CN208693265U - A kind of miniature LED probe - Google Patents

Abstract

The utility model discloses a kind of miniature LED probes.The miniature LED probe includes probe and the interconnecting piece that connect with probe；Probe includes active panel, driving circuit, Minitype LED array and SPAD fluorescent probe；Driving circuit includes multiple driving units being arranged in array, and Minitype LED array includes multiple miniature LED in matrix arrangement；Driving unit and miniature LED are corresponded, and each driving unit is for driving corresponding miniature LED；SPAD fluorescent probe includes multiple SPAD fluorescence detection elements being arranged in array.Technical solutions of the utility model realize the direct stimulation and monitoring to nerve cell, and by the activity situation real time imagery of nerve cell.Further, since each miniature LED is by corresponding to driving unit independent control illumination effect, therefore the stimulation to single or multiple nerve cells may be implemented, and then obtain the 3-D view effect of nerve cell.

Description

A kind of miniature LED probe

Technical field

The utility model embodiment is related to neural Clinics more particularly to a kind of miniature LED probe.

Background technique

Miniature nerve probe is the important tool for Neuscience.Nerve probe is mainly used for brain in medical domain at present Disease, such as epilepsy, migraine, Alzheimer's disease, the neurological diseases such as dementia.In recent years, in microelectric technique and light heredity It learns and continues to develop under perfect background, the research of nerve probe also achieves quickly progress and development.By by nerve probe The different zones of brain are implanted into, to record and stimulate specific site in brain, thus allow for detection, the processing of cell grade And explain neural deta, to help medical personnel to understand neurological disease in depth and make reasonable response.

However, existing nerve probe, although can be realized the stimulation and monitoring to brain nervous cell, needs pair Brain is dissected, to observe the optical signal of the sending of the fluorescent material in nerve cell.It, can not will be refreshing in the case where not dissecting Activity situation through cell intuitively shows in real time, so that medical personnel be hindered to further appreciate that neurological disease.

Utility model content

The utility model provides a kind of miniature LED probe, with realize to nerve cell directly stimulation and monitoring, not into It can be by the activity situation real time imagery of nerve cell in the case where row human dissection.

In a first aspect, the utility model embodiment provides a kind of miniature LED probe, including probe and with the probe The interconnecting piece of head connection；

The probe includes active panel, driving circuit, Minitype LED array and single-photon avalanche diode SPAD fluorescence Detector；The driving circuit is integrated in the first side of the active panel, including multiple driving units being arranged in array, The Minitype LED array is located at side of the driving circuit far from the active panel, including multiple in the micro- of matrix arrangement Type LED；The driving unit and the miniature LED are corresponded, and each driving unit is described miniature for driving correspondence LED；

The SPAD fluorescent probe is integrated in the second side of the active panel, is arranged in array including multiple SPAD fluorescence detection element, the SPAD fluorescence detection element and the driving unit correspond.

Specifically, the SPAD fluorescence detection element includes SPAD, first resistor and memory element；The first resistor First end is electrically connected with the first voltage line on the active panel, the first pole of second end and the memory element and described The cathode of SPAD is electrically connected, the second pole of the memory element and the plus earth of the SPAD.

Specifically, the memory element is first capacitor.

Specifically, the miniature LED probe further includes the first clad, and the first clad uniform thickness cladding is described miniature Region of the LED probe in addition to the miniature LED and SPAD.

Specifically, the material of first clad is Parylene Parylene C.

Alternatively, the miniature LED probe further includes the second clad and third clad, the second clad uniform thickness Region of the probe in addition to the miniature LED and SPAD is coated, described in the third clad uniform thickness cladding Interconnecting piece.

Specifically, the driving unit includes the first transistor, second transistor and the second capacitor；The first crystal The grid of pipe is electrically connected with the control terminal of the driving unit, and the first pole of the first transistor is defeated with the driving unit Enter end electrical connection, the first of the second pole of the first transistor and the grid of the second transistor and the second capacitor is extremely electric Connection；Second voltage line on first pole of the second transistor and the second pole of second capacitor and the active panel Electrical connection, the anode electrical connection of the second pole of the second transistor miniature LED corresponding with the driving unit；The driving The minus earth of the corresponding miniature LED of unit.

