CN208568804U - A kind of full-automatic protein chip and its detection system - Google Patents
A kind of full-automatic protein chip and its detection system Download PDFInfo
- Publication number
- CN208568804U CN208568804U CN201821138657.4U CN201821138657U CN208568804U CN 208568804 U CN208568804 U CN 208568804U CN 201821138657 U CN201821138657 U CN 201821138657U CN 208568804 U CN208568804 U CN 208568804U
- Authority
- CN
- China
- Prior art keywords
- tooth shape
- upper cover
- lower cover
- full
- protein chip
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The application belongs to the technical field of medical diagnosis on disease, more particularly to full-automatic protein chip and its detection system.Full-automatic protein chip provided by the present application, comprising: tooth shape upper cover, tooth shape lower cover lead fuse, welding groove, front and back sides mark mouth and reaction film；The bottom of tooth shape upper cover and tooth shape lower cover is jagged, and reaction film is fixed in the notch of the bottom of the tooth shape upper cover and tooth shape lower cover；It is covered with welding groove under tooth shape, fuse is led in the setting of tooth shape upper cover, so that it is described when leading fuse dissolution, progress welding contact with welding groove；The top of tooth shape upper cover and the tooth shape lower cover is equipped with front and back sides mark mouth, and when tooth shape upper cover and tooth shape lower cover welding, the front and back sides mark mouth of the tooth shape upper cover and the tooth shape lower cover is mutually aligned；Wherein, the fuse of leading is bulge-structure.This application, which solves, can effectively solve the technological deficiency technological deficiency that current protein chip is not used to full-automatic machine.
Description
Technical field
The application belongs to the technical field more particularly to a kind of full-automatic protein chip and its detection system of medical diagnosis on disease.
Background technique
If many malignant diseases such as tumour, pernicious infectious disease etc. can be greatly increased not as good as early diagnosis, the death rate, consequence
It is hardly imaginable.Existing methods for the diagnosis of diseases includes chemical diagnosis method and physical diagnostic method.Since physical method cannot be right
Early stage disease makes diagnosis, and needs a large amount of instrument, equipment and necessarily required environment, somewhat expensive, therefore multiple purpose
The disease related protein of method detection patient's body or the changes of contents of small-molecule substance diagnose the illness.
But the chemical method of disease is detected at present, such as ELISA, labelled with radioisotope, Jin Biao, fluorescence, chemistry hair
Light, time-resolved fluorescence etc. are single index detection mostly, and amount of confidence is few, and all has limitation, as markers step is complicated,
Instrument and expensive reagents, cumbersome, sensitivity is low, easy to pollute etc..Since protein chip technology can overcome the disadvantages that chemical detection method
Limitation, so, protein chip technology is a kind of emerging technology of multi objective parallel detection developed in recent years, is had
The characteristics of high throughput, high information quantity, is with a wide range of applications in scientific research and clinical diagnosis field.But due to technically,
Factor in cost limits its practical application, especially obtains due popularization not yet in clinical diagnosis field.Currently,
Low cost, without complex and expensive equipment, it is sensitive and accurate, can make rapidly a multivariate detection, it is easy to operate be suitable for quick bedside
The low-density protein chip of detection (POCT) is an important research and development direction in protein chip field.
In the past 20 years, using lateral flow immunochromatography technology, percolation, spotting method as representative, development & production is supervised for disease
It surveys and the immunologic function test reagent of diagnosis has been widely used for fast bed frontier inspection and surveys (POCT), with enzyme colour developing, colloidal gold, colloid
Selenium, fluorescent microsphere, chemiluminescence, the development of quantum dot and other more sensitive labelling techniques, field of fast detection labelling technique
Diversified trend is presented；Mature application due to these technologies and its advantage and practicability in the application of quick context of detection,
They are similarly applied to the research and development of protein chip.
Currently, this type is applied in order to avoid based on epidemic disease chromatographic technique, percolation, spot law technology with POCT as target
Protein chip product has had greater advance in technology and using upper, but traditional glass slide, silicon wafer etc. is used as chip slapper
The protein chip of base type is there are complicated for operation, and the reaction film on this protein chip is only simply secured to protein chip
On, cause this reaction film that can only just set mostly and is reacted in chip chip base with sample；And this protein chip structure
With design there are sizable limitation, full-automatic machine is difficult to that this protein chip is grabbed and shifted, and causes to work as
Preceding many protein chips are not available in full-automatic machine.
