CN208841627U - A kind of micro liposome high pressure extrusion device - Google Patents
A kind of micro liposome high pressure extrusion device Download PDFInfo
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- CN208841627U CN208841627U CN201821611170.3U CN201821611170U CN208841627U CN 208841627 U CN208841627 U CN 208841627U CN 201821611170 U CN201821611170 U CN 201821611170U CN 208841627 U CN208841627 U CN 208841627U
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Abstract
The utility model relates to a kind of micro liposome high pressure extrusion devices, including cylinder assembly and micro extrusion container, cylinder assembly includes air cylinder support, cylinder, piston rod and pressure head component, cylinder is erected on air cylinder support, micro extrusion container includes cylinder, end socket and filter assemblies, piston rod, pressure head component, cylinder and end socket constitute piston extruder structure, cylinder side is equipped with injection port, cylinder body bottom is equipped with outlet, end socket offers lautertuns on top surface, end socket bottom is equipped with extrusion, filter assemblies are filled in lautertuns, pressure head component includes along the sealing pressure head and size extrusion pressure head compatible with outlet for squeezing out direction sequence arrangement, it further include the insulation jacket being arranged circumferentially respectively in cylinder and end socket outer wall；The utility model provide it is a kind of can meet use for laboratory simultaneously reach 200bar or more operating pressure, and the few liposomal samples of required sample size are squeezed out and are required, and have the micro liposome high pressure extrusion device for improving attemperator.
Description
Technical field
The utility model relates to a kind of pharmaceutical fields, more particularly to a kind of micro liposome high pressure extrusion device.
Background technique
With the development of domestic pharmaceutical industry, the kind for targeting and being sustained contour end preparation is more and more, liposome conduct
A kind of application of the miniature vesica of similar cell membrane structure is also more and more extensive, since it is very good to there is prepared preparation
Targeting and slow releasing function, so pharmaceutical industry is to liposome technology using more and more in recent years.Due to liposome vesicle
Reach desired effect, it is necessary to whole grain control be carried out to prepared liposome particles, its partial size and distribution must all be controlled
System within the scope of one preferable, as size controlling in 100nm hereinafter, PDI distributed controll is below 0.1.
The whole grain control of liposome is realized by the way of generally being squeezed out using high pressure in the prior art, by power source by rouge
Plastid particle is squeezed out by the PC polycarbonate leaching film of special pore size distribution, makes liposome particles under the shearing force of filter membrane
Partial size become smaller, be distributed the uniform of change.Since there are larger difference, laboratory equipments for laboratory and production technology currently on the market
Since maximum working (operation) pressure (MWP) is too low, pressure needed for being unable to reach preferable whole grain, so good processing can not be carried out to sample,
Additionally, due to the difference of extrusion way, there is also larger problems in being amplified to production process for laboratory process, such as: 1, existing reality
When testing room extrusion device and being squeezed out using air pressure as power source, the pressure that can generate only about 70bar, for comparing
The liposomal samples of difficult whole grain are unable to reach extrusion effect；2, the existing extrusion for being able to achieve high pressure and squeezing out and (being not less than 200bar)
Sample size needed for device is big (being not less than 50ml), for expensive liposomal samples, the cost when laboratory uses
It is too high, and remain too big；3, existing laboratory extrusion device generally only keeps the temperature the module of extruded film upper end, not under
Portion is kept the temperature, this is easy for causing top and the bottom temperature inhomogenous, largely effects on extrusion effect.
In view of the above shortcomings, the designer, is actively subject to research and innovation, a kind of experiment can be met simultaneously to found
Room reaches 200bar or more operating pressure, and the liposomal samples of required sample size few (minimum is only 2ml) are squeezed out and required,
And the micro liposome high pressure extrusion device with perfect attemperator, make it with more the utility value in industry.
Utility model content
In order to solve the above technical problems, meeting micro high pressure extrusion liposome simultaneously the purpose of the utility model is to provide a kind of
The micro liposome high pressure extrusion device that can be kept the temperature simultaneously.
The micro liposome high pressure extrusion device of the utility model, including cylinder assembly and micro extrusion container, the gas
Cylinder component includes air cylinder support, cylinder, piston rod and pressure head component, and the cylinder is erected on the air cylinder support, described micro-
It includes cylinder, end socket and filter assemblies that amount, which squeezes out container, and the piston rod, pressure head component, cylinder and end socket constitute piston and squeeze out
Mechanism, the cylinder side are equipped with injection port, and the cylinder body bottom is equipped with outlet, offers filtering on the end socket top surface
Slot, the end socket bottom are equipped with extrusion, and the filter assemblies are filled in the lautertuns, and the pressure head component includes along crowded
Out direction sequence arrangement sealing pressure head and size extrusion pressure head compatible with the outlet, further include respectively circumferential direction set
Set the insulation jacket in the cylinder and end socket outer wall.
Further, it is fixed between the cylinder and end socket by supported flange.
Further, several seal grooves and compatible sealing are offered on the contact surface between the cylinder and end socket
Circle.
