CN208627331U - A kind of magnetic bead liquid memory structure - Google Patents
A kind of magnetic bead liquid memory structure Download PDFInfo
- Publication number
- CN208627331U CN208627331U CN201821093159.2U CN201821093159U CN208627331U CN 208627331 U CN208627331 U CN 208627331U CN 201821093159 U CN201821093159 U CN 201821093159U CN 208627331 U CN208627331 U CN 208627331U
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- China
- Prior art keywords
- magnetic bead
- connecting pipe
- memory structure
- bead liquid
- liquid memory
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Abstract
The utility model discloses a kind of magnetic bead liquid memory structures.The magnetic bead liquid memory structure includes the reagent chamber for storing magnetic bead liquid；The bottom of the reagent chamber is pyramidal structure, is that the magnetic bead with opening accumulates area at the cone end of pyramidal structure, which is connected to connecting pipe；It is equipped with micro-valve in the connecting pipe, one section of air column being located between opening and micro-valve is being equipped in connecting pipe.The memory structure of the utility model makes magnetic bead natural sediment in some positions, (does not rock) the inflow designated position that magnetic bead is more as far as possible under pressure.
Description
Technical field
The utility model relates to a kind of magnetic bead liquid memory structures, belong to micro-fluidic chip field.
Background technique
Immunomagnetic beads ((ImpetiCbead, IMB abbreviation magnetic bead)), are a new immunologys developed in recent years
Technology, the high degree of specificity of the peculiar advantage of solidified reagents and immunological response is incorporated into one by it, based on immunology,
The every field such as pathology, physiology, pharmacology, microorganism, biochemistry and molecular genetics are penetrated into, in immune detection, cell point
It is more and more widely used from, biological macromolecule purifying and molecular biology etc..
Prior art magnetic bead liquid using when need to be an externally injected into, magnetic bead liquid is stored in round or rectangular flat reagent bottle
Interior, bottom of bottle can be deposited to by being long placed in rear magnetic bead, and a certain amount of injection is absorbed after shaking up before use.Magnetic bead liquid is stored in meeting when in flat bottle
For natural subsidence in entire bottom of bottle, storage bottle can make magnetic bead exposure when being placed upside down in air.
Utility model content
The utility model is intended to provide a kind of magnetic bead liquid memory structure, which makes magnetic bead natural sediment in a point
It sets, (does not rock) the inflow designated position that magnetic bead is more as far as possible under pressure.
To achieve the goals above, the technical scheme adopted by the utility model is
A kind of magnetic bead liquid memory structure, including the reagent chamber for storing magnetic bead liquid；It is structurally characterized in that, the reagent chamber
Bottom be pyramidal structure, be that the magnetic bead with opening accumulates area at the cone end of pyramidal structure, the opening and connecting pipe connect
It is logical；It is equipped with micro-valve in the connecting pipe, one section of air column being located between opening and micro-valve is being equipped in connecting pipe.
Magnetic bead liquid is previously implanted in chip as a result, is subsequently deposited upon reagent bottle cone end magnetic bead and is accumulated area (storage area), this
The inflow commitment positions that sample is convenient for magnetic bead more as far as possible in magnetic bead liquid use process.
Embodiment according to the present utility model can also make further optimization to the utility model, and the following are after optimization
The technical solution of formation:
Preferably, the top open part of the reagent bottle is equipped with plunger, and on the one hand plunger plays sealing process, on the other hand
When needing magnetic bead being sent into commitment positions, depresses plunger be can be realized.In order to guarantee reagent bottle, magnetic bead is not in reversing the process
In air, the distance between the plunger and reagent chamber top liquid level are 1mm-3mm for exposure.
In order to avoid magnetic bead because self weight is fallen into connecting pipe as far as possible, axial line and the cone end of the connecting pipe
The central axis of opening.
Preferably, the length of the air column is greater than 5mm.
Preferably, the caliber of the connecting pipe is 10 um -1000um.It is highly preferred that the caliber of the connecting pipe
For 100 um -300um.
In order to thoroughly avoid magnetic bead exposure in air, the connecting pipe is full of in one section of the opening at cone end
Liquid.
Micro-valve described in the utility model is the key that microfluidic system execution unit, is flowed to fluid in chip channel
The device of control metering function is played, effect is the open and close for realizing fluid channel and the switching of fluid flow direction.
Preferably, the reagent chamber and connecting pipe are provided in biochip substrate.
Compared with prior art, the utility model has the beneficial effects that
1, magnetic bead natural sediment is conducive to magnetic bead indentation more as far as possible and refers in a bit (reagent bottle cone end magnetic bead accumulates area)
Positioning is set.
2, by setting plunger, the magnetic bead in reagent bottle reverses the process may be implemented and be not exposed in air.
Detailed description of the invention
Fig. 1 is the structure principle chart of the utility model one embodiment；
Fig. 2 is the left view of Fig. 1；
Fig. 3 is the top view (being stored with magnetic bead) of reagent chamber in Fig. 1.
Specific embodiment
The utility model is described in detail below with reference to attached drawing and in conjunction with the embodiments.It should be noted that not conflicting
In the case where, the feature in the embodiments of the present invention and embodiment can be combined with each other.For sake of convenience, hereinafter such as
There is "upper", "lower", "left", "right" printed words, only indicates consistent with the upper and lower, left and right direction of attached drawing itself, not to structure
Play restriction effect.
