CN208808486U - A kind of light sound blood sugar detection device of blood vessel automatic positioning - Google Patents
A kind of light sound blood sugar detection device of blood vessel automatic positioning Download PDFInfo
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- CN208808486U CN208808486U CN201720890839.6U CN201720890839U CN208808486U CN 208808486 U CN208808486 U CN 208808486U CN 201720890839 U CN201720890839 U CN 201720890839U CN 208808486 U CN208808486 U CN 208808486U
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- ultrasonic detector
- mobile platform
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- blood vessel
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Abstract
The utility model provides a kind of light sound blood sugar detection device of blood vessel automatic positioning, including excitation light source device, sampling device, detection device and signal processing apparatus.Excitation light source device includes laser, diaphragm, collimation lens and condenser lens, detection device is successively electrically connected by signal amplifier, data acquisition card and computer and is constituted to ultrasonic detector, lateral ultrasonic detector, scanning mobile platform, mobile platform controller and miniature focusing controller, signal processing apparatus after including.Lateral ultrasonic detector is fixed on scanning mobile platform, is moved with the movement of scanning mobile platform, scanning mobile platform is connect by mobile platform controller with computer.Signal amplifier input terminal is connected with backward ultrasonic detector, lateral ultrasonic detector respectively, and data acquisition card is connect with laser.The utility model discloses a kind of light sound blood sugar detection device of blood vessel automatic positioning, realizes to the photo-acoustic detection of blood sugar concentration in blood vessel, greatly improves accuracy.
Description
Technical field
The utility model belongs to bio-medical technology field, and in particular to a kind of light sound blood sugar detection of blood vessel automatic positioning
Device.
Background technique
Currently, diabetes number is suffered from the whole world alreadys exceed 400,000,000 people, and China is global the first big country of diabetic, sugar
Urine disease, which has become, seriously threatens one of three big killers of people's life and health and life quality.Due to up to the present, medicine
Upper treatment diabetes can only be equipped with the metabolic function of medicament adjusting insulin by regularly tracking measurement blood glucose value and variation,
To blood sugar concentration in control volume and tend towards stability.Therefore, the measurement of blood glucose and its variation accurately whether to control diabetes disease
Feelings have a very important role.Traditional blood sugar measuring method is aculeus blood-taking method, and this method not only brings body to patient
The heart and financial burden, and continually aculeus blood-taking can make the risk that superinfection is brought to sufferer.Therefore, the blood of non-invasi
Sugar detection method is the development trend of the following blood sugar test.
Up to the present several undamaged detection methods are applied to blood sugar test, wherein optical means most generation
Table, such as: close/mid-infrared light spectrometry, polarized light measurement method, coherent light mensuration and optoacoustic mensuration.Wherein, photoacoustic technique
Have the advantages that optical high resolution rate and ultrasonic high contrast, also, optoacoustic method is to replace spectrum using detecting ultrasonic signal
The characteristics of detection photon signal of method, thus strongly dry to useful signal bring from scattering light in tissue is avoided in principle
It disturbs, the signal-to-noise ratio and accuracy of measurement of photoacoustic signal can be improved.Since measurement blood glucose value and its variation are finally intended to apply to
Human body is surveyed in physical examination, and for photoacoustic technique measures blood glucose, the optoacoustic source position that incident light generates in human body, for
The reasonability and accuracy of blood glucose value measurement are most important.Some researches show that blood sugar concentration is in human epidermal, corium, subcutaneous group
Knit with the endovascular blood distribution property that is that there are great differences, although also have come using the blood glucose value in Skin tissue fluid it is indirect
Reflect the blood sugar concentration in blood, but whether completely correctly there is presently no final conclusions for its correlation, are still in conceptual phase.
Also, the interference of component (such as: fat, fibr tissue and bone) there are many containing in other tissue positions, so that measurement
Blood glucose characteristic light acoustic signal extraction it is difficult.In addition, research also indicates that other tissue positions are (such as: between the tissue in skin
Liquid) in blood sugar concentration content and blood vessel between whole blood blood sugar concentration content there are certain time delay effect, these factors are all
It can affect to the precise measurement of the true blood sugar concentration content of human body and variation tendency.And to blood vessel or capillary
In blood directly carry out photo-acoustic detection, measured photoacoustic signal can most characterize the real information of human blood glucose concentration.Therefore,
Incident light in tissue photoacoustic source positioning be the key that measurement of blood sugar concentration accurately whether.
