CN209123945U - A kind of micro- reaction chip - Google Patents

A kind of micro- reaction chip Download PDF

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Publication number
CN209123945U
CN209123945U CN201821153832.7U CN201821153832U CN209123945U CN 209123945 U CN209123945 U CN 209123945U CN 201821153832 U CN201821153832 U CN 201821153832U CN 209123945 U CN209123945 U CN 209123945U
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fluid
micro
reaction
channel
fluid channel
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沙俊
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Changzhou Na Yang Biotechnology Co Ltd
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Changzhou Na Yang Biotechnology Co Ltd
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Abstract

The utility model provides a kind of micro- reaction chip, this micro- reaction chip includes micro- reaction channel unit;Micro- reaction channel unit includes: the fluid channel of two settings stacked on top of one another, and two fluid channels are interconnected, so that the fluid in two fluid channels is mutually mixed.Such micro- reaction chip rationally utilizes solid space firstly, reducing the occupancy of plane space by being stacked two fluid channels;Secondly, realizing the crossings on different level mixing of fluid by the connection between stacking fluid channel, micro- reaction channel is extended, reaction efficiency is improved;And without terminating the narrowed outlet of place's design in each micro- reaction channel unit, the pressure drop of fluid is thereby reduced, ensure that the high flow rate of fluid, and while guaranteeing mixing efficiency, improves yield.

Description

A kind of micro- reaction chip
Technical field
The utility model relates to chips, and in particular to a kind of micro- reaction chip.
Background technique
Chinese patent: micro- reaction channel system, application number: 201621259350.0, provide a kind of micro- reaction channel system System, comprising: bottom plate and micro- reaction channel, wherein micro- reaction channel includes that at least one material inlet, at least two positions are opposite The curve reaction wall and two chambers as defined by it of title and at least one material outlet;Material inlet is in position phase Pair the first, second straight line reaction wall between, the first curve reaction wall is connected with first, third straight line reaction wall respectively, two Chamber is connected and middle part is provided with the barrier component of curve shape, and the two-end part cross section of barrier component is S-shaped shape, Intermediate position cross section is rectilinear form, and two single step position of barrier component is not contacted with curve reaction wall.
But such micro- reaction channel system, due to using planarization micro- reaction channel design, needed on chip compared with Big micro- reaction channel layout area, limits the effective length of micro- reaction channel;And it needs in each micro- reaction channel list Narrowed outlet is designed at first end, is improved the pressure drop of fluid, is affected yield.
Utility model content
In order to solve the above-mentioned technical problem, the utility model is in order to provide a kind of micro- reaction chip, used technical side Case is:
A kind of micro- reaction chip, including micro- reaction channel unit;
Micro- reaction channel unit includes: the fluid channel of two settings stacked on top of one another, and two fluid channels are interconnected, So that the fluid in two fluid channels is mutually mixed.
Preferably, being equipped with one group of convection holes between two fluid channels, one group of convection holes include two convection holes, so that The round-trip cross-mixing of fluid in two fluid channels.
Preferably, the fluid channel is L-shaped;And
In two fluid channels stacked on top of one another,
Pass through a convection holes with the end for the fluid channel for being located at lower part at the inflection point of the superposed fluid channel Connection;
With the end of the superposed fluid channel by described another at the inflection point of the fluid channel of lower part Convection holes connection.
Preferably, the fluid channel is L-shaped, and one and another miniflow are provided at the circulation end of a fluid channel The interconnected drainage end in road,
In two fluid channels stacked on top of one another,
It is suitable for flowing to the described micro- of top through draining end by a convection holes positioned at the fluid of the fluid channel of lower part In runner;And
Fluid in superposed fluid channel is suitable for flowing to by another convection holes through drainage end described positioned at lower part The fluid channel in.
Preferably, several micro- reaction channel unit arranged in series and bending place pass through half cylindrical cavity transition;
Several turbulence columns are distributed with the semicircle is intracavitary.
Preferably, micro- reaction chip is arranged using multilayer, and including middle layer and upper and lower layer, wherein
Offer the groove along the distribution of fluid channel track respectively on upper and lower layer and the contact surface of middle layer;
One group of convection holes is offered in middle layer;And
Upper and lower layer forms two fluid channels after its groove is bonded with middle layer, and two fluid channels are suitable for passing through one group of convection current Hole makes two kinds of fluids realize cross-mixing by round-trip two fluid channel.