Specifically, the size of the miniature LED is 5 μm.

Specifically, the probe with a thickness of 10 μm.

Specifically, the miniature LED probe includes substrate, and the substrate includes the first sub-portion and the second sub-portion, and described the One sub-portion is the substrate of the active panel, and second sub-portion is the substrate of the interconnecting piece；The material of the substrate is soft Property material.

Specifically, the flexible material is Parylene C.

Technical solution provided by the embodiment of the utility model, by the way that active panel, driving circuit, micro- is arranged in probe Type LED array and SPAD fluorescent probe make Minitype LED array issue the fluorescent material in visible light stimulus brain nervous cell It shines, SPAD fluorescent probe receives the light that fluorescent material issues and the conversion for carrying out photosignal, and fluorescent material is issued Optical signal is converted into electric signal, is transmitted in external equipment and performs image display, to realize the direct thorn to nerve cell Swash and monitoring, can be by the activity situation real time imagery of nerve cell in the case where dissecting human body.Another party Face, driving circuit and SPAD fluorescent probe are all made of the mode of active matrix driving, therefore Minitype LED array shines, stimulation fluorescence Material luminescence and SPAD fluorescent probe receive the sustainable progress of three processes of the optical signal of fluorescent material transmitting, thus real Show and nerve cell activity has been continued to monitor.Further, since each miniature LED is by corresponding to the luminous effect of driving unit independent control Fruit, therefore the stimulation to single or multiple nerve cells may be implemented, and then obtain the 3-D view effect of nerve cell.

Detailed description of the invention

Fig. 1 is a kind of cross-sectional view of miniature LED probe provided by the embodiment of the utility model；

Fig. 2 is a kind of top view of miniature LED probe provided by the embodiment of the utility model；

Fig. 3 is a kind of structural schematic diagram of SPAD fluorescence detection element provided by the embodiment of the utility model；

Fig. 4 is a kind of structural schematic diagram of reading circuit provided by the embodiment of the utility model；

Fig. 5 is a kind of structural schematic diagram of driving unit provided by the embodiment of the utility model.

Specific embodiment

The utility model is described in further detail with reference to the accompanying drawings and examples.It is understood that herein Described specific embodiment is used only for explaining the utility model, rather than the restriction to the utility model.It further needs exist for It is bright, part relevant to the utility model is illustrated only for ease of description, in attached drawing rather than entire infrastructure.

Fig. 1 is a kind of cross-sectional view of miniature LED probe provided by the embodiment of the utility model, and Fig. 2 is that the utility model is real A kind of top view of miniature LED probe of example offer is applied, the present embodiment is applicable to not observe human body progress when dissected intuitively The scene of cellular activity situation.As depicted in figs. 1 and 2, which includes probe 100 and connect with probe 100 Interconnecting piece 200.Probe 100 includes active panel 110, driving circuit 120, Minitype LED array 130 and single-photon avalanche two Pole pipe SPAD fluorescent probe 140；Driving circuit 120 is integrated in the first side 111 of active panel 110, including multiple is in battle array The driving unit 121 of arrangement is arranged, Minitype LED array 130 is located at side of the driving circuit 120 far from active panel 110, including more A miniature LED131 in matrix arrangement；Driving unit 121 and miniature LED131 are corresponded, and each driving unit 121 is used for The corresponding miniature LED131 of driving；SPAD fluorescent probe 140 is integrated in the second side 112 of active panel 110, including multiple is in The SPAD fluorescence detection element 141 of array arrangement, SPAD fluorescence detection element 141 and driving unit 121 correspond.

