CN209253963U - A kind of neutron capture therapy system based on proton linac - Google Patents
A kind of neutron capture therapy system based on proton linac Download PDFInfo
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- CN209253963U CN209253963U CN201821431534.XU CN201821431534U CN209253963U CN 209253963 U CN209253963 U CN 209253963U CN 201821431534 U CN201821431534 U CN 201821431534U CN 209253963 U CN209253963 U CN 209253963U
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Abstract
The neutron capture therapy system based on proton linac that the utility model discloses a kind of, comprising: proton generates section, for generating high current proton beam；Proton emission section, for being accelerated to proton beam and being transported；Proton application section, including production application system and neutron capture therapy system, production application system are produced and are extracted for radionuclide, and neutron capture therapy system is used for human tumor external exposure；Control system generates section, the Proton emission section and the proton application section electric signal with the proton respectively and connect.Neutron capture therapy system structure provided by the utility model is compact, integrated level is high, compact, easy for installation and save the cost, can be convenient cloth and build in existing hospital, has the function of BNCT treatment and production radioactive isotope function.
Description
Technical field
The utility model belongs to medicine technology field more particularly to a kind of neutron absorption based on proton linac is controlled
Treatment system.
Background technique
Boron neutron capture therapy (Boron Neutron Capture Therapy, BNCT) is a kind of " medical instruments combination ", peace
The better biological targeting binary radiotherapy mode of full property, with the excellent of the means such as radiotherapy, chemotherapy, heavy particle therapy from principle
Point is most hopeful to realize the wonderful dream that the mankind eradicate tumour.BNCT treatment will be first by that will have the nontoxic of close tumor tissues
Take boron infusion of medicine blood of human body, it is multi-direction suitable using epithermal neutron wait take boron (boron -10) drug-rich after tumor tissues
Shape irradiates tumor locus, and -10 nucleic of boron in neutron and cancer cell meets and occurs nuclear reaction, the alpha particle of releasing and
- 7 particle of lithium has very strong lethality to cell, and fragmentation effect is higher than existing X-ray, gamma ray radiotherapy and proton and puts
It treats, the side effect of BNCT is smaller, and with taking further increasing for boron drug parent's tumor effect, BNCT normal tissue
Damage will further decrease.The expansion in extensive range, and having can treat proton, heavy particle therapy not of the tumour indication of BNCT
Dissipate the tumor cases that recur again after type malignant tumour or treatment, such as in glioblastoma multiforme (the pernicious cancer of the brain), multiple
Hair property head and neck cancer, maligna element cutaneum carcinoma, metastatic liver cancer etc., therapeutic effect is significantly better than existing treatment technology.
BNCT treating cancer mainly provides thermal source using fission nuclear reactor in the past, due to being limited by nuclear reactor
The factors such as number is few, transformation difficulty is big and operating cost is high, thus be actually used in the reactor number of oncotherapy always without
Method has breakthrough raising, seriously constrains BNCT and worldwide develops and popularize.Pile neutron source facility is because of core
The outstanding problems such as safety are beyond affordability at present to be built in existing hospital, is unfavorable for it and is promoted and popularize.
As cancer and the important screening means of other illness, the in-vivo diagnostic of nuclear medicine be by radionuclide and its
After marker injection into the human body, due to body function and metabolic alterations, thus it can be existed by active nucleus and its marker
Distribution in vivo and metabolism are to reflect the intracorporal pathology of people or physiological change.Positron emission tomography (PET), the list of Nuclear Medicine Dept
The equipment such as photon tomography scanner (SPECT) need to inject before scanning the radionuclide of doses to subject, therefore
Such equipment needs preparation, production or the adoption process of mating radionuclide.For example PET or PET-CT possesses mechanism generally
A set of radionuclide production system based on proton precessional magnetometer, production radionuclide Value linear, carbon -11 etc. need to be individually purchased,
It to be also equipped in relation to facility and place needed for pharmaceutical synthesis simultaneously.The hospital for introducing PET would generally build an independent PET
Center, for accommodating the radioactive isotope production system based on low energy proton accelerator, so that setting for hospital be significantly greatly increased
Standby input cost, expands additional land demand, is unable to satisfy the requirement of most of hospitals.
Based on the above situation, we can be convenient cloth it is necessary to designing one kind and build in existing hospital and economy
Excellent BNCT change system.
Utility model content
One purpose of the utility model is: providing a kind of neutron capture therapy system based on proton linac
System, this system be provided simultaneously with BNCT treatment function with produce radioactive isotope function, and it is compact-sized, integrated level is high, volume
It is small and exquisite, easy for installation, it can be convenient cloth and build in existing hospital.
For this purpose, the utility model uses following technical scheme:
A kind of neutron capture therapy system based on proton linac, comprising:
Proton generates section, for generating high current proton beam；
Proton emission section generates section with the proton and connect for being accelerated to proton beam and being transported,
Proton application section is connect with the Proton emission section, including production application system and neutron capture therapy system, institute
It states production application system to produce and extract for radionuclide, the neutron capture therapy system outside human tumor for shining
It penetrates, the production application system and the neutron capture therapy system are connect with the Proton emission section respectively；
Control system generates section, the Proton emission section and the proton application section electric signal with the proton respectively and connects
It connects.
