CN208667715U - A kind of biochip hybridizing device - Google Patents
A kind of biochip hybridizing device Download PDFInfo
- Publication number
- CN208667715U CN208667715U CN201821246455.1U CN201821246455U CN208667715U CN 208667715 U CN208667715 U CN 208667715U CN 201821246455 U CN201821246455 U CN 201821246455U CN 208667715 U CN208667715 U CN 208667715U
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- Prior art keywords
- laminate
- hybridizing
- hybrid heater
- biochip
- neighbouring
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Abstract
The utility model provides a kind of biochip hybridizing device, including hybrid heater, the side wall of hybrid heater is equipped with fire door, rack is equipped in hybrid heater, rack includes two vertical plates, two vertical plates are oppositely arranged, several laminates are equipped at intervals between two vertical plates, laminate is horizontal positioned rectangular slab, the line at the center of neighbouring laminate is that the angle between an inclined straight line and the line and horizontal plane at the center of neighbouring laminate is 30 ° -60 °, the upper surface of laminate is placed with hybridizing box, the bottom of hybrid heater, which is equipped with, provides the humidification disk of the hybridization environment of constant humidity.Biochip hybridizing device described in the utility model facilitates pick-and-place hybridizing box, structure is simple, easy to operate by the way that stair-stepping rack is arranged.
Description
Technical field
The utility model belongs to biochip hybridization technical field, and in particular to a kind of biochip hybridizing device.
Background technique
Biochip concept refers to biomolecule (oligonucleotides, cDNA, polypeptide, antibody, antigen through distinct methods
Deng) it is bonded to the biomolecule dot matrix formed in the solid phase mediators such as silicon wafer, sheet glass, plastic sheet, gel, nylon membrane.In biology
During the detection test of chip, carrying out hybridization processing to biochip is indispensable process.When hybridization, by biology to be hybridized
Chip is placed into hybrid heater, is hybridized under certain temperature and humidity.
The Chinese patent of Publication No. CN205761217U discloses a kind of biochip hybridizing device, feature be include miscellaneous
Wet box and hybridizing box are handed over, hybridizing to be horizontally disposed in wet box there are multiple storing chambers for being used to put hybridizing box.
Although the hybrid device structure is simple, the generation of slide plate phenomenon can be effectively avoided, guarantees the success rate of hybridization,
The hybridizing box of the hybrid device is inserted in horizontal slot, and hybridizing box picks and places inconvenient.
Utility model content
In view of this, the utility model is directed to a kind of biochip hybridizing device, inconvenience is picked and placed to solve hybridizing box
The problem of.
In order to achieve the above objectives, the technical solution of the utility model is achieved in that
A kind of biochip hybridizing device, including hybrid heater, the side wall of hybrid heater are equipped with fire door, are equipped with and put in hybrid heater
Frame is set, rack includes two vertical plates, and two vertical plates are oppositely arranged, and is equipped at intervals with several laminates between two vertical plates, laminate is
Horizontal positioned rectangular slab, the line at the center of neighbouring laminate are an inclined straight line and neighbouring laminate
Angle between the line and horizontal plane at center is 30 ° -60 °, and the upper surface of laminate is placed with hybridizing box, and the bottom of hybrid heater is set
It is provided with the humidification disk of the hybridization environment of constant humidity.
Further, the projection of neighbouring laminate in the horizontal plane overlaps, two neighbouring laminates
The width of the lap projected in the horizontal plane is the 1/4-3/4 of the width of laminate.
Further, the equal length of the length of laminate and hybridizing box, the distance between neighbouring laminate with hybridize
The thickness of box is equal, and the marginal center of laminate is recessed inwardly to form arc notch.
Further, the center of the upper surface of humidification disk is recessed forms Storage water tank downwards, and water, humidification disk are filled in Storage water tank
Between two vertical plates and it is fixed on the bottom of hybrid heater.
Further, hybridizing box includes upper cover and bottom plate, and upper cover and bottom plate are equipped with 12 by connection axis connection, bottom plate
A chip slot offers 12 and the one-to-one well of chip slot on upper lid.
Further, aperture is gradually small funnel-shaped from top to bottom for well.
Further, the material of hybrid heater and the material of fire door are heat-barrier material.
Compared with the existing technology, biochip hybridizing device described in the utility model has the advantage that
(1) biochip hybridizing device described in the utility model facilitates pick-and-place miscellaneous by the way that stair-stepping rack is arranged
Box is handed over, structure is simple, easy to operate；
(2) biochip hybridizing device described in the utility model further facilitates pick-and-place to hybridize by arc notch
Box；
(3) biochip hybridizing device described in the utility model facilitates the fixation of chip to put by the hybridization slot of setting
It sets, by the upper cover and bottom plate of the rotatable folding of setting, facilitates the pick-and-place of chip.
