CN206945622U - A kind of non-invasive glucose monitoring device based on photoacoustic technique - Google Patents
A kind of non-invasive glucose monitoring device based on photoacoustic technique Download PDFInfo
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- CN206945622U CN206945622U CN201720890413.0U CN201720890413U CN206945622U CN 206945622 U CN206945622 U CN 206945622U CN 201720890413 U CN201720890413 U CN 201720890413U CN 206945622 U CN206945622 U CN 206945622U
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Abstract
The utility model provides a kind of non-invasive glucose monitoring device based on photoacoustic technique, including light source cell, tested tissue, ring-shaped ultrasonic detector and signal processing apparatus, light source cell is made up of along optical propagation direction laser, collimation lens and condenser lens, and the outlet of laser and the center of collimation lens and condenser lens are on an axis.Signal processing apparatus includes signal amplifier, digital oscilloscope, GPIB usb cards, computer and focus controller, and is electrically connected successively；Laser is electrically connected with digital oscilloscope, ring-shaped ultrasonic detector is electrically connected with signal amplifier, it is electrically connected between condenser lens and computer by focus controller, ultrasonic coupling liquid, the close contact parallel with the surface of tested tissue of the front end face of ring-shaped ultrasonic detector are uniformly smeared between ring-shaped ultrasonic detector and tested tissue.The utility model discloses a kind of non-invasive glucose monitoring device based on photoacoustic technique, simple in construction, be easily achieved, strong applicability.
Description
Technical field
The utility model belongs to biologic medical detection technique field, and in particular to a kind of blood glucose based on photoacoustic technique is noninvasive
Detection means.
Background technology
The positive serious threat of diabetes the life and health and life quality of people.Up to the present, it is medically also no to appoint
A kind of what specific drug or method can effect a radical cure diabetes, can only be blood sugar concentration and the blood glucose value progress to diabetic itself
Long term monitoring, and be controlled by according to monitoring change of illness state by medicine, stabilizing blood sugar concentration is come with this and avoided concurrent
The generation of disease.Therefore, monitor is carried out to blood sugar concentration and variation tendency, is that control diabetes are most important.At present, cure
Blood sugar concentration is monitored substantially using acupuncture and vein haemospasia detection method on learning, this method is to need to utilize pin
Human body skin or vein blood vessel blood sampling are punctured, then using biochemical analyzer (such as：Enzyme exempts from reaction method or electrochemical process) next pair
Whole blood or the serum progress Analysis of Biochemical by centrifuge separation, obtain corresponding blood glucose concentration value.Can be better.It is this
There are some drawbacks in method, on the one hand, this method is the detection method for having to tissue damage；On the other hand, the detection side
Method process is cumbersome, sample preparation is complicated, operability is not high；Also, the diabetic for being in a bad way and needs are frequent
For the patients for monitoring blood glucose value changes, acupuncture or vein haemospasia are continually carried out, huge body and mind and financial burden can be brought,
And easily trigger the risk of superinfection.Therefore, the hair that monitoring with no damage is future therapeutic diabetes is carried out to blood sugar concentration
Exhibition trend.At present, existing a variety of lossless detection methods apply to the detection of blood sugar concentration, such as：Near infrared spectroscopy, mid-infrared light
Spectrometry, polarized light approach, optical coherence tomography, Terahertz method and photic ultrasonic method etc..Wherein, photic ultrasonic method (also known as " optoacoustic
Method ") optics and ultrasonic technique have been merged, excite tested tissue using pulse laser, tissue resorption or release energy and produce
The ultrasonic signal of tested tissue attribute can be characterized by carrying, by surpassing using caused by the capture of highly sensitive ultrasonic detector
Acoustical signal, then by Data Analysis Services algorithm can be parsed to the signal that some features are carried in tested tissue, from
And understand the specific object of tested tissue.It is similar with spectroscopic methodology for excitation source although excitation source is pulse laser,
It is for the signal of capture, completely different with spectroscopic methodology, optoacoustic method is come instead of the spy of spectroscopic methodology using detecting ultrasonic signal
The characteristics of light-metering subsignal, the strong interference that is brought to useful signal of light is scattered in tissue so as to be avoided from principle, can be with
Improve the signal to noise ratio and accuracy of measurement of photic ultrasonic signal.
