CN208695034U - Micro-fluidic chip - Google Patents
Micro-fluidic chip Download PDFInfo
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- CN208695034U CN208695034U CN201821356666.0U CN201821356666U CN208695034U CN 208695034 U CN208695034 U CN 208695034U CN 201821356666 U CN201821356666 U CN 201821356666U CN 208695034 U CN208695034 U CN 208695034U
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- sliding block
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- fluidic chip
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Abstract
The utility model relates to a kind of micro-fluidic chips, including chip body and sliding block.It include more than two chip runners disconnected each other in the chip body；The sliding block can be slidably arranged relatively with the chip body, and include at least one sliding block runner in the sliding block；The relatively described chip body sliding of the sliding block can make the sliding block runner be connected to the different chip runners to form flow path between different chip runners.The microfluidic chip structure of the utility model can satisfy the control requirement of a variety of flow paths, and control method is simple, reliable, while being able to satisfy the requirement of batch micro operations, low in cost.
Description
Technical field
The utility model relates to microfluidic art, in particular to a kind of micro-fluidic chip.
Background technique
Micro-fluidic chip is the processing pipeline, reaction chamber on chip, and reagent is driven to flow in pipeline and chamber, with
Complete a kind of technology of various biological and chemical processes.In recent years, micro-fluidic chip starts at full speed to functionalization, integrated direction
Development, the important biological and chemical process such as nucleic acid amplification reaction, immune response become new hot spot.And to complete these
Complicated test process, must realize the switching between a plurality of flow path on chip, the multiple opening of flow path and close, this is just needed
One simple and reliable valve could be completed.And on micro-fluidic chip, by factors such as difficulty of processing, cost, volume, reliabilities
Influence, realize be easy to make on micro-fluidic chip, be simple and reliable, is low in cost, be suitble to batch control valve, be always
One problem.
Utility model content
The purpose of this utility model is to provide a kind of micro-fluidic chip, the control that structure can satisfy a variety of flow paths is wanted
It asks, control method is simple, reliable, while being able to satisfy the requirement of batch micro operations, low in cost.
The utility model relates to a kind of micro-fluidic chips, comprising:
Chip body, the interior chip body includes more than two chip runners disconnected each other；With
Sliding block, the sliding block and the chip body opposite can be slidingly arranged on the chip body, and described
It include sliding block runner in sliding block；It is different described that sliding block chip body sliding relatively can be such that the sliding block runner is connected to
Chip runner is to form flow path between the different chip runner.
Further, the relatively described chip body sliding of the sliding block makes the sliding block runner and two chips
Runner connection, to form flow path between described two chip runners.
Further, the flow path is no bifurcated line style flow path.
Further, the sliding block includes multiple sliding block runners, sliding block sliding opposite with the chip body
During, at most only one sliding block runner is connected to at least two chip runners, and different sliding block runners are connected to
Chip runner it is not exactly the same.
Further, the micro-fluidic chip further includes being set between the sliding block and the chip body to be located at the core
Chip coating on the surface of piece ontology, the chip coating are equipped with and the institute on the surface of the chip body
State the corresponding through-hole of aperture of chip runner, the coating for lubricate the sliding block and/or the sealing sliding block runner with
Gap between the chip runner；And/or the micro-fluidic chip further include be set to the sliding block and the chip body it
Between be located at the sliding block surface on sliding block coating, the sliding block coating be equipped with and be located at the sliding block surface on
The sliding block runner the corresponding through-hole of aperture, the sliding block coating is for lubricating the sliding block and/or the sealing cunning
Gap between block runner and the chip runner.
Further, the material of the chip coating or the sliding block coating is polytetrafluoroethylene (PTFE) and/or poly- perfluor
Second propylene.
Further, the surface of the sliding block is equipped with positioning region corresponding with the position of the sliding block runner.
Further, the positioning region includes raised correspondingly with the sliding block runner.
Further, the sliding block includes sliding block upper layer and the sliding block lower layer that is connected with sliding block upper layer bottom, institute
It stating sliding block upper layer bottom and is provided with strip groove, the sliding block lower layer offers the two through hole being connected with the strip groove, and described two
The sliding block runner is collectively formed in through-hole and the strip groove and the two through hole forms the inlet and outlet of the sliding block runner.