Detailed description of the invention
The attached drawing for constituting a part of the utility model is used to provide a further understanding of the present invention, this is practical new
The illustrative embodiments and their description of type are not constituteed improper limits to the present invention for explaining the utility model.?
In attached drawing:
Fig. 1 is the structural schematic diagram of the hybrid heater of the biochip hybridizing device of the utility model embodiment；
Fig. 2 is the structural schematic diagram of the rack of the biochip hybridizing device of the utility model embodiment；
Fig. 3 is the structural schematic diagram of the laminate of the biochip hybridizing device of the utility model embodiment；
Fig. 4 is the cross-sectional view (hybridizing box is omitted) of the biochip hybridizing device of the utility model embodiment；
Fig. 5 is the structural schematic diagram of the hybridizing box of the biochip hybridizing device of the utility model embodiment.
Description of symbols:
1, hybrid heater；11, fire door；2, rack；21, vertical plate；22, laminate；221, arc notch；3, hybridizing box；31, on
Lid；311, well；32, bottom plate；321, chip slot；33, connecting shaft；4, humidification disk；41, Storage water tank.
Specific embodiment
It should be noted that in the absence of conflict, the feature in the embodiments of the present invention and embodiment can
To be combined with each other.
In the description of the present invention, it should be understood that term " center ", " longitudinal direction ", " transverse direction ", "upper", "lower",
The orientation or positional relationship of the instructions such as "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outside" is
It is based on the orientation or positional relationship shown in the drawings, is merely for convenience of describing the present invention and simplifying the description, rather than indicate
Or imply that signified device or element must have a particular orientation, be constructed and operated in a specific orientation, therefore cannot understand
For limitations of the present invention.In addition, term " first ", " second " etc. are used for description purposes only, and should not be understood as indicating
Or it implies relative importance or implicitly indicates the quantity of indicated technical characteristic." first ", " second " etc. are defined as a result,
Feature can explicitly or implicitly include one or more of the features.It is in the description of the present invention, unless another
It is described, the meaning of " plurality " is two or more.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " is pacified
Dress ", " connected ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or integrally
Connection；It can be mechanical connection, be also possible to be electrically connected；Can be directly connected, can also indirectly connected through an intermediary,
It can be the connection inside two elements.For the ordinary skill in the art, on being understood by concrete condition
State the concrete meaning of term in the present invention.
The utility model will be described in detail below with reference to the accompanying drawings and embodiments.
A kind of biochip hybridizing device, as shown in Figure 1, including the hybrid heater 1 of cuboid.Hybrid heater 1 is settable to be added
Hot temperature, the side wall of hybrid heater 1 is equipped with openable and closable fire door 11, and when fire door 11 is closed, the sky of sealing is formed in hybrid heater 1
Between.To reduce scattering and disappearing for heat, the material of hybrid heater 1 and the material of fire door 11 are heat-barrier material.It is equipped with and places in hybrid heater 1
Frame 2, as shown in Fig. 2, rack 2 includes two vertical plates 21, two vertical plates 21 are oppositely arranged.In conjunction with shown in Fig. 2 and Fig. 3, two
Several laminates 22 are equipped at intervals between vertical plate 21, laminate 22 is horizontal positioned rectangular slab.As shown in figure 4, neighbouring
The line at the center of laminate 22 is an inclined straight line and between the line and horizontal plane at the center of neighbouring laminate 22
Angle is 30 ° -60 °.
The upper surface of laminate 22 is placed with hybridizing box 3, as shown in figure 5, hybridizing box 3 includes upper cover 31 and bottom plate 32, upper cover
31 and bottom plate 32 be rotatablely connected by connecting shaft 33, bottom plate 32 is equipped with 12 chip slots 321, offers 12 in upper cover 31
A and one-to-one well 311 of chip slot 321.Aperture is gradually small funnel-shaped from top to bottom for well 311, guides sample flow
Onto chip.
The projection of neighbouring laminate 22 in the horizontal plane overlaps, so set, hybridizing box 3 is placed into laminate
When on 22, a part of the upper surface of hybridizing box 3 is exposed, and facilitates and picks and places hybridizing box 3.Specifically, neighbouring two
The width for the lap that laminate 22 projects in the horizontal plane is the 1/4-3/4 of the width of laminate 22.As shown in figure 4, laminate 22
Length and hybridizing box 3 equal length, the distance between neighbouring laminate 22 is equal with the thickness of hybridizing box 3.For into
One step, which facilitates, picks and places hybridizing box 3, and the marginal center of laminate 22 is recessed inwardly to form arc notch 221.