Specifically, the miniature LED in Minitype LED array 130 can arrange in matrix, including x row y column, share x × y Miniature LED131, wherein x and y is the arbitrary integer more than or equal to 1, and x and y can be equal or unequal.It is corresponding , driving circuit 120 may include x × y driving unit 121, each driving unit 121 respectively correspond one it is miniature LED131.Illustratively, as shown in Fig. 2, Minitype LED array 130 includes the miniature LED131 of 5 × 5 array arrangements, driving electricity Road 120 includes 5 × 5 driving units 121, each driving unit 121 respectively corresponds a miniature LED131, and each drives Moving cell 121 drives its corresponding miniature LED131 to shine.Fig. 2 is only the explanation to Minitype LED array 130 illustratively, Rather than limit, the line number and columns of Minitype LED array 130 are not limited to shown in Fig. 2.The structure of each driving unit 121 can It include a drive sub-circuits with identical, the corresponding miniature LED131 forward bias of driving unit 121 connects in drive sub-circuits Output end.When driving unit 121 control terminal 122 output control signal when drive sub-circuits are connected, driving unit 121 it is defeated Enter the luminous signal that 123 input of end keeps miniature LED131 luminous, then the output end of drive sub-circuits exports luminous signal, and shine letter Number voltage it is generally relatively high, therefore miniature LED131 forward bias is connect, miniature LED131 according to the current value of luminous signal into Row shines.Driving unit 121 is electrically connected with miniature LED131, illustratively, can realize Minitype LED array by pad 150 130 are electrically connected with driving unit 121 in driving circuit 120, and the drive sub-circuits in driving unit 121 are driven Corresponding miniature LED131 shines, it should be noted that the wavelength for the light that miniature LED is issued should be able to meet and make in human body cell The luminous wavelength requirement of fluorescent material.For example, the fluorescent material of cell is by wave-length coverage in 420mm-450mm inside cerebral tissue It shines after visible light stimulus in range, then the wave-length coverage for the visible light that miniature LED is issued in Minitype LED array 130 is 420mm-450mm.Multiple driving units 121 of driving circuit 120 can respectively drive multiple micro- in Minitype LED array 130 Type LED131, and corresponding miniature LED131 can be independently driven mutually, therefore can arbitrarily select Minitype LED array Any miniature LED131 shines in 130, and single or multiple minds may be implemented when stimulating the fluorescent material in brain nervous cell Stimulation through cell, and then the 3-D view effect of available nerve cell.In addition, driving circuit 120 can pass through complementation Metal-oxide semiconductor (MOS) (Complementary Metal Oxide Semiconductor, COMS) technique is integrated in active On panel 110, the highly integrated one chip effect of driving circuit 120 and Minitype LED array 130 is realized.In the present embodiment, The integrated of miniature LED probe is carried out using active panel 110, Minitype LED array 130 can be controlled by active matrix driving mode It shines, 130 continuous illumination of Minitype LED array can be made, so as to realize holding to the fluorescent material in brain nervous cell Continuous stimulation, realizes and continues to monitor to nerve cell activity.

In the processing procedure of miniature LED131, electrode can be removed LED gusts miniature by laser lift-off technique after manufacturing The substrate of column 130, illustratively, substrate can be Sapphire Substrate.The strip operation of above-mentioned substrate to work as Minitype LED array After miniature LED131 in 130 shines, the light that miniature LED131 is issued can be emitted directly toward cerebral tissue and avoid LED gusts miniature Absorption of the substrate of column 130 to light, enables light source to be deep into inside cerebral tissue, to realize to glimmering inside cerebral tissue The stimulation of stimulative substance makes fluorescent material shine.Wherein, the fluorescent material inside cerebral tissue can be has in itself into the cell , it is also possible to artificially be put into cell.

As shown in Figure 1, first side 111 is parallel with second side 112 opposite, single-photon avalanche diode (Single Photon Avalanche Diode, SPAD) it also may include x × y SPAD fluorescence detection element 141 in fluorescent probe, Light emitting diode in each SPAD fluorescence detection element 141 carries out luminous under the active matrix driving of active panel 110, works as SPAD When the wavelength of the optical signal of wavelength and the fluorescent material transmitting for the light that fluorescence detection element 141 issues matches, SPAD fluorescence is visited The optical signal that element 141 emits fluorescent material is surveyed to receive and store.SPAD fluorescence detection element 141 and driving unit 121 correspond, and the arrangement of SPAD fluorescence detection element 141 can be identical with the arrangement of Minitype LED array 131, can also not Together.Illustratively, as shown in Fig. 2, the miniature LED131 in Minitype LED array 130 is arranged with 5 × 5 matrixes, SPAD fluorescence detection Element 141 is equally with the arrangement of 5 × 5 matrixes, the arrangement and the arrangement phase of Minitype LED array 131 of SPAD fluorescence detection element 141 Together, and SPAD fluorescence detection element 141 and miniature LED131 along the first side 111 of active panel 110 vertical direction pair Together.Specifically, the corresponding driving unit 121 of SPAD fluorescence detection element 141 can share it is same on active panel 110 Ground terminal.

