CN209271495U

CN209271495U - A kind of blood separating mechanism

Info

Publication number: CN209271495U
Application number: CN201822138184.4U
Authority: CN
Inventors: 张学军
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-12-20
Filing date: 2018-12-20
Publication date: 2019-08-20
Anticipated expiration: 2028-12-20

Abstract

Blood separating mechanism provided by the utility model, serum separation gel is wired up using flexible bag body, even if substance discharges in serum separation gel after long-time, blood sample will not be affected, it more will not thus lead to the blocking of measuring device, the long shelf-life of product, storage and transportation conditions is required low, and the production of the blood separating mechanism is not necessarily to special equipment, production cost is low, the device is compared to traditional approach, in centrifugal separation processes, the barrier of serum and haemocyte can be formed within the shorter time, and the isolation effect of the device is more preferable, the serum and blood cell sample obtained using the device is more cleaned, cross contamination is smaller, it ensure that separating effect is excellent, also ensure the accuracy of subsequent measurement.

Description

A kind of blood separating mechanism

Technical field

The utility model relates to the technical fields of medical treatment detection instrument, and in particular to a kind of blood that blood separating effect is excellent Liquid separating apparatus.

Background technique

In the diagnostic test of sufferer, it is often necessary to the whole blood sample of patient is separated into component, usually by specific gravity compared with Light serum carries out separation component with the heavier haemocyte of specific gravity.Usually then needle or casing connection are passed through by venipuncture Collect whole blood sample to syringe or the collecting pipe of evacuation, then by rotated in centrifuge by blood be separated into serum and Haemocyte.In order to guarantee separation after two-phase isolation, use serum separation gel as the barrier of two-phase in the prior art, it is this The pipe that serum separation gel serum separates and collects pipe needs special manufacturing equipment to prepare, and in addition the shelf-life of product is limited System, because over time, only the middle substance adulterated is possible to be released serum separation gel, and there are blocking measuring instruments The risk of device, causes measurement efficiency to reduce, and the interface that in addition serum separation gel is contacted with serum or haemocyte may be changed Reaction is learned, causes sample contaminated.

It is, therefore, desirable to provide a kind of blood separating mechanism, to solve the above problems.

Utility model content

The purpose of this utility model is to provide a kind of blood separating mechanisms, to solve prior art blood separating mechanism system Substance, which is easy release blocking instrument, in the easy contaminated samples of standby higher cost, serum separation gel, serum separation gel leads to measurement effect The technical issues of rate reduces.

The utility model provides a kind of blood separating mechanism, and the blood separating mechanism includes collecting pipe, flexible bag body, bullet Property cock body；Wherein: the collecting pipe is unidirectionally open, and the flexible bag body is arranged inside collecting pipe, inside flexible bag body Equipped with serum separation gel, resilient plug body, which can be inserted into the opening of collecting pipe, will collect the seal of tube；The flexible bag body and blood The averag density of clear separation gel is between serum density and blood cell density；When carrying out centrifugal blood separation, flexible bag body Interior serum separation gel can be changed to the second position from first position, to establish between upper serum and lower layer's haemocyte Physical isolation.

When being not injected into blood inside collecting pipe, the intracorporal serum separation gel of flexible pouch will be in due to gravity Blood sample is injected into inside collecting pipe, in use, piercing through elastic cock body with syringe needle then by syringe needle by the bottom end of collecting pipe Collecting pipe, is then placed in centrifuge apparatus by removal and resilient plug weight novel sealing, carries out conventional centrifuge separation operation, In centrifugal process, highdensity haemocyte (density 1.08g/cm³Left and right) it mutually will be mobile to the closed lower of collecting pipe；It is low close Serum (the density 1.02g/cm of degree³Left and right) mutually will be mobile to upper, open end, due to being equipped with the flexible bag body of serum separation gel Density is between serum and haemocyte, and serum separation gel gradually moves up in flexible bag body from the bottom end of collecting pipe, together When serum will be pressed upwards, and haemocyte is pressed down against, and when separation finishes, serum separation gel is in flexible bag body, And between serum and haemocyte, physical isolation is formed between, at this point, serum separation gel is in flexible bag body, And the position in the middle part of collecting pipe, the i.e. second position.

