CN207964612U - A kind of blood glucose optoacoustic non-destructive testing device of multi-wavelength joint excitation - Google Patents
A kind of blood glucose optoacoustic non-destructive testing device of multi-wavelength joint excitation Download PDFInfo
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- CN207964612U CN207964612U CN201820378651.8U CN201820378651U CN207964612U CN 207964612 U CN207964612 U CN 207964612U CN 201820378651 U CN201820378651 U CN 201820378651U CN 207964612 U CN207964612 U CN 207964612U
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- light source
- blood glucose
- destructive testing
- wavelength
- optoacoustic
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Abstract
The utility model discloses a kind of blood glucose optoacoustic non-destructive testing devices of multi-wavelength joint excitation, including light source activation unit, tested tissue, sonac and data processing control units to constitute.The utility model discloses a kind of blood glucose optoacoustic non-destructive testing devices of multi-wavelength joint excitation, excitation is combined using multi-wavelength to carry out photo-acoustic detection to blood glucose constituents, it not only can disposably excite to obtain the optoacoustic amplitude under multiple wavelength, the combination of light sources that can also selectively control different number carries out joint excitation.Also, it is used as excitation light source using multiple laser diodes of different blood glucose characteristic wavelengths, can makes entire blood glucose photoacoustic detection device compact.Compared to the blood glucose optoacoustic non-destructive testing device excited using multi-wavelength joint with other kinds of photoacoustic detection device, the utility model, portability, functionality and the applicability of device can be greatly improved.
Description
Technical field
The utility model belongs to biologic medical detection technique field, and in particular to a kind of blood glucose light of multi-wavelength joint excitation
Sound non-destructive testing device.
Background technology
Currently, there is no the method and specific drug for curing diabetes completely, only by being monitored to blood glucose value, then according to
Increase and decrease dose by blood glucose value to reach blood glucose value in liptinite.Therefore, blood glucose it is accurate detection for diabetic and
It says most important.The method of detection blood glucose is still using aculeus blood-taking, then using biochemical analyzer come to blood glucose at present
Value is measured, although the obtained blood glucose value of this method is relatively accurate, heavier for the state of an illness and need frequently monitoring blood glucose
The diabetic of value but brings huge economy and physical and mental burden, and frequently acupuncture treatment makes the surface of a wound be difficult to heal, to
The risk of superinfection is increased again.Therefore, blood glucose non-destructive testing is that the inevitable development of the following diabetes glucose monitoring technology becomes
Gesture.Currently, most representative in blood glucose non-destructive testing technology have an optical detecting method, such as：Closely/mid-infrared light spectrometry, polarization
Light technology, optical coherence tomography, Raman spectroscopy etc..Since these pure spectrum methods by tissue, interfere by his component, such as：Water
Point, protein etc., spectroscopic data generates seriously overlapping and aliasing so that the signal extraction of blood glucose characteristic spectrum is difficult, the day of one's doom
Progress of the pure spectrum technology in terms of blood glucose non-destructive testing is made.But photoacoustic technique has had both optics high contrast and acoustics
The advantages of high-resolution, replaces detection photon signal using detection acoustical signal, can preferably overcome tissue scatter's light and he
The interference that component spectra aliasing etc. is brought may finally improve the stability and accuracy of blood sugar test.But blood glucose light at present
Sound detection, which is largely still, to be studied imitating body and in vitro sample, in the research of body light sound blood sugar detection relatively fewer.
Meanwhile present light sound blood sugar detection is all studied with some fixed wave length, but blood glucose photoacoustic signal characteristic wave
It is long up to the present to be determined there are no complete, and for some fixed wave length, there is also deposited on this wavelength
The phenomenon that the photoacoustic signal that other components characteristic absorption generates interferes.Therefore, the photo-acoustic detection side of single wavelength is relied solely on
Formula cannot be satisfied complex dielectrics and the numerous sample of influence factor, especially tissue.Therefore, it is necessary to seek optoacoustic
The improved method of blood glucose non-destructive testing.
Invention content
The utility model be solve blood glucose photo-acoustic detection presently, there are the technical issues of, a kind of joint excitation of multi-wavelength is provided
Blood glucose optoacoustic non-destructive testing device.
The technical issues of in order to solve the utility model, the utility model are achieved through the following technical solutions：It is a kind of
The blood glucose optoacoustic non-destructive testing device of multi-wavelength joint excitation, including light source activation unit, tested tissue, sonac sum number
According to processing and control element (PCE), the light source activation unit includes light source one, light source two, light source three, light source four, light source drive, light
Source coupler, single mode optical fiber, multimode fibre, collimation lens and condenser lens are constituted；The light source coupler passes through single mode optical fiber
It is connect respectively with light source one, light source two, light source three, light source four, the light after the light source coupler is integrated is defeated by multimode fibre
Go out, becomes focal beam spot after being focused by collimation lens collimation and condenser lens；The data processing control units are along signal transmission
Direction sets gradually signal amplifier, signal picker, computer and signal synchronization circuit；The signal synchronization circuit input terminal
Be connected with computer, the signal synchronization circuit output end is connected with signal amplifier and signal picker respectively, by will based on
The synchronizing signal of calculation machine is sent to signal amplifier and signal picker, to realize synchronous amplification and the acquisition operations of signal；Institute
Light source drive input terminal is stated with the computer in data processing control units to be connected, the light source drive output end respectively with
Light source one, light source two, light source three, light source four connect, and its role is to receive the light of the computer in data processing control units
Source enabled instruction, come control light source one, light source two, light source three, light source four single or multiple light sources opening operation.