Further, the micro-fluidic chip further includes compressing structure, and the compressing structure and the chip body are affixed,
The sliding block is pressed on the surface of the chip body by the compressing structure.Further, the compressing structure with it is described
The friction-reducing structure for reducing the frictional force between the compressing structure and the sliding block is equipped between sliding block.
Further, the friction-reducing structure includes being equipped with set on the part of the compressing structure or the contact on the sliding block
Arcuation protrusion or self-lubricating material layer.
Further, the friction-reducing structure includes set on the rolling element between the compressing structure and the sliding block.
Further, the friction-reducing structure includes retainer, and the retainer is set to the compressing structure or the cunning
Between block, the rolling element and be located at the retainer on and can be rotated relative to the retainer.
Further, the compressing structure includes:
First guide part, for limiting the glide direction of the sliding block；And/or
First stopper section, for limiting the sliding distance of the sliding block.
Further, the compressing structure includes top plate, and the sliding block is slidably disposed in the top plate and the core
Between piece ontology, the top plate includes the opening or sliding slot with the cooperation of the top slide of the sliding block, the opening or sliding slot
Inner wall forms first guide part and/or first stopper section.
Further, the chip body is equipped with stiffening plate far from the side of the sliding block, and the micro-fluidic chip includes
It is set to the reinforcement structure of side of the chip body far from the sliding block, the reinforcement structure is for reducing the chip sheet
Bending deformation of the body to the separate sliding block side.
Further, the micro-fluidic chip further include:
Second guide part is set on the chip body, and second guide part limits the glide direction of the sliding block；
And/or
Second stopper section is set on the chip body, and second stopper section limits the sliding block and the chip
The distance of the opposite sliding of ontology.
Further, second guide part includes two the first bar blocks of parallel interval setting, second backstop
Portion includes that parallel interval is arranged and perpendicular to two the second bar blocks of two first bar blocks, two first bar shapeds
Block and two second bar blocks form the accommodation space for accommodating the slider bottom.
Further, the material of the sliding block is plastics or rubber.
Based on micro-fluidic chip provided by the utility model, a plurality of stream of micro-fluidic chip may be implemented by the way that sliding block is arranged
Connection and disconnection switching between road, simple and reliable for structure, control method is simple, easy to manufacture, suitable for mass production, at
This is cheap.
By the detailed description referring to the drawings to the exemplary embodiment of the utility model, the utility model it is other
Feature and its advantage will become apparent.
Detailed description of the invention
Attached drawing described herein is used to provide a further understanding of the present invention, and is constituted part of this application,
The exemplary embodiment of the utility model and the description thereof are used to explain the utility model, does not constitute to the improper of the utility model
It limits.In the accompanying drawings:
Fig. 1 is the structural schematic diagram of the micro-fluidic chip of the utility model embodiment；
Fig. 2 is the structural schematic diagram of sliding block cross-sectional direction section view shown in FIG. 1；
Fig. 3 is that the chip runner of the sliding block runner of sliding block and chip body is in disconnected in another embodiment of the utility model
The schematic illustration of open state；
Fig. 4 is that the sliding block runner of sliding block shown in Fig. 3 and the chip runner of chip body are in the principle of connected state and show
It is intended to；
Fig. 5 is the structural schematic diagram of the sliding block runner of sliding block in another embodiment of the utility model；
Fig. 6 is the structural schematic diagram of the chip runner of chip body in embodiment illustrated in fig. 5；
Fig. 7 is that a sliding block runner of sliding block and chip body chip runner connectivity structure are illustrated in embodiment illustrated in fig. 5
Figure；
Fig. 8 is that another sliding block runner of sliding block in embodiment illustrated in fig. 5 shows with chip body chip runner connectivity structure
It is intended to；
Fig. 9 is that another sliding block runner of sliding block in embodiment illustrated in fig. 5 shows with chip body chip runner connectivity structure
It is intended to；
Figure 10 is the structural schematic diagram of the micro-fluidic chip of another embodiment of the utility model；
Figure 11 is the structural schematic diagram of the micro-fluidic chip of another embodiment of the utility model；
Figure 12 is the structural schematic diagram of the positioning region of sliding block and sliding block runner positional relationship in embodiment illustrated in fig. 11.
Specific embodiment
The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model
Clearly and completely describe, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than whole
Embodiment.Be to the description only actually of at least one exemplary embodiment below it is illustrative, never as to this is practical
Novel and its application or any restrictions used.Based on the embodiments of the present invention, those of ordinary skill in the art are not having
Every other embodiment obtained under the premise of creative work is made, is fallen within the protection scope of the utility model.