Therefore, in conclusion research and develop it is a kind of can use in full-automatic machine, and low-cost protein chip is ability
Field technique personnel technical problem urgently to be resolved.
Apply for content
In view of this, can effectively solve current egg this application provides a kind of full-automatic protein chip and its detection system
White chip is not used to the technological deficiency of full-automatic machine.
This application provides a kind of full-automatic protein chips, comprising: tooth shape upper cover, leads fuse, welding at tooth shape lower cover
Groove, front and back sides mark recess and reaction film；
The bottom of the tooth shape upper cover and the tooth shape lower cover is jagged, and the reaction film is fixed on the tooth
In the notch of the bottom of shape upper cover and the tooth shape lower cover；
The edge of the notch of the tooth shape lower cover is equipped with welding groove, and the edge of the notch of the tooth shape upper cover is arranged
Lead fuse, it is described when leading fuse dissolution, welding is carried out with the welding groove, so that the reaction film is fixed on the tooth shape
Between upper cover and the notch of the tooth shape lower cover；
The top of the tooth shape upper cover and the tooth shape lower cover is equipped with front and back sides mark recess, when the tooth shape
When upper cover and the tooth shape lower cover welding, the front and back sides mark recess of the tooth shape upper cover and the tooth shape lower cover is mutual
Alignment, the front and back sides mark recess are used to distinguish the front and back sides of the reaction film；
Wherein, the fuse of leading is bulge-structure.
Further, the bulge-structure is the bulge-structure of triangle.
Wherein, the tooth shape upper cover, the front and back sides mark recess for leading fuse and the tooth shape upper cover are integrated
Molding is prepared；The front and back sides mark recess of the tooth shape lower cover, the welding groove and the tooth shape lower cover is one
It is body formed to be prepared.
Preferably, the reaction film is fixed at least one antibody or antigen.
Preferably, described when the tooth shape upper cover and the tooth shape lower cover are melted according to ultrasonic fusing technology
It connects.
Preferably, the full-automatic protein chip further includes limit hole and retention bead；
The retention bead is arranged in the tooth shape lower cover, and the limit hole is arranged in the tooth shape upper cover, so that described
The retention bead of tooth shape lower cover is placed in the limit hole of the tooth shape upper cover and is limited.
Wherein, the tooth shape lower cover is prepared with retention bead integrated molding.
Preferably, the tooth shape upper cover, the tooth shape lower cover, the fuse and the welding groove of leading are heat
Thermoplastic plastic is prepared.
Further, the full-automatic protein chip of the application uses ultrasonic bonding machine by the tooth shape upper cover and the tooth
Dentation lower cover rapid fusion is together.
Further, the time is set as stopping ultrasound at once when chip cavity face above has just touched chip.Vibration and
Heat namely leads the instantaneous high-temperature in fuse encircled.It will not pass on chip.Absorb ultrasonic energy to be that this is led molten
Line, time are set as chip above and touch chip to be to stop at once.Heat namely leads the instantaneous high-temperature above fuse.
Disclosed herein as well is a kind of full-automatic protein chip detection systems, comprising: full-automatic protein chip and reaction cup；
The reaction cup includes cup body；
The full-automatic protein chip is socketed in inside the cup body of the reaction cup.
Preferably, the two sides of the tooth shape upper cover are additionally provided with position-limited edge；The two sides of the tooth shape lower cover are additionally provided with
Position-limited edge, so that the position-limited edge of the position-limited edge of the tooth shape upper cover and the tooth shape lower cover is mutually aligned；
The reaction cup further includes limiting groove, and the limiting groove is arranged in the opening of the cup body of the reaction cup,
It is limited so that the position-limited edge of the two sides of the tooth shape lower cover and tooth shape upper cover is placed in the limiting groove.
Wherein, the position-limited edge of the position-limited edge of the tooth shape upper cover and the tooth shape lower cover be integrally formed preparation and
At；The limiting groove and the cup body of the reaction cup are integrally formed and are prepared.
Preferably, the reaction film of full-automatic protein chip is fixed at least one antibody or antigen.
