part II be used for supporting described Part I and
With direct current fluid communication.In a preferred embodiment of the present invention, described Part I is formed by elastomeric material,
Described elastomeric material include but is not limited to silicone rubber, butadiene-styrene rubber, butadiene rubber, isoprene rubber, EP rubbers,
Butyl rubber, neoprene and nitrile rubber, polyurethane elastomer, SBS elastomer, POE elastomer, fluorine-containing
Elastomer or a combination thereof.In another preferred embodiment of the present invention, described elastomeric material includes fluoroelastomer
Or a combination thereof.Described fluoroelastomer includes but is not limited to politef, Kynoar, polytrifluorochloroethylene
Or a combination thereof.During percolation, ordinary rubber (such as silicone rubber) etc. is in the condition of Long Term Contact percolation solvent
Under, its elastic deformation can change (such as elastic deformation can become big), thus formed by elastomeric material
A part can change for the regulation of flow.For example, in the case that described Part I is formed by silicone rubber,
Flow control valve in use for some time, because the elastic deformation of Part I becomes big, causes in DC tube
Flow diminishes.But, there is not above-mentioned elasticity using the Part I that fluoroelastomer is formed in life-time service process
The change of deformation, such that it is able to keep the constant of flow in DC tube.Therefore, in a preferred embodiment of the present invention
In, described Part I by fluoroelastomer or its formed.
Herein, described second DC tube or receiving bottle may also include monitoring device, for judging that percolation is
No complete.Described monitoring device includes but is not limited to visual mirror, optical detection apparatus, chromatograph etc..For example,
By visual observation in mirror observable second DC tube percolate color, thus judging whether to complete percolation.Example again
As by optical detection apparatus, the concentration of percolate in the second DC tube can be measured, thus having judged whether
Become percolation.
Percolator as herein described preferably has total enclosing state after assembling, so that in percolation process
In, solvent injection rate and percolation solvent flux remain synchronous, ensure that in percolator, solvent level is all the time
Higher than 3-5 centimetre of natural product, to ensure to be sufficiently impregnated with natural product.A preferred embodiment in the present invention
In, by the air pressure in control percolator, the flow control valve on the first DC tube and/or the second direct current
Flow control valve on pipe, can keep liquid level in percolator to keep constant.
In a preferred embodiment of the present invention, the described percolator bottom of percolator (preferably) has filtration
Device, to prevent the solid in percolate from blocking pipeline and carrying out percolation and filtration simultaneously, improves and produces effect
Rate.
In a preferred embodiment of the present invention, all parts of described Liquid storage container are dismountable, thus
Facilitate fixed time cleaning or be by cleaning changing different percolation solvents.
In a preferred embodiment mode of the present invention, described percolating device can also include control device, its
Including logic control element and controller.When the flow velocity in the first DC tube is not equal to the stream in the second DC tube
When fast, control device adjusts the flow control valve on the first DC tube and the/the second DC tube by controller,
So that the flow velocity in the first DC tube and the second DC tube is consistent.
Herein, described receiving bottle can be conventional, its can be any can be used in store liquid
Container, for example, it can be canister, glass container, ceramic vessel etc..Generally, store
Liquid container can be open or airtight.
At some aspects, the extraction for natural materials needs substep to carry out.For example, some Chinese medicinal materials
Effective ingredient comprises fat-soluble ingredient and water-soluble component simultaneously.In this case it is necessary to natural materials
Extracted with different solvents (such as low-concentration ethanol aqueous solution and high concentration ethanol aqueous solution).At this
In the case of kind, the percolating device of the present invention can also include the second leaching device.Described second leaching device can
To be other percolating devices or soaking container etc..In a preferred embodiment of the present invention, institute
Stating the second leaching device is soaking container, for soaking natural materials before or after percolation.In the present invention
A preferred embodiment in, described second leaching device be used for before percolation extract natural materials.At this
In another bright preferred embodiment, described percolating device also includes conveyer device (such as artificial, delivery pipe etc.),
For the extraction product (including natural materials and extracting solution) in the second leaching device is transported to percolator
In.
In a preferred embodiment of the present invention, described percolating device can also include communicator and intelligence is whole
End, described intelligent terminal is connected with described communicator by communication network, thus realizing for percolating device
Remote auto control.