Unless specifically stated otherwise, positioned opposite, the digital table of the component and step that otherwise illustrate in these embodiments
Up to the unlimited the scope of the utility model processed of formula and numerical value.Simultaneously, it should be appreciated that for ease of description, each shown in attached drawing
The size of a part is not to draw according to actual proportionate relationship.For skill known to person of ordinary skill in the relevant
Art, method and apparatus may be not discussed in detail, but in the appropriate case, and the technology, method and apparatus should be considered as awarding
Weigh part of specification.In shown here and discussion all examples, any occurrence should be construed as merely example
Property, not as limitation.Therefore, the other examples of exemplary embodiment can have different values.It should also be noted that similar
Label and letter similar terms are indicated in following attached drawing, therefore, once be defined in a certain Xiang Yi attached drawing, then with
In attached drawing afterwards do not need that it is further discussed.
For ease of description, spatially relative term can be used herein, as " ... on ", " ... top ",
" ... upper surface ", " above " etc., for describing such as a device shown in the figure or feature and other devices or spy
The spatial relation of sign.It should be understood that spatially relative term is intended to comprising the orientation in addition to device described in figure
Except different direction in use or operation.For example, being described as if the device in attached drawing is squeezed " in other devices
It will be positioned as " under other devices or construction after part or construction top " or the device of " on other devices or construction "
Side " or " under other devices or construction ".Thus, exemplary term " ... top " may include " ... top " and
" in ... lower section " two kinds of orientation.The device can also be positioned with other different modes and (is rotated by 90 ° or in other orientation), and
And respective explanations are made to the opposite description in space used herein above.
As shown in Fig. 1, Figure 10, Figure 11, the present embodiment discloses a kind of micro-fluidic chip, including chip body 10 and sliding block
20.It include more than two chip runners disconnected each other in chip body 10.Sliding block 20 and chip body 10 can opposite slidings
Ground setting, and include sliding block runner in sliding block 20.The sliding of 20 opposite chip ontology 10 of sliding block can make the connection of sliding block runner different
Chip runner, to form flow path between the different chip runner.
For example, as shown in Figure 3 and Figure 4, sliding block 20 may include a sliding block runner u, for two with chip body 10
The connection of a chip runner, i.e. the first chip runner a and the second chip runner b and disconnection.
Micro-fluidic chip disclosed in the present embodiment, by be arranged sliding block 20 may be implemented on micro-fluidic chip a plurality of flow path it
Between connection and disconnection switching, it is simple and reliable.In switching connection and off-state, it is only necessary to external force, such as driving device
The thrust or pulling force effect of application can be driven in the respective surfaces of sliding block 20.In the case where driving device is arranged, to driving
Relatively orientation between device and sliding block 20 requires lower.The micro-fluidic chip of the present embodiment switches flow path state controlling party
Method is simple, easy to manufacture, suitable for mass production, low in cost.
In some embodiments, can also be as shown in Fig. 5, Fig. 6, Fig. 7, Fig. 8, sliding block 20 includes multiple sliding block runners, example
First sliding block runner u as shown, the second sliding block runner v, third sliding block runner w, for respectively with the first core of chip body
It piece runner a, the second chip runner b, third chip runner c, two connections in fourth chip runner d and disconnects.
In some embodiments, sliding block 20 can also include multiple sliding block runners, more than two sliding block runners simultaneously with
The connection of multiple chip runners and disconnection in chip body, to be connected to simultaneously and disconnect a plurality of mutually isolated flow path or be connected to
With disconnection main line and multiple branch flow passages.
In some embodiments, as shown in Fig. 3, Fig. 7, Fig. 8 and Fig. 9, the sliding of 20 opposite chip ontology 10 of sliding block makes one
Sliding block runner is connected to two chip runners, to form flow path between two chip runners.Sliding block runner two in the present embodiment
End is connected to a chip runner respectively, no branch flow passage, when fluid flows in runner, always along a flow path stream
It is dynamic, when having avoided flow path branch at bifurcated mouth fluid residuals problem, improve the reliability of micro-fluidic chip fluid reaction.
In some embodiments, sliding block runner and chip runner are no bifurcated line style runner, the shape that sliding block runner and chip runner are formed
At flow path be no bifurcated line style flow path.The setting further avoids fluid residuals problem at bifurcated mouth.
