CN110756235B - Microfluidic control valve capable of adding liquid and microfluidic chip - Google Patents
Microfluidic control valve capable of adding liquid and microfluidic chip Download PDFInfo
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- CN110756235B CN110756235B CN201911108490.6A CN201911108490A CN110756235B CN 110756235 B CN110756235 B CN 110756235B CN 201911108490 A CN201911108490 A CN 201911108490A CN 110756235 B CN110756235 B CN 110756235B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/12—Specific details about manufacturing devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
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Abstract
The invention provides a liquid-adding control valve for microfluidics and a microfluidic chip, which comprise a control head, a valve body and a chip substrate, wherein the chip substrate, the valve body and the control head are sequentially arranged above the microfluidic chip from bottom to top; the valve body is arranged in the mounting hole, a liquid inlet hole I penetrating through the valve body is formed in the valve body in the vertical direction, and a plurality of drainage ports are formed in the bottom end of the valve body; the control head comprises a pressing block and a guide tube, the guide tube is arranged below the pressing block, the bottom end of the guide tube is arranged in a guide groove I, an extrusion rod is arranged in the guide tube and arranged below the pressing block, a liquid inlet hole II is formed in the control head and communicated with the liquid inlet hole I, and the extrusion rod is arranged right above the valve body.
Description
Technical Field
The invention relates to the technical field of microfluidics, in particular to a liquid-adding control valve for microfluidics and a microfluidic chip.
Background
Microfluidics is a technology for precisely controlling and manipulating microscale fluids, and integrates basic operation units of sample preparation, reaction, separation, detection and the like in biological, chemical and medical analysis processes on a microscale chip to automatically complete the whole analysis process. The microfluidic chip is used as a highly integrated microfluidic detection carrier, and the integration level of the detection platform is higher, so that the optimization of the detection platform is one of the key problems of the popularization of the microfluidic technology. And the first link of micro-fluidic detection is the control of liquid feeding and valve, and the micro-fluidic chip that is commonly used at present mostly is liquid feeding district and valve district separation, and the control of liquid feeding and valve is accomplished by different actuating mechanism, and liquid feeding, valve district mostly are two side control about the chip, and mechanism space volume is great, and simultaneously, most micro-fluidic chip adopts the PDMS tectorial membrane to utilize opening of PDMS's elasticity control flow way, its driving force is mostly pneumatic, and the gas circuit structure is complicated and the noise is great.
Disclosure of Invention
The control valve integrates the liquid adding area and the valve area into one area, so that the volume of the micro-fluidic system can be further reduced, the number of execution structures of detection equipment is reduced, and the equipment is further simplified.
The technical scheme adopted by the invention for solving the technical problems is as follows: a liquid adding control valve for micro-fluidic and a micro-fluidic chip are provided, the control valve is arranged above the micro-fluidic chip, the surface of the micro-fluidic chip is coated with a film, the upper surface of the micro-fluidic chip is provided with a reaction area and a flow channel for transferring samples and reaction reagents, the flow channel is communicated with the reaction area, the control valve is arranged right above the flow channel, the control valve comprises a control head, a valve body and a chip substrate, the valve body and the control head are sequentially arranged above the micro-fluidic chip from bottom to top, the chip substrate comprises a base, a guide groove I for mounting the control head and a mounting hole for mounting the valve body are arranged in the base, and the guide groove I is an annular groove;
the valve body is arranged in the mounting hole, a liquid inlet hole I penetrating through the valve body is formed in the valve body in the vertical direction, and a plurality of drainage ports communicated with the liquid inlet hole I are formed in the bottom end of the valve body;
the control head is including pressing according to briquetting and stand pipe, the stand pipe setting is in the below of pressing according to the briquetting, the bottom setting of stand pipe is in guide way I, be provided with the extrusion stem in the stand pipe, the extrusion stem setting is pressing the below of briquetting and extrusion stem and pressing a briquetting an organic whole setting, the control head is provided with the feed liquor hole II that runs through according to briquetting and extrusion stem in vertical direction, and feed liquor hole II is linked together with feed liquor hole I, the extrusion stem sets up directly over the valve body.
