CN209052688U - For the fermentation system in griseofulvin production process - Google Patents
For the fermentation system in griseofulvin production process Download PDFInfo
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- CN209052688U CN209052688U CN201821671024.XU CN201821671024U CN209052688U CN 209052688 U CN209052688 U CN 209052688U CN 201821671024 U CN201821671024 U CN 201821671024U CN 209052688 U CN209052688 U CN 209052688U
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- tank
- fermentor
- feed supplement
- fermentation
- heat exchange
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Abstract
The utility model discloses a kind of fermentation systems in griseofulvin production process, including seeding tank, feed supplement tank and fermentor, the upper end of the seeding tank is provided with seeding tank feed inlet, the lower end of the seeding tank is provided with seeding tank discharge port and seeding tank compressed air inlet, the upper end of the feed supplement tank is provided with feed supplement tank feed inlet, the lower end of the feed supplement tank is provided with feed supplement tank discharge port and feed supplement tank compressed air inlet, the upper end of the fermentor is provided with fermentor strain entrance and fermentor material-feeding port, the lower end of the fermentor is provided with fermentor discharge port and fermentor compressed air inlet, the seeding tank discharge port is connect by pipeline with the fermentor strain entrance, the feed supplement tank discharge port is connect by pipeline with the fermentor material-feeding port.The utility model is structurally reasonable, the operation is stable, can preferably carry out fermenting and producing.
Description
Technical field
The utility model relates to griseofulvin production equipment technologies, and in particular to one kind was produced for griseofulvin
Fermentation system in journey.
Background technique
Griseofulvin is antibiotics bulk pharmaceutical chemicals, and Chinese nickname grisein, crystallite griseofulvin, griseofulvin finished product is white
The attritive powder of color or off-white color has good mainly for the superficials such as trichophyta, sporidiole bacteria, Epidermophyton portion fungi
Antibacterial action, griseofulvin are suitable for the treatment of various tinea diseases, including favus of the scalp, barber's itch, ringworm of the body, jock itch, tinea pedis and onychomycosis.
Largely prepared in the method for griseofulvin in the prior art is typically all to pass through using griseofulvin fermentation liquid as raw material
A series of preparation step, condensing crystallizing obtain griseofulvin recrystallizer, and last griseofulvin recrystallizer is washed by butanol
Wash, ethanol washing, plate-frame filtering, granulation, drying, ultramicro grinding and etc. obtain griseofulvin bulk pharmaceutical chemicals.
Currently, the manufacturing enterprise of China's griseofulvin is less, relevant production units structure is reasonable not enough, and the prior art is urgently
Need structurally reasonable one kind, the operation is stable, the fermentation being used in griseofulvin production process that can preferably carry out fermenting and producing
System.
Summary of the invention
The purpose of this utility model is to overcome the shortcomings of the prior art, provide it is a kind of it is structurally reasonable, work is steady
The fermentation system being used in griseofulvin production process that is fixed, can preferably carrying out fermenting and producing.
The utility model is achieved through the following technical solutions: a kind of fermentation system in griseofulvin production process
System, including seeding tank, feed supplement tank and fermentor, the upper end of the seeding tank are provided with seeding tank feed inlet, the seeding tank
Lower end is provided with seeding tank discharge port and seeding tank compressed air inlet, and the upper end of the feed supplement tank is provided with the charging of feed supplement tank
Mouthful, the lower end of the feed supplement tank is provided with feed supplement tank discharge port and feed supplement tank compressed air inlet, the fermentor it is upper
End is provided with fermentor strain entrance and fermentor material-feeding port, and the lower end of the fermentor is provided with fermentor discharge port and fermentation
Tank compressed air inlet, the seeding tank discharge port are connect by pipeline with the fermentor strain entrance, and the feed supplement tank goes out
Material mouth is connect by pipeline with the fermentor material-feeding port.
The fermentor includes fermentation tank, the fermentor insulating layer being set on the outside of fermentation tank, is uniformly arranged
It is passed in multiple heat exchange coil mechanisms of fermentor tank interior avris, the upright fermentor being set among fermentor tank interior
Moving axis, is set to fermentor top of the tank central closing at the multiple fermentor agitating paddles being set on fermentor transmission shaft
Motor flange connecting bottom board and the fermentor motor for being set to motor flange connecting bottom board upper end, the fermentor transmission shaft are upward
It is connect across the motor flange connecting bottom board with the power output end of the fermentor motor.