In some embodiments, sliding block 20 includes multiple sliding block runners, the mistake of sliding block 20 and the opposite sliding of chip body 10
Cheng Zhong, at most only one sliding block runner are connected to at least two chip runners, between at least two chip runners
Flow path is formed, and the chip runner that different sliding block runners are connected to is not exactly the same.
As shown in Fig. 7, Fig. 8, Fig. 9, in the first sliding block runner u, the second sliding block runner v and third sliding block runner w one
It is a with the first chip runner a, the second chip runner b, third chip runner c and fourth chip runner d among at least two
When chip runner forms flow path, other two sliding block runner does not form flow path, and the flow path that each sliding block runner is formed is each other
It is different.
In the present embodiment, sliding block 20 has multiple sliding block runners, can be realized a plurality of flow path switching function of micro-fluidic chip
Can, meanwhile, each chip runner is corresponding with a flow path, and connection and handover security are reliable, and 20 one-way movement of sliding block can be real
Switching between existing different flow paths helps to reduce micro-fluidic chip flow path designs difficulty, promotes designability.
In some embodiments, as shown in Figure 10 and Figure 11, micro-fluidic chip further includes being set to sliding block 20 and chip body
Chip coating 50 between 10 on the surface of chip body 10, chip coating 50 are equipped with and are located at chip body
The corresponding through-hole of aperture of chip runner on 10 surface, chip coating 50 are used to lubricate the sliding of sliding block 20 and/or close
Seal the connection and disconnection between sliding block runner and chip runner.Chip coating 50 can use chemical adhesive, hot pressing or double
The mode of face glue sticking is fixed on the surface of chip body 10.50 material therefor of chip coating is not reacted with reagent, in core
When the material that piece coating 50 is selected has sealing effect, chip coating 50 has certain elasticity, when sliding block 20 pushes
Wait, certain deformation can be generated, so that chip coating 50 can eliminate its gap between 20 contact surface of sliding block, reach compared with
Good sealing effect.In chip coating 50 for when lubricating sliding block 20, the selection of coating 50 can to make the sliding of sliding block 20
It is more stable, smooth.
In some embodiments, micro-fluidic chip further includes being set between sliding block 20 and chip body 10 to be located at sliding block 20
Surface on sliding block coating, sliding block coating be equipped with to be located at sliding block 20 surface on the aperture of sliding block runner it is corresponding
Through-hole, sliding block coating is used to lubricate sliding block and/or seals the gap between sliding block runner and chip runner.
In some embodiments, the material of chip coating 50 or sliding block coating is polytetrafluoroethylene (PTFE) and/or poly- perfluor
Second propylene.The chip coating 50 or sliding block coating for selecting the material are not reacted with reagent, in addition can be had simultaneously preferably
The effect that sliding block 20 is lubricated and have the function of sealing the gap between sliding block runner and chip runner simultaneously.
In some embodiments, as is illustrated by figs. 11 and 12, the surface of sliding block 20 is equipped with corresponding to the position of sliding block runner
Positioning region.The setting detects the position of these positioning regions by sensors such as optoelectronic switches when sliding block 20 slides,
It is assured that the position of the sliding block runner of sliding block 20, so as to judge whether sliding block runner is correctly connected to chip runner,
It improves the detectability of sliding block runner and improves the accuracy and reliability of micro-fluidic chip.
In some embodiments, as is illustrated by figs. 11 and 12, positioning region includes and the one-to-one protrusion 23 of sliding block runner.
By in the setting of the side of sliding block 20 and the one-to-one protrusion 23 of sliding block runner, so that the position of sliding block runner 23 is more straight
It sees, has further facilitated the detection to 23 position of sliding block runner.
In some embodiments, as shown in Figure 1, Figure 2, shown in Figure 10, Figure 11, sliding block 20 include sliding block upper layer 21 and on sliding block
The sliding block lower layer 22 that 21 bottom of layer are connected, sliding block upper layer bottom are provided with strip groove 211, and sliding block lower layer 22 offers and strip groove
Sliding block runner and two through-holes 221 are collectively formed in 211 two through-holes 221 being connected, two through-holes 221 and strip groove 211
Form the inlet and outlet of sliding block runner.One end of chip runner is equipped with connecting hole, sliding block 20 and chip sheet on 10 surface of chip body
The opposite sliding of body 10 can be such that connecting hole of the inlet and outlet of sliding block runner respectively with two chip runners is connected to each other, so that two cores
Flow path is formed between piece runner.The bonding patterns such as hot pressing, gluing, ultrasound, laser welding company can be used in the upper layer and lower layer of sliding block 20
It connects.