Further, the Proton emission section includes radio frequency four polar field linear accelerator system, draft tube linac
System and radio frequency power source, the radio frequency four polar field linear accelerator system generate section with the proton and connect, the drift tube
Linear accelerator system is connect with the radio frequency four polar field linear accelerator system, the radio frequency four polar field linear accelerator system
And the draft tube linac system is connect with the radio frequency power source respectively again.
Further, the radio frequency four polar field linear accelerator system, comprising: transfers section, rfq accelerator, middle energy
Span line；The transfers section and the proton generate section and connect, the rfq accelerator and the transfers section and described
Radio frequency power source connection, the middle energy span line are connect with the rfq accelerator and the draft tube linac system, institute
Transfers section, the rfq accelerator, the middle energy span line is stated to connect with the control system electric signal respectively.
Specifically, the transfers section, for being adjusted to proton beam stream；The rfq accelerator, for proton
Line is accelerated；The middle energy span line is further speeded up for adjusting to proton beam stream so that proton beam meets
Requirement；The radio frequency power source, for providing radio-frequency power for rfq accelerator；The control system, for being generated to proton
Section, transfers section, rfq accelerator, middle energy span line are controlled.
Further, the transfers section, comprising: the first solenoidal lens, the first guidance magnets, the second guidance magnets
With the second solenoidal lens；First solenoidal lens generates section with the proton and connect, first guidance magnets and institute
The connection of the first solenoidal lens is stated, second guidance magnets are connect with first guidance magnets, and second solenoid is saturating
Mirror is connect with second guidance magnets.
Specifically, first solenoidal lens, for being focused to proton, to adjust the oval ginseng of the line of proton
Number；First guidance magnets carry out the adjusting of X-direction for the line to proton；Second guidance magnets, for confronting
The line of son carries out the adjusting of Y-direction；Second solenoidal lens, the line for the proton after adjusting to direction gather
Coke, to adjust the elliptic parameter of the line of proton.
Further, the rfq accelerator is four aerofoil profiles or four rod-type, is equipped with RFQ cooling system inside the rfq accelerator
System.
Specifically, the rfq accelerator, accelerates for the line to proton, proton is generated to the energy of section output
Proton beam for keV magnitude accelerates to 2.5-5MeV；The RFQ cooling system, for carrying out temperature to the rfq accelerator
It adjusts.Further, it is described it is middle can span line, comprising: third solenoidal lens, third guidance magnets, the 4th guidance magnets and
4th solenoidal lens；The third solenoidal lens is connect with the rfq accelerator, the third guidance magnets and described the
The connection of three solenoid lens, the 4th guidance magnets connect with the third guidance magnets, the 4th solenoidal lens and
The 4th guidance magnets connection.
Specifically, the third solenoidal lens, for being focused to proton, to adjust the oval ginseng of the line of proton
Number；The third guidance magnets carry out the adjusting of X-direction for the line to proton；4th guidance magnets, for confronting
The line of son carries out the adjusting of Y-direction；4th solenoidal lens, the line for the proton after adjusting to direction gather
Coke, to adjust the elliptic parameter of the line of proton.
Further, the draft tube linac system, comprising: DTL accelerator, high energy transmission section, line switching
System；The DTL accelerator is connect with the radio frequency four polar field linear accelerator system and the radio frequency power source, the high energy
Span line is connect with the DTL accelerator, and the line switching system is connect with the high energy transmission section, the DTL accelerator,
The high energy transmission section, the line switching system are connect with the control system electric signal respectively.
Specifically, the line switching system, for proton beam to be oriented to production application system and neutron capture therapy
System, in the treatment period, by the line switching system neutron capture therapy system that beam steering is different, in the line free time
Section, by line switching system by beam steering production application system；The radio frequency power source, for being mentioned for the DTL accelerator
For radio-frequency power；The control system, for the DTL accelerator, the high energy transmission section, the line switching system into
Row control.
Further, the DTL accelerator is support rod-type accelerating cavity, is equipped with DTL cooling system inside the DTL accelerator
System.
Specifically, the DTL accelerator, further speeds up for the line to proton, the rfq accelerator is defeated
Proton beam of the energy out between 2.5-5MeV accelerates to 8-20MeV；The DTL cooling system, for accelerating to the DTL
Device carries out temperature adjusting.
Further, the high energy transmission section includes: that magnetic steering, three combination quadrupole lenses, beams examine chamber and beam transformer；
The magnetic steering is connect with the DTL accelerator, it is described three combination quadrupole lense is connect with the magnetic steering, the beam examine chamber and
The three combinations quadrupole lense connection, the beam transformer are examined chamber with the beam and are connect.Further, the beam examines intracavitary set
There are beam position detector and fluorescent target beam simulation device.
Specifically, the magnetic steering, for the line off-axis state of proton and angled state amount to be directed back to sympodium zero bias
Horn shape state；The three combinations quadrupole lense, is focused for the line to proton, controls the cross section size of proton beam；
The beam transformer, the beam intensity for recording and displaying proton；The beam position detector, for the beam to proton
Stream carries out the monitoring of location information；The fluorescent target beam simulation device, for obtaining the beam profile information of proton.