Summary of the invention
The utility model is to solve the shortcomings of the prior art, provides a kind of light sound blood sugar detection of blood vessel automatic positioning
Device can greatly improve the accuracy and reliability of blood sugar test.
The technical issues of in order to solve the utility model, the utility model are achieved through the following technical solutions: a kind of
The light sound blood sugar detection device of blood vessel automatic positioning, including excitation light source device 1, sampling device 2, at detection device 3 and signal
Device 4 is managed, the excitation light source device 1 is along optical propagation direction by laser 11, diaphragm 12, collimation lens 13 and condenser lens 14
It constitutes；The sampling device 2 for loading and fixing sample, the detection device 3 include after to ultrasonic detector 31, side
To ultrasonic detector 32, scanning mobile platform 33, mobile platform controller 34 and miniature focusing controller 35, the signal processing
Device 4 is successively electrically connected by signal amplifier 41, data acquisition card 42 and computer 43 and is constituted；The laser 11 exports
On an axis with the center of diaphragm 12, collimation lens 13 and condenser lens 14, the lateral ultrasonic detector 32 is fixed on
It scans on mobile platform 33, is moved with the movement of scanning mobile platform 33；The scanning mobile platform 33 is controlled with mobile platform
Device 34 is electrically connected, and the mobile platform controller 34 is connect with computer 43；41 input terminal of signal amplifier respectively with
The backward ultrasonic detector 31 is connected with the signal output end of lateral ultrasonic detector 32；The data acquisition card 42 with swash
Light device 11 is electrically connected, and the outside of signal acquisition operation is carried out using the periodic pulse signal of laser 11 as data acquisition card 42
Trigger condition.
Preferably, the condenser lens 14 is focus adjustable formula condenser lens.
Preferably, the backward ultrasonic detector 31 is a ring-shaped ultrasonic detector, in the backward ultrasonic detector 31
Ring diameter be equal to the condenser lens 14 outer diameter, the condenser lens 14 be embedded in after into ultrasonic detector 31, with focusing
14 being integrally formed of lens, backward 31 position of ultrasonic detector change with the variation of 14 focal length of condenser lens.
Preferably, the 31 ring central point of backward ultrasonic detector is overlapped with 14 central point of condenser lens, after described
To ultrasonic detector 31 leading portion face and the condenser lens 14 sagittal plane in the same plane.
Preferably, the sampling device 2 be located at the backward ultrasonic detector 31 and lateral ultrasonic detector 32 it
Between, 90 degree each other of axis direction of the axis direction of the backward ultrasonic detector 31 and the lateral ultrasonic detector 32.
Preferably, the lateral ultrasonic detector 32 is unit or polynary or ring-shaped ultrasonic detector, the lateral ultrasound
Detector is fixedly connected on the scanning mobile platform 33, is sent and is specified to mobile platform controller 34 by computer 43,
To control the movement of scanning mobile platform 33, and then the translation of the lateral ultrasonic detector 32 of control in either the vertical or horizontal direction
Movement.
Preferably, the quilt on the front end face and sampling device of the backward ultrasonic detector 31 and lateral ultrasonic detector 32
The surface for surveying tissue is in close contact in parallel, the backward ultrasonic detector 31 and lateral ultrasonic detector 32 and tested tissue it
Between smear ultrasonic coupling liquid.
Preferably, it is realized between the computer 43 and data acquisition card 42 by graphical programming software LabVIEW
The external trigger of data acquires and the functions such as preservation.
Compared with prior art, the beneficial effect that the utility model obtains is:
The light sound blood sugar detection device of a kind of blood vessel automatic positioning disclosed by the utility model, to ultrasonic detector after
Not only blood sugar concentration information in vitro or in body can be detected with non-invasi with lateral ultrasonic detector, but also can be accurate
Ground obtains the specific location of tested tissue body vessel, passes through the automatic adjustment to condenser lens focus, it can be ensured that incident arteries and veins
Impulse light accurately drops into blood vessel, to realize the photo-acoustic detection to blood sugar concentration in blood vessel, greatly improves blood glucose inspection
The accuracy of survey.