Sliding block 20 divides for upper layer and lower layer, bottom slot and hole is got through in lower layer on upper layer, so that the upper sliding block of sliding block 20
Runner processing is more convenient and easy, helps to improve the machining accuracy of sliding block runner.Chip runner and sliding block runner pass through end
Aperture connection, helps to further avoid fluid residuals problem, meanwhile, it helps to ensure that the independence of flow path, reduces by every stream
Road communication port helps to improve the integrated level and designability of chip surface in chip surface area occupied.
In some embodiments, as shown in Fig. 1, Figure 10 and Figure 11, micro-fluidic chip further includes compressing structure 30, compresses knot
Structure 30 and chip body 10 are affixed, and sliding block 20 is pressed on 10 surface of chip body by compressing structure 30, so that sliding block 20 slides
When with chip body intimate surface contact.Sliding block 20 is pressed on the surface of chip body 10 by compressing structure 30, so that
Sliding block 20 and chip 10 are in close contact, achieve the effect that it is closed, improve chip runner and the docking of sliding block runner reliability and
Airtightness.
In some embodiments, as shown in Fig. 1, Figure 10 and Figure 11, compressing structure 30 includes sliding for limiting sliding block 20
First guide part in direction and/or the first stopper section for limiting 20 sliding distance of sliding block.By the way that the first guide part is arranged, make
Obtaining sliding block 20 can be along linear slide, so that the connection of sliding block runner and disconnection chip runner are more controllable and reliable.Setting first
Stopper section limits the sliding distance of sliding block 20, and sliding block 20 and chip body 10 can be made in specific positions such as the different runners of connection
When accurate positioning or reduce sliding block 20 idle stroke, further improve sliding block 20 manipulation controllability.
In some embodiments, as shown in Fig. 1, Figure 10 and Figure 11, compressing structure includes top plate, and sliding block 20 is slideably set
It is placed between top plate and chip body 10.Top plate includes the opening or sliding slot with the cooperation of the top slide of sliding block 20, opening or sliding
The inner wall of slot forms the first guide part and/or the first stopper section.As shown in Fig. 1, Figure 10 and Figure 11, in some embodiments, the
One guide part includes the strip gab set on 30 top of compressing structure, and 20 top of sliding block further includes a protrusion, and protrusion is stretched from opening
Out.The long side inner wall of opening limits the linear slide on 10 surface of chip body of sliding block 20.And the short side inner wall being open forms limit
First stopper section of the sliding distance of sliding block 20 processed.20 middle section of sliding block protrusion, and the intermediate hollow out of compressing structure 30, just may be used
It is stretched out and is gone with the part for allowing sliding block 20 to protrude.For compressing structure 30 when pressed slider, driving device can be convenient ground in this way
Apply active force in the convex portion of sliding block 20, so that sliding block be driven to slide.
In some embodiments, between compressing structure 30 and sliding block 20 be equipped with for reduce the compressing structure 30 with it is described
The friction-reducing structure of frictional force between sliding block 20.
In some embodiments, the part that compressing structure 30 is contacted with sliding block 20 is equipped with arcuation protrusion or self-lubricating material
Layer.As shown in Figure 10, arcuation protrusion is set on the surface that can be contacted in the first guide part of compressing structure 30 with sliding block 20
31a.Arcuation protrusion 31b can also be set on surface of the compressing structure 30 for pressed slider 20.It is convex by setting arcuation
It rises, it is possible to reduce the sliding contact area of compressing structure 30 and sliding block 20 can guarantee guiding or compression to sliding block 20
While effect, the force of sliding friction of sliding block 20 and compressing structure 30 is reduced.Similarly, self-lubricating material can also be set in above-mentioned position
The bed of material, self-lubricating material layer have self-lubricating function, also can reduce the frictional force between sliding block 20 and compressing structure 30.From profit
Sliding material layer can select the materials such as polytetrafluoroethylene (PTFE) and/or perfluoroethylene-propylene.