The utility model has the beneficial effects that such micro- reaction chip, firstly, being subtracted by being stacked two fluid channels The occupancy of few plane space, rationally utilizes solid space, extends micro- reaction channel;Secondly, by between stacking fluid channel The crossings on different level mixing of fluid is realized in connection, and without terminating the narrowed outlet of place's design in each micro- reaction channel unit, The pressure drop for thereby reducing fluid ensure that the high flow rate of fluid, and while guaranteeing mixing efficiency, improve yield.
Detailed description of the invention
The present invention will be further described with reference to the accompanying drawings and examples.
Fig. 1 is a kind of a kind of structural schematic diagram of embodiment of micro- reaction chip of the utility model.
Fig. 2 is the structural schematic diagram of micro- reaction channel unit in the first embodiment of the utility model.
Fig. 3 is cross-sectional view of the Fig. 2 at A-A.
Fig. 4 is cross-sectional view of the Fig. 2 at C-C.
Fig. 5 is that fluid flows to schematic diagram in two fluid channels corresponding to the first embodiment of the utility model.
Fig. 6 is a kind of structural schematic diagram of second of embodiment of micro- reaction chip of the utility model.
Fig. 7 is the structural schematic diagram of micro- reaction channel unit in second of embodiment of the utility model.
Fig. 8 is cross-sectional view of the Fig. 7 at A-A.
Fig. 9 is cross-sectional view of the Fig. 7 at C-C.
Figure 10 is that second of embodiment fluid of the utility model flows to schematic diagram.
Figure 11 is the result figure of second of embodiment fluid mixing example of the utility model.
In figure:
Micro- reaction channel unit 1
Fluid channel 100, the fluid channel 100a on top, the fluid channel 100b of lower part, inflection point 101, end 102;
Convection holes 200 drain end 300;
Semicircle adapter cavity 401, turbulence columns 402;
First enters agent mouth 501, and second enters agent mouth 502;
Liquid inlet 6;Liquid outlet 7.
Specific embodiment
The embodiments of the present invention are described below in detail, examples of the embodiments are shown in the accompanying drawings, wherein from beginning Same or similar element or element with the same or similar functions are indicated to same or similar label eventually.Below by ginseng The embodiment for examining attached drawing description is exemplary, and is only used for explaining the utility model, and should not be understood as to the utility model Limitation.On the contrary, the embodiments of the present invention include falling into owning within the scope of the spirit and intension of attached claims Variation, modification and equivalent.
In the description of the present invention, it should be understood that term " center ", " longitudinal direction ", " transverse direction ", " length ", " width Degree ", " thickness ", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom" "inner", "outside", " axis To ", " radial direction ", the orientation or positional relationship of the instructions such as " circumferential direction " be to be based on the orientation or positional relationship shown in the drawings, be only for Convenient for description the utility model and simplify description, rather than the device or element of indication or suggestion meaning must have specifically Orientation is constructed and operated in a specific orientation, therefore should not be understood as limiting the present invention.
In addition, term " first ", " second " etc. are used for description purposes only, it is not understood to indicate or imply relatively important Property.In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " connected " " connects Connect " it shall be understood in a broad sense, for example, it may be being fixedly connected, it may be a detachable connection, or be integrally connected;It can be machine Tool connection, is also possible to be electrically connected;It can be directly connected, it can also be indirectly connected through an intermediary.For this field For those of ordinary skill, the concrete meaning of above-mentioned term in the present invention can be understood with concrete condition.In addition, in this reality With in novel description, unless otherwise indicated, the meaning of " plurality " is two or more.
Any process described otherwise above or method description are construed as in flow chart or herein, and expression includes It is one or more for realizing specific logical function or process the step of executable instruction code module, segment or portion Point, and the range of preferred embodiments of the present invention includes other realization, wherein can not be by shown or discussion Sequence, including according to related function by it is basic simultaneously in the way of or in the opposite order, Lai Zhihang function, this should be by this The embodiment person of ordinary skill in the field of utility model is understood.
Embodiment
Fig. 1 is a kind of a kind of structural schematic diagram of embodiment of micro- reaction chip of the utility model.
Fig. 2 is the structural schematic diagram of micro- reaction channel unit in the first embodiment of the utility model.
As depicted in figs. 1 and 2, a kind of micro- reaction chip, including micro- reaction channel unit 1 are present embodiments provided;It is micro- anti- Answering channel unit 1 includes: the fluid channel 100 of two settings stacked on top of one another, and two fluid channels 100 are interconnected, so that two is micro- Fluid in runner 100 is mutually mixed.After two different fluids inject micro- reaction chip from liquid inlet 6, by least one After being sufficiently mixed of a micro- reaction channel unit 1, it is discharged by liquid outlet 7.Micro- reaction channel unit 1 be micro- reaction chip most Subsection, micro- reaction chip can be arranged in series by several micro- reaction channel units 1 completes a complete reaction channel.