Preferably, the light source one, light source two, light source three, light source four are pulse laser, both can be tunable wave length
Pulse laser, or the pulse laser of fixed wave length or warbled pulse laser.
Preferably, the tested tissue is human body in body tissue, in vitro tissue or liquid sample.If tested tissue is human body
In body tissue or in vitro tissue, it is used directly for detecting；For fluid blood sample, need using transparent vessel (quartz or
The cuvette etc. of glass material) it is loaded.
Preferably, the sonac is focusing or non-focusing type ultrasonic detector, for detecting in tested tissue
Blood glucose photoacoustic signal.
Preferably, the number of light source is no less than 2 in the light source activation unit.
Preferably, ultrasonic coupling agent is filled between the sonac and tested tissue, for improving sonac
With the impedance matching of blood glucose photoacoustic signal in tested tissue, the signal-to-noise ratio and signal quality of blood glucose photoacoustic signal are improved.
Preferably, the sonac is cell sensor or multielement bar or ring-shaped ultrasonic sensor, described super
The center response frequency of sonic transducer is not less than 1MHz.
Compared with prior art, the advantageous effect of the utility model acquisition is：
A kind of blood glucose optoacoustic non-destructive testing device of multi-wavelength joint excitation provided by the utility model, is joined using multi-wavelength
It closes excitation to carry out photo-acoustic detection to blood glucose constituents, can disposably excite to obtain the optoacoustic amplitude under multiple wavelength；Meanwhile also
Joint excitation can be carried out to control the combination of light sources of different number by light source drive, substantially increase blood glucose photo-acoustic detection
Applicability.Also, multiple laser diodes that different blood glucose characteristic wavelengths may be used in the utility model are used as exciting light
Source can make entire blood glucose photoacoustic detection device compact, be conducive to the portability design of device.With other kinds of light
Sound detection device is compared, and a kind of blood glucose optoacoustic non-destructive testing device of multi-wavelength joint excitation provided by the utility model is applicable in
Property is stronger, function is more complete, easy to carry.
Description of the drawings
Fig. 1 is a kind of theory structure schematic diagram of the blood glucose optoacoustic non-destructive testing device of multi-wavelength joint excitation.
Reference numeral：1, light source activation unit；101, light source one；102, light source two；103, light source three；104, light source four；
105, light source drive；106, light source coupler；107, single mode optical fiber；108, multimode fibre；109, collimation lens；110, it focuses
Lens；2, tested tissue；3, sonac；4, data processing control units；401, signal amplifier；402, signal acquisition
Device；403, computer；404, signal synchronization circuit.
Specific implementation mode
Below in conjunction with the accompanying drawings, embodiment is described in detail.
Referring to attached drawing 1, a kind of blood glucose optoacoustic non-destructive testing device of multi-wavelength joint excitation, including light source activation unit 1,
Tested tissue 2, sonac 3 and data processing control units 4, the light source activation unit 1 include light source 1, light source
2 102, light source 3 103, light source 4 104, light source drive 105, light source coupler 106, single mode optical fiber 107, multimode fibre
108, collimation lens 109 and condenser lens 110 are constituted；The light source coupler 106 by single mode optical fiber 107 respectively with light source one
101, light source 2 102, light source 3 103, light source 4 104 connect, and the light after the light source coupler 106 is integrated passes through multimode fibre
108 outputs become focal beam spot after being focused by the collimation of collimation lens 109 and condenser lens 110；The data processing control units
4 set gradually signal amplifier 401, signal picker 402, computer 403 and signal synchronization circuit along signal transmission direction
404；404 input terminal of the signal synchronization circuit is connected with computer 403,404 output end of the signal synchronization circuit respectively with
Signal amplifier 401 is connected with signal picker 402, for sending the synchronizing signal of computer 403 to 401 He of signal amplifier
Signal picker 402, to realize synchronous amplification and the acquisition operations of signal；105 input terminal of the light source drive and data
In processing and control element (PCE) 4 computer 403 be connected, 105 output end of the light source drive respectively with light source 1, light source two
102, light source 3 103, light source 4 104 connect, and its role is to receive the light of the computer 403 in data processing control units 4
Source enabled instruction, come control light source 1, light source 2 102, light source 3 103, light source 4 104 single or multiple light sources open
Open operation.