Further, the radio frequency power source, comprising: high frequency transmitter, coaxial feed tube, power coupling ring and radio-frequency power
Source cooling system；The coaxial feed tube is connect with the high frequency transmitter, the power coupling ring respectively with the coaxial feed tube,
The rfq accelerator is connected with the DTL accelerator, and the radio frequency power source cooling system is set in the radio frequency power source
Portion.
Specifically, the same radio frequency power source can be used in the rfq accelerator and the DTL accelerator, it can also be each
A radio frequency power source is used from each.
Specifically, the high frequency transmitter, for emitting high-frequency signal；The coaxial feed tube, for by high-frequency signal
Power is transmitted；The power coupling ring, for by the power of high-frequency signal on coaxial feed tube be coupled to rfq accelerator and
In DTL accelerator；The radio frequency power source cooling system, for cooling down to radio frequency power source.
Further, the high frequency transmitter, comprising: signal generator, solid-state amplifier, pre-amplifier and final stage are put
Big device；The signal generator is connect with the input terminal of the solid-state amplifier；The output end of the solid-state amplifier with it is described
The input terminal of pre-amplifier connects；The output end of the pre-amplifier is connect with the input terminal of the final amplifier；Institute
The output end for stating final amplifier is connect with the rfq accelerator and DTL accelerator.
Further, the proton application section, including production application system and neutron capture therapy system.
Further, the production application system, including production span line, production application device；The production span line
It is connect with the draft tube linac system, the production application device is connect with the production span line, the production
Span line and the production application device are connect with the control system electric signal respectively.
Specifically, the production span line is connect with the line switching system, it is used for transmission proton beam, and to proton
Line is adjusted, so that proton beam meets the requirement of production application；The production application device is raw for radionuclide
It produces and extracts；The control system, for controlling production span line, production application device.
Further, the production application device include: the first beam channel, target nucleus, production application device cooling system,
Draw duct and shield；The shield wraps up the target nucleus, and first beam channel is set to the inside of the shield,
The entrance of first beam channel is set on the surface of the shield, and is connect by pipeline with the production span line,
The outlet of first beam channel is connect with described target nucleus one end, and the extraction duct is set to inside the shield, described
Production application device cooling system is set to inside the production application device.
The target nucleus, for generating radioactive isotope；The shield, for shielding the same position of radioactivity of target nucleus generation
Element；The beam channel is used to the line of proton being introduced into target nucleus；The extraction duct, the radioactivity for generating target nucleus
Isotope is drawn；The production application device cooling system, for cooling down to production application device.
Further, the neutron capture therapy system, including treatment span line, neutron-exposure facility；The treatment passes
Defeated section connect with the draft tube linac system, and the neutron-exposure facility is connect with the treatment span line, described
Treatment span line and the neutron-exposure facility are connect with the control system electric signal respectively.
Specifically, the treatment span line is connect with the line switching system, it is used for transmission proton beam, and to proton
Line is adjusted, so that proton beam meets the requirement of target practice；The control system, for the treatment span line, institute
Neutron-exposure facility is stated to be controlled.
Further, the neutron-exposure facility, including the second beam channel, expand section, target assembly, neutron beam adjust dress
It sets, collimator, radiation shield.
Further, the target assembly, including target, target supporting body, cooling system, target regenerative system；The target
Material in solid metal lithium, liquid metal lithium, the compound of lithium, metallic beryllium any one or combinations thereof；The lithium
Compound in lithium hydride, lithium deuteride, lithium fluoride any one or combinations thereof；The neutron beam regulating device, including
Neutron degradation body, neutron relfector, low energy neutron filtering body, gamma ray filtering body；The collimator, including fixed collimation
Body alternatively collimates body.
More specifically, the target, for proton beam to be converted to neutron beam；The target supporting body, for coating
Target is stated, and conducts heat caused by the target nuclear reaction；The cooling system, for conducting the target supporting body
Heat out is taken away, and cools down to the target assembly；The target regenerative system, for updating the target.
The production application system, in the line idle period treated without BNCT, using line switching system by matter
Sub- beam steering production application system carries out the production of Short-lived radionuclide Value linear, one-step synthesis of going forward side by side boron medicine BPA's
Tracer drug 18F-BPA, the tracer drug are widely used in the screening of BNCT indication, tumour boron concentration and normal tissue boron medicine
The fields such as the measurement of the ratio (T/N) of concentration and the assessment of BNCT therapeutic effect.By using different target nucleus, production application system
System can be used for producing different radionuclides.
The neutron capture therapy system is generally disliked for treating the tumor patient for meeting BNCT treatment screening condition
Property cancer of the brain patient, recurrent neck cervical cancer patients, chromoma patient.Tumor patient photograph is being carried out using neutron-exposure facility
Before penetrating, a certain amount of boron-doping drug is transfused to patient and sets patient when boron-doping drug when the distribution of tumor tissues reaches best
Neutron exposure is carried out to prospective tumor before the collimator of neutron-exposure facility, when the dosage that patient receives reaches the dosage of setting
When, terminate irradiation.
Further, the quantity of the production application system (310) be at least one, the neutron capture therapy system
(320) quantity is at least two.