Such micro- reaction chip, firstly, by being stacked two fluid channels 100, i.e., to micro- reaction channel using vertical The mode of body layout, rationally utilizes solid space, compared with the micro- reaction chip of tradition, in same micro- reaction channel layout area On the basis of, micro- reaction channel of this micro- reaction chip is longer, therefore, reacts more abundant, it is micro- anti-to be especially suitable for extremely difficult mixing The fluid answered;And narrow outlet is collected without terminating place in each micro- reaction channel unit and being all provided with, thereby reduces fluid Pressure drop ensure that the high flow rate of fluid, and while guaranteeing mixing efficiency, improve yield.
As a kind of optional embodiment of micro- reaction channel unit 1, in conjunction with Fig. 1 and Fig. 3, set between two fluid channels 100 There is one group of convection holes 200, one group of convection holes 200 includes two convection holes 200, so that the fluid in two fluid channels 100 is handed over back and forth Fork mixing.Fluid channel 100 can be L-shaped (using Fig. 2 dotted portion as boundary);And in two fluid channels 100 stacked on top of one another (in order to more clearly indicate two fluid channels up and down, the fluid channel on top is used into label 100a, the fluid channel of lower part is using mark Number 100b), pass through one with the end 102 for the fluid channel 100b for being located at lower part at the inflection point 101 of superposed fluid channel 100a Convection holes 200 are connected to;At the inflection point 101 of the fluid channel 100b of lower part with the end of superposed fluid channel 100a 102 are connected to by another convection holes 200, and then realize the round-trip cross-mixing of fluid in two fluid channels 100.
It can be seen that two fluid channels 100 of upper and lower lamination from the angle of top view in U shape, L shape from Fig. 1 and Fig. 2 Two fluid channels using near symmetrical lay.
Fig. 3 is cross-sectional view of the Fig. 2 at A-A.The cross-sectional view flow to the micro- of top from the fluid channel 100b of lower part for fluid Runner 100a.
Fig. 4 is cross-sectional view of the Fig. 2 at C-C.The cross-sectional view flow to the micro- of lower part from the fluid channel 100a on top for fluid Runner 100b.
Shown in Fig. 3 and Fig. 4, two fluids can be clearly seen that by convection holes respectively in the fluid channel of upper and lower part Intersect repeatedly.
In Fig. 2, for the clearer specific location for indicating inflection point 101 and end 102, therefore convection holes are not shown.
Fig. 5 is that fluid flows to schematic diagram in two fluid channels corresponding to the first embodiment of the utility model, and the figure is mainly anti- It answers the flow direction of fluid in the fluid channel 100a on top to be distributed, and respectively indicates the flow direction of two kinds of fluids by two kinds of arrows, I.e. after two kinds of fluids are injected separately into fluid channel 100, fluid channel 100a, the fluid channel 100b of lower part on top are two kinds corresponding Fluid can flow to the fluid channel 100 of lower part respectively at inflection point 101, end 102, the fluid channel 100a on top is intersected with realizing Mixing, is perpendicular to paper downwardly direction at inflection point 101, and the fluid of the fluid channel 100a on top is flowed into the miniflow of lower part Road 100b is perpendicular to paper upwardly direction to realize mixing at end 102, will be in the fluid channel 100b inflow of lower part The fluid channel 100a in portion can be clearly seen that two kinds of fluids upper to realize mixing, by two kinds of arrows signal in Fig. 5 The fluid channel 100a in portion is mixed;Fluid is then exhausted to the next micro- reaction channel unit 1 being arranged in series, weight after blending The multiple above process.
As another optional embodiment of micro- reaction channel unit 1.
Fig. 6 is a kind of structural schematic diagram of second of embodiment of micro- reaction chip of the utility model.
Fig. 7 is the structural schematic diagram of micro- reaction channel unit in second of embodiment of the utility model.
In conjunction with shown in Fig. 6 and Fig. 7, fluid channel 100 is L-shaped, and is provided with one at the circulation end of a fluid channel 100 The drainage end 300 being interconnected with another fluid channel 100.
Fig. 8 is cross-sectional view of the Fig. 7 at A-A.The cross-sectional view flow to the micro- of top from the fluid channel 100b of lower part for fluid Runner 100a.