It further, further include the extrusion pipeline being connect with the extrusion.
Further, the sealing pressure head outer wall is equipped with seal groove and sealing ring compatible with the seal groove.
Further, the sealing pressure head passes through the sealing ring and cylinder inboard wall contact sealing.
Further, the filter assemblies include along the filter membrane and support plate for squeezing out direction sequence arrangement.
Further, the diameter of the outlet is equal to the diameter for squeezing out pressure head.
Further, one end of the piston rod is connected with cylinder, and the other end of the piston rod is fixed with the sealing
Pressure head.
According to the above aspect of the present invention, the utility model at least has the following advantages:
1, high pressure squeezes out: by the gas pressure less than 10bar as power source, pressurization conversion is carried out inside equipment, it can
It is converted into the internal extrusion operating pressure for being no less than 200bar, 316L stainless steel material is in addition all made of in working chamber, thickness is not
Lower than 25mm, it can sufficiently meet the pressure-resistant demand of 200bar operating pressure；
2, sample size is few: the sample size range that single squeezes out is 2ml~25ml, and consumed sample size is considerably less, and energy
It is enough completely exhausted out, not will cause residual.
3, attemperator: extrusion device is designed with jacket heat-preservation device in design, to the module before and after film excessively, is pressing from both sides
It is passed through thermal insulation medium in set, temperature control can be carried out to extrusion device, it is ensured that extrusion process carries out within required temperature range.
The above description is merely an outline of the technical solution of the present invention, in order to better understand the skill of the utility model
Art means, and can be implemented in accordance with the contents of the specification, below on the preferred embodiment of the present invention and the accompanying drawings in detail
It describes in detail bright as after.
Detailed description of the invention
Fig. 1 is the cross-sectional view of the micro liposome high pressure extrusion device of the utility model；
Fig. 2 is cross-sectional view when liposome all squeezes out in Fig. 1.
1 air cylinder support, 2 cylinder
3 piston rod, 4 cylinder
5 end socket, 6 injection port
7 outlet, 8 lautertuns
9 extrusions 10 seal pressure head
11 squeeze out 12 insulation jacket of pressure head
13 supported flange, 14 seal groove
15 sealing rings 16 squeeze out pipeline
17 filter membrane, 18 support plate
Specific embodiment
With reference to the accompanying drawings and examples, specific embodiment of the present utility model is described in further detail.Below
Embodiment is not intended to limit the scope of the present invention for illustrating the utility model.
Fig. 1 and a kind of micro liposome high pressure extrusion device shown in Fig. 2, including 2 component of cylinder and micro extrusion container,
2 component of cylinder includes air cylinder support 1, cylinder 2, piston rod 3 and pressure head component, and cylinder 2 is erected on air cylinder support 1, micro to squeeze
Container includes cylinder 4, end socket 5 and filter assemblies out, and piston rod 3, pressure head component, cylinder 4 and end socket 5 constitute piston extruder
Structure, 4 side of cylinder are equipped with injection port 6, and 4 bottom of cylinder is equipped with outlet 7, offers lautertuns 8,5 bottom of end socket on 5 top surface of end socket
Portion is equipped with extrusion 9, and filter assemblies are filled in lautertuns 8, and pressure head component includes along the sealing pressure for squeezing out direction sequence arrangement
First 10 and size extrusion pressure head 11 compatible with outlet 7, it further include being arranged circumferentially outside cylinder 4 and end socket 5 respectively
The insulation jacket 12 of wall.
The principle of micro liposome high pressure extrusion device provided by the utility model is as follows:
The cylinder 2 being erected on air cylinder support 1 pushes piston rod 3, and pressure head component is driven to enter in micro extrusion container
In 4 inner cavity of cylinder, the sealing pressure head 10 in pressure head component prevents the gas pressure leak in 4 inner cavity of cylinder, squeezes out pressure head 11 for squeezing
Liposome out, liposome are entered in 4 inner cavity of cylinder by the injection port 6 opened up on 4 side of cylinder, are driven in piston rod 3 close
It is concentrated at the outlet 7 of 4 bottom of cylinder under the action of envelope 10 component of pressure head, when squeezing out arrival 4 bottom of cylinder of pressure head 11, with
Cylinder 4 seals and offers lautertuns 8 corresponding with outlet 7 on 5 top surface of end socket that connects, in this way, squeezing out pressure head 11 can be with
The liposome that 4 bottom of cylinder is concentrated slowly is squeezed out into outlet 7 and the filter assemblies by filling in lautertuns 8 are obtained by filtration
The liposome particles of certain partial size and PDI distribution, liposome particles go out sample through the extrusion 9 of 5 bottom of end socket, in extrusion process
The insulation jacket 12 being arranged circumferentially respectively in 5 outer wall of cylinder 4 and end socket can carry out temperature control to extrusion device, it is ensured that squeeze out
Journey carries out within required temperature range, ensure that the extrusion effect of liposome.