The quantity of the production application system is one to ten, that is to say, that the quantity of the production application system can be with
It is one or two or three or four or five or six or seven or eight or nine or ten, to meet different nucleic
The needs of production.
The quantity of the neutron capture therapy system is two to 20, that is to say, that the number of the production application system
Amount can be one or two or three or four or five or six or seven or eight or nine or ten or 11 or
12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20, to meet
The needs of different irradiation treatments.
Further, the quantity of the production application system is one, and the quantity of the neutron capture therapy system is two
It is a.
Further, the quantity of the production application system is two, and the quantity of the neutron capture therapy system is two
It is a.
Further, the quantity of the production application system is two, and the quantity of the neutron capture therapy system is four
It is a.
Further, the quantity of the production application system is three, and the quantity of the neutron capture therapy system is four
It is a.
Further, the neutron capture therapy system is rotatable, can enclose and be rotated about a patient during treatment
Certain angle, direction of illumination can be according to rotation angular adjustments, to provide different direction of illumination and/or neutron prisoner
Obtaining treatment system is fixed setting, and direction of illumination includes horizontal direction, at least one in oblique 45 degree of directions and vertical direction
A direction or combinations thereof.The horizontal direction refers to the direction being parallel to the horizontal plane, and the vertical direction refers to and horizontal direction
Vertical direction, oblique 45 degree of directions refer on the basis of horizontal direction, to 45 degree of direction inclined vertically.
By the way that neutron capture therapy system and production application system, Ke Yiti is arranged simultaneously in neutron capture therapy system
High proton generates the utilization rate for the proton beam that section generates.It needs to carry out proton energy by linear accelerator because proton generates section
Accelerate to meet the requirement of application, and linear accelerator equipment is huge, operation is complicated, and under normal circumstances, starting runs to guarantor
The time for holding output stable particle line is also longer, and under normal circumstances, after opening steady operation, when situation without exception is not related to
Machine, to guarantee that particle beam can stablize output, if only connect with neutron capture therapy system, neutron capture therapy system is general
It diurnally uses, proton beam can be made to cannot be fully utilized, cause the waste of resource.
By the way that more than two neutron capture therapy systems are arranged, in the treatment period, using line switching system by line
It is oriented to the neutron capture therapy system that ready patient is distributed, which receives neutron exposure；Other patients with distributed
Other neutron capture therapy systems carry out preparation, it is ready after enter queueing condition.
It, can be with more or more the positions of irradiation treatment by the way that the neutron capture therapy system of different direction of illuminations is arranged
Tumour, with widen neutron capture therapy systematic difference range and improve therapeutic effect.
In order to further improve the utilization rate and service life of proton linac, a set of accelerator system is proposed
Configure the neutron capture therapy system of a production application system and two, when daytime, two neutron capture therapy systems can
With alternating treatment tumor patient, when idle at night, radionuclide needed for can use production application system production.
The utility model has the following beneficial effects: a kind of neutron capture therapy system based on proton linac is provided,
Realize the application of rfq accelerator, DTL accelerator in boron neutron capture therapy tumor area, and compact-sized, integrated level
Height, compact, easy for installation and save the cost can be convenient cloth and build in existing hospital.It is controlled in addition to BNCT can be carried out
It treats outside function, section can also produce radioactive isotope during idle time, meet nuclear medicine in the illness diagnosis and treatment process such as tumour and detect
Demand to radionuclide improves the utilization rate of accelerator, further improves the neutron based on proton linac
Capture the economy for the treatment of system.
Detailed description of the invention
Fig. 1 is that a kind of structure of neutron capture therapy system based on proton linac provided by the utility model is shown
It is intended to；
Fig. 2 is the structure chart of production application device provided by the utility model；
Fig. 3 is the structure chart of neutron-exposure facility provided by the utility model；
Fig. 4 is the sectional view of neutron-exposure facility provided by the utility model；
Fig. 5 is the sectional view of target assembly provided by the utility model.
In figure: proton generates section 100；Proton emission section 200, radio frequency four polar field linear accelerator system 210, transfers
Section 211, rfq accelerator 212, middle energy span line 213, draft tube linac system 220, DTL accelerator 221, high energy pass
Defeated section 222, line switching system 223, radio frequency power source 230；Proton application section 300, production application system 310, production transmission
Section 311, production application device 312, the first beam channel 3121, target nucleus 3122, production application device cooling system 3123 draw
Duct 3124 out, shield 3125, neutron capture therapy system 320, treatment span line 321, neutron-exposure facility 322, second
Beam channel 3221 expands section 3222, target assembly 3223, target 32231, target supporting body 32232, cooling system 32233, target
Regenerative system 32234, neutron beam regulating device 3224, neutron degradation body 32241, neutron relfector 32242, low energy neutron mistake
Filter body 32243, gamma ray filtering body 32244, collimator 3225, fixed collimation body 32251 are replaceable to collimate body 32252, spoke
Penetrate shield 3226；Control system 400.
Specific embodiment
The utility model is described in further detail with reference to the accompanying drawings and examples.It is understood that herein
Described specific embodiment is used only for explaining the utility model, rather than the restriction to the utility model.It further needs exist for
It is bright, part relevant to the utility model is illustrated only for ease of description, in attached drawing rather than full content.