The heat exchange coil mechanism includes the lateral upper supporting beam for being set to the inner cavity top of the fermentation tank, sets
The lateral lower supporting beam for being placed in the inner cavity lower part of the fermentation tank, the heat exchange being set around in supporting beam and lower supporting beam
The fixed frame of the lateral position for fixing the heat exchange coil of the inner wall setting of coil pipe and the tank that ferments, the heat exchange plate
The beginning of pipe is located at the lower part of the fermentor, and the beginning of the heat exchange coil is protruding across the fermentation tank, institute
The beginning for stating heat exchange coil is provided with coil inlet, and the end of the heat exchange coil is located at the top of the fermentor, described to change
The end of hot coil is protruding across the fermentation tank, and the end of the heat exchange coil is provided with coil outlets.
The top of the fermentation tank is provided with sight glass mechanism.
The sight glass mechanism includes being connected at the top visor installing port of the fermentation tank by fixing bolt
The flange of circular ring shape and the visor being set in the middle part of flange are provided with annular frame on the outside of the visor, the annular frame position
In the inner ring of the flange, the annular frame is fixedly connected with connecting plate, the connecting plate by the fixing bolt with it is described
Flanged joint, the top of the annular frame are fixedly connected with lamp bracket, and visor described in the lamp bracket face is provided with headlamp, institute
State the switch being provided on the outside of lamp bracket for controlling the headlamp.
The sight glass mechanism further include main steam header road, be set to main steam header road beginning section the first air intake valve and
Two air intake valves and be set to main steam header road middle section supervisor's triple valve, the end on the main steam header road passes through the hair
Fermentation tank tank body protrudes into the fermentation tank, and the end on the main steam header road is provided with steam (vapor) outlet, and the steam (vapor) outlet is just
To the inner surface of the visor, the entrance and first outlet of supervisor's triple valve are connect with the main steam header road, the master
The second outlet of pipe triple valve is connected with condensate water discharging valve, and the outlet of the condensate water discharging valve is connected with condensate water discharging
It manages, is provided with condensation water collection bucket below the condensate water discharging valve, the condensate draining pipe extends downwardly into the condensation
In water collection bucket, the lower end outlet of the condensation water collection bucket is provided with collection bucket drainpipe.
It is connected at the top end opening of the feed supplement tank and is provided with flange bottom plate, the upper end of the flange bottom plate is provided with feed supplement
Tank motor is provided with feed supplement tank transmission shaft in the feed supplement tank, feed supplement tank agitating paddle, institute is provided on the feed supplement tank transmission shaft
It states feed supplement tank transmission shaft and is upward through the flange bottom plate and connect with the power output end of the feed supplement tank motor.
The beneficial effects of the utility model are: the utility model is structurally reasonable, the operation is stable can preferably ferment
Production.
Detailed description of the invention
Fig. 1 is the overall structure diagram of the utility model；
Fig. 2 is the structural schematic diagram of fermentor；
Fig. 3 is the structural schematic diagram of sight glass mechanism.
In figure: 100- seeding tank；101- seeding tank feed inlet；102- seeding tank discharge port；The compression of 103- seeding tank is empty
Gas entrance；
200- feed supplement tank；201- feed supplement tank feed inlet；202- feed supplement tank discharge port；203- feed supplement tank compressed air inlet；
204- feed supplement tank motor；205- feed supplement tank transmission shaft；206- feed supplement tank agitating paddle；
300- fermentor；301- fermentor strain entrance；302- fermentor discharge port；303- fermentor compressed air enters
Mouthful；304- fermentor motor；305- fermentor transmission shaft；306- fermentor agitating paddle；307- fermentation tank；308- fermentor
Insulating layer；309- heat exchange coil；The upper supporting beam of 310-；Supporting beam under 311-；312- fixed frame；313- maintenance ladder；314- visor
Mechanism；315- flange；316- visor；317- fixing bolt；318- connecting plate；319- annular frame；320- lamp bracket；321- illumination
Lamp；322- switch；323- steam (vapor) outlet；324- main steam header road；325- is responsible for triple valve；326- condensate water discharging valve；327-
Condensate draining pipe；The first air intake valve of 328-；The second air intake valve of 329-；330- condensation water collection bucket；331- collection bucket row
Water pipe；332- fermentor material-feeding port；333- coil outlets；334- coil inlet；335- supporting beam.
Specific embodiment
The utility model is described in detail below in conjunction with attached drawing.