Fig. 9 is cross-sectional view of the Fig. 7 at C-C.The cross-sectional view flow to the micro- of lower part from the fluid channel 100a on top for fluid Runner 100b.
Shown in Fig. 8 and Fig. 9, in two fluid channels 100 stacked on top of one another, positioned at the stream of the fluid channel 100b of lower part Body is suitable for flowing to top through draining end 300 (the drainage end 300 of superposed fluid channel 100a) by a convection holes 200 Fluid channel 100a in;And the fluid in superposed fluid channel 100a is suitable for through another convection holes 200 through draining end First 300 flow in the fluid channel 100b of lower part (positioned at the drainage end 300 of the fluid channel 100b of lower part).
The end 300 of setting drainage herein can increase fluid and the fluid channel into top in the fluid channel 100 of lower part The mixing of 100 fluid, greatly improves mixing efficiency.
See Fig. 6, when two kinds of fluids respectively from first enter agent mouth 501 and second enter agent mouth 502 inject fluid channel 100 after, Two kinds of fluids realize mixing at two drainage ends, 300 downstream respectively, and then, the fluid after being sufficiently mixed is from liquid outlet 7 Discharge.
Figure 10 is that second of embodiment fluid of the utility model flows to schematic diagram, the fluid channel 100a on the figure key reaction top The flow direction of interior fluid is distributed;Wherein, superposed drainage end 300 is in corresponding diagram at the convection holes 200 in left side, and fluid is It flows up, i.e., upward perpendicular to paper, and is located at the drainage end 300 of lower part, i.e., in figure at the convection holes 200 on right side, stream Body is to flow downward, i.e., downward perpendicular to paper;The flow direction that two kinds of fluids are respectively indicated by two kinds of arrows, passes through two kinds Arrow signal can be clearly seen that fluid channel 100a of two kinds of fluids on top is mixed.
As shown in figures 1 to 6, two kinds of structures of above-mentioned micro- reaction chip can be by the way of semicircle adapter cavity 401 Carry out transition;Several micro- 1 arranged in series of reaction channel unit and bending place pass through 401 transition of semicircle adapter cavity;In semicircle mistake It crosses in chamber 401 and several turbulence columns 402 is distributed with.
As the specific embodiment of semicircle adapter cavity 401, a common cavity, the i.e. miniflow of upper and lower part can be used Road can be connected to the common cavity, and improve mixed effect by its internal turbulence columns 402.
The specific embodiment of semicircle adapter cavity 401 using two and half cylindrical cavity independences and can also be stacked, that is, be located at Half cylindrical cavity on top is the fluid channel 100a for being connected to top;Half cylindrical cavity positioned at lower part is the fluid channel for being connected to lower part 100b。
Above two embodiment can be realized the transitional function after several micro- 1 arranged in series of reaction channel unit, make The length of micro- reaction channel is improved on the area of micro- reaction chip.
Turbulence columns 402 are set in semicircle adapter cavity 401, are had the following advantages that, it can it is right to improve semicircle adapter cavity 401 In the bearing strength of fluid, and the fluid of circulation is made to change flow direction under the influence of turbulence columns 402, is sufficiently mixed to play Effect.
For the semicircle adapter cavity 401 of two and half cylindrical cavity independences and overlapped way setting, when fluid is flow in half cylindrical cavity, The fluid in half cylindrical cavity above and below being now placed in will not realize mixing again, but realize to hit under the action of turbulence columns 402 and mix It closes, then, until in outflow semicircle adapter cavity 401 to subsequent fluid channel 100, then realize further mixing.
As a kind of optional structure of micro- reaction chip, micro- reaction chip is arranged using multilayer, and including middle layer and it is upper, Lower layer;Its fluid channel 100a for corresponding to top at the middle and upper levels, lower layer correspond to the fluid channel 100b of lower part;In upper and lower layer and middle layer Contact surface on offer respectively along 100 track of fluid channel distribution groove;One group of convection holes 200 is offered in middle layer;With And upper and lower layer forms two fluid channels 100 after its groove is bonded with middle layer, and two fluid channels are suitable for passing through one group of convection holes 200 make two kinds of fluids realize cross-mixing by round-trip two fluid channel.
Independent for two semicircle adapter cavities 401 and stacking mode, turbulence columns 402 are fastened on middle layer.
Figure 11 is the result figure of second of embodiment fluid mixing example of the utility model.
The fluid mixing resultant be input fluid flow rate be 0.6m/s under carry out.