In some embodiments, friction-reducing structure further includes set on the rolling element between compressing structure 30 and the sliding block 20.
When the setting of rolling element can reduce sliding block 20 and compressing structure 30 with respect to sliding by the way that sliding friction is become rolling friction
Frictional force.Chamber can be arranged on compressing structure 30 or sliding block 20 in the setting of rolling element, be then directly arranged in chamber
Rolling element.Can also be as shown in figure 11, rolling element structure 60, rolling element structure 60 are set between compressing structure 30 and sliding block 20
It on retainer and can be incited somebody to action including retainer and relative to the rolling element of retainer rotation, compressing structure 30 by rolling element structure
Sliding block 20 is pressed on the surface of chip body 10.Sliding block 2 is pressed on core by setting rolling element structure 60 by compressing structure 30
On piece ontology 10, rolling friction is become from sliding friction with the friction of compressing structure 30 when sliding block 20 slides, sliding block 20 is sliding
When further decreased with the frictional force of compressing structure 30.
In some embodiments, micro-fluidic chip further includes the second guide part and/or the second stopper section.Second guide part is set
It is placed on chip body 20, the second guide part limits the glide direction of sliding block 20.Second stopper section is set on chip body 20,
Second stopper section limits sliding block 20 at a distance from chip body 10 relatively sliding.The setting of second guide part and the second stopper section
Further improve the navigability of the guidance capability and sliding block 20 to sliding block 20.When the second guide part and the second stopper section and the
When one guide part and the first stopper section cooperate, by the guiding and backstop to 20 top and bottom of sliding block, sliding block 20 can be more steady
It is fixed reliable.
In some embodiments, as shown in Fig. 1 and Figure 10, the second guide part includes being located at 20 linear slide direction of sliding block
On two bar blocks 42, the second stopper section includes two bar blocks 41 vertical with 20 linear slide direction of sliding block, the second guide part
The holding tank for accommodating 20 bottom of sliding block is formed with the second stopper section.Holding tank is set by the second guide part and the second stopper section
Shape bar shaped block structure, it is simple and reliable, while two bar blocks 42 and two bar blocks 41 can play micro-fluidic chip outside one
The protective effect enclosed helps to prevent foreign matter from sliding under sliding block 20, helps to prevent foreign matter to sliding block runner and chip stream
Road has an impact.
In some embodiments, the material of sliding block 20 is plastics or rubber.Plastics or rubber is not anti-with biological reagent
It answers, is resistant to certain acid-base property, be provided simultaneously with relatively good lubricity and leakproofness, chip body table can be pressed in
Face, while realization seals chip runner in chip body, moreover it is possible to compare smoothly under the driving of external force, in chip body
Surface sliding.Further, the material of the sliding block 20 is preferably polytetrafluoroethylene (PTFE), or to be capable of the solubility of injection molding
Polytetrafluoroethylene (PTFE), perfluoroethylene-propylene.
In some embodiments, compressing structure 30 can be plastics or metal material, the common plastics of micro-fluidic chip
Material, for example, polycarbonate, polymethyl methacrylate, polypropylene, polystyrene, polyethylene terephthalate or cyclenes
One of hydrocarbon type copolymer, these materials are not reacted with biological reagent, are resistant to certain acid-base property.The micro-fluidic core of the present embodiment
Piece has preferable rigidity, smooth with the contact surface of sliding block.
In some embodiments, chip body 10 includes multilayered structure.For example, in embodiment shown in FIG. 1, chip body
10 include three-decker, including top plate 11, mesosphere board 12, bottom plate 13.It include chip runner connecting hole on top plate 11,
Mesosphere board is equipped with long hole, after top plate, mesosphere board and bottom plate three-decker are integrated, the aperture on long hole and top plate
Connection forms chip runner.Three-decker can be bonded by modes such as gluing, hot pressing, ultrasound or laser weldings.One
In a little embodiments, as shown in Figure 10 and Figure 11, chip body 10 may also include two-layer structure, including top plate 11 ' and bottom plate
12'.It include chip runner connecting hole on top plate 11, mesosphere board is equipped with elongated slot, and top plate 11 ' and bottom plate 12 ' are combined into one
After body, elongated slot is connected with the aperture on top plate, forms chip runner.