When the driving unit 121 in driving circuit 120 drives corresponding miniature LED131 to shine, nerve is thin in stimulation brain After fluorescent material in born of the same parents shines, the SPAD fluorescence detection element 141 in SPAD fluorescent probe 140 is in active panel 110 It shines under active matrix driving, the wavelength of wavelength and the optical signal of the transmitting of the fluorescent material in brain nervous cell matches, and makes SPAD fluorescent probe 140 receives the optical signal of the fluorescent material transmitting in brain nervous cell, and fluorescent material is emitted Optical signal is converted to electric signal and is stored, the equipment for being sent to big external brain by the interconnecting piece 200 connecting with probe 100 In, to form image in the device, reflect the activity situation of nerve cell.Driving circuit 120 and SPAD fluorescence detection Device 140 is to drive miniature LED131 and SPAD fluorescence detection element 141 luminous therefore miniature by way of active matrix driving LED array can stimulate the fluorescent material continuous illumination in nerve cell with continuous illumination, and SPAD fluorescent probe 140 persistently connects The optical signal of nerve cell transmitting is received, and is sent to external equipment and forms image, to realize the work for continuing to monitor nerve cell It is dynamic.

Probe 100 is connect by interconnecting piece 200 with external equipment, and therefore, interconnecting piece 200 is including probe 100 and outside The connecting pin 121 of portion's power supply connection can be that the driving circuit 120 and SPAD fluorescent probe 140 on probe 100 persistently mention Power supply source.In addition, SPAD fluorescent probe 140 is passed by the electric signal that interconnecting piece 200 stores SPAD fluorescence detection element 141 External equipment is transported to, therefore, interconnecting piece 200 further includes the connecting pin 121 for transmitting signal.In conclusion interconnecting piece 200 includes more A connecting pin 121 is connect for probe 100 with external equipment.

Illustratively, miniature LED probe provided by the utility model can be used in transgenic mouse being tested, and utilize light Genetics technology makes miniature LED probe as fluorescent material, and by light genetics technology in the ChR2 that transgenic mouse is expressed It is inserted into transgenic mouse cerebral tissue, stimulation is irradiated to the ChR2 fluorescent material of specific cells in selected brain area domain, When Minitype LED array 130 reaches the excitation wavelength of fluorescent material ChR2 by the light that active matrix driving mode issues, ChR2 fluorescence Substance will be excited luminous, and the wavelength of the light that SPAD fluorescent probe 140 is issued by active matrix driving mode at this time is corresponding ChR2 fluorescent material be excited sending light wavelength, SPAD fluorescent probe 140 receive ChR2 fluorescent material transmitting light letter Number, and the optical signal that ChR2 fluorescent material emits is converted into electric signal and is stored, pass through the connection connecting with probe 100 Portion 200 is sent in the equipment of big external brain, to form image, in a device so as to observe the moving type of nerve cell Condition.Because driving circuit 120 and SPAD fluorescent probe 140 are to drive miniature LED131 and SPAD by way of active matrix driving Fluorescence detection element 141 shines, therefore Minitype LED array can be with continuous illumination, so as to stimulate ChR2 fluorescent material to continue It shines, SPAD fluorescent probe 140 persistently receives the optical signal of ChR2 fluorescent material transmitting, and is sent to external equipment formation figure Picture, to realize the activity for continuing to monitor nerve cell.Minitype LED array 130 is shone by the independent domination control of driving unit 121 Effect, therefore may be implemented to stimulate single or multiple nerve cell activities, realize the 3-D view effect of nerve cell.

It should be noted that interconnecting piece 200 respectively with driving circuit 120, the SPAD fluorescent probe on probe 100 140 and external equipment electrical connection, it may be implemented to the supply of the power supply of driving circuit 120 and SPAD fluorescent probe 140, simultaneously The electric signal that can receive the transmission of SPAD fluorescent probe 140, forms image in external equipment, observes big intracerebral nerve cell Activity situation.