Present invention also provides a kind of applications of full-automatic protein chip detection system, comprising the following steps:
S101: sample to be tested or sample to be tested and dilution are added in reaction cup；
S102: full-automatic protein chip is placed in the reaction cup of S101 and occur Ag-Ab specific binding；
S103: it specifically binds in Ag-Ab after reaction, by the way that full-automatic protein chip is washed and used
After the secondary antibody of enzyme label is incubated for, testing result reading is carried out by detection readout instrument.
Preferably, the reaction film of the full-automatic protein chip is fixed at least one antibody or antigen
Further, the fixed antibody of the reaction film or antigen are fixed for matrix arrangement.
Further, the fixed antibody of the reaction film or antigen are the antibody or antigen of qualitative detection or/and quantitative inspection
The antibody or antigen of survey.Antibody is monoclonal antibody, and the antibody-solutions of certain volume are fixed on film using film mode.
Wherein, it should be noted that when tooth shape upper cover and tooth shape lower cover carry out welding, tooth shape upper cover and tooth shape
The front and back sides mark recess of lower cover is mutually aligned；The retention bead of tooth shape lower cover and the limit hole of tooth shape upper cover are mutually right
Together, the retention bead of tooth shape lower cover is placed in the limit hole of tooth shape upper cover and is limited；On tooth shape lower cover and tooth shape
The position-limited edge of the two sides of lid is mutually aligned, and the position-limited edge of the two sides of tooth shape lower cover and tooth shape upper cover is placed in limiting groove progress
Limit.
This application provides a kind of full-automatic protein chips, comprising: tooth shape upper cover, leads fuse, welding at tooth shape lower cover
Groove, front and back sides mark recess and reaction film；The bottom of tooth shape upper cover and tooth shape lower cover is jagged, and reaction film is fixed on
In the notch of the bottom of tooth shape upper cover and tooth shape lower cover；The edge of the notch of tooth shape lower cover is equipped with welding groove, tooth
Fuse is led in the edge setting of the notch of shape upper cover, when leading fuse dissolution, welding is carried out with welding groove, so that reaction film is fixed on
Between tooth shape upper cover and the notch of tooth shape lower cover.Leading fuse is that protrusion knot is formed on the edge of the notch of tooth shape upper cover
Structure, the basic role for leading fuse is focused energy (absorbing ultrasonic energy), makes it possible to the temperature for reaching melting as early as possible, and will not
High temperature is passed on chip, to obtain better welding effect, therefore reaction film be rigidly mounted tooth shape upper cover and
In the notch of the bottom of tooth shape lower cover, enable the application protein chip reaction film suspension type carried out with sample it is anti-
It answers, and applies not easy to fall off in full-automatic machine；The top of tooth shape upper cover and tooth shape lower cover is equipped with front and back sides
Recess is identified, when tooth shape upper cover and tooth shape lower cover welding, the front and back sides mark of tooth shape upper cover and tooth shape lower cover is recessed
Mouth is mutually aligned, and front and back sides mark recess is used to distinguish the front and back sides of reaction film, can guarantee the accurate of the data analysis of reaction film
Property.The structure of this full-automatic protein chip is tooth shape, reaction film is fixed in the notch of detiform bottom, full-automatic
The top that machine grabs full-automatic protein chip can suspend reaction film in midair, on the one hand can facilitate full-automatic machine crawl simultaneously
This protein chip is shifted, reaction film on the other hand will not be contacted or destroy, it is convenient that the protein chip of the application grabs, structure letter
It is single, this full-automatic protein chip need to be only moved in sample solution by full-automatic machine, it is anti-that reacting antigen-can be carried out
Precursor reactant, it is easy to operate, meanwhile, this full-automatic protein chip preparation is simple, low in cost.
Detailed description of the invention
In order to illustrate the technical solutions in the embodiments of the present application or in the prior art more clearly, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described.