Detailed description of the invention
Fig. 1 is the utility model principle schematic diagram
Fig. 2 be after to the positional diagram between ultrasonic detector, side minder and tested tissue.
Appended drawing reference: 1, excitation light source device；11, laser；12, diaphragm；13, collimation lens；14, condenser lens；2,
Sampling device；21, epithelial tissue；22, subcutaneous tissue；23, blood vessel；24, musculature；25, bone；3, detection device；31, after
To ultrasonic detector；32, lateral ultrasonic detector；33, mobile platform is scanned；34, mobile platform controller；35, miniature focusing
Controller；4, signal processing apparatus；41, signal amplifier；42, data acquisition card；43, computer.
Specific embodiment
With reference to the accompanying drawing, embodiment is described in detail.
Referring to attached drawing 1 and attached drawing 2, a kind of light sound blood sugar detection device of blood vessel automatic positioning, including excitation light source device
1, sampling device 2, detection device 3 and signal processing apparatus 4, the excitation light source device 1 is along optical propagation direction by laser
11, diaphragm 12, collimation lens 13 and condenser lens 14 are constituted；The sampling device 2 is tested for loading and fixing sample
Sample or histoorgan from outward appearance to inner essence can successively include epithelial tissue 21, subcutaneous tissue 22, blood vessel 23, musculature 24 and bone
Bone 25；The detection device 3 is flat to ultrasonic detector 31, lateral ultrasonic detector 32, scanning mobile platform 33, movement after including
Platform controller 34 and miniature focusing controller 35, the signal processing apparatus 4 is by signal amplifier 41, data acquisition card 42 and meter
Calculation machine 43 is successively electrically connected composition；The center of laser 11 outlet and diaphragm 12, collimation lens 13 and condenser lens 14
On an axis, the lateral ultrasonic detector 32 is fixed on scanning mobile platform 33, mobile with scanning mobile platform 33
And it moves；The scanning mobile platform 33 is electrically connected with mobile platform controller 34, the mobile platform controller 34 and meter
Calculation machine 43 connects；41 input terminal of signal amplifier respectively with the backward ultrasonic detector 31 and lateral ultrasonic detector
32 signal output end is connected；The data acquisition card 42 is electrically connected with laser 11, and the recurrent pulse of laser 11 is believed
Number as data acquisition card 42 carry out signal acquisition operation external trigger conditions.
Further, the condenser lens 14 is focus adjustable formula condenser lens.
Further, the backward ultrasonic detector 31 is a ring-shaped ultrasonic detector, the backward ultrasonic detector 31
Annular diameters are equal to the outer diameter of the condenser lens 14, the condenser lens 14 be embedded in after into ultrasonic detector 31, and it is poly-
14 being integrally formed of focus lens, backward 31 position of ultrasonic detector change with the variation of 14 focal length of condenser lens.
Further, the 31 ring central point of backward ultrasonic detector is overlapped with 14 central point of condenser lens, described
The sagittal plane of the leading portion face of backward ultrasonic detector 31 and the condenser lens 14 is in the same plane.
Further, the sampling device 2 be located at the backward ultrasonic detector 31 and lateral ultrasonic detector 32 it
Between, 90 degree each other of axis direction of the axis direction of the backward ultrasonic detector 31 and the lateral ultrasonic detector 32.
Further, the lateral ultrasonic detector 32 is unit or polynary or ring-shaped ultrasonic detector, described lateral super
Detector of sound is fixedly connected on the scanning mobile platform 33, is referred to by computer 43 to the transmission of mobile platform controller 34
It is fixed, to control the movement of scanning mobile platform 33, and then control lateral ultrasonic detector 32 in either the vertical or horizontal direction flat
It is mobile to make.
Further, on the front end face and sampling device of the backward ultrasonic detector 31 and lateral ultrasonic detector 32
The surface of tested tissue is in close contact in parallel, the backward ultrasonic detector 31 and lateral ultrasonic detector 32 and tested tissue it
Between smear ultrasonic coupling liquid.
Further, between the computer 43 and data acquisition card 42 by graphical programming software LabVIEW come real
The functions such as the external trigger acquisition and preservation of existing data.