Furthermore, the valve body is made of elastic silica gel.
Further, the valve body includes valve body and lower valve body, lower valve body setting is in the below of last valve body and goes up valve body and lower valve body an organic whole setting, the feed liquor hole I that runs through last valve body and lower valve body is seted up to the inherent vertical direction of valve body, the drainage mouth that a plurality of and feed liquor hole I are linked together is seted up to the bottom of lower valve body.
Furthermore, the longitudinal section of the valve body formed by the upper valve body and the lower valve body is T-shaped, and a guide block is arranged outside the upper valve body.
Furthermore, the longitudinal section of the mounting hole is T-shaped, the mounting hole is matched with the valve body, and a guide groove II matched with the guide block is formed in the inner wall of the mounting hole.
Furthermore, the number of the drainage openings is 1-3.
Furthermore, liquid inlet hole II is arranged right above liquid inlet hole I, and the central axis of liquid inlet hole II coincides with the central axis of liquid inlet hole I.
Further, the diameter of the lower valve body is larger than the width of the flow passage.
A microfluidic chip comprises a chip body and a liquid-adding control valve arranged on the chip body, wherein the liquid-adding control valve is any one of the liquid-adding control valves for microfluidic control.
The beneficial effects of the invention are mainly shown in the following aspects: the liquid adding control valve is used for controlling the opening and closing of a flow channel on the microfluidic chip, and the liquid adding area and the valve area are integrated into one area, so that the microfluidic volume can be further reduced, the number of execution structures of detection equipment is reduced, and the equipment is further simplified.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic structural view of the valve body of the present invention;
FIG. 3 is a schematic diagram of the structure of the chip substrate of the present invention;
FIG. 4 is a schematic structural view of embodiment 2 of the present invention;
FIG. 5 is a schematic structural view of embodiment 3 of the present invention;
FIG. 6 is a schematic structural view of embodiment 4 of the present invention;
the labels in the figure are: 1. the device comprises a pressing block, 101, a guide pipe, 102, an extrusion rod, 103, a liquid inlet hole II, 2, a valve body, 201, an upper valve body, 2011, a guide block, 202, a lower valve body, 203, a liquid inlet hole I, 204, a drainage port, 3, a base, 301, a guide groove I, 302, a mounting hole, 303, a guide groove II, 4, a film, 5, a flow channel, 6 and a reaction zone.
Detailed Description
The embodiments of the present invention are described in detail with reference to the accompanying drawings, and the embodiments and specific operations of the embodiments are provided on the premise of the technical solution of the present invention, but the scope of the present invention is not limited to the following embodiments.
According to the attached drawings, the liquid adding control valve for the micro-fluidic and the micro-fluidic chip are arranged above the micro-fluidic chip, the surface of the micro-fluidic chip is coated with the thin film 4, the thin film 4 can be made of a hard film with relatively low price, such as PC and the like, and the liquid adding control valve is more suitable for commercial popularization of the micro-fluidic chip. The upper surface of the microfluidic chip is provided with a reaction area 6 and a flow channel 5 for transferring a sample and a reaction reagent, the flow channel 5 is communicated with the reaction area 6, the control valve is arranged right above the flow channel 5 and used for controlling the opening and closing of the flow channel, the control valve comprises a control head, a valve body 2 and a chip substrate, the valve body 2 and the control head are sequentially arranged above the microfluidic chip from bottom to top, the chip substrate comprises a base 3, a guide groove I301 for mounting the control head and a mounting hole 302 for mounting the valve body 2 are arranged in the base 3, and the guide groove I301 is an annular groove; the longitudinal section of the mounting hole 302 is T-shaped, the mounting hole 302 is matched with the valve body 2, and a guide groove II 303 matched with a guide block 2011 is arranged on the inner wall of the mounting hole 302;