Embodiment one
A kind of neutron capture therapy system based on High Intensity Proton Linac, as shown in Figure 1, comprising: proton generates
Section 100, Proton emission section 200, proton application section 300 and control system 400；The proton generates section 100, the Proton emission
Section 200, the proton application section 300 are sequentially connected, and the control system 400 generates section 100, the matter with the proton respectively
Sub- accelerating sections 200,300 electric signal of proton application section connection.
Wherein, the proton generates section 100, for generating high current proton beam.In this present embodiment, the proton generates section
100 can generate section or penning using electron cyclotron resonace (Electron Cyclotron Resonanc, ECR) proton
Source, the ion of generation are preferably proton, and in some other embodiment, the ion can also go out for other ions, ion
Mouth energy is tens kiloelectron-volts, and beam intensity is tens of-hundreds of milliamperes of magnitudes.
The Proton emission section 200, for being accelerated to proton beam and being transported.Including radio frequency four polar field linear accelerator
System 210, draft tube linac system 220 and radio frequency power source 230, the radio frequency four polar field linear accelerator system
210, which generate section 100 with the proton, connect, for being accelerated to proton beam and being transported；The draft tube linac system
System 220 is connect with the radio frequency four polar field linear accelerator system 210, for being accelerated to proton beam and being transported；It is described to penetrate
Frequency power source 230 respectively with the radio frequency four polar field linear accelerator system 210 and the draft tube linac system 220
Connection, for providing radio-frequency power for accelerator.
The field radio frequency four polar field linear accelerator system 210, including transfers section 211, rfq accelerator 212, middle energy
Span line 213；The transfers section 211 generates section 100 with the proton and connect, for adjusting to proton beam stream；Institute
It states rfq accelerator 212 to connect with the transfers section 211 and the radio frequency power source 230, for adding proton beam stream
Speed, and be that the rfq accelerator 212 provides radio-frequency power by radio frequency power source 230；It is described it is middle can span line 213 with it is described
Rfq accelerator 212 and the draft tube linac system 220 connection, for being adjusted to proton beam stream, so that proton
Line meets the requirement further speeded up；The transfers section 211, the rfq accelerator 212, the middle energy span line 213
It connect with 400 electric signal of control system, the transfers section 211, the RFQ is added respectively by control system 400
Fast device 212, the middle energy span line 213 are controlled.
In this present embodiment, the rfq accelerator 212 is four aerofoil profiles.Four aerofoil profile rfq accelerator operating frequency ranges are general
In 200MHz-400MHz, therefore more suitable for accelerating lighter particle.Energy needed for proton is practiced shooting is different, and the RFQ adds
Fast device 212 is also different, and in the present embodiment, after the rfq accelerator 212 is to the beam acceleration of proton, makes the energy of proton
Amount reaches 2.5-5MeV.
The draft tube linac system 220, including DTL accelerator 221, high energy transmission section 222, line switching system
System 223；The DTL accelerator 221 and the field radio frequency four polar field linear accelerator system 210 and the radio frequency power source 230
Connection, for further speeding up to proton beam stream, in the present embodiment, the DTL accelerator 221 adds the line of proton
After speed, the energy of proton is made to reach 8-20MeV；The high energy transmission section 222 is connect with the DTL accelerator 221, for adding
The adjusting of proton beam quality after speed；The line switching system 223 is connect with the high energy transmission section 222, is used for matter
Sub- beam steering proton application section 300；The DTL accelerator 221, the high energy transmission section 222, the line switching system
223 connect with 400 electric signal of control system respectively, by control system 400 to the DTL accelerator 221, the height
Energy span line 222, the line switching system 223 are controlled.
In this present embodiment, the DTL accelerator 221 be support rod-type accelerating cavity, for the line to proton carry out into
One step accelerates, and proton beam of the energy of RFQ output between 2.5-5MeV is accelerated to 8-20MeV；Inside the DTL accelerator
Equipped with DTL cooling system, for cooling down to DTL accelerator.
The proton application section 300, including a production application system 310 and a neutron capture therapy system 320；Institute
Production application system 310 and the neutron capture therapy system 320 is stated to connect with the draft tube linac system 220 respectively
It connects, the production application system 310 is produced and extracted for radionuclide；The neutron capture therapy system 320 is used for people
Body tumour external exposure.
The production application system 310 is produced and is extracted for radionuclide.It is answered including production span line 311, production
With device 312, the production span line 311 is connect with the draft tube linac system 220, for flowing into proton beam
Row is adjusted, so that proton beam meets the requirement of production application；The production application device 312 is connect with production span line 311,
Production and extraction for radionuclide；The production span line 311 and the production application device 312 respectively with the control
400 electric signal of system processed connection, by control system 400 to the production span line 311, the production application device 312 into
Row control.
The neutron capture therapy system 320 is used for human tumor external exposure.Including treating span line 321, neutron exposure
Device 322.The treatment span line 321 is connect with the draft tube linac system 220, for flowing into proton beam
Row is adjusted, so that proton beam meets the requirement of target practice；The neutron-exposure facility 322 is connect with the treatment span line, is used
In the neutron capture therapy of tumor patient；The treatment span line 321 and the neutron-exposure facility 322 respectively with the control
The connection of 400 electric signal of system, is controlled by control system 400 pairs for the treatment of span lines 321, neutron-exposure facilities 322.