A kind of light sound blood sugar detection method of blood vessel automatic positioning, includes the following steps:
The first step, after being reset to the front end face cental axial position of lateral ultrasonic detector 32 by scanning mobile platform 33
To 31 front end face horizontal position of ultrasonic detector, it may be assumed that using the rear front end face horizontal position to ultrasonic detector 31 as lateral super
Zero initial position of space of the scanning shift action of detector of sound 32.
Second step opens the power switch of laser 11, after the prediction of laser 11 about half an hour, on sampling device 2
Ultrasonic coupling liquid is uniformly smeared on the surface of tested tissue measured zone, by condenser lens 14 together with backward ultrasonic detector 31 and side
It is in close contact to ultrasonic detector 32 is parallel with tested tissue surface.
Third step, the power switch of open signal amplifier 41, data acquisition card 42 and computer 43, sets laser
The parameters such as energy, frequency and the wavelength of 1-1, click 11 excitation beam key of laser, and pulsed laser beam goes out from laser 11
It is projected at mouthful.
4th step, the pulsed laser beam that laser 11 issues first pass through diaphragm 12 and remove part stray light, then successively
It is incident in the tested tissue on sampling device 2 after the collimation of collimation lens 13 and condenser lens 14 focus, tested tissue produces
Third contact of a total solar or lunar eclipse acoustical signal.Backward ultrasonic detector 31 and lateral ultrasonic detector 32 capture the photoacoustic signal of tested tissue generation simultaneously.
5th step sends scanning move from computer 43 to mobile platform controller 34, and scanning mobile platform 33 is opened
Begin to operate, lateral ultrasonic detector 32 is driven to carry out the translation scan in the direction Z, side to the tested tissue in entire sampling device 2
To the real-time optoacoustic signal of 32 synchronization acquistion tested tissue of ultrasonic detector.
6th step, the tested tissue real-time optoacoustic signal that lateral ultrasonic detector 32 captures, puts by signal amplifier 41
After big, it is sent to data acquisition card 42 and synchronizes acquisition, then figure of the collected photoacoustic signal data in computer 43
Change under programming software operation, and remember the peak-to-peak value of tested tissue real-time optoacoustic signal, and lateral ultrasonic detector 32 with it is backward
The distance H of 31 probe distal end plane of ultrasonic detector.
7th step, the peak-to-peak value of the real-time optoacoustic signal for the tested tissue that the 6th step is obtained, passes through the number of computer 43
According to Processing Algorithm, (that is: blood vessel 23 exists for the maximum optoacoustic peak-to-peak value for obtaining the lateral scanning of ultrasonic detector 32 acquisition and spatial position
The position of Z-direction) and its corresponding lateral ultrasonic detector 32 and backward 31 probe distal end plane distance H of ultrasonic detector.
8th step, the lateral ultrasonic detector 32 and backward ultrasonic detector 31 that computer 43 is obtained according to the 7th step are visited
The distance H of head front plan, sends to miniature focusing controller 35 and instructs, be by the focal length adjust automatically length of convergent lens 14
Δ L, as shown in Fig. 2, it may be assumed that Δ L=L-H, wherein L is the focal length of condenser lens 14, i.e., condenser lens 14 to blood vessel 23 away from
From so that the incident aggregation hot spot of convergent lens 14 is fairly fallen in blood vessel 23.
9th step is determined after incident aggregation hot spot falls into blood vessel 23 according to the 8th step, is caught by backward ultrasonic detector 31
Blood glucose real-time optoacoustic signal is obtained, then, successively by the amplification of signal amplifier 41 and 42 synchronous acquisition of data acquisition card, by light
Sound data are sent into storage and the analysis processing that computer 43 carries out blood glucose photoacoustic signal in blood vessel 23.
Energy of lasers after the above-mentioned all steps for completing a measurand, is adjusted to 0, replaced different by the tenth step
Then detection position or measurand repeat the first step to the 9th step until completing the blood of the blood vessel positioning of all measurands
Sugared photo-acoustic detection, and obtained the photoacoustic data of blood glucose in all measurand blood vessels, constitute a different detection positions or by
Then the blood glucose photoacoustic data matrix for surveying object establishes the relational model of photoacoustic data matrix Yu blood sugar concentration matrix, and final
Realize the prediction to blood sugar concentration in unknown blood vessel.