Serum separation gel is using existing, such as polysiloxane-based serum separation gel, by polysiloxanes, silica, dilution Agent and additive composition, polysiloxane level 80%-90%, silica 10%-15% and add 2% or so diluent Add agent, appearance is translucent, the general colloid for having blue light, density 1.04g/cm³Left and right；Or polyacrylate serum point It from glue, is made of polyacrylate, fumed silica and additive, polyacrylic acid ester content is 96%, fumed silica It is 3%, additive 1%；Appearance is colorless and transparent colloid, density 1.05g/cm³Left and right.

Further, the material of the flexible bag body is selected from polyethylene, polyurethane, polyvinyl chloride, polyester fiber, polyene One of hydrocarbon, polyethers.These materials all have good elastic characteristic, and intensity supports serum separation gel being centrifuged enough The impact force generated in rotary course, and with blood sample interfacial reaction does not occur for these materials, advantageously ensures that blood sample Product are not contaminated, meanwhile, the density of these materials and the density difference of serum separation gel are little, are conducive to flexible bag body and blood The control of clear separation gel averag density.

Further, a part of the flexible bag body is fixed on the inner tubal wall of collecting pipe side；Serum separation Glue is only filled with a part of flexible bag body, and the remainder of flexible bag body is in collapsed mode, when serum separation gel is in first When position, serum separation gel is located at collecting pipe bottom end side；When serum separation gel is in the second position, serum separation gel is located at The middle part of collecting pipe.Control serum separation gel is partially filled in flexible bag body, facilitate serum separation gel in first position and Variation between the second position reduces the impact force to flexible bag body.

Further, the collection inside pipe wall is additionally provided with several annular protrusion ribs, and each annular protrusion rib both corresponds to Second position setting.When this structure design can guarantee that serum separation gel is in the second position, in flexible bag body and collecting pipe There is bigger frictional force, to guarantee the validity that serum and haemocyte is isolated in flexible bag body between wall.

Further, the recessed portion that there is the tube wall of the collecting pipe at least one to be recessed from the inside to the outside, the recess Portion forms protrusion in the outside of tube wall；When serum separation gel is in the second position, at least part of flexible bag body is located at upper It states in recessed portion, when this structure design can make serum separation gel be in the second position, the flexible pouch equipped with serum separation gel A part of body is in recessed portion, to provide the support force of vertical direction for recessed portion, flexible bag body has been effectively ensured It is stable in the position that serum and haemocyte are isolated, preferably, recessed portion is provided with one, recessed portion setting with On the other side inner tubal wall that the inner tubal wall of the fixed side of flexible bag body is correspondingly arranged and it is semicircle, is in the in serum separation gel Inner tubal wall when two positions, in all recessed portion regions of contact area of flexible bag body and other side inner tubal wall.

Further, the outer surface of the flexible bag body is also coated with functional layer.This design can be according to actual survey Corresponding functional layer is arranged in examination demand, and functional layer includes but is not limited to surfactant, heparin, protamine sulfate.

Further, the functional layer be polysiloxanes, it is any in polyvinylpyrrolidone.Polysiloxanes, poly- second Vinyl pyrrolidone all has anticoagulant effect, uses it as functional coating, and blood sample can be effectively prevented and separating Condensation afterwards.

Blood separating mechanism provided by the utility model is wired up serum separation gel using flexible bag body, even if long Substance discharges in serum separation gel after time, will not affect to blood sample, and measurement more will not thus be caused to set Standby blocking, the long shelf-life of product is low to storage and transportation conditions requirement, and the production of the blood separating mechanism is without spy Different equipment, production cost is low, and the device is compared to traditional approach, can be within the shorter time in centrifugal separation processes The barrier of serum and haemocyte is formed, and the isolation effect of the device is more preferable, the serum and haemocyte obtained using the device Sample more cleans, and cross contamination is smaller, ensure that separating effect is excellent, also ensures the accuracy of subsequent measurement.

Detailed description of the invention

It, below will be right in order to illustrate more clearly of specific embodiment of the present invention or technical solution in the prior art Specific embodiment or attached drawing needed to be used in the description of the prior art are briefly described, it should be apparent that, it is described below In attached drawing be that some embodiments of the utility model are not paying creativeness for those of ordinary skill in the art Under the premise of labour, it is also possible to obtain other drawings based on these drawings.