Up to the present, people using photoacoustic technique to detecting blood sugar concentration, mainly using light path and probe unit
Fixed detection mode to carry out blood glucose photo-acoustic detection to measurand, although there is certain effect, the structure is excessively single
One, can not meet the needs of different shape detection object and different detection positions.Also, the detection mode of this fixation, can only
The blood sugar concentration of some constant depth in tissue is detected, but due to different detection objects and same detection object
Different detection positions, the institutional framework in its internal depth direction is different, if still using fixed light path and probe unit
Fixed detection mode, the result of different detection position detections will certainly be caused very big difference to be present.
The content of the invention
What the utility model solved is that existing blood glucose optoacoustic Non-invasive detection structure is single, and testing result has larger difference
Technical problem, there is provided a kind of non-invasive glucose monitoring device based on photoacoustic technique, have it is simple in construction, be easily achieved, applicability
The characteristics of strong.
In order to solve technical problem of the present utility model, the utility model is achieved through the following technical solutions：It is a kind of
Non-invasive glucose monitoring device based on photoacoustic technique, including light source cell 1, tested tissue 2, ring-shaped ultrasonic detector 3 and signal
Processing unit 4, the light source cell 1 is made up of along optical propagation direction laser 11, collimation lens 12 and condenser lens 13, described
The outlet of laser 11 and the center of the collimation lens 12 and condenser lens 13 are on an axis；The signal processing apparatus
4 include signal amplifier 41, digital oscilloscope 42, GPIB-USB interface cards 43, computer 44 and focus controller 45；The letter
Number electrically connect successively between amplifier 41, digital oscilloscope 42, GPIB-USB interface cards 43, computer 44 and focus controller 45
Connect, the signal amplified by signal amplifier 41 is sent into digital oscilloscope 42 and is acquired and shows, then, is connect by GPIB-USB
The digital data transmission that digital oscilloscope 42 collects is carried out subsequent analysis and processing into computer 44 by mouth card 43；It is described to swash
Light device 11 is electrically connected with digital oscilloscope 42, and the cyclic pulse signal of laser 11 gathers in real time as digital oscilloscope 42
The outer triggering signal of photoacoustic signal, synchronous triggering and collection so as to photoacoustic data；The ring-shaped ultrasonic detector 3 and signal
Amplifier 41 is electrically connected, and is electrically connected between the condenser lens 13 and computer 44 by focus controller 45, the ring
Between shape ultrasonic detector 3 and tested tissue 2 uniformly smear ultrasonic coupling liquid, the front end face of the ring-shaped ultrasonic detector 3 with
The parallel close contact in surface of the tested tissue 2.
Preferably, the condenser lens 13 is embedded in the inner ring of ring-shaped ultrasonic detector 3, the ring-shaped ultrasonic detection
The annular diameters of device 3 are equal with the external diameter of the condenser lens 13, and the ring-shaped ultrasonic detector 3 is one with the condenser lens 13
It body structure, can not only allow ring-shaped ultrasonic detector 3 to detect blood glucose photoacoustic signal, and light source cell 1 can be caused to launch
Laser beam enter tested tissue so that structure of the detecting device is compact, convenient, the convenient noninvasive inspection of light sound blood sugar concentration in body
Survey.
Preferably, the condenser lens 13 is focus adjustable formula condenser lens, the detection position of the ring-shaped ultrasonic detector 3
Put with the focus adjustment of condenser lens 13 and be adjusted in synchronism, can cause tested tissue 2 exciting light sound source position obtain compared with
Adjust well, can both carry out photo-acoustic detection to the blood glucose in the epidermal tissue of body, can also be to the blood vessel or skin of deeper
The blood glucose of undertissue carries out photo-acoustic detection, substantially increases the applicable depth bounds of detection means.