The technical solution of the present embodiment, by be arranged in probe active panel, driving circuit, Minitype LED array and SPAD fluorescent probe makes Minitype LED array issue the fluorescent material in visible light stimulus brain nervous cell and shines, and SPAD is glimmering Optical detector receives the light that fluorescent material issues and the conversion for carrying out photosignal, and the optical signal that fluorescent material issues is converted into Electric signal is transmitted in external equipment and performs image display, so that the direct stimulation and monitoring to nerve cell are realized, not It can be by the activity situation real time imagery of nerve cell in the case where dissecting human body.On the other hand, driving circuit and SPAD fluorescent probe is all made of the mode of active matrix driving, therefore Minitype LED array shines, stimulation fluorescent material shines and SPAD Fluorescent probe receives the sustainable progress of three processes of the optical signal of fluorescent material transmitting, to realize to nerve cell It is movable to continue to monitor.Further, since each miniature LED is by corresponding to driving unit independent control illumination effect, therefore can be real Now to the stimulation of single or multiple nerve cells, and then obtain the 3-D view effect of nerve cell.

Optionally, on the basis of the various embodiments described above, miniature LED probe includes substrate, substrate include the first sub-portion and Second sub-portion, the first sub-portion are the substrate of active panel, and the second sub-portion is the substrate of interconnecting piece；Substrate material is chosen as flexible material Material.

Specifically, substrate includes the first sub-portion as the substrate of active panel 110 and the substrate as interconnecting piece 200 Second sub-portion.As shown in Fig. 2, active panel 110 should be including the cabling in the first sub-portion and the first sub-portion of substrate (in figure not It shows).Interconnecting piece 200 includes the second sub-portion of the connecting pin 201 and substrate drawn by the connecting line of probe 100.It is exemplary Ground, the second sub-portion of substrate can be the extension of the first sub-portion.Connecting pin 201 and the lead-out wire being connect with connecting pin 201 printing In the second sub-portion of substrate, fixed connection end 201 and the lead-out wire connecting with connecting pin 201, probe 100 pass through connecting pin 201 are electrically connected with external equipment realization.The probe 100 and interconnecting piece 200 of miniature LED probe share a substrate, Ke Yijian Change structure.

In addition, substrate material can use flexible material, miniature LED probe is made to reduce the traction applied to cerebral tissue Power increases biocompatibility and affinity, human body rejection is reduced, to increase the use scope of miniature LED probe. Illustratively, the flexible material of active panel 110 be can be Parylene Parylene C.

Fig. 3 is a kind of structural schematic diagram of SPAD fluorescence detection element provided by the embodiment of the utility model, in above-mentioned skill On the basis of art scheme, SPAD fluorescence detection element may include SPAD, first resistor R1 and memory element C；First resistor R1 First end be electrically connected with the first voltage line VSS on active panel, the first pole a and SPAD of second end and memory element C Cathode electrical connection, the plus earth of the second pole b and SPAD of memory element C.

Specifically, SPAD is a kind of single-photon detectors, and the quantity of different photons can be converted into different electric signals. The anode of SPAD is electrically connected with first voltage line VSS, minus earth.Free current-carrying under the action of extra electric field, in SPAD Sub- electrons and holes can drift about under the action of electric field, respectively to two electrode movements of SPAD, be formed on external loop in this way Photoelectric current generates certain pressure drop, to detect optical signals.Under normal circumstances, the voltage of first voltage line VSS is relatively high, Make SPAD reverse breakdown, what the photoelectric current that SPAD is generated by optical signal can double is amplified, and applies SPAD weak The occasion of optical power.After SPAD fluorescence detection element receives the optical signal that fluorescent material issues, SPAD absorbs the energy of optical signal Amount converts optical signals into photoelectric current, forms electric signal, and will be in electric signal storage to memory element C.Further, it stores Electric signal in memory element can be transmitted to external equipment by the reading circuit being correspondingly arranged, which is formed in Interconnecting piece.Fig. 4 is a kind of structural schematic diagram of reading circuit provided by the embodiment of the utility model, reading circuit and SPAD fluorescence The both ends memory element C are electrically connected in detecting element, read the electric signal on memory element C.Reading circuit is read using column are parallel Mode accelerates the speed that reading circuit reads electric signal.