Embodiment two
It is further improvement on the basis of embodiment one, is with the difference of embodiment one, it is in this present embodiment, described
Proton application section 300, including a production application system 310 and two neutron capture therapy systems 320, described two neutron prisoners
Obtaining treatment system 320 is respectively the first neutron capture therapy system and the second neutron capture therapy system.
Specifically, the first patient is assigned in the first neutron capture therapy system when carrying out BNCT treatment, it is to be prepared
After ready, using line switching system 223 by beam steering the first neutron capture therapy system, the first patient receives neutron photograph
It penetrates；In the first neutron capture therapy systematic treating, the second patient can be distributed to the second neutron capture therapy system, and carry out
Preparation is treated to the first neutron capture therapy system irradiation and is completed, after the second neutron capture therapy system readiness, benefit
With line switching system 223 by beam steering the second neutron capture therapy system, the second patient receives neutron exposure；In second
When neutron capture therapy systematic treating, third patient can be distributed to the first neutron capture therapy system, and carry out preparation, with
This alternating treatment effectively improves neutron capture therapy systematic treating efficiency.
Specifically, the space of the treatment span line 321 and neutron-exposure facility 322 of each neutron capture therapy system 320
Layout will be different, to realize the irradiation treatment of different directions, in the present embodiment, and the irradiation of the first neutron capture therapy system
Direction is that in the horizontal direction, the direction of illumination of the second neutron capture therapy system is along oblique 45 degree of directions.
Embodiment three
The present embodiment and the difference of embodiment one be, in this present embodiment, the proton application section 300, including one
Production application system 310 and two neutron capture therapy systems 320, described two neutron capture therapy systems 320 are respectively the
One neutron capture therapy system and the second neutron capture therapy system.The direction of illumination of first neutron capture therapy system is along vertical
Histogram is to the second neutron capture therapy system can rotate by a certain angle during treatment around patient, and direction of illumination can be with
It is adjusted according to rotation angle.
Example IV
The present embodiment and the difference of embodiment one be, in this present embodiment, the proton application section 300, including one
Production application system 310 and two neutron capture therapy systems 320, described two neutron capture therapy systems 320 are respectively the
One neutron capture therapy system and the second neutron capture therapy system.First neutron capture therapy system is vertically the
Two neutron capture therapy systems are along oblique 45 degree of directions.
Embodiment five
The present embodiment is further improvement on the basis of embodiment one or embodiment two, with embodiment one or embodiment two
Difference be, as shown in Fig. 2, in this present embodiment, the production application device 312 includes: the first beam channel 3121, target
Core 3122, draws duct 3124, shield 3125 at production application device cooling system 3123；The shield 3125 wraps up institute
Target nucleus 3122 is stated, for shielding the radioactive isotope of target nucleus generation；First beam channel 3121 is set to shield 3125
Inside, the entrance of first beam channel 3125 is set on the surface of shield 3125, first beam channel 3125
Entrance connect with high energy transmission section 222 by pipeline；The outlet and 3122 one end of target nucleus of first beam channel 3125 connect
It connects, the extraction duct 3124 is set to inside shield 3125, and the radioactive isotope for generating target nucleus 3122 draws
Out；The production application device cooling system 3123 is set to inside production application device, for carrying out to production application device 312
Cooling.
As shown in figure 3, in this present embodiment, the neutron-exposure facility 322, including the second beam channel 3221, expand
Section 3222, target assembly 3223, neutron beam regulating device 3224, collimator 3225, radiation shield 3226.
As shown in figure 5, in this present embodiment, the target assembly 3223, including target 32231, target supporting body 32232,
Cooling system 32233, target regenerative system 32234.The material of the target 32231 is selected from solid metal lithium, liquid metal lithium, lithium
Compound, in metallic beryllium in any one or combinations thereof, for proton beam to be converted to neutron beam；The target supporting body
32232, for closely coating target, and conductive targets stone reacts produced heat；The cooling system 32233 is used for target
The heat that material supporting body transfers out is taken away, and target pair device is cooled down；The target regenerative system 32234, for updating target.
As shown in figure 4, in this present embodiment, the neutron beam regulating device 3224, including neutron degradation body 32241, in
Sub- reflector 32242, low energy neutron filtering body 32243, gamma ray filtering body 32244.
The collimator 3225, including fixed collimation body 32251, replaceable collimation body 32252.
Embodiment six
The present embodiment is further improvement on the basis of embodiment one, is with one difference of embodiment, in the present embodiment
In, the transfers section 211, comprising: the first solenoidal lens, the first guidance magnets, the second guidance magnets and the second helical
Pipe lens；First solenoidal lens generates section 100 with the proton and connect, for being focused to proton, to adjust matter
The elliptic parameter of the line of son；First guidance magnets are connect with first solenoidal lens, for the line to proton
Carry out the adjusting in the direction X；Second guidance magnets are connect with first guidance magnets, carry out Y for the line to proton
The adjusting in direction；Second solenoidal lens is connect with second guidance magnets, for the proton after adjusting to direction
Line is with regard to line focusing, to adjust the elliptic parameter of the line of proton.