As shown in Figure 1, a kind of fermentation system in griseofulvin production process, including seeding tank 100, feed supplement tank
200 and fermentor 300, the upper end of seeding tank 100 be provided with seeding tank feed inlet 101, the lower end of seeding tank 100 is provided with seed
Tank discharge port 102 and seeding tank compressed air inlet 103, the upper end of feed supplement tank 200 are provided with feed supplement tank feed inlet 201, feed supplement
The lower end of tank 200 is provided with feed supplement tank discharge port 202 and feed supplement tank compressed air inlet 203, and the upper end of fermentor 300 is provided with
Fermentor strain entrance 301 and fermentor material-feeding port 332, the lower end of fermentor 300 are provided with fermentor discharge port 302 and fermentation
Tank compressed air inlet 303, seeding tank discharge port 102 are connect by pipeline with fermentor strain entrance 301, feed supplement tank discharge port
202 are connect by pipeline with fermentor material-feeding port 332.
When work, fermentation nutriment is prepared with rice meal, water, inorganic salts.The fermentation nutriment prepared is put into feed supplement tank 200
In, it is put into based on Partial fermentation nutriment and expects into seeding tank 100 and fermentor 300.Strain is added into seeding tank 100,
It is bred.After the completion of breeding, the strain of seeding tank 100 is added in fermentor 300, is fermented, in fermentation process constantly
The afterfermentation nutriment into fermentor 300.The input and output of seeding tank 100, feed supplement tank 200 and the material in fermentor 300
It is completed by compressed air.Seeding tank compressed air inlet 103 and fermentor compressed air inlet 303 are in addition to when conveying material
It inputs outside compressed air, also in 300 fermentation process of 100 culture propagation of seeding tank and fermentor, input air provides requisite oxygen
Gas.
As shown in Fig. 2, fermentor 300 includes fermentation tank 307, the fermentor for being set to 307 outside of fermentation tank
Insulating layer 308, is uprightly set to fermentor at the multiple heat exchange coil mechanisms for being uniformly arranged on fermentation 307 inside avris of tank
The fermentor transmission shaft 305 of 307 bosom of tank body, the multiple fermentor agitating paddles being set on fermentor transmission shaft 305
306, it is set to the motor flange connecting bottom board of fermentation 307 top center opening of tank and is set to motor flange connection bottom
The fermentor motor 304 of plate upper end, fermentor transmission shaft 305 are upward through motor flange connecting bottom board and fermentor motor 304
Power output end connection.
When work, fermentor motor 304 drives fermentor agitating paddle 306 to rotate by fermentor transmission shaft 305, stirring thing
Material is uniformly distributed the strain in fermentation nutriment, and water is inputted in heat exchange coil mechanism, reduces material in fermentor 300 in time
Temperature guarantees technological temperature condition, and fermentor agitating paddle 306, which stirs material, also makes temperature of charge uniform.
Referring to fig. 2, heat exchange coil mechanism includes being set to the lateral upper supporting beam on the inner cavity top of fermentation tank 307
310, it is set to the lateral lower supporting beam 311 of the inner cavity lower part of fermentation tank 307, is set around supporting beam 310 and lower branch
The lateral position for being used to fix heat exchange coil 309 of the inner wall setting of heat exchange coil 309 and the tank 307 that ferments on support beam 311
The fixed frame 312 set, the beginning of heat exchange coil 309 are located at the lower part of fermentor 300, and the beginning of heat exchange coil 309 passes through fermentation
Tank 307 is protruding, and the beginning of heat exchange coil 309 is provided with coil inlet 334, and the end of heat exchange coil 309 is located at hair
The end on the top of fermentation tank 300, heat exchange coil 309 is protruding across fermentation tank 307, and the end of heat exchange coil 309 is set
It is equipped with coil outlets 333.
Referring to fig. 2, maintenance ladder 313 and supporting beam 335 are additionally provided in fermentation tank 307.
As shown in Figure 2 and Figure 3, the top of fermentation tank 307 is provided with sight glass mechanism 314.Sight glass mechanism 314 includes logical
Cross flange 315 and the setting of the circular ring shape that fixing bolt 317 is connected at 316 installing port of top visor of fermentation tank 307
Visor 316 in 315 middle part of flange, the outside of visor 316 are provided with annular frame 319, which is located at flange
315 inner ring, annular frame 319 are fixedly connected with connecting plate 318, which passes through fixing bolt 317 and flange 315
Connection, the top of annular frame 319 are fixedly connected with lamp bracket 320, and 320 face visor 316 of lamp bracket is provided with headlamp 321, lamp
The outside of frame 320 is provided with the switch 322 for controlling headlamp 321.When operator observes 300 inner case of fermentor,
Headlamp 321 is opened, headlamp 321 can illuminate inside fermentation tank 307, and 300 inside feelings of fermentor can be seen in operator
Condition.