the valve body 2 is arranged in the mounting hole 302, a liquid inlet hole I203 penetrating through the valve body 2 is formed in the valve body 2 in the vertical direction, and a plurality of drainage ports 204 communicated with the liquid inlet hole I203 are formed in the bottom end of the valve body 2; the valve body 2 is made of elastic silica gel, the valve body 2 comprises an upper valve body 201 and a lower valve body 202, the lower valve body 202 is arranged below the upper valve body 201, the upper valve body 201 and the lower valve body 202 are integrally arranged, a liquid inlet hole I203 penetrating through the upper valve body 201 and the lower valve body 202 is formed in the valve body 2 in the vertical direction, and a plurality of drainage ports 204 communicated with the liquid inlet hole I203 are formed in the bottom end of the lower valve body 202; the number of the drainage openings 204 is 1-3; the longitudinal section of the valve body 2 formed by the upper valve body 201 and the lower valve body 202 is in a T shape, and a guide block 2011 is arranged outside the upper valve body 201; the diameter of the lower valve body 202 is larger than the width of the flow passage 5;
the control head includes according to briquetting 1 and stand pipe 101, stand pipe 101 sets up in the below of pressing briquetting 1, the bottom setting of stand pipe 101 is in guide way I301, be provided with extrusion pole 102 in the stand pipe 101, extrusion pole 102 sets up in the below of pressing briquetting 1 and extrusion pole 102 and press briquetting 1 an organic whole setting, the control head is provided with the feed liquor hole II 103 that runs through according briquetting 1 and extrusion pole 102 in vertical direction, the central axis of feed liquor hole II 103 and the coincidence of the central axis of extrusion pole, and feed liquor hole II 103 is linked together with feed liquor hole I203, extrusion pole 102 sets up directly over valve body 2. The liquid inlet hole II 103 is arranged right above the liquid inlet hole I203, the diameter of the liquid inlet hole II 103 is the same as that of the liquid inlet hole I203, and the central axis of the liquid inlet hole II 103 coincides with that of the liquid inlet hole I203.
The working process is as follows: the valve body 2 of the elastic silica gel is of a T-shaped structure and is matched with a T-shaped mounting hole arranged in the base 3, the bottom of the valve body 2 is slightly higher than the top of the flow channel 5 or is flush with the top of the flow channel, and the control head moves downwards under the action of external force to extrude the valve body 2 to deform and seal the chip flow channel 5; when the external force is removed, the valve body 2 is restored to the initial position by the support of the T-shaped mounting hole in the core tablet core substrate and the self elastic restoring force, and the flow passage is opened. The control head comprises a pressing block 1 and a guide tube 101, the bottom of an extrusion rod 102 is provided with a fillet, and the guide tube firstly enters a guide groove I301 on a chip base 3 when being pressed down so as to ensure the positioning precision of the control head; the bottom of the extrusion rod 102 is provided with a fillet and a sealing plane, the inside of the extrusion rod is provided with a liquid inlet hole II 103, the top end of the liquid inlet hole II 103 is connected with a liquid feeding pipeline (not shown in the figure), the bottom end of the liquid inlet hole II 103 is centered with a liquid inlet hole I203 in the valve body 2 and then is continuously pressed downwards, and the liquid inlet hole I is sealed by means of elastic deformation of the valve body 2, so that the leakage of reagent liquid, namely; a liquid inlet hole I203 is also formed in the valve body 2 and corresponds to a liquid inlet hole II 103 in the control head; the lower part of the valve body 2 can be provided with drainage ports with different directions and different quantities according to the requirements of the chip detection process; when control head 1 pushed down, the chip runner was sealed through warping to the runner direction to the silica gel valve body, and the valve body lower part is provided with the chip runner of the direction of drainage mouth can communicate feed liquor hole I203 and drainage mouth direction, and liquid reagent accessible control head in feed liquor hole II 103-the valve body in feed liquor hole I203 pour into the chip runner in, accomplish directional liquid feeding, the control head rises after the liquid feeding is accomplished, and the valve body leans on self elastic restoring force to reset. The invention integrates the liquid adding area and the valve area into one area, which can further reduce the volume of the micro-fluidic, reduce the number of executing structures of the detection equipment and further simplify the equipment.