In order to realize that high pressure squeezes out micro liposome, the liposome particles of certain partial size and PDI distribution, 4 He of cylinder are formed
It is fixed by supported flange 13 between end socket 5.
Pressure leakage in order to prevent offers several seal grooves 14 and Xiang Shi on the contact surface between cylinder 4 and end socket 5
The sealing ring 15 matched.
In order to extrusion device carry out temperature control, guarantee extrusion process carried out within required temperature range, further include with
The extrusion pipeline 16 that extrusion 9 connects.
In order to guarantee the air-tightness in 4 inner cavity of cylinder, guarantee that high pressure squeezes out liposome, sealing 10 outer wall of pressure head is equipped with close
Sealing groove 14 and sealing ring 15 compatible with seal groove 14, sealing pressure head 10 are contacted close by sealing ring 15 and 4 inner wall of cylinder
Envelope.
In order to realize that the liposome particles for squeezing out certain partial size and PDI distribution, filter assemblies include that edge is squeezed out to liposome
The filter membrane 17 and support plate 18 of direction sequence arrangement.
In order to realize liposome noresidue to be extruded in cylinder 4, it can all be extruded into papery body particle, outlet
7 diameter is equal to the diameter for squeezing out pressure head 11.
In order to realize the automatic precision control squeezed out to liposome, one end of piston rod 3 and cylinder 2 are connected, piston rod 3
The other end be fixed with sealing pressure head 10.
Above are merely preferred embodiments of the utility model, it is not intended to limit the utility model, it is noted that for
For those skilled in the art, without deviating from the technical principle of the utility model, if can also make
Dry improvement and modification, these improvements and modifications also should be regarded as the protection scope of the utility model.
Claims (9)
1. a kind of micro liposome high pressure extrusion device, it is characterised in that: including cylinder assembly and micro extrusion container, the gas
Cylinder component includes air cylinder support, cylinder, piston rod and pressure head component, and the cylinder is erected on the air cylinder support, described micro-
It includes cylinder, end socket and filter assemblies that amount, which squeezes out container, and the piston rod, pressure head component, cylinder and end socket constitute piston and squeeze out
Mechanism, the cylinder side are equipped with injection port, and the cylinder body bottom is equipped with outlet, offers filtering on the end socket top surface
Slot, the end socket bottom are equipped with extrusion, and the filter assemblies are filled in the lautertuns, and the pressure head component includes along crowded
Out direction sequence arrangement sealing pressure head and size extrusion pressure head compatible with the outlet, further include respectively circumferential direction set
Set the insulation jacket in the cylinder and end socket outer wall.
2. micro liposome high pressure extrusion device according to claim 1, it is characterised in that: between the cylinder and end socket
It is fixed by supported flange.
3. micro liposome high pressure extrusion device according to claim 1, it is characterised in that: between the cylinder and end socket
Contact surface on offer several seal grooves and compatible sealing ring.
4. micro liposome high pressure extrusion device according to claim 1, it is characterised in that: further include and the extrusion
The extrusion pipeline of connection.
5. micro liposome high pressure extrusion device according to claim 1, it is characterised in that: on the sealing pressure head outer wall
Equipped with seal groove and sealing ring compatible with the seal groove.
6. micro liposome high pressure extrusion device according to claim 5, it is characterised in that: the sealing pressure head passes through institute
State sealing ring and cylinder inboard wall contact sealing.
7. micro liposome high pressure extrusion device according to claim 1, it is characterised in that: the filter assemblies include edge
Squeeze out the filter membrane and support plate of direction sequence arrangement.
8. micro liposome high pressure extrusion device according to claim 1, it is characterised in that: the diameter of the outlet is big
The small diameter equal to the extrusion pressure head.
9. micro liposome high pressure extrusion device according to claim 1, it is characterised in that: one end of the piston rod and
Cylinder connection, the other end of the piston rod are fixed with the sealing pressure head.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821611170.3U CN208841627U (en) | 2018-09-30 | 2018-09-30 | A kind of micro liposome high pressure extrusion device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821611170.3U CN208841627U (en) | 2018-09-30 | 2018-09-30 | A kind of micro liposome high pressure extrusion device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208841627U true CN208841627U (en) | 2019-05-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821611170.3U Active CN208841627U (en) | 2018-09-30 | 2018-09-30 | A kind of micro liposome high pressure extrusion device |
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| Country | Link |
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| CN (1) | CN208841627U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109291298A (en) * | 2018-09-30 | 2019-02-01 | 苏州艾特森制药设备有限公司 | A kind of micro liposome high pressure extrusion device |
-
2018
- 2018-09-30 CN CN201821611170.3U patent/CN208841627U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109291298A (en) * | 2018-09-30 | 2019-02-01 | 苏州艾特森制药设备有限公司 | A kind of micro liposome high pressure extrusion device |
| CN109291298B (en) * | 2018-09-30 | 2024-03-29 | 苏州艾特森制药设备有限公司 | Trace liposome high pressure extrusion device |
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