Preferably, the focus adjustment of the condenser lens 13 can be sent to focus controller 45 by computer 44 and be instructed
Regulation, can also be adjusted manually, and flexibly selection, easy to use.
Preferably, the number of rings of the ring-shaped ultrasonic detector 3 is at least 1 ring.
Preferably, the tested tissue 2 is biological vital tissue, in vitro tissue or solution, applied widely.
Preferably, by graphical between the computer 44, GPIB-USB interface cards 43 and the three of digital oscilloscope 42
Programming software LabVIEW come realize the external trigger of data collection and preserve etc. function.
Compared with prior art, the beneficial effect of the utility model acquisition is：
A kind of non-invasive glucose monitoring device based on photoacoustic technique disclosed in the utility model, using light source cell and annular
Ultrasonic detector integration, and ring-shaped ultrasonic detector embed the structure of condenser lens and obtain the blood glucose optoacoustic of tested tissue
Signal, can not only allow ultrasonic detector detect blood glucose photoacoustic signal while, and can cause light source cell launch swash
Light light beam enters tested tissue so that structure of the detecting device is compact, convenient, the convenient light sound blood sugar concentration Non-invasive detection in body.
A kind of non-invasive glucose monitoring device based on photoacoustic technique disclosed in the utility model, by adjusting condenser lens
Focal length size, and the position of ring-shaped ultrasonic detector can be adjusted in synchronism, the exciting light sound source position of tested tissue can be caused to obtain
To preferably adjusting, can both photo-acoustic detection be carried out to the blood glucose in the epidermal tissue of body, can also be to the blood vessel of deeper
Or the blood glucose of hypodermis carries out photo-acoustic detection, the applicable depth bounds of detection means is substantially increased.
Brief description of the drawings
Fig. 1 is the block diagram of the utility model.
Reference：1st, light source cell；11st, laser；12nd, collimation lens；13rd, condenser lens；2nd, tested tissue；3rd, ring
Shape ultrasonic detector；4th, signal processing apparatus；41st, signal amplifier；42nd, digital oscilloscope；43rd, GPIB-USB interface cards；44、
Computer；45th, focus controller.
Embodiment
Below in conjunction with the accompanying drawings, embodiment is described in detail.
Referring to accompanying drawing 1, a kind of non-invasive glucose monitoring device based on photoacoustic technique, including light source cell 1, tested tissue 2,
Ring-shaped ultrasonic detector 3 and signal processing apparatus 4, the light source cell 1 is along optical propagation direction by laser 11, collimation lens 12
Formed with condenser lens 13, the outlet of the laser 11 and the center of the collimation lens 12 and condenser lens 13 are in an axle
On line；The signal processing apparatus 4 includes signal amplifier 41, digital oscilloscope 42, GPIB-USB interface cards 43, computer 44
With focus controller 45；The signal amplifier 41, digital oscilloscope 42, GPIB-USB interface cards 43, computer 44 and focal length
Be electrically connected successively between controller 45, by signal amplifier 41 amplify signal be sent into digital oscilloscope 42 be acquired and
It has been shown that, then, the digital data transmission that digital oscilloscope 42 collects is entered into computer 44 by GPIB-USB interface cards 43
Row subsequent analysis and processing；The laser 11 is electrically connected with digital oscilloscope 42, the cyclic pulse signal of laser 11
The outer triggering signal of real-time optoacoustic signal is gathered as digital oscilloscope 42, synchronous triggering and collection so as to photoacoustic data；
The ring-shaped ultrasonic detector 3 is electrically connected with signal amplifier 41, passes through Jiao between the condenser lens 13 and computer 44
It is electrically connected away from controller 45, ultrasonic coupling liquid is uniformly smeared between the ring-shaped ultrasonic detector 3 and tested tissue 2, it is described
The close contact parallel with the surface of the tested tissue 2 of the front end face of ring-shaped ultrasonic detector 3.