In a preferred embodiment of the present invention, the invention provides one aspect of the present invention provides a kind of direct current
Formula percolating device, described percolating device includes：
Percolator, described percolator has holding pad and air bleeding valve；
Receiving bottle, and
For storing the Liquid storage container of percolation solvent, described Liquid storage container has photoscope and air bleeding valve；
Described Liquid storage container is tightly connected by the top of the first direct current connecting tube and percolator, the bottom of percolator
It is connected with receiving bottle by the second direct current connecting tube, described first DC tube and/or the second DC tube are provided with liquid
Flow control valve；
The position of described Liquid storage container is higher than described percolator, with will be molten for the percolation in Liquid storage container by gravity
Agent is transported in percolator.
In a preferred embodiment of the present invention, the invention provides one aspect of the present invention provides a kind of direct current
Formula percolating device, described percolating device includes：
Percolator, described percolator has holding pad, air bleeding valve and control device, and described control device includes
The sensor of air pressure, logic control element and exhaust valve controller in monitoring percolator；
Receiving bottle, and
For storing the Liquid storage container of percolation solvent, described Liquid storage container has photoscope, air bleeding valve and controls dress
Put, described control device is included for monitoring the sensor of percolation solvent, logic control in Liquid storage container
Unit and the controller of material inlet valve and/or air bleeding valve；
Described Liquid storage container is tightly connected by the top of the first direct current connecting tube and percolator, the bottom of percolator
It is connected with receiving bottle by the second direct current connecting tube, described first DC tube and/or the second DC tube are provided with liquid
Flow control valve；
The position of described Liquid storage container is higher than described percolator, with will be molten for the percolation in Liquid storage container by gravity
Agent is transported in percolator；
Described percolating device also includes control device, and it includes logic control element and controller；When first is straight
When flow velocity in flow tube is not equal to the flow velocity in the second DC tube, it is straight that control device adjusts first by controller
Flow control valve in flow tube and the/the second DC tube, so that the stream in the first DC tube and the second DC tube
Speed is consistent.
In a preferred embodiment of the present invention, the invention provides one aspect of the present invention provides a kind of direct current
Formula percolating device, described percolating device includes：
Percolator, described percolator has holding pad, air bleeding valve and control device, and described control device includes
The sensor of air pressure, logic control element and exhaust valve controller in monitoring percolator；
Receiving bottle, and
For storing the Liquid storage container of percolation solvent, described Liquid storage container has photoscope, air bleeding valve and controls dress
Put, described control device is included for monitoring the sensor of percolation solvent, logic control in Liquid storage container
Unit and the controller of material inlet valve and/or air bleeding valve；
Described Liquid storage container is tightly connected by the top of the first direct current connecting tube and percolator, the bottom of percolator
It is connected with receiving bottle by the second direct current connecting tube, described first DC tube and/or the second DC tube are provided with liquid
Flow control valve；
The position of described Liquid storage container is higher than described percolator, with will be molten for the percolation in Liquid storage container by gravity
Agent is transported in percolator；
Described percolating device also includes control device, and it includes logic control element and controller；When first is straight
When flow velocity in flow tube is not equal to the flow velocity in the second DC tube, it is straight that control device adjusts first by controller
Flow control valve in flow tube and the/the second DC tube, so that the stream in the first DC tube and the second DC tube
Speed is consistent；
Described percolating device also includes the second leaching device, and described second leaching device is soaking container, is used for
Natural materials were soaked before or after percolation.
Percolating device as herein described not only can meet industrialization large-scale production it is also possible to apply to house
The miniaturization device in front yard.Percolating device due to the present invention can realize the automatic stream of percolation solvent using gravity
Dynamic, thus having the advantages that energy-conservation and automatic continuous production.On the other hand, the percolating device of the present invention
Can also be connected with intelligent terminal by communication network, realize remote auto control.
Another aspect of the present invention provides a kind of percolation method, and described percolation method includes：
Percolation solvent is provided；
Natural product for percolation is provided；
Single flow percolating device of the present invention is provided；
With above-mentioned percolation solvent, percolation is carried out to described natural product by described single flow percolating device and obtain percolation
Liquid.