The middle energy span line 213, comprising: magnetic steering, three combination quadrupole lenses, beam examine chamber and beam transformer；It is described
Magnetic steering is connect with the rfq accelerator 212, for the line off-axis state of proton and angled state amount to be directed back to sympodium zero
Drift angle state；The three combinations quadrupole lense is connect with the magnetic steering, is focused for the line to proton, is controlled proton
The cross section size of line；The beam examines chamber and combines quadrupole lense connection with described three, and the beam is examined intracavitary equipped with beam position
Detector and fluorescent target beam simulation device, the beam position detector carry out location information for the line to proton
Monitoring；The fluorescent target beam simulation device, for obtaining the beam profile information of proton；The beam transformer and institute
It states beam and examines chamber connection, the beam intensity for recording and displaying proton.
The high energy transmission section 222, comprising: magnetic steering, three combination quadrupole lenses, beam examine chamber and beam transformer；It is described
Magnetic steering is connect with the DTL accelerator 221, for the line off-axis state of proton and angled state amount to be directed back to sympodium zero
Drift angle state；The three combinations quadrupole lense is connect with the magnetic steering, is focused for the line to proton, is controlled proton
The cross section size of line；The beam examines chamber and combines quadrupole lense connection with described three, and the beam is examined intracavitary equipped with beam position
Detector and fluorescent target beam simulation device, the beam position detector carry out location information for the line to proton
Monitoring, the fluorescent target beam simulation device, for obtaining the beam profile information of proton；The beam transformer and institute
It states beam and examines chamber connection, the beam intensity for recording and displaying proton.
The radio frequency power source 230, comprising: high frequency transmitter, coaxial feed tube, power coupling ring and radio-frequency power source cooling
System；The high frequency transmitter, for emitting high-frequency signal；The coaxial feed tube is connect with the high frequency transmitter, and being used for will
The power of high-frequency signal is transmitted；The power coupling ring respectively with the coaxial feed tube, the rfq accelerator 212 and institute
The connection of DTL accelerator 221 is stated, for the power of high-frequency signal on coaxial feed tube to be coupled in the rfq accelerator 212；Institute
Radio frequency power source cooling system is stated inside the radio frequency power source, for cooling down to the radio frequency power source.
The same radio frequency power source 230 can be used in the rfq accelerator 212 and the DTL accelerator 221,
It respectively can respectively use a radio frequency power source 230.
The high frequency transmitter includes: signal generator, solid-state amplifier, pre-amplifier and final amplifier；It is described
Signal generator is connect with the solid-state amplifier input terminal；The solid state amplifier output is defeated with the pre-amplifier
Enter end connection；The output end of the pre-amplifier is connect with the input terminal of the final amplifier；The final amplifier
Output end is connect with the rfq accelerator 212.
Finally, it should be noted that above embodiments are only to illustrate the technical solution of the utility model, rather than its limitations；
Although the utility model is described in detail with reference to the foregoing embodiments, it will be understood by those of skill in the art that its according to
It can so modify to technical solution documented by previous embodiment, or part of technical characteristic is replaced on an equal basis
It changes；And these are modified or replaceed, various embodiments of the utility model technical solution that it does not separate the essence of the corresponding technical solution
Spirit and scope.
Claims (10)
1. a kind of neutron capture therapy system based on proton linac characterized by comprising
Proton generates section (100), for generating high current proton beam；
Proton emission section (200) generates section (100) with the proton and connect for being accelerated to proton beam and being transported；
Proton application section (300), including production application system (310) and neutron capture therapy system (320), the production application
System (310) is produced and is extracted for radionuclide, and the neutron capture therapy system (320) outside human tumor for shining
Penetrate, the production application system (310) and the neutron capture therapy system (320) respectively with the Proton emission section (200)
Connection；
Control system (400) generates section (100), the Proton emission section (200) and the proton application with the proton respectively
Section (300) electric signal connection.
2. the neutron capture therapy system according to claim 1 based on proton linac, which is characterized in that described
Proton emission section (200) include radio frequency four polar field linear accelerator system (210), draft tube linac system (220) and
Radio frequency power source (230), the radio frequency four polar field linear accelerator system (210) generate section (100) with the proton and connect, institute
It states draft tube linac system (220) to connect with the radio frequency four polar field linear accelerator system (210), the radio frequency four
Pole linear accelerator system (210) and the draft tube linac system (220) respectively with the radio frequency power source
(230) it connects.
3. the neutron capture therapy system according to claim 2 based on proton linac, which is characterized in that described
Radio frequency four polar field linear accelerator system (210), comprising: transfers section (211), rfq accelerator (212), middle energy span line
(213)；The transfers section (211) and the proton generate section (100) and connect, the rfq accelerator (212) with it is described low
It can span line (211) and the radio frequency power source (230) connection, the middle energy span line (213) and the rfq accelerator
(212) and the draft tube linac system (220) connects, the transfers section (211), the rfq accelerator
(212), the middle energy span line (213) connect with the control system (400) electric signal respectively.