Listed above is only one of specific embodiment of the utility model.Obviously, the utility model is not limited to the above reality
Example is applied, it can also be there are many similar reshaping.Those skilled in the art can be direct from content disclosed by the utility model
All deformations for exporting or associating, are considered as the utility model scope of the claimed.
Claims (6)
1. a kind of light sound blood sugar detection device of blood vessel automatic positioning, it is characterised in that: including excitation light source device (1), sample
Device (2), detection device (3) and signal processing apparatus (4), the excitation light source device (1) is along optical propagation direction by laser
(11), diaphragm (12), collimation lens (13) and condenser lens (14) are constituted；The sampling device (2) is for loading and fixing quilt
Sample, the detection device (3) include after to ultrasonic detector (31), lateral ultrasonic detector (32), scanning mobile platform
(33), mobile platform controller (34) and miniature focusing controller (35), the signal processing apparatus (4) is by signal amplifier
(41), data acquisition card (42) and computer (43) are successively electrically connected composition；The laser (11) outlet and diaphragm (12),
On an axis, the lateral ultrasonic detector (32) is fixed on scanning at the center of collimation lens (13) and condenser lens (14)
On mobile platform (33), moved with scanning mobile platform (33) movement；The scanning mobile platform (33) and mobile platform control
Device (34) electrical connection processed, the mobile platform controller (34) connect with computer (43)；The signal amplifier (41) is defeated
Enter end to be connected with the signal output end of the backward ultrasonic detector (31) and lateral ultrasonic detector (32) respectively；The signal
Capture card (42) and laser (11) are electrically connected.
2. a kind of light sound blood sugar detection device of blood vessel automatic positioning as described in claim 1, it is characterised in that: the focusing
Lens (14) are focus adjustable formula condenser lens.
3. a kind of light sound blood sugar detection device of blood vessel automatic positioning as claimed in claim 2, it is characterised in that: described backward
Ultrasonic detector (31) is a ring-shaped ultrasonic detector, and backward ultrasonic detector (31) annular diameters are equal to described focus thoroughly
The outer diameter of mirror (14), the condenser lens (14) be embedded in after in ultrasonic detector (31), with condenser lens (14) constitute one
Body, backward ultrasonic detector (31) position change with the variation of condenser lens (14) focal length.
4. a kind of light sound blood sugar detection device of blood vessel automatic positioning as claimed in claim 3, it is characterised in that: described backward
Ultrasonic detector (31) ring central point is overlapped with the condenser lens (14) central point, before the backward ultrasonic detector (31)
The sagittal plane of section face and the condenser lens (14) is in the same plane.
5. a kind of light sound blood sugar detection device of blood vessel automatic positioning as described in claim 1, it is characterised in that: the sample
Product device (2) is between the backward ultrasonic detector (31) and lateral ultrasonic detector (32).
6. a kind of light sound blood sugar detection device of blood vessel automatic positioning as described in claim 1, it is characterised in that: described lateral
Ultrasonic detector (32) is unit or polynary or ring-shaped ultrasonic detector.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201720890839.6U CN208808486U (en) | 2017-07-21 | 2017-07-21 | A kind of light sound blood sugar detection device of blood vessel automatic positioning |
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| CN201720890839.6U CN208808486U (en) | 2017-07-21 | 2017-07-21 | A kind of light sound blood sugar detection device of blood vessel automatic positioning |
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| CN208808486U true CN208808486U (en) | 2019-05-03 |
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| CN201720890839.6U Expired - Fee Related CN208808486U (en) | 2017-07-21 | 2017-07-21 | A kind of light sound blood sugar detection device of blood vessel automatic positioning |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107157491A (en) * | 2017-07-21 | 2017-09-15 | 江西科技师范大学 | Light sound blood sugar detection means and method that a kind of blood vessel is automatically positioned |
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2017
- 2017-07-21 CN CN201720890839.6U patent/CN208808486U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107157491A (en) * | 2017-07-21 | 2017-09-15 | 江西科技师范大学 | Light sound blood sugar detection means and method that a kind of blood vessel is automatically positioned |
| CN107157491B (en) * | 2017-07-21 | 2023-04-14 | 江西科技师范大学 | Photoacoustic blood glucose detection device and method for automatically positioning blood vessel |
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
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Granted publication date: 20190503 Termination date: 20200721 |