In the present invention, described percolation solvent can be any percolation solvent commonly used in the art, including but not
It is limited to water, alcohol, ether, ketone, ester, aldehyde or a combination thereof.In a preferred embodiment of the present invention, described ooze
Solvent of filtering is selected from water, C1-C4 alcohol or a combination thereof.In another preferred embodiment of the present invention, described percolation is molten
Agent is selected from water, ethanol and combinations thereof.In an also preferred embodiment of the present invention, described percolation solvent choosing
From the ethanol water of variable concentrations, such as volumetric concentration is the ethanol water of 1-70%, preferably volume
Concentration is the ethanol water of 25-70%.
Herein, described natural product refers to naturally occurring various forms of material, including but not limited to
Dehydration product.For example, described natural product includes Chinese medicinal material.Described Chinese medicinal material includes but is not limited to Huang
Company, Radix Angelicae Sinensis, Bulbus Fritillariae Uninbracteatae, Rhizoma Gastrodiae, Flos Lonicerae, Radix Salviae Miltiorrhizae, Rhizoma Corydalis, Stigma Croci, Radix Ginseng, Radix Panacis Quinquefolii, Radix Scutellariae,
Radix Glycyrrhizae, Radix Glehniae, Fructus Lycii, Radix Platycodoniss, Flos Carthami, Radix Paeoniae, Paeonia suffruticosa, Fructus Corni, Radix Rehmanniae, Flos Trollii, Du
Secondary, Semen Coiciss, Rhizoma Dioscoreae, Semen Ginkgo, Galla Chinensiss, Polyporus, the Radix Astragali, Rhizoma Fagopyri Dibotryiss, Herba Cistanches and/or Os Tigriss.
In the method for the invention, described percolating device refers to must be exactly percolating device of the present invention and its each
Plant preferred implementation.
At some aspects, the extraction for natural materials needs substep to carry out.For example, some Chinese medicinal materials
Effective ingredient comprises fat-soluble ingredient and water-soluble component simultaneously.In this case it is necessary to natural materials
Extracted with different solvents (such as low-concentration ethanol aqueous solution and high concentration ethanol aqueous solution).At this
In the case of kind, method of the present invention also includes the step using percolation extraction natural product.Described
Step using percolation extraction natural product can be carried out before or after percolation step.In the present invention
A preferred implementation in, described leach step was carried out before percolation.In described leach step
The percolation solvent using can be identical or different with the percolation solvent in percolation step.One in the present invention excellent
Select in example, used in described leach step, percolation solvent can with the percolation solvent in percolation step not
With.In another preferred embodiment of the present invention, using percolation solvent in described leach step and percolation step
It is all the concentration of ethanol water used in ethanol water, and leach step higher than use in percolation step
Ethanol water.In an example more typically of the present invention, ethanol water used in leach step
The concentration of solution be 50-70 volume % (preferably 55-70 volume %, more preferably 60-70 volume %, most preferably
70 volumes %), used in percolation step, the concentration of ethanol water is 40-55 volume % (preferably 45-55
Volume %, more preferably 45 volumes %).In a preferred embodiment of the present invention, method of the present invention
Also include the step that the natural product of extraction is transported to percolator, including but not limited to by the natural product of extraction
Thing is poured in percolator together with extracting solution.
In a preferred embodiment of the present invention, the invention provides a kind of percolation method, described percolation method
Including：
First percolation solvent and the second percolation solvent are provided；
Natural product for percolation is provided；
With natural product described in the first percolation solvent soaking；
Percolating device described in single flow percolating device is provided to include：
Percolator, described percolator has holding pad and air bleeding valve；
Receiving bottle, and
For storing the Liquid storage container of the second percolation solvent, described Liquid storage container has photoscope and aerofluxuss
Valve；
Described Liquid storage container is tightly connected by the top of the first direct current connecting tube and percolator, percolator
Bottom is connected with receiving bottle by the second direct current connecting tube, on described first DC tube and/or the second DC tube
It is provided with liquid flow volume adjustment switch；
The position of described Liquid storage container is higher than described percolator, with by gravity by oozing in Liquid storage container
Filter solvent delivery in percolator；
Carry out percolation by described single flow percolating device to the natural product after soaking with the second percolation solvent to obtain
Percolate.