Fig. 1 is the structural schematic diagram for the blood separating mechanism that the utility model one of which embodiment provides, at this point, serum Separation gel is in first position；

Fig. 2 conveys structural schematic diagram when blood for the blood separating mechanism that syringe needle is inserted into Fig. 1；

Schematic diagram after the blood separating mechanism acquisition blood that Fig. 3 is Fig. 1 in centrifugal separation processes；

Schematic diagram after being centrifugated after the blood separating mechanism acquisition blood that Fig. 4 is Fig. 1, at this point, at serum separation gel In the second position；

Fig. 5 is the collecting pipe inside pipe wall schematic diagram that the utility model another kind embodiment provides；

Fig. 6 is the collecting pipe inside pipe wall schematic diagram that another embodiment of the utility model provides.

Appended drawing reference:

1- collecting pipe；101- salient rib；102- recessed portion；2- elasticity cock body；3- flexible bag body；4- serum separation gel；5- Syringe needle；6- blood；601- serum；602- haemocyte.

Specific embodiment

In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " is pacified Dress ", " connected ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or integrally Connection；It can be mechanical connection, be also possible to be electrically connected；Can be directly connected, can also indirectly connected through an intermediary, It can be the connection inside two elements.For the ordinary skill in the art, above-mentioned art can be understood with concrete condition The concrete meaning of language in the present invention.

Fig. 1 is the structural schematic diagram for the blood separating mechanism that the utility model one of which embodiment provides, at this point, serum Separation gel is in first position；Fig. 2 conveys structural schematic diagram when blood for the blood separating mechanism that syringe needle is inserted into Fig. 1；Fig. 3 is Schematic diagram after the blood separating mechanism acquisition blood of Fig. 1 in centrifugal separation processes；The blood separating mechanism that Fig. 4 is Fig. 1 acquires Schematic diagram after being centrifugated after blood, at this point, serum separation gel is in the second position；Fig. 5 is that the utility model is another real The collecting pipe inside pipe wall schematic diagram of example offer is provided；Fig. 6 is that the collecting pipe inside pipe wall that another embodiment of the utility model provides shows It is intended to.

As shown in Figs 1-4, it is provided in this embodiment can blood separating mechanism, including collecting pipe 1, flexible bag body 3, resilient plug Body 2；Wherein: the collecting pipe 1 is unidirectionally open, and a part of the flexible bag body 3 is fixed at 1 side of collecting pipe On inner tubal wall, serum separation gel 4 is housed inside flexible bag body 3, serum separation gel 4 is only filled with a part of flexible bag body 3, flexible The remainder of bag body 3 is in collapsed mode, and elastic cock body 2 is inserted into sealing collecting pipe 1 into the opening of collecting pipe 1； The averag density of the flexible bag body 3 and serum separation gel 4 is between 601 density of serum and 602 density of haemocyte；To blood When liquid 6 is centrifuged, the serum separation gel 4 in flexible bag body 3 can be changed to second from first position (as described in Figure 1) Position (as shown in Figure 4), to establish physical isolation between upper serum 601 and lower layer's haemocyte 602；

Serum separation gel 4 is made of polyacrylate, fumed silica and additive, wherein polyacrylic acid ester content It is 96%, fumed silica 3%, additive 1%, appearance is colorless and transparent colloid, density 1.05g/cm³, soft Property bag body 3 select polyethylene material, density of pe 0.95g/cm³, select serum separation gel and the volume of 6ml for 1ml's Flexible bag body, the averag density of the two are 1.043g/cm³；

When being not injected into blood inside collecting pipe 1, serum separation gel 4 in flexible bag body 3 will due to gravity and Bottom end in collecting pipe 1, i.e. first position (as shown in Figure 1), in use, elastic cock body 2 is pierced through with syringe needle 5, by 6 sample of blood Originally it is injected into 1 inside (as shown in Figure 2) of collecting pipe, then syringe needle 5 is removed and elastic cock body 2 reseals, then will be received Collector 1 is placed in centrifuge apparatus, carries out conventional centrifuge separation operation, in centrifugal process, highdensity haemocyte 602 (density 1.08g/cm³Left and right) it mutually will be mobile to the closed lower of collecting pipe 1；(the density 1.02g/cm of serum 601 of low-density³It is left It is right) mutually will be mobile to upper, open end, since 3 density of flexible bag body equipped with serum separation gel 4 is between serum 601 and haemocyte Between 602, serum separation gel 4 is gradually moved up (as shown in Figure 3) in flexible bag body 3 from 1 bottom end of collecting pipe, while blood Clear 601 will be pressed upwards, and haemocyte 602 is pressed down against, and when separation finishes, serum separation gel 4 is in flexible bag body 3 It is interior, and between serum 601 and haemocyte 602, physical isolation is formed between, at this point, serum separation gel 4 is in soft Property bag body 3 in, and the position in the middle part of collecting pipe 1, i.e., the second position (as shown in Figure 4).