In some embodiments, micro-fluidic core sign includes being set to reinforcement knot of the chip body 10 far from 20 side of sliding block
Structure, reinforcement structure can be stiffening plate 70 as shown in figure 11, reinforcement structure be used to reduce chip body 10 to far from sliding block
The bending deformation of 20 sides.After sliding block 20 is pressed on chip body 1 by compressing structure 30,10 middle section of chip body may
Bending deformation can be generated downwards, and reinforcement structure is set in the bottom of chip body 10, facilitates the deformation for reducing chip body 10
Bending, keeps micro-fluidic chip more reliable and more stable.Preferably, the material stiffness of reinforcement structure is rigid greater than the material of chip body 10
Degree.
In some embodiments, micro-fluidic chip can also include multiple sliding blocks 20, and multiple sliding blocks 20 can jointly or extremely
Small part independently executes connection and the opening operation of chip runner.
Finally it should be noted that: above embodiments are only to illustrate the technical solution of the utility model rather than limit it
System；Although the utility model has been described in detail with reference to the preferred embodiment, those of ordinary skill in the art should
Understand: specific implementation of the utility model can still be modified or is equally replaced to some technical characteristics
It changes；Without departing from the spirit of technical solutions of the utility model, should all cover in the claimed technical solution of the utility model
In range.
Claims (20)
1. a kind of micro-fluidic chip characterized by comprising
Chip body (10), the interior chip body (10) includes more than two chip runners disconnected each other；With
Sliding block (20), the sliding block (20) and the chip body (10) opposite can be slidingly arranged at the chip body (10)
On, and include sliding block runner in the sliding block (20)；Relatively described chip body (10) sliding of the sliding block (20) can make institute
It states sliding block runner and is connected to the different chip runners to form flow path between the different chip runner.
2. micro-fluidic chip as described in claim 1, which is characterized in that the relatively described chip body (10) of the sliding block (20)
Sliding is connected to the sliding block runner with two chip runners, to form stream between described two chip runners
Road.
3. micro-fluidic chip as described in claim 1, which is characterized in that the flow path is no bifurcated line style flow path.
4. micro-fluidic chip as described in claim 1, which is characterized in that the sliding block (20) includes multiple sliding block streams
Road, during the opposite sliding in the sliding block (20) and the chip body (10), at most only one sliding block runner at least
Two chip runner connections, and the chip runner that different sliding block runners are connected to is not exactly the same.
5. micro-fluidic chip as described in claim 1, which is characterized in that
The micro-fluidic chip further includes being set between the sliding block (20) and the chip body (10) to be located at the chip sheet
Chip coating (50) on the surface of body (10), the chip coating (50) are equipped with and are located at the chip body (10)
Surface on the chip runner the corresponding through-hole of aperture, the chip coating (50) is for lubricating the sliding block (20)
The gap between the sealing sliding block runner and the chip runner and/or；And/or
The micro-fluidic chip further includes being set between the sliding block (20) and the chip body (10) to be located at the sliding block
(20) the sliding block coating on surface, the sliding block coating be equipped with be located at the sliding block (20) surface on it is described
The corresponding through-hole of the aperture of sliding block runner, the sliding block coating is for lubricating the sliding block (20) and/or the sealing sliding block
Gap between runner and the chip runner.
6. micro-fluidic chip as claimed in claim 5, which is characterized in that the chip coating (50) or sliding block covering
The material of layer is polytetrafluoroethylene (PTFE) and/or perfluoroethylene-propylene.
7. micro-fluidic chip as described in claim 1, which is characterized in that the surface of the sliding block (20) is equipped with and the sliding block
The corresponding positioning region in the position of runner.
8. micro-fluidic chip as claimed in claim 7, which is characterized in that the positioning region include with the sliding block runner one by one
Corresponding protrusion.
9. micro-fluidic chip as described in claim 1, which is characterized in that the sliding block (20) include sliding block upper layer (21) and with
The sliding block lower layer (22) that sliding block upper layer (21) bottom is connected, sliding block upper layer (21) bottom are provided with strip groove (211),
The sliding block lower layer (22) offers the two through hole (221) being connected with the strip groove, the two through hole (221) and the item
The sliding block runner is collectively formed in shape slot (211) and the two through hole (221) forms the inlet and outlet of the sliding block runner.
10. micro-fluidic chip as described in claim 1, which is characterized in that the micro-fluidic chip further includes compressing structure
(30), the compressing structure (30) and the chip body (10) are affixed, and the compressing structure (30) presses the sliding block (20)
Tightly on the surface of the chip body (10).