In a preferred embodiment of the present invention, the invention provides a kind of percolation method, described percolation method
Including：
The Chinese liquor of 40-55 volume % and the Chinese liquor of 50-70 volume % are provided；
Natural product (such as Chinese medicinal material) for percolation is provided；
With natural product described in the soaking in Chinese liquor of 50-70 volume %；
Percolating device described in single flow percolating device is provided to include：
Percolator, described percolator has holding pad and air bleeding valve；
Receiving bottle, and
For storing the Liquid storage container of the second percolation solvent, described Liquid storage container has photoscope and aerofluxuss
Valve；
Described Liquid storage container is tightly connected by the top of the first direct current connecting tube and percolator, percolator
Bottom is connected with receiving bottle by the second direct current connecting tube, on described first DC tube and/or the second DC tube
It is provided with liquid flow volume adjustment switch；
The position of described Liquid storage container is higher than described percolator, with by gravity by oozing in Liquid storage container
Filter solvent delivery in percolator；
Natural product after soaking is oozed by described single flow percolating device with the Chinese liquor of 40-55 volume %
Filter and obtain percolate.
By the percolation method of the present invention, extraction (for example soaking) step can be first passed through and soak solvent (example
As high concentration Chinese liquor) a certain component (such as oil-soluble constitents) in natural product is soaked out, then use
Percolation solvent (such as low concentration Chinese liquor) carries out percolation by percolator, by another component (such as water solublity
Component) percolation out, such that it is able to make full use of all active components in natural product.Meanwhile, oozing
During filtering, for example low concentration Chinese liquor is added continuously in percolator by direct current connecting tube, thus by percolation
Chinese liquor concentration in cylinder constantly dilution that is to say, that Chinese liquor concentration consecutive variations over time, such that it is able to
Using different Chinese liquor concentration, continuous percolation is carried out to natural product, it is possible to achieve abundant for natural product
Extract.Constantly carrying out with percolation, the Chinese liquor concentration carrying out percolation constantly declines, can be in receiving bottle
Substantially observe that percolation solution colour constantly shoals, finally reach colourless.Therefore, it can by receiving bottle
The color of the percolate receiving is judging whether percolation completes.
Describe the present invention with reference to the accompanying drawings in detail.Fig. 1 describes an embodiment party of percolating device of the present invention
Formula.Described percolating device 1 includes percolator 13, receiving bottle 14 and the Liquid storage container for storing percolation solvent
12, described Liquid storage container 12 is tightly connected by the top of the first direct current connecting tube 15 and percolator 13, percolation
The bottom of cylinder 13 is connected with receiving bottle 14 by the second direct current connecting tube 16, and described second DC tube 16 is provided with
Liquid flow volume adjustment switch 17, described percolator 14 has the row for adjusting the flow rate of liquid in the first DC tube
Air valve 18.First, liquid flow volume adjustment switch 17 arranges in off position, and air bleeding valve 18 is arranged on open shape
State.Natural product (including but not limited to Chinese medicinal material) (not shown) is placed in percolator 13, so
Pour percolation solvent into afterwards in percolator, simultaneously close off air bleeding valve.Described natural product can be soaked in advance with solvent
Product after bubble, and the solvent for soaking can be identical or different with the percolation solvent for percolation.Soak in advance
In the case of bubble, together with soaking solvent, natural product can be loaded in percolator 13, be simultaneously introduced or be added without
Percolation solvent.By percolation solvent delivery in Liquid storage container 12.Then, adjust liquid flow volume adjustment switch 17,
The percolation solvent in percolator is made to flow into receiving bottle 14, Liquid storage container 12 simultaneously by the second direct current connecting tube 16
In percolation solvent by the first direct current connecting tube 15 flow into percolator.Adjust air bleeding valve 18 and fluid flow is adjusted
Switch 17 so that the flow rate of liquid in the first direct current connecting tube 15 and the second direct current connecting tube 17 is consistent,
Thus maintaining liquid level constant in percolator (for example, liquid level and percolator top have 3-5 centimetre of space).