Example 2
The lower part of the valve body 2 can be provided with drainage ports with different directions and different quantities according to the requirements of the chip detection process; in this embodiment, when the number of the drainage ports is 1, the liquid feeding control valve of the present invention acts on the flow channel, as can be seen from fig. 4, the liquid feeding control valve of the present invention is a one-way valve, the drainage port is disposed at the position C of the valve body, when the valve body is closed, the direction a is cut off, and the reagent can be injected into the flow channel 5 along the direction C after liquid feeding.
Example 3
In this embodiment, when the number of the drainage ports is 2, the liquid feeding control valve of the present invention acts on the flow channel, as can be seen from fig. 5, the liquid feeding control valve of the present invention is a two-way valve, the drainage port is disposed at the position C of the valve body, when the valve body is closed, the B direction is cut off, and after liquid feeding, the reagent can be injected into the flow channel 5 along the a/C direction.
Example 4
The invention relates to various microfluidic chip liquid adding/valve control detection processes using the liquid adding control valve, in the embodiment, two liquid adding control valves of the patent are simultaneously applied to a chip for detection, and as can be known from fig. 6, the control processes can be as follows:
(1) closing the control valve a, opening the control valve b, and allowing the liquid reagent I to enter the reaction zone from the port A;
(2) the reaction zone completes the reaction;
(3) closing the control valve a, opening the control valve b, allowing sterile gas to enter the reaction zone from the port A, blowing out the reacted liquid reagent I from the port C, and allowing the reacted liquid reagent I to enter a waste liquid pool (not shown);
(4) closing the control valve B, opening the control valve a, and allowing the liquid reagent II to enter the reaction zone from the port B;
(5) the reaction zone completes the reaction;
(6) and closing the control valve B, opening the control valve a, enabling the liquid reagent III to enter the reaction zone from the port B, and pushing the reacted liquid reagent II out from the port D to enter the next reaction zone.
The directions and the number of the drainage ports are not limited to those shown in the attached figures 4-6, and the drainage ports can be arranged in a large number and in any angle direction according to the design of the microfluidic chip flow channel and the allowable range of material performance.
It is further noted that relational terms such as i, ii, and iii may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.
Claims (8)
1. The utility model provides a but micro-fluidic with liquid feeding control valve, this control valve sets up in the top of micro-fluidic chip, and the surface cladding of micro-fluidic chip has film (4), and the upper surface of micro-fluidic chip sets up reaction zone (6) and is used for transmitting sample and reaction reagent's runner (5), runner (5) are linked together with reaction zone (6), its characterized in that: the control valve is arranged right above the flow channel (5), and comprises a control head, a valve body (2) and a chip substrate, wherein the chip substrate, the valve body (2) and the control head are sequentially arranged above the microfluidic chip from bottom to top, the chip substrate comprises a base (3), a guide groove I (301) for mounting the control head and a mounting hole (302) for mounting the valve body (2) are arranged in the base (3), and the guide groove I (301) is an annular groove;
the valve body (2) is arranged in the mounting hole (302), a liquid inlet hole I (203) penetrating through the valve body (2) is formed in the valve body (2) in the vertical direction, and a plurality of drainage ports (204) communicated with the liquid inlet hole I (203) are formed in the bottom end of the valve body (2);
the control head is including pressing according to briquetting (1) and stand pipe (101), stand pipe (101) set up in the below of pressing according to briquetting (1), the bottom setting of stand pipe (101) is in guide way I (301), be provided with in stand pipe (101) squeeze stem (102), squeeze stem (102) set up in the below of pressing briquetting (1) and squeeze stem (102) and press briquetting (1) an organic whole to set up, the control head is provided with feed liquor hole II (103) that run through and press briquetting (1) and squeeze stem (102) in vertical direction, and feed liquor hole II (103) are linked together with feed liquor hole I (203), squeeze stem (102) set up directly over valve body (2), the material of valve body (2) is elastic silica gel.