A kind of magnetic bead liquid memory structure, for being previously implanted the preservation of chip magnetic bead solution, the memory structure includes using
In the reagent chamber 1 of magnetic bead liquid, reagent chamber 1 is provided with magnetic bead liquid 5.The bottom of the reagent chamber 1 is pyramidal structure, in pyramidal structure
Cone end be the magnetic bead with opening accumulate area, which is connected to connecting pipe 2, the axial line of the connecting pipe 2 and
The central axis of the opening at cone end.
It is equipped with micro-valve 3 in the connecting pipe 2, one section of sky being located between opening and micro-valve 3 is being equipped in connecting pipe 2
Air column 7.The length of the air column 7 is greater than 5mm.
In order to guarantee that reagent bottle magnetic bead 4 in reversing the process is not exposed in air, the top open part of the reagent bottle 1
Equipped with plunger 6.The distance between the plunger 6 and reagent chamber top liquid level are 0mm-3mm.The connecting pipe 2 is close to cone
It is hydraulically full in one section of the opening at end.
The caliber of the connecting pipe 2 is that can choose within the scope of 10-1000 um, preferably 100 um -300um,
Guarantee that air column can be formed.
The lower end of the reagent chamber of magnetic bead liquid storage is the conical structure at tip.When needing to store, by aequum magnetic bead liquid
It being added in reagent chamber, the upper end of reagent chamber is sealed with rubber plunger, and the lower end of reagent chamber is connected to by connecting pipe with micro-valve, and
One section of air column is equipped in connecting pipe, so that magnetic bead liquid and micro-valve be completely cut off by air column.
In this way, 4 natural sediment of magnetic bead is at memory structure tip, after micro-valve variation is got through, by depresses plunger to
Magnetic bead 4 is pressed into designated position.
In addition, plunger is mounted in reagent chamber upper end, it can guarantee the gap very little of magnetic bead liquid 5 Yu plunger, generally 0- in this way
3mm, therefore, biochip is during reverse rock, the activity space very little of magnetic bead liquid 5, thus magnetic bead can be in liquid always
Body is not exposed in air in impregnating.
The storage organization of the utility model make magnetic bead liquid during storage magnetic bead natural sediment in a bit, storage device
It will not make the exposure of magnetic bead 4 in reversing the process in air, and be conducive to magnetic bead indentation more as far as possible both in the case where not shaking up
Positioning is set.
The content that above-described embodiment illustrates should be understood as that these embodiments are only used for being illustrated more clearly that the utility model,
Rather than limitation the scope of the utility model, after having read the utility model, those skilled in the art are practical new to this
The modification of the various equivalent forms of type each falls within the application range as defined in the appended claims.
Claims (9)
1. a kind of magnetic bead liquid memory structure, including the reagent chamber (1) for storing magnetic bead liquid；It is characterized in that, the reagent chamber
(1) bottom is pyramidal structure, is that the magnetic bead with opening accumulates area at the cone end of pyramidal structure, the opening and connecting pipe
(2) it is connected to；Micro-valve (3) are equipped in the connecting pipe (2), one section is equipped in connecting pipe (2) and is located at opening and micro-valve (3)
Between air column (7).
2. magnetic bead liquid memory structure according to claim 1, which is characterized in that the top open part of the reagent chamber (1)
Equipped with plunger (6).
3. magnetic bead liquid memory structure according to claim 2, which is characterized in that liquid at the top of the plunger (6) and reagent chamber
The distance between face is 0mm-3mm.
4. magnetic bead liquid memory structure according to claim 1, which is characterized in that the axial line of the connecting pipe (2) with
The central axis of the opening at cone end.
5. magnetic bead liquid memory structure described in any one of -4 according to claim 1, which is characterized in that the air column (7)
Length is greater than 5mm.
6. magnetic bead liquid memory structure described in any one of -4 according to claim 1, which is characterized in that the connecting pipe (2)
Caliber be 10 um -1000um.
7. magnetic bead liquid memory structure according to claim 6, which is characterized in that the caliber of the connecting pipe (2) is 100
um -300um。
8. magnetic bead liquid memory structure described in any one of -4 according to claim 1, which is characterized in that the connecting pipe (2)
It is hydraulically full in one section of the opening at cone end.
9. magnetic bead liquid memory structure described in any one of -4 according to claim 1, which is characterized in that the reagent chamber (1) and
Connecting pipe (2) is provided in biochip substrate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821093159.2U CN208627331U (en) | 2018-07-11 | 2018-07-11 | A kind of magnetic bead liquid memory structure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821093159.2U CN208627331U (en) | 2018-07-11 | 2018-07-11 | A kind of magnetic bead liquid memory structure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208627331U true CN208627331U (en) | 2019-03-22 |
Family
ID=65736800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821093159.2U Active CN208627331U (en) | 2018-07-11 | 2018-07-11 | A kind of magnetic bead liquid memory structure |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN208627331U (en) |
-
2018
- 2018-07-11 CN CN201821093159.2U patent/CN208627331U/en active Active
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