Fig. 2 describes another embodiment of percolating device of the present invention.Described percolating device 2 includes percolation
Cylinder 23, receiving bottle 24 and the Liquid storage container 22 for storing percolation solvent, described Liquid storage container 22 passes through first
Direct current connecting tube 25 is tightly connected with the top of percolator 23, and the bottom of percolator 23 is passed through the second direct current and connected
Pipe 26 is connected with receiving bottle 24, and described second DC tube 26 is provided with liquid flow volume adjustment switch 27, and described
One direct current connecting tube 25 is provided with liquid flow volume adjustment switch 29, and described percolator 24 has for adjusting first
The air bleeding valve 28 of the flow rate of liquid in DC tube, described Liquid storage container has air bleeding valve 210 and inlet adjusting switch
211, described percolator has holding pad 212.First, liquid flow volume adjustment switch 27 and 29 is arranged on closing
State, air bleeding valve 28 and 210 is arranged on open mode, and inlet adjusting switch 211 is arranged on open mode.Will
Natural product (including but not limited to Chinese medicinal material) (not shown) is placed in percolator 23, is then oozing
Filter and pour percolation solvent in cylinder 22, simultaneously close off air bleeding valve 28.Described natural product can be soaked in advance with solvent
Product after bubble, and the solvent for soaking can be identical or different with the percolation solvent for percolation.Soak in advance
In the case of bubble, together with soaking solvent, natural product can be loaded in percolator 23, be simultaneously introduced or be added without
Percolation solvent.By percolation solvent delivery in Liquid storage container 22, simultaneously close off air bleeding valve 210 and inlet adjusting is opened
Close 211, open liquid flow volume adjustment switch 29.Then, adjust liquid flow volume adjustment switch 27,29, make to ooze
The percolation solvent filtered in cylinder flows into receiving bottle 24 by the second direct current connecting tube 26, simultaneously in Liquid storage container 22
Percolation solvent flows into percolator by the first direct current connecting tube 25.Adjust air bleeding valve 28,210 and fluid flow is adjusted
Section switch 27,29 so that the flow rate of liquid in the first direct current connecting tube 25 and the second direct current connecting tube 27 keeps
Unanimously, thus maintaining liquid level constant in percolator.Percolation solvent can be controlled to flow into by inlet adjusting switch 211
Liquid storage container 22, thus keep required percolation solvent in Liquid storage container.
Fig. 3 describes an embodiment of fluid present invention flow control valve.Described fluid flow adjusts and opens
Close 3 and include Part I 31 and Part II 32, described Part I 31 is used for controlling the flow in DC tube,
Described Part II 32 be used for supporting described Part I and with direct current fluid communication.Described Part I is excellent
Choosing formed by elastomeric material, described elastomeric material include but is not limited to silicone rubber, butadiene-styrene rubber, butadiene rubber,
Isoprene rubber, EP rubbers, butyl rubber, neoprene and nitrile rubber, polyurethane elastomer, SBS elasticity
Body, POE elastomer, fluoroelastomer or a combination thereof.
Unless expressly stated otherwise, otherwise, should not be construed to any method as herein described must be according to spy
Fixed order carries out its step.Therefore, when claim to a method is practically without stating what its step should be followed
When order, or should be limited to spy when in addition not illustrating described step in claim or description
When determining order, should not be inferred to any particular order.
It will be apparent to those skilled in the art can be in the spirit without departing from the present invention and model
In the case of enclosing, various modifications and changes are carried out to the present invention.Because those skilled in the art can be in conjunction with this
Bright spirit and essence, carry out various improved combination, subitem combination and change to described embodiment, should
Think that the present invention includes the full content in scope and its equivalents.
Further describe the preferred embodiment of the present invention with reference to embodiments, but the protection model of the present invention
Enclose and be not limited thereto.