Illustratively, as shown in figure 3, memory element C can be first capacitor C1.First resistor R1 connects with SPAD, when When SPAD reverse breakdown, current rush, first resistor R1 can play the role of current limliting at this time, so that circuit is from damage.

It should be noted that the voltage value of first voltage line VSS is related with the brightness that SPAD shines, and SPAD luminous wave The long launch wavelength to shine with fluorescent material is related, therefore selects suitable voltage according to the launch wavelength of fluorescent material and SPAD Value.

On the basis of above-mentioned each embodiment, miniature LED probe can also include the first clad, first clad etc. Thickness coats region of the miniature LED probe in addition to miniature LED and SPAD.

Specifically, the first clad can be with integral coating probe and interconnecting piece.First clad is biocompatibility Material, makes miniature LED probe biocompatibility with higher and stronger affinity, and miniature LED probe can be in brain group The free floating of middle holding is knitted, so as to be monitored to cell specific in selected brain area domain, and do not will cause very Big injury.Illustratively, the material of the first clad is Parylene C.In addition, during miniature LED probe face, The SPAD in Minitype LED array and SPAD fluorescence detection element is needed to carry out luminous, therefore, the first clad coats miniature LED It needs except miniature LED and SPAD, to avoid blocking miniature LED and SPAD when probe to shine.

A kind of embodiment arranged side by side is that miniature LED probe may include the second clad and third with above-described embodiment Clad, the second clad uniform thickness coat region of the probe in addition to miniature LED and SPAD, third clad uniform thickness cladding Interconnecting piece.

Specifically, the material of the second clad and third clad is the material of biocompatibility, can it is identical can also With difference.The process for coating miniature LED probe can be divided into the progress of two steps, first be wrapped using the second clad to probe It covers, cladding process is consistent with the process of miniature LED probe is coated using the first clad, needs miniature LED and SPAD It is exposed outside, avoid blocking miniature LED and SPAD and shine；Then interconnecting piece is coated using third clad.

It should be noted that carrying out integral coating to miniature LED probe using the first clad, or using the second cladding Layer and third clad respectively coat probe and interconnecting piece, as long as the material of each clad is the material of biocompatibility Material, so that it may which, so that miniature LED probe biocompatibility with higher and stronger affinity, miniature LED probe can be big It keeps free in brain tissue to float, so as to be monitored to cell specific in selected brain area domain, and will not make At very big injury.

Fig. 5 is a kind of structural schematic diagram of driving unit provided by the embodiment of the utility model, and driving unit 121 includes the One transistor T1, second transistor T2 and the second capacitor C2；The grid of the first transistor T1 and the control terminal of driving unit 121 Ctrl electrical connection, the first pole of the first transistor T1 is electrically connected with the input terminal in of driving unit 121, and the of the first transistor T1 Two poles are electrically connected with the first pole of the grid of second transistor T2 and the second capacitor C2；The first pole of second transistor T2 and The second pole of two capacitor C2 is electrically connected with the second voltage line VDD on active panel, the second pole of second transistor T2 and driving The anode of the corresponding miniature LED of unit 121 is electrically connected；The minus earth of the corresponding miniature LED of driving unit 121.

When the control terminal ctrl of driving unit 121 control the first transistor T1 conducting, the first pole of the first transistor T1 The signal for receiving the input terminal in input of driving unit 121, is transmitted to the grid of second transistor T2.When driving unit 121 The signal of input terminal in input is the signal for keeping miniature LED luminous, then second transistor T2 conducting is controlled, to make second voltage The voltage-drop loading of line VDD is on the anode of miniature LED, and under normal circumstances, the voltage of second voltage line VDD is greater than zero, and miniature The minus earth of LED, therefore, when second transistor T2 conducting, miniature LED shines.

It should be noted that excitation wavelength and miniature LED of the voltage value of second voltage line VDD also according to fluorescent material Select suitable voltage value.

On the basis of the various embodiments described above, the size of miniature LED can be 5 μm.The thickness of probe can be 10 μm.