Referring to Fig. 3, sight glass mechanism 314 further include main steam header road 324, be set to main steam header road 324 beginning section
One air intake valve 328 and the second air intake valve 329 and be set to main steam header road 324 middle section supervisor's triple valve 325, steam
The end of main line 324 passes through fermentation tank 307 and protrudes into fermentation tank 307, and the end on main steam header road 324 is provided with
Steam (vapor) outlet 323, the inner surface of the 323 face visor 316 of steam (vapor) outlet, be responsible for triple valve 325 entrance and first outlet with
Main steam header road 324 connects, and the second outlet of supervisor's triple valve 325 is connected with condensate water discharging valve 326, condensate water discharging valve
326 outlet is connected with condensate draining pipe 327, and the lower section of condensate water discharging valve 326 is provided with condensation water collection bucket 330, cold
Condensate drainpipe 327 extends downwardly into condensation water collection bucket 330, and the lower end outlet of condensation water collection bucket 330 is provided with collection bucket
Drainpipe 331.
When work, the first air intake valve 328 and the second air intake valve 329 are opened, supervisor's triple valve 325 is reached first and is opened
Condensate water discharging valve 326 is opened in position, and the condensed water in main steam header road 324 is put into condensed water by condensate draining pipe 327 and is received
Collection bucket 330, condensed water is drained by collection bucket drainpipe 331.It is cold after all releasing the condensed water in main steam header road 324
Condensate drainpipe 327 exports vapor, at this moment closes condensate water discharging valve 326, and supervisor's triple valve 325 is reached the second open position,
Vapor is discharged by steam (vapor) outlet 323, the inner surface of 323 face visor 316 of steam (vapor) outlet, vapor is by table in visor 316
The water mist in face is rinsed well.Rinse visor 316 before, the condensed water in main steam header road 324 be in order to avoid condensed water with
Miscellaneous bacteria enters in fermentor 300, influences normal fermentation work.
The structure and working principle of seeding tank 100 is identical as fermentor 300, herein not to the structure and work of seeding tank 100
It does as principle and excessively repeats.
It referring to Fig. 1, is connected at the top end opening of feed supplement tank 200 and is provided with flange bottom plate, the upper end of the flange bottom plate is set
It is equipped with feed supplement tank motor 204, feed supplement tank transmission shaft 205 is provided in feed supplement tank 200, is provided with benefit on feed supplement tank transmission shaft 205
Batch can agitating paddle 206, feed supplement tank transmission shaft 205 are upward through flange bottom plate and connect with the power output end of feed supplement tank motor 204.
When work, feed supplement tank motor 204 drives feed supplement tank agitating paddle 206 to rotate by feed supplement tank transmission shaft 205, stirring thing
Material guarantees the material uniformity.
Finally it should be noted that the above content is only to illustrate the technical solution of the utility model, rather than it is practical to this
The limitation of novel protected range, those skilled in the art to the technical solution of the utility model carry out it is simple modification or
Person's equivalent replacement, all without departing from the spirit and scope of technical solutions of the utility model.
Claims (7)
1. a kind of fermentation system in griseofulvin production process, it is characterised in that: described to be produced for griseofulvin
Fermentation system in journey includes seeding tank, feed supplement tank and fermentor, and the upper end of the seeding tank is provided with seeding tank feed inlet, institute
The lower end for stating seeding tank is provided with seeding tank discharge port and seeding tank compressed air inlet, and the upper end of the feed supplement tank is provided with benefit
Batch can feed inlet, the lower end of the feed supplement tank are provided with feed supplement tank discharge port and feed supplement tank compressed air inlet, the fermentor
Upper end be provided with fermentor strain entrance and fermentor material-feeding port, the lower end of the fermentor be provided with fermentor discharge port and
Fermentor compressed air inlet, the seeding tank discharge port are connect by pipeline with the fermentor strain entrance, the feed supplement
Tank discharge port is connect by pipeline with the fermentor material-feeding port.