Further, the condenser lens 13 is embedded in the inner ring of ring-shaped ultrasonic detector 3, and the ring-shaped ultrasonic is visited
The survey annular diameters of device 3 are equal with the external diameter of the condenser lens 13, and the ring-shaped ultrasonic detector 3 is with the condenser lens 13
It integral structure, can not only allow ring-shaped ultrasonic detector 3 to detect blood glucose photoacoustic signal, and light source cell 1 can be caused to send out
The laser beam penetrated enters tested tissue so that structure of the detecting device is compact, convenient, and the convenient light sound blood sugar concentration in body is noninvasive
Detection.
Further, the condenser lens 13 is focus adjustable formula condenser lens, the detection of the ring-shaped ultrasonic detector 3
Position is adjusted in synchronism with the focus adjustment of condenser lens 13, and the exciting light sound source position of tested tissue 2 can be caused to obtain
Preferably adjust, can both carry out photo-acoustic detection to the blood glucose in the epidermal tissue of body, can also to the blood vessel of deeper or
The blood glucose of hypodermis carries out photo-acoustic detection, substantially increases the applicable depth bounds of detection means.
Further, the focus adjustment of the condenser lens 13 can be sent to focus controller 45 by computer 44 and be referred to
Order regulation, can also be adjusted manually, and flexibly selection, easy to use.
Further, the number of rings of the ring-shaped ultrasonic detector 3 is at least 1 ring.
Further, the tested tissue 2 is biological vital tissue, in vitro tissue or solution, applied widely.
Further, figure is passed through between the computer 44, GPIB-USB interface cards 43 and the three of digital oscilloscope 42
Change programming software LabVIEW to realize the functions such as the collection of the external trigger of data and preservation.
A kind of detection method of the non-invasive glucose monitoring device based on photoacoustic technique, comprises the following steps：
The first step, the power switch of laser 11 is opened, the ginseng such as energy, frequency and excitation wavelength of laser 11 is set
Number, laser 11 is preheated about 30 minutes.
Second step, ultrasonic coupling liquid is uniformly smeared in the outer surface of tested tissue 2, then inner chamber is had to the annular of condenser lens 13
The close contact parallel with the outer surface of tested tissue 2 of the front end face of ultrasonic detector 3.
3rd step, click on the light source activation button of laser 11 so that the pulsed laser light of certain wavelength, frequency and energy
Beam is exported from laser 11 and projected, and the pulse laser beam of injection focuses on by the collimation of collimation lens 12 and condenser lens 13 successively
Afterwards, focus on light beam is incided in tested tissue 2.
4th step, the blood glucose photoacoustic signal of tested tissue 2 is detected by ring-shaped ultrasonic detector 3, by signal amplifier 41
After amplification, it is acquired and is shown by digital oscilloscope 42, and is adopted digital oscilloscope 42 by GPIB-USB interface cards 43
The blood glucose photoacoustic signal collected, which transmits, to be analyzed and is handled into computer 44, while preserves what the tested tissue 2 was differentiated
Blood glucose optoacoustic live signal waveform and blood glucose signal peak value or peak-to-peak value.
5th step, send and instruct from computer 4-4 to focus controller 4-5, it is big to adjust condenser lens 1-3 focal length
It is small so that condenser lens 1-3 focal beam spot carries out the scanning of depth direction inside tested tissue 2, is so obtained with
And preserve blood glucose optoacoustic live signal and blood glucose optoacoustic peak value or peak-to-peak value under different focal.
6th step, after completing the above blood glucose photo-acoustic detection of a tested tissue 2, the energy of laser 11 is adjusted to null value,
Change another tested tissue 2, according to second step to the 5th step, obtain inside a new tested tissue 2 in different depth
Blood glucose optoacoustic live signal and optoacoustic peak value or peak-to-peak value on direction.
Listed above is only one of specific embodiment of the utility model.Obviously, the utility model is not limited to above reality
Example is applied, there can also be many similar reshapings.One of ordinary skill in the art can be direct from the utility model disclosure
All deformations for exporting or associating, are considered as the utility model scope of the claimed.