Fig. 1 shows a kind of full-automatic protein chip decomposition diagram provided by the present application；
Fig. 2 shows schematic diagram after a kind of full-automatic protein chip welding provided by the present application；
Fig. 3 shows a kind of top view of full-automatic protein chip provided by the present application；
Fig. 4 shows a kind of full-automatic protein chip fusion process schematic diagram provided by the present application；
Fig. 5 shows a kind of full-automatic protein chip perspective view provided by the present application；
Fig. 6 shows the assembling stereogram of a kind of full-automatic protein chip and reaction cup provided by the present application；
Fig. 7 shows the assembling front view of a kind of full-automatic protein chip and reaction cup provided by the present application；
Fig. 8 shows the work flow diagram of the application of the full-automatic protein chip analysis system of the application；
Wherein, 1 be tooth shape lower cover, 2 be tooth shape upper cover, 3 be limit hole, 4 for lead fuse, 5 be front and back sides mark it is recessed
Mouthful, 6 be notch, 7 be reaction film, 8 be reaction cup, 9 be welding groove, 10 be limiting groove, 11 be position-limited edge, A is full-automatic
Protein chip welding pre-structure figure, B, C, D are respectively structure chart between full-automatic protein chip welding, and E is full-automatic protein chip
Structure chart when welding is completed.
Specific embodiment
This application provides a kind of full-automatic protein chip and its detection systems, for solving protein chip in the prior art
It is not used to the technological deficiency of full-automatic machine.
Below by the technical scheme in the embodiment of the application is clearly and completely described, it is clear that described implementation
Example is merely a part but not all of the embodiments of the present application.Based on the embodiment in the application, this field is common
Technical staff's every other embodiment obtained without making creative work belongs to the model of the application protection
It encloses.
Wherein, the reagent and material of the embodiment of the present application are commercially available.
Wherein, the secondary antibody abbreviation ELIAS secondary antibody marked with enzyme；CCD imaging technique abbreviation CCD imaging.
Embodiment 1
Referring to Fig. 1, embodiment 1 provided by the present application is a kind of full-automatic protein chip, embodiment 1 includes: tooth shape
Lower cover 1, tooth shape upper cover 2 lead fuse 4, front and back sides mark recess 5, reaction film 7 and welding groove 9；Tooth shape upper cover 2 and tooth
The bottom of shape lower cover 1 jagged 6, reaction film 7 are fixed in the notch 6 of the bottom of tooth shape upper cover 2 and tooth shape lower cover 1；
The edge of the notch 6 of tooth shape lower cover 1 is equipped with welding groove 9, and the edge setting of the notch 6 of tooth shape upper cover 2 is led fuse 4, led
When fuse 4 dissolves, welding is carried out with welding groove 9, so that reaction film 7 is fixed on lacking for tooth shape upper cover 2 and tooth shape lower cover 1
Between mouth 6；The top of tooth shape upper cover 2 and tooth shape lower cover 1 is equipped with front and back sides mark recess 5, when tooth shape upper cover 2 and tooth
When dentation 1 welding of lower cover, the front and back sides mark recess 5 of tooth shape upper cover 2 and tooth shape lower cover 1 is mutually aligned, front and back sides mark
Recess 5 is used to distinguish the front and back sides of reaction film 7.
Further, leading fuse 4 is bulge-structure.
The edge of the notch of 1 dens in dente dentation lower cover 1 of embodiment is equipped with welding groove 9, the edge of the notch of tooth shape upper cover 2
Fuse 4 is led in setting, when leading the dissolution of fuse 4, welding is carried out with welding groove 9, so that reaction film 7 is fixed on 2 He of tooth shape upper cover
Between the notch of tooth shape lower cover 1, leading fuse 4 is bulge-structure, and in dissolution, raised leads 4 energy focused energy of fuse, is reached
The high temperature of moment, and will not pass on reaction film 7, instantaneous high-temperature leads fuse 4 and the progress welding of welding groove 9,7 quilt of reaction film
It is firmly fixed between tooth shape upper cover 2 and the notch 6 of tooth shape lower cover 1.Therefore, full-automatic machine grabs full-automatic egg
Reaction film can be suspended in midair and reacted from different reaction solutions by the top of white chip, realize the full-automation of protein chip
Using.In addition, front and back sides mark recess is used to distinguish the front and back sides of reaction film, the accurate of the data analysis of reaction film can guarantee
Property.
Embodiment 2
Fig. 1 to Fig. 7 is please referred to, embodiment 1 provided by the present application is a kind of full-automatic protein chip, and embodiment 2 includes: tooth
Dentation lower cover 1, tooth shape upper cover 2 lead fuse 4, front and back sides mark recess 5, limit hole 3, reaction film 7 and welding groove 9；Tooth shape
The bottom jagged 