Specifically, the smaller integrated level of the size of miniature LED is higher.In the present embodiment, the size of miniature LED is 5 μm, Size and subcellular adjoining dimensions, therefore can integrate more miniature LED in the Minitype LED array of same size, thus Realize the high-resolution of miniature LED probe.In addition, the size of the SPAD being arranged in array in SPAD fluorescent probe can also be with It is 5 μm.Equally, the thickness of probe is thinner, and the biocompatibility and affinity of miniature LED probe are better.Selecting miniature LED Size and SPAD size after, the thickness of the first clad or the second clad and third clad is meeting miniature LED It is thin as far as possible after the biocompatibility and affinity of probe, illustratively, probe with a thickness of 10 μm, can take into account miniature The one-piece construction of LED probe and higher biocompatibility and affinity.

Note that above are only the preferred embodiment and institute's application technology principle of the utility model.Those skilled in the art's meeting Understand, the utility model is not limited to specific embodiment described here, is able to carry out for a person skilled in the art various bright Aobvious variation, readjustment and substitution is without departing from the protection scope of the utility model.Therefore, although passing through above embodiments The utility model is described in further detail, but the utility model is not limited only to above embodiments, is not departing from It can also include more other equivalent embodiments in the case that the utility model is conceived, and the scope of the utility model is by appended Scope of the claims determine.

Claims (11)

1. a kind of miniature LED probe, which is characterized in that including probe and the interconnecting piece being connect with the probe；

The probe includes active panel, driving circuit, Minitype LED array and single-photon avalanche diode SPAD fluorescence detection Device；The driving circuit is integrated in the first side of the active panel, described including multiple driving units being arranged in array Minitype LED array is located at side of the driving circuit far from the active panel, including multiple in the miniature of matrix arrangement LED；The driving unit and the miniature LED are corresponded, and each driving unit is described miniature for driving correspondence LED；

The SPAD fluorescent probe is integrated in the second side of the active panel, glimmering including multiple SPAD being arranged in array Optical detection device, the SPAD fluorescence detection element and the driving unit correspond.

2. miniature LED probe according to claim 1, which is characterized in that the SPAD fluorescence detection element include SPAD, First resistor and memory element；The first end of the first resistor is electrically connected with the first voltage line on the active panel, the Two ends are electrically connected with the cathode of the first pole of the memory element and the SPAD, the second pole of the memory element and institute State the plus earth of SPAD.

3. miniature LED probe according to claim 2, which is characterized in that the memory element is first capacitor.

4. miniature LED probe according to claim 2, which is characterized in that it further include the first clad, first cladding Layer uniform thickness coats region of the miniature LED probe in addition to the miniature LED and SPAD.

5. miniature LED probe according to claim 4, which is characterized in that the material of first clad is poly- to two Toluene Parylene C.

6. miniature LED probe according to claim 2, which is characterized in that further include the second clad and third cladding Layer, the second clad uniform thickness coat region of the probe in addition to the miniature LED and SPAD, and described the Three clad uniform thickness coat the interconnecting piece.

7. miniature LED probe according to claim 1, which is characterized in that the driving unit includes the first transistor, Two-transistor and the second capacitor；The grid of the first transistor is electrically connected with the control terminal of the driving unit, and described First pole of one transistor is electrically connected with the input terminal of the driving unit, the second pole of the first transistor and described second The electrical connection of first pole of the grid of transistor and the second capacitor；First pole of the second transistor and second capacitor Second pole is electrically connected with the second voltage line on the active panel, the second pole of the second transistor and the driving unit The anode of corresponding miniature LED is electrically connected；The minus earth of the corresponding miniature LED of the driving unit.

8. miniature LED probe according to claim 1, which is characterized in that the size of the miniature LED is 5 μm.

9. miniature LED probe according to claim 1, which is characterized in that the probe with a thickness of 10 μm.

10. miniature LED probe according to claim 1, which is characterized in that including substrate, the substrate includes the first son Portion and the second sub-portion, first sub-portion are the substrate of the active panel, and second sub-portion is the substrate of the interconnecting piece； The material of the substrate is flexible material.

11. miniature LED probe according to claim 10, which is characterized in that the flexible material is Parylene C.