As the preferred embodiment of the present embodiment, the inner wall of collecting pipe 1 is improved, as shown in figure 5, the receipts 1 inner wall of collector is additionally provided with three annular protrusion ribs 101, and three annular protrusion ribs 101 both correspond to second position setting.It is this When structure design can guarantee that serum separation gel is in the second position, there is bigger rub between flexible bag body and collection inside pipe wall Power is wiped, to guarantee the validity that serum and haemocyte is isolated in flexible bag body.

As the preferred embodiment of the present embodiment, the inner wall of collecting pipe 1 is improved, as shown in fig. 6, the receipts The tube wall of collector 1 has a recessed portion 102 being recessed from the inside to the outside, and outside of the recess 102 in tube wall forms convex It rises, which is arranged on the other side inner tubal wall being correspondingly arranged with the inner tubal wall of the fixed side of flexible bag body 3 and is half Circle, when serum separation gel 4 is in the second position, all recess of contact area of flexible bag body 3 and other side inner tubal wall Inner tubal wall in 102 region of portion is equipped with serum separation gel when this structure design can make serum separation gel be in the second position A part of flexible bag body be in recessed portion, to provide the support force of vertical direction for recessed portion, be effectively ensured The stable position in serum and haemocyte isolation of flexible bag body.

Finally, it should be noted that above embodiments are only to illustrate the technical solution of the utility model, rather than its limitations； Although the present invention has been described in detail with reference to the aforementioned embodiments, but those skilled in the art should manage Solution: it is still possible to modify the technical solutions described in the foregoing embodiments, or to some or all of skills Art feature is equivalently replaced；And these are modified or replaceed, it does not separate the essence of the corresponding technical solution the utility model The range of each embodiment technical solution.

Claims

1. a kind of blood separating mechanism, which is characterized in that the blood separating mechanism includes collecting pipe, flexible bag body, resilient plug Body；Wherein:

The collecting pipe is unidirectionally open, and the flexible bag body is arranged inside collecting pipe, and serum is housed inside flexible bag body Separation gel, resilient plug body, which can be inserted into the opening of collecting pipe, will collect the seal of tube；

The averag density of the flexible bag body and serum separation gel is between serum density and blood cell density；

When carrying out centrifugal blood separation, the intracorporal serum separation gel of flexible pouch can be changed to the second position from first position, To establish physical isolation between upper serum and lower layer's haemocyte.

2. a kind of blood separating mechanism according to claim 1, which is characterized in that the material of the flexible bag body is selected from poly- Ethylene, polyurethane, polyvinyl chloride, polyester fiber, polyolefin, one of polyethers.

3. a kind of blood separating mechanism according to claim 1, which is characterized in that a part of the flexible bag body is fixed It is arranged on the inner tubal wall of collecting pipe side；Serum separation gel is only filled with a part of flexible bag body, the remainder of flexible bag body Divide and be in collapsed mode, when serum separation gel is in first position, serum separation gel is located at collecting pipe bottom end side；Work as serum When separation gel is in the second position, serum separation gel is located at the middle part of collecting pipe.

4. a kind of blood separating mechanism according to claim 3, which is characterized in that if the collection inside pipe wall is additionally provided with Dry annular protrusion rib, each annular protrusion rib both correspond to second position setting.

5. a kind of blood separating mechanism according to claim 3, which is characterized in that the tube wall of the collecting pipe has at least One recessed portion being recessed from the inside to the outside, the recessed portion form protrusion in the outside of tube wall；The is in serum separation gel When two positions, at least part of flexible bag body is located in above-mentioned recessed portion.

6. a kind of blood separating mechanism described in any one of -5 claims according to claim 1, which is characterized in that the flexibility The outer surface of bag body is also coated with functional layer.

7. a kind of blood separating mechanism according to claim 6, which is characterized in that the functional layer is polysiloxanes, gathers It is any in vinyl pyrrolidone.