The bottom of hybrid heater 1 is equipped with humidification disk 4, and the center of the upper surface of humidification disk 4, which is recessed downwards, forms Storage water tank 41, contains
Water is filled in sink 41, under hybridization temperature, the water evaporation in Storage water tank 41 generates saturated humidity, to provide the hybridization ring of constant humidity
Border.Humidification disk 4 is located between two vertical plates 21 and is fixed on the bottom of hybrid heater 1.Humidifier progress can also be arranged in hybrid heater 1
Humidification.
Working principle of the utility model is:
When hybridization, chip is put into chip slot 321, covers upper cover 31, the hybridization solution containing hybridization ingredient is injected
To well 311, hybridization solution is flowed on chip.Hybridizing box 3 is placed on rack 2, rack 2 is placed into hybrid heater 1
Interior, the water evaporation in humidification disk 4 provides constant saturated humidity, shuts fire door 11, and the heating temperature of setting hybrid heater 1 is added
Heat after the temperature and humidity of the inner cavity of hybrid heater 1 reaches constant, after reaching setting value, starts to hybridize.
The above is only the preferred embodiment of the utility model only, is not intended to limit the utility model, all at this
Within the spirit and principle of utility model, any modification, equivalent replacement, improvement and so on should be included in the utility model
Protection scope within.
Claims (7)
1. a kind of biochip hybridizing device, it is characterised in that: including hybrid heater (1), the side wall of hybrid heater (1) is equipped with fire door
(11), rack (2) being equipped in hybrid heater (1), rack (2) includes two vertical plates (21), and two vertical plates (21) are oppositely arranged,
It is equipped at intervals with several laminates (22) between two vertical plates (21), laminate (22) is horizontal positioned rectangular slab, neighbouring
The line at the center of laminate (22) be the center of an inclined straight line and neighbouring laminate (22) line and horizontal plane it
Between angle be 30 ° -60 °, the upper surface of laminate (22) is placed with hybridizing box (3), and the bottom of hybrid heater (1), which is equipped with, provides constant humidity
Hybridization environment humidification disk (4).
2. biochip hybridizing device according to claim 1, it is characterised in that: neighbouring laminate (22) is in level
Projection on face overlaps, and the width for the lap that two neighbouring laminates (22) project in the horizontal plane is layer
The 1/4-3/4 of the width of plate (22).
3. biochip hybridizing device according to claim 1 or 2, it is characterised in that: the length of laminate (22) with hybridize
The equal length of box (3), the distance between neighbouring laminate (22) is equal with the thickness of hybridizing box (3), laminate (22)
Marginal center is recessed inwardly to form arc notch (221).
4. biochip hybridizing device according to claim 1 or 2, it is characterised in that: in the upper surface of humidification disk (4)
The heart, which is recessed downwards, to be formed Storage water tank (41), and water is filled in Storage water tank (41), and humidification disk (4) is located between two vertical plates (21) and solid
Due to the bottom of hybrid heater (1).
5. biochip hybridizing device according to claim 1 or 2, it is characterised in that: hybridizing box (3) includes upper cover (31)
With bottom plate (32), upper cover (31) and bottom plate (32) are connected by connecting shaft (33), and bottom plate (32) is equipped with 12 chip slots
(321), 12 and chip slot (321) one-to-one well (311) are offered in upper cover (31).
6. biochip hybridizing device according to claim 5, it is characterised in that: well (311) aperture from top to bottom
It is gradually small funnel-shaped.
7. biochip hybridizing device according to claim 1, it is characterised in that: the material and fire door of hybrid heater (1)
(11) material is heat-barrier material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821246455.1U CN208667715U (en) | 2018-08-03 | 2018-08-03 | A kind of biochip hybridizing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821246455.1U CN208667715U (en) | 2018-08-03 | 2018-08-03 | A kind of biochip hybridizing device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208667715U true CN208667715U (en) | 2019-03-29 |
Family
ID=65833230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821246455.1U Expired - Fee Related CN208667715U (en) | 2018-08-03 | 2018-08-03 | A kind of biochip hybridizing device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN208667715U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112158474A (en) * | 2020-10-27 | 2021-01-01 | 中国医学科学院北京协和医院 | Large-capacity flat slide glass box |
-
2018
- 2018-08-03 CN CN201821246455.1U patent/CN208667715U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112158474A (en) * | 2020-10-27 | 2021-01-01 | 中国医学科学院北京协和医院 | Large-capacity flat slide glass box |
| CN112158474B (en) * | 2020-10-27 | 2022-05-13 | 中国医学科学院北京协和医院 | Large-capacity flat slide glass box |
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20190329 Termination date: 20200803 |
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| CF01 | Termination of patent right due to non-payment of annual fee |