2. the fermentation system according to claim 1 in griseofulvin production process, it is characterised in that: the fermentation
Tank includes fermentation tank, the fermentor insulating layer being set on the outside of fermentation tank, is uniformly arranged on fermentor tank interior
Multiple heat exchange coil mechanisms of avris, are set to fermentation at the fermentor transmission shaft being uprightly set among fermentor tank interior
Multiple fermentor agitating paddles on tank transmission shaft, the motor flange connecting bottom board for being set to fermentor top of the tank central closing
And it is set to the fermentor motor of motor flange connecting bottom board upper end, the fermentor transmission shaft is upward through the motor flange
Connecting bottom board is connect with the power output end of the fermentor motor.
3. the fermentation system according to claim 2 in griseofulvin production process, it is characterised in that: the heat exchange
Coil pipe mechanism includes the lateral upper supporting beam for being set to the inner cavity top of the fermentation tank, is set to the fermentor tank
The lateral lower supporting beam of the inner cavity lower part of body, the heat exchange coil being set around in supporting beam and lower supporting beam and fermentation tank
Inner wall setting the lateral position for fixing the heat exchange coil fixed frame, the beginning of the heat exchange coil is located at described
The beginning of the lower part of fermentor, the heat exchange coil is protruding across the fermentation tank, the beginning of the heat exchange coil
It is provided with coil inlet, the end of the heat exchange coil is located at the top of the fermentor, and the end of the heat exchange coil passes through
The fermentation tank is protruding, and the end of the heat exchange coil is provided with coil outlets.
4. the fermentation system according to claim 3 in griseofulvin production process, it is characterised in that: the fermentation
The top of tank is provided with sight glass mechanism.
5. the fermentation system according to claim 4 in griseofulvin production process, it is characterised in that: the visor
Mechanism includes being connected to the flange of the circular ring shape at the top visor installing port of the fermentation tank by fixing bolt and setting
The visor being placed in the middle part of flange is provided with annular frame on the outside of the visor, which is located at the inner ring of the flange,
The annular frame is fixedly connected with connecting plate, which passes through the fixing bolt and the flanged joint, the annular
The top of frame is fixedly connected with lamp bracket, and visor described in the lamp bracket face is provided with headlamp, the outside setting of the lamp bracket
There is the switch for controlling the headlamp.
6. the fermentation system according to claim 5 in griseofulvin production process, it is characterised in that: the visor
Mechanism further include main steam header road, be set to main steam header road beginning section the first air intake valve and the second air intake valve and setting
Supervisor's triple valve in the middle section on main steam header road, the end on the main steam header road are protruded into described across the fermentation tank
It ferments in tank, the end on the main steam header road is provided with steam (vapor) outlet, the interior table of visor described in the steam (vapor) outlet face
Face, the entrance and first outlet of supervisor's triple valve are connect with the main steam header road, and the second of supervisor's triple valve goes out
Mouth is connected with condensate water discharging valve, and the outlet of the condensate water discharging valve is connected with condensate draining pipe, the condensate water discharging
Condensation water collection bucket is provided with below valve, the condensate draining pipe extends downwardly into the condensation water collection bucket, described cold
The lower end outlet of Condensed water collection bucket is provided with collection bucket drainpipe.
7. the fermentation system according to claim 1 in griseofulvin production process, it is characterised in that: the feed supplement
It is connected at the top end opening of tank and is provided with flange bottom plate, the upper end of the flange bottom plate is provided with feed supplement tank motor, the feed supplement
It is provided with feed supplement tank transmission shaft in tank, feed supplement tank agitating paddle, the feed supplement tank transmission shaft are provided on the feed supplement tank transmission shaft
The flange bottom plate is upward through to connect with the power output end of the feed supplement tank motor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821671024.XU CN209052688U (en) | 2018-10-16 | 2018-10-16 | For the fermentation system in griseofulvin production process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821671024.XU CN209052688U (en) | 2018-10-16 | 2018-10-16 | For the fermentation system in griseofulvin production process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209052688U true CN209052688U (en) | 2019-07-02 |
Family
ID=67050664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821671024.XU Active CN209052688U (en) | 2018-10-16 | 2018-10-16 | For the fermentation system in griseofulvin production process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209052688U (en) |
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2018
- 2018-10-16 CN CN201821671024.XU patent/CN209052688U/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: Fermentation system for griseofulvin production Effective date of registration: 20210120 Granted publication date: 20190702 Pledgee: Agricultural Bank of China Limited Chifeng Changqing sub branch Pledgor: INNER MONGOLIA GLINT PHARMACEUTICAL Co.,Ltd. Registration number: Y2021150000003 |