Further, the light source 1, light source 2 102, light source 3 103, light source 4 104 are pulse laser, both may be used
Think the pulse laser of tunable wave length, or the pulse laser of fixed wave length or warbled pulse laser
Device.
Further, the tested tissue 2 be human body body tissue, in vitro tissue or liquid sample (such as：Blood, human body
Tissue fluid).If tested tissue 2 be human body in body tissue or in vitro tissue, be used directly for detecting；For fluid blood sample
This, needs to be loaded using transparent vessel (cuvette etc. of quartz or glass material).
Further, the sonac 3 is focusing or non-focusing type ultrasonic detector, for detecting in tested tissue
Blood glucose photoacoustic signal.
Further, the number of light source is no less than 2 in the light source activation unit 1.
Further, ultrasonic coupling agent is filled between the sonac 3 and tested tissue 2, for improving ultrasonic biography
The impedance matching of sensor 3 and blood glucose photoacoustic signal in tested tissue 2 improves the signal-to-noise ratio and signal quality of blood glucose photoacoustic signal.
Further, the sonac 3 is cell sensor or multielement bar or ring-shaped ultrasonic sensor, described
The center response frequency of sonac is not less than 1MHz.
Listed above is only one of specific embodiment of the utility model.Obviously, the utility model is not limited to the above reality
Example is applied, it can also be there are many similar reshaping.Those skilled in the art can be direct from content disclosed by the utility model
All deformations for exporting or associating, are considered as the utility model scope of the claimed.
Claims (7)
1. a kind of blood glucose optoacoustic non-destructive testing device of multi-wavelength joint excitation, it is characterised in that：Including light source activation unit, quilt
Survey tissue, sonac and data processing control units, the light source activation unit include light source one, light source two, light source three,
Light source four, light source drive, light source coupler, single mode optical fiber, multimode fibre, collimation lens and condenser lens are constituted；The light
Source coupler is connect with light source one, light source two, light source three, light source four respectively by single mode optical fiber, and the light source coupler is integrated
Light afterwards is exported by multimode fibre, becomes focal beam spot after being focused by collimation lens collimation and condenser lens；At the data
Reason control unit sets gradually signal amplifier, signal picker, computer and signal synchronization circuit along signal transmission direction；Institute
Signal synchronization circuit input terminal is stated with computer to be connected, the signal synchronization circuit output end respectively with signal amplifier and signal
Collector is connected, and the light source drive input terminal is connected with the computer in data processing control units, the light source driving
Device output end is connect with light source one, light source two, light source three, light source four respectively.
2. a kind of blood glucose optoacoustic non-destructive testing device of multi-wavelength joint excitation as described in claim 1, it is characterised in that：Institute
It is pulse laser to state light source one, light source two, light source three, light source four.
3. a kind of blood glucose optoacoustic non-destructive testing device of multi-wavelength joint excitation as described in claim 1, it is characterised in that：Institute
State tested tissue be human body in body tissue, in vitro tissue or liquid sample.
4. a kind of blood glucose optoacoustic non-destructive testing device of multi-wavelength joint excitation as described in claim 1, it is characterised in that：Institute
It is focusing or non-focusing type ultrasonic detector to state sonac, for detecting the blood glucose photoacoustic signal in tested tissue.
5. a kind of blood glucose optoacoustic non-destructive testing device of multi-wavelength joint excitation as described in claim 1, it is characterised in that：Institute
The number for stating light source in light source activation unit is no less than 2.
6. a kind of blood glucose optoacoustic non-destructive testing device of multi-wavelength joint excitation as described in claim 1, it is characterised in that：Institute
It states and fills ultrasonic coupling agent between sonac and tested tissue.
7. a kind of blood glucose optoacoustic non-destructive testing device of multi-wavelength joint excitation as described in claim 1, it is characterised in that：Institute
It is cell sensor or multielement bar or ring-shaped ultrasonic sensor, the center response of the sonac to state sonac
Frequency is not less than 1MHz.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820378651.8U CN207964612U (en) | 2018-03-20 | 2018-03-20 | A kind of blood glucose optoacoustic non-destructive testing device of multi-wavelength joint excitation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820378651.8U CN207964612U (en) | 2018-03-20 | 2018-03-20 | A kind of blood glucose optoacoustic non-destructive testing device of multi-wavelength joint excitation |
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| CN207964612U true CN207964612U (en) | 2018-10-12 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112641443A (en) * | 2019-10-12 | 2021-04-13 | 潍坊学院 | Device for nondestructive testing of glucose in subcutaneous tissue fluid |
-
2018
- 2018-03-20 CN CN201820378651.8U patent/CN207964612U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112641443A (en) * | 2019-10-12 | 2021-04-13 | 潍坊学院 | Device for nondestructive testing of glucose in subcutaneous tissue fluid |
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Granted publication date: 20181012 Termination date: 20190320 |