2. A microfluidic refillable control valve according to claim 1, wherein: the improved valve is characterized in that the valve body (2) comprises an upper valve body (201) and a lower valve body (202), the lower valve body (202) is arranged below the upper valve body (201) and integrally arranged with the upper valve body (201) and the lower valve body (202), a liquid inlet hole I (203) penetrating through the upper valve body (201) and the lower valve body (202) is formed in the valve body (2) in the vertical direction, and a plurality of drainage ports (204) communicated with the liquid inlet hole I (203) are formed in the bottom end of the lower valve body (202).
3. A microfluidic refillable control valve according to claim 2, wherein: the vertical section of a valve body (2) formed by the upper valve body (201) and the lower valve body (202) is T-shaped, and a guide block (2011) is arranged outside the upper valve body (201).
4. A microfluidic refillable control valve according to claim 3, wherein: the vertical section of mounting hole (302) is the T type, mounting hole (302) and valve body (2) cooperate the setting, be provided with on the inner wall of this mounting hole (302) with guide block (2011) matched with guide way II (303).
5. A microfluidic refillable control valve according to claim 1, wherein: the number of the drainage openings (204) is 1-3.
6. A microfluidic refillable control valve according to claim 1, wherein: the liquid inlet hole II (103) is arranged right above the liquid inlet hole I (203), and the central axis of the liquid inlet hole II (103) is coincided with the central axis of the liquid inlet hole I (203).
7. A microfluidic refillable control valve according to claim 2, wherein: the diameter of the lower valve body (202) is larger than the width of the flow passage (5).
8. A micro-fluidic chip comprises a chip body and a liquid-adding control valve arranged on the chip body, and is characterized in that: the liquid-adding control valve for microfluidics is the liquid-adding control valve for microfluidics in any one of claims 1 to 7.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911108490.6A CN110756235B (en) | 2019-11-13 | 2019-11-13 | Microfluidic control valve capable of adding liquid and microfluidic chip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911108490.6A CN110756235B (en) | 2019-11-13 | 2019-11-13 | Microfluidic control valve capable of adding liquid and microfluidic chip |
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| CN110756235A CN110756235A (en) | 2020-02-07 |
| CN110756235B true CN110756235B (en) | 2021-07-16 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111929460B (en) * | 2020-08-19 | 2024-03-01 | 河南科技大学 | Sampling, chip and liquid inlet control device suitable for microfluidic automatic detection |
| CN115138409A (en) * | 2022-06-30 | 2022-10-04 | 中国科学院苏州生物医学工程技术研究所 | Rotary valve suitable for microfluidic system integration |
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| DE102008002674B9 (en) * | 2008-06-26 | 2010-10-21 | INSTITUT FüR MIKROTECHNIK MAINZ GMBH | Microvalve and sealing device for use in a microfluidic system and method of making same |
| CH705468A1 (en) * | 2011-09-06 | 2013-03-15 | Tecan Trading Ag | Chamber system and sample containers with inlet. |
| DE102012220407A1 (en) * | 2012-11-09 | 2014-05-28 | Robert Bosch Gmbh | Valve arrangement in a microfluidic system |
| JP6081800B2 (en) * | 2013-01-07 | 2017-02-15 | 株式会社堀場エステック | Fluid control valve and mass flow controller |
| US11255465B2 (en) * | 2016-11-30 | 2022-02-22 | Agilent Technologies, Inc. | Microfluidic check valve and related devices and systems |
| CN206631607U (en) * | 2017-04-01 | 2017-11-14 | 苏州岚轩生物科技有限公司 | Liquid control valve door gear and its micro-fluidic chip for micro-fluidic chip |
| CN107542973B (en) * | 2017-08-02 | 2023-11-28 | 南京岚煜生物科技有限公司 | Microfluidic chip with latching valve and method of use thereof |
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