11. micro-fluidic chip as claimed in claim 10, which is characterized in that the compressing structure (30) and the sliding block (20)
Between be equipped with friction-reducing structure for reducing the frictional force between the compressing structure (30) and the sliding block (20).
12. micro-fluidic chip as claimed in claim 11, which is characterized in that the friction-reducing structure includes being set to the compression to tie
Arcuation protrusion or self-lubricating material layer on structure or the sliding block (20).
13. micro-fluidic chip as claimed in claim 11, which is characterized in that the friction-reducing structure includes being set to the compression to tie
Rolling element between structure (30) and the sliding block (20).
14. micro-fluidic chip as claimed in claim 13, which is characterized in that the friction-reducing structure includes retainer, the guarantor
It holds erection to be placed between the compressing structure (30) or the sliding block (20), the rolling element is located on the retainer and can phase
The retainer is rotated.
15. micro-fluidic chip as claimed in claim 10, which is characterized in that the compressing structure (30) includes:
First guide part, for limiting the glide direction of the sliding block (20)；And/or
First stopper section, for limiting the sliding distance of the sliding block (20).
16. micro-fluidic chip as claimed in claim 15, which is characterized in that the compressing structure includes top plate, the sliding block
(20) it is slidably disposed between the top plate and the chip body (10), the top plate includes and the sliding block (20)
The inner wall of the opening or sliding slot of top slide cooperation, the opening or sliding slot forms first guide part and/or described first
Stopper section.
17. the micro-fluidic chip as described in claim 1 to 16 is any, which is characterized in that the micro-fluidic chip includes setting
Reinforcement structure in the side of the chip body (10) far from the sliding block (20), the reinforcement structure is for reducing the core
Bending deformation of the piece ontology (10) to the separate sliding block (20) side.
18. the micro-fluidic chip as described in claim 1 to 16 is any, which is characterized in that the micro-fluidic chip further include:
Second guide part is set on the chip body (10), and second guide part limits the sliding of the sliding block (20)
Direction；And/or
Second stopper section is set on the chip body (10), second stopper section limit the sliding block (20) with it is described
The distance of the opposite sliding of chip body (10).
19. micro-fluidic chip as claimed in claim 18, which is characterized in that second guide part includes parallel interval setting
Two the first bar blocks (42), second stopper section include parallel interval setting and perpendicular to two first bar blocks
(42) two the second bar blocks (41), two first bar blocks (42) and two second bar blocks (41), which are formed, holds
Receive the accommodation space of the sliding block (20) bottom.
20. the micro-fluidic chip as described in claim 1 to 16 is any, which is characterized in that the material of the sliding block (20) is modeling
Material or rubber.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821356666.0U CN208695034U (en) | 2018-08-22 | 2018-08-22 | Micro-fluidic chip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821356666.0U CN208695034U (en) | 2018-08-22 | 2018-08-22 | Micro-fluidic chip |
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| Publication Number | Publication Date |
|---|---|
| CN208695034U true CN208695034U (en) | 2019-04-05 |
Family
ID=65943912
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821356666.0U Active CN208695034U (en) | 2018-08-22 | 2018-08-22 | Micro-fluidic chip |
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| CN (1) | CN208695034U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110856824A (en) * | 2018-08-22 | 2020-03-03 | 厦门大学 | Micro-fluidic chip |
| CN111454831A (en) * | 2020-04-21 | 2020-07-28 | 东莞市东阳光诊断产品有限公司 | Microfluidic chip and cell separation device |
| WO2021173075A1 (en) * | 2020-02-27 | 2021-09-02 | One Biomed Pte Ltd | Device, system and method for isolating a biological material |
-
2018
- 2018-08-22 CN CN201821356666.0U patent/CN208695034U/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110856824A (en) * | 2018-08-22 | 2020-03-03 | 厦门大学 | Micro-fluidic chip |
| CN110856824B (en) * | 2018-08-22 | 2024-06-04 | 厦门大学 | Microfluidic chip |
| WO2021173075A1 (en) * | 2020-02-27 | 2021-09-02 | One Biomed Pte Ltd | Device, system and method for isolating a biological material |
| CN111454831A (en) * | 2020-04-21 | 2020-07-28 | 东莞市东阳光诊断产品有限公司 | Microfluidic chip and cell separation device |
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