The fluid channel 100a on upper layer and the fluid channel 100b of lower layer inject different fluids, define fluid A, fluid respectively B, first micro- reaction channel unit can be seen that apparent fluid cross-mixing phenomenon since fluid inlet, wherein two fluids White line part (being indicated in figure with AB) indicates that the two carries out hybrid reaction;After second micro- reaction channel unit, Obvious white line part is increased, and after the micro- reaction channel unit of third, white line part be increased significantly, and When ten micro- reaction channel unit to half 401 positions of cylindrical cavity, two kinds of fluids are thoroughly mixed.
It can be seen from the results above that this micro- reaction chip can realize that Quick uniform mixes in the case where high flow rate, Mixing efficiency than traditional microchip is higher.
In conclusion this micro- reaction chip using the fluid channel 100 and convection holes 200 of the double-deck setting realize fluid it is upper, Lower cross-mixing increases the length of micro- reaction channel by the way of three-dimensional, can be realized more on identical micro- reaction chip Long fluid channel reaction channel layout improves micro- reaction effect, and sets without terminating place in each micro- reaction channel unit Narrow outlet is collected, the pressure drop of fluid is thereby reduced, ensure that the high flow rate of fluid, and while guaranteeing mixing efficiency, Improve yield.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show The description of example " or " some examples " etc. means specific features, structure, material or spy described in conjunction with this embodiment or example Point is contained at least one embodiment or example of the utility model.In the present specification, to the schematic table of the term Stating may not refer to the same embodiment or example.Moreover, particular features, structures, materials, or characteristics described can be It can be combined in any suitable manner in any one or more embodiment or examples.
It is enlightenment, through the above description, related work people with the above-mentioned desirable embodiment according to the utility model Member can carry out various changes and amendments in the range of without departing from this item utility model technical idea completely.This item is real It is not limited to the contents of the specification with novel technical scope, it is necessary to its technology is determined according to scope of the claims Property range.

Claims (4)

1. a kind of micro- reaction chip, which is characterized in that including micro- reaction channel unit;
Micro- reaction channel unit includes: the fluid channel of two settings stacked on top of one another, and two fluid channels are interconnected, so that Fluid in two fluid channels is mutually mixed;
One group of convection holes is equipped between two fluid channels, one group of convection holes include two convection holes, so that in two fluid channels The round-trip cross-mixing of fluid;
The fluid channel is L-shaped;And
In two fluid channels stacked on top of one another,
It is connected to the end for the fluid channel for being located at lower part by a convection holes at the inflection point of the superposed fluid channel;
Pass through another convection current with the end of the superposed fluid channel at the inflection point of the fluid channel of lower part Hole connection.
2. micro- reaction chip as described in claim 1, which is characterized in that
The drainage end being interconnected with another fluid channel is provided at the circulation end of one fluid channel,
In two fluid channels stacked on top of one another,
The fluid channel for being suitable for flowing to top through draining end by a convection holes positioned at the fluid of the fluid channel of lower part In;And
Fluid in superposed fluid channel, which is suitable for being drained end by another convection holes, flow to the institute for being located at lower part It states in fluid channel.
3. micro- reaction chip as described in claim 1, which is characterized in that
Several micro- reaction channel unit arranged in series and bending place pass through half cylindrical cavity transition;
Several turbulence columns are distributed with the semicircle is intracavitary.
4. micro- reaction chip as claimed in claim 1 or 2, which is characterized in that
Micro- reaction chip is used to be arranged using multilayer, and including middle layer and upper and lower layer, wherein
Offer the groove along the distribution of fluid channel track respectively on upper and lower layer and the contact surface of middle layer;
One group of convection holes is offered in middle layer;And
Upper and lower layer forms two fluid channels after its groove is bonded with middle layer, and two fluid channels are suitable for making by one group of convection holes Two kinds of fluids realize cross-mixing by round-trip two fluid channel.
CN201821153832.7U 2018-07-19 2018-07-19 A kind of micro- reaction chip Active CN209123945U (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108854891A (en) * 2018-07-19 2018-11-23 常州那央生物科技有限公司 A kind of micro- reaction chip, Microfluidic Mixing method and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108854891A (en) * 2018-07-19 2018-11-23 常州那央生物科技有限公司 A kind of micro- reaction chip, Microfluidic Mixing method and preparation method thereof
CN108854891B (en) * 2018-07-19 2023-10-24 常州那央生物科技有限公司 Micro-reaction chip, preparation method thereof and micro-fluid mixing method

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