Embodiment
Embodiment 1
Percolation is carried out according to the embodiment of Fig. 1 description.First, with the 70 volume % Chinese liquor leachings of 100ml
Bubble 24 hours of 100g Radix Notoginseng powder.Then, liquid flow volume adjustment switch 17 arranges in off position, aerofluxuss
Valve 18 is arranged on open mode.Radix Notoginseng powder after soaking is placed in percolator 13 together with soaking solvent, with
When close air bleeding valve 18.The 40-55 volume % Chinese liquor of 500ml is transported in Liquid storage container 12.Then, adjust
Section liquid flow volume adjustment switch 17, makes the percolation solvent in percolator pass through the second direct current connecting tube 16 and flows into reception
Bottle 14, the percolation solvent in Liquid storage container 12 is by the first direct current connecting tube 15 inflow percolator simultaneously.Adjust
Air bleeding valve 18 and liquid flow volume adjustment switch 17 are so that the first direct current connecting tube 15 and the second direct current connecting tube 17
In flow rate of liquid be held at 1ml/ minute, thus maintaining liquid level and percolator top in percolator to have 3 lis
The space of rice.Percolation is completed after 10 hours.
Embodiment 2
Percolation is carried out according to the embodiment of Fig. 2 description.First, with the 70 volume % Chinese liquor leachings of 100ml
Bubble 24 hours of 100g Radix Notoginseng powder.
Then, liquid flow volume adjustment switch 27 and 29 is arranged in off position, and air bleeding valve 28 and 210 is arranged on
Open mode, inlet adjusting switch 211 is arranged on open mode.By the Radix Notoginseng powder after soaking together with immersion solvent one
Rise and be placed in percolator 23, simultaneously close off air bleeding valve 28.The Chinese liquor of 40-55 volume % is transported to Liquid storage container
In 22, simultaneously close off air bleeding valve 210 and inlet adjusting switch 211, open liquid flow volume adjustment switch 29.Connect
, adjust liquid flow volume adjustment switch 27,29, make the percolation solvent in percolator pass through the second direct current connecting tube
26 flow into receiving bottles 24, and the percolation solvent in Liquid storage container 22 is flowed into by the first direct current connecting tube 25 and oozes simultaneously
Filter cylinder.Adjust air bleeding valve 28,210 and liquid flow volume adjustment switch 27,29 so that the first direct current connecting tube 25
Be held at 1ml/ minute with the flow rate of liquid in the second direct current connecting tube 27, thus maintain in percolator liquid level with
Percolator top has 3 centimetres of space.Percolation is completed after 10 hours.
Claims (10)
1. a kind of single flow percolating device, described percolating device includes：Percolator, receiving bottle and ooze for storage
Filter the Liquid storage container of solvent, described Liquid storage container is tightly connected by the top of the first direct current connecting tube and percolator,
The bottom of percolator is connected with receiving bottle by the second direct current connecting tube, described first DC tube and/or the second direct current
Pipe is provided with liquid flow volume adjustment switch, and described percolator has for adjusting flow rate of liquid in the first DC tube
Air bleeding valve.
2. device as claimed in claim 1 is it is characterised in that described Liquid storage container has air bleeding valve,
For adjusting air pressure in Liquid storage container；And/or, the charging aperture of described Liquid storage container has material inlet valve, uses
In the percolation solvent controlling entrance Liquid storage container；And/or, described Liquid storage container may also include control device,
Described control device is included for monitoring the sensor of percolation solvent, logic control element in Liquid storage container
And the controller of material inlet valve and/or air bleeding valve.
3. device as claimed in claim 1 is it is characterised in that the position of described Liquid storage container is higher than institute
State percolator, with by gravity by the percolation solvent delivery in Liquid storage container in percolator.
4. device as claimed in claim 1 it is characterised in that in described percolator arrange holding pad,
All of natural product to be maintained at below the liquid level of percolation solvent；And/or, described percolator has control
Device processed, described control device includes monitoring the sensor of air pressure, logic control element and aerofluxuss in percolator
Valve control.
5. device as claimed in claim 1 is it is characterised in that described first DC tube or the second DC tube
It is provided with liquid flow volume adjustment switch；And/or, described first DC tube and the second DC tube are designed with liquid flow
Volume adjustment switch；And/or, described flow control valve has Part I and Part II, described Part I
For controlling the flow in DC tube, described Part II be used for supporting described Part I and with direct current pipe fluid
Connection.And/or, described Part I is formed by elastomeric material, and described elastomeric material includes but is not limited to silicon
Rubber, butadiene-styrene rubber, butadiene rubber, isoprene rubber, EP rubbers, butyl rubber, neoprene and butyronitrile rubber
Glue, polyurethane elastomer, SBS elastomer, POE elastomer, fluoroelastomer or a combination thereof；And/or, described
Elastomeric material includes fluoroelastomer or a combination thereof；And/or, described fluoroelastomer include politef,
Kynoar, polytrifluorochloroethylene or a combination thereof.