Claims (6)
- A kind of 1. non-invasive glucose monitoring device based on photoacoustic technique, it is characterised in that：Including light source cell (1), tested tissue (2), ring-shaped ultrasonic detector (3) and signal processing apparatus (4), the light source cell (1) is along optical propagation direction by laser (11), collimation lens (12) and condenser lens (13) are formed, the outlet of the laser (11) and the collimation lens (12) and The center of condenser lens (13) is on an axis；The signal processing apparatus (4) includes signal amplifier (41), digital oscillography Device (42), GPIB-USB interface cards (43), computer (44) and focus controller (45)；The signal amplifier (41), numeral It is electrically connected successively between oscillograph (42), GPIB-USB interface cards (43), computer (44) and focus controller (45), it is described Laser (11) is electrically connected with digital oscilloscope (42), and the ring-shaped ultrasonic detector (3) is electric with signal amplifier (41) Connection, it is electrically connected between the condenser lens (13) and computer (44) by focus controller (45)；The ring-shaped ultrasonic Between detector (3) and tested tissue (2) uniformly smear ultrasonic coupling liquid, the front end face of the ring-shaped ultrasonic detector (3) with The parallel close contact in surface of the tested tissue (2).
- A kind of 2. non-invasive glucose monitoring device based on photoacoustic technique as claimed in claim 1, it is characterised in that：The focusing Lens (13) are embedded in ring-shaped ultrasonic detector (3) inner ring, the ring-shaped ultrasonic detector (3) and the condenser lens (13) it is integrated.
- A kind of 3. non-invasive glucose monitoring device based on photoacoustic technique as claimed in claim 2, it is characterised in that：The focusing Lens (13) are focus adjustable formula condenser lens, and the detecting location of the ring-shaped ultrasonic detector (3) is with condenser lens (13) Focus adjustment and be adjusted in synchronism.
- A kind of 4. non-invasive glucose monitoring device based on photoacoustic technique as claimed in claim 3, it is characterised in that：The focusing The focus adjustment of lens (13) can send instruction regulation by computer (44) to focus controller (45), can also adjust manually Section.
- A kind of 5. non-invasive glucose monitoring device based on photoacoustic technique as claimed in claim 1, it is characterised in that：The annular The number of rings of ultrasonic detector (3) is at least 1 ring.
- A kind of 6. non-invasive glucose monitoring device based on photoacoustic technique as claimed in claim 1, it is characterised in that：It is described tested It is biological vital tissue, in vitro tissue or solution to organize (2).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201720890413.0U CN206945622U (en) | 2017-07-21 | 2017-07-21 | A kind of non-invasive glucose monitoring device based on photoacoustic technique |
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| CN201720890413.0U CN206945622U (en) | 2017-07-21 | 2017-07-21 | A kind of non-invasive glucose monitoring device based on photoacoustic technique |
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| CN201720890413.0U Expired - Fee Related CN206945622U (en) | 2017-07-21 | 2017-07-21 | A kind of non-invasive glucose monitoring device based on photoacoustic technique |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107228904A (en) * | 2017-07-21 | 2017-10-03 | 江西科技师范大学 | A kind of photic ultrasonic non-invasive glucose monitoring device and method |
| CN110037711A (en) * | 2019-04-23 | 2019-07-23 | 江西科技师范大学 | A kind of blood glucose optoacoustic precise positioning detection device and its method |
-
2017
- 2017-07-21 CN CN201720890413.0U patent/CN206945622U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107228904A (en) * | 2017-07-21 | 2017-10-03 | 江西科技师范大学 | A kind of photic ultrasonic non-invasive glucose monitoring device and method |
| CN110037711A (en) * | 2019-04-23 | 2019-07-23 | 江西科技师范大学 | A kind of blood glucose optoacoustic precise positioning detection device and its method |
| CN110037711B (en) * | 2019-04-23 | 2023-06-16 | 江西科技师范大学 | Blood glucose optoacoustic accurate positioning detection device and method thereof |
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Granted publication date: 20180130 Termination date: 20180721 |