4. the neutron capture therapy system according to claim 3 based on proton linac, which is characterized in that described
Transfers section (211), comprising: the first solenoidal lens, the first guidance magnets, the second guidance magnets and the second solenoid are saturating
Mirror；First solenoidal lens generates section (100) with the proton and connect, first guidance magnets and first helical
The connection of pipe lens, second guidance magnets connect with first guidance magnets, second solenoidal lens and described the
The connection of two guidance magnets.
5. the neutron capture therapy system according to claim 3 based on proton linac, which is characterized in that described
Draft tube linac system (220), comprising: DTL accelerator (221), high energy transmission section (222), line switching system
(223)；The DTL accelerator (221) and the radio frequency four polar field linear accelerator system (210) and the radio frequency power source
(230) connect, the high energy transmission section (222) connect with the DTL accelerator (221), the line switching system (223) and
High energy transmission section (222) connection, the DTL accelerator (221), the high energy transmission section (222), line switching system
System (223) is connect with the control system (400) respectively.
6. the neutron capture therapy system according to claim 5 based on proton linac, which is characterized in that described
Radio frequency power source (230), comprising: high frequency transmitter, coaxial feed tube, power coupling ring and radio frequency power source cooling system；It is described
Coaxial feed tube is connect with the high frequency transmitter, the power coupling ring respectively with the coaxial feed tube, the rfq accelerator
(212) it is set in the radio frequency power source (230) with the DTL accelerator (221) connection, the radio frequency power source cooling system
Portion.
7. the neutron capture therapy system according to claim 1 based on proton linac, which is characterized in that described
The quantity of production application system (310) is at least one, and the quantity of the neutron capture therapy system (320) is at least two.
8. the neutron capture therapy system according to claim 2 based on proton linac, which is characterized in that described
Production application system (310), including production span line (311), production application device (312)；The production span line (311) with
Draft tube linac system (220) connection, the production application device (312) and the production span line (311)
Connection, the production span line (311) and the production application device (312) respectively with the control system (400) electric signal
Connection.
9. the neutron capture therapy system according to claim 8 based on proton linac, which is characterized in that described
Production application device (312) includes: the first beam channel (3121), target nucleus (3122), production application device cooling system
(3123), duct (3124) and shield (3125) are drawn；The shield (3125) wraps up the target nucleus (3122), and described the
One beam channel (3121) is set to the inside of the shield (3125), and the entrance of first beam channel (3121) is set to institute
On the surface for stating shield (3125), the entrance of first beam channel (3121) is connect with the production span line (311)；
The outlet of first beam channel (3121) is connect with described target nucleus one end, and the extraction duct (3124) is set to the shielding
Body (3125) is internal, and it is internal that the production application device cooling system (3123) is set to the production application device (312).
10. the neutron capture therapy system according to claim 2 based on proton linac, which is characterized in that institute
It states neutron capture therapy system (320), including treatment span line (321), neutron-exposure facility (322)；The treatment span line
(321) it is connect with the draft tube linac system (220), the neutron-exposure facility (322) and the treatment are transmitted
Section (321) connection, the treatment span line (321) and the neutron-exposure facility (322) respectively with the control system (400)
Electric signal connection.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201821431534.XU CN209253963U (en) | 2018-09-03 | 2018-09-03 | A kind of neutron capture therapy system based on proton linac |
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| CN201821431534.XU CN209253963U (en) | 2018-09-03 | 2018-09-03 | A kind of neutron capture therapy system based on proton linac |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109045487A (en) * | 2018-09-03 | 2018-12-21 | 东莞东阳光高能医疗设备有限公司 | A kind of neutron capture therapy system based on proton linac |
| CN111420307A (en) * | 2020-04-16 | 2020-07-17 | 中国原子能科学研究院 | Neutron beam device and neutron irradiation device |
| CN112657072A (en) * | 2021-01-05 | 2021-04-16 | 中国科学院上海高等研究院 | Ultrahigh-dose-rate proton treatment device based on linear accelerator and scanning method |
| RU2824926C1 (en) * | 2020-10-14 | 2024-08-15 | Нойборон Терапи Систем Лтд. | Boron-neutron capture therapy system and method of creating treatment plan therefor |
-
2018
- 2018-09-03 CN CN201821431534.XU patent/CN209253963U/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109045487A (en) * | 2018-09-03 | 2018-12-21 | 东莞东阳光高能医疗设备有限公司 | A kind of neutron capture therapy system based on proton linac |
| CN111420307A (en) * | 2020-04-16 | 2020-07-17 | 中国原子能科学研究院 | Neutron beam device and neutron irradiation device |
| RU2824926C1 (en) * | 2020-10-14 | 2024-08-15 | Нойборон Терапи Систем Лтд. | Boron-neutron capture therapy system and method of creating treatment plan therefor |
| CN112657072A (en) * | 2021-01-05 | 2021-04-16 | 中国科学院上海高等研究院 | Ultrahigh-dose-rate proton treatment device based on linear accelerator and scanning method |
| CN112657072B (en) * | 2021-01-05 | 2022-09-16 | 中国科学院上海高等研究院 | Ultrahigh-dose-rate proton treatment device based on linear accelerator and scanning method |
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