6. a kind of single flow percolating device, described percolating device includes：
Percolator, described percolator has holding pad, air bleeding valve and control device, and described control device includes
The sensor of air pressure, logic control element and exhaust valve controller in monitoring percolator；
Receiving bottle, and
For storing the Liquid storage container of percolation solvent, described Liquid storage container has photoscope, air bleeding valve and controls dress
Put, described control device is included for monitoring the sensor of percolation solvent, logic control in Liquid storage container
Unit and the controller of material inlet valve and/or air bleeding valve；
Described Liquid storage container is tightly connected by the top of the first direct current connecting tube and percolator, the bottom of percolator
It is connected with receiving bottle by the second direct current connecting tube, described first DC tube and/or the second DC tube are provided with liquid
Flow control valve；
The position of described Liquid storage container is higher than described percolator, with will be molten for the percolation in Liquid storage container by gravity
Agent is transported in percolator；
Described percolating device also includes control device, and it includes logic control element and controller；When first is straight
When flow velocity in flow tube is not equal to the flow velocity in the second DC tube, it is straight that control device adjusts first by controller
Flow control valve in flow tube and the/the second DC tube, so that the stream in the first DC tube and the second DC tube
Speed is consistent；
Described percolating device also includes the second leaching device, and wherein said second leaching device is soaking container,
For soaking natural materials before or after percolation.
7. a kind of percolation method, described percolation method includes：
Percolation solvent is provided；
Natural product for percolation is provided；
Single flow percolating device any one of claim 1-6 is provided；
With above-mentioned percolation solvent, percolation is carried out to described natural product by described single flow percolating device and obtain percolation
Liquid.
8. percolation method as claimed in claim 7 is it is characterised in that described percolation solvent is that volume is dense
Spend the ethanol water for 1-75%, preferably volumetric concentration is the ethanol water of 25-75%.
9. a kind of percolation method, described percolation method includes：
First percolation solvent and the second percolation solvent are provided；
Natural product for percolation is provided；
With natural product described in the first percolation solvent soaking；
Percolating device described in single flow percolating device is provided to include：
Percolator, described percolator has holding pad and air bleeding valve；
Receiving bottle, and
For storing the Liquid storage container of the second percolation solvent, described Liquid storage container has photoscope and aerofluxuss
Valve；
Described Liquid storage container is tightly connected by the top of the first direct current connecting tube and percolator, percolator
Bottom is connected with receiving bottle by the second direct current connecting tube, on described first DC tube and/or the second DC tube
It is provided with liquid flow volume adjustment switch；
The position of described Liquid storage container is higher than described percolator, with by gravity by oozing in Liquid storage container
Filter solvent delivery in percolator；
Carry out percolation by described single flow percolating device to the natural product after soaking with the second percolation solvent to obtain
Percolate.
10. a kind of percolation method, described percolation method includes：
The ethanol water of 25-45 volume % and the ethanol water of 50-75 volume % are provided；
Natural product for percolation is provided；
Soak described natural product with the ethanol water of 50-75 volume %；
Percolating device described in single flow percolating device is provided to include：
Percolator, described percolator has holding pad and air bleeding valve；
Receiving bottle, and
For storing the Liquid storage container of the second percolation solvent, described Liquid storage container has photoscope and aerofluxuss
Valve；
Described Liquid storage container is tightly connected by the top of the first direct current connecting tube and percolator, percolator
Bottom is connected with receiving bottle by the second direct current connecting tube, on described first DC tube and/or the second DC tube
It is provided with liquid flow volume adjustment switch；
The position of described Liquid storage container is higher than described percolator, with by gravity by oozing in Liquid storage container
Filter solvent delivery in percolator；
With the ethanol water of 25-45 volume % by described single flow percolating device to the natural product after soaking
Carry out percolation and obtain percolate.
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| CN107744674A (en) * | 2017-10-25 | 2018-03-02 | 西南科技大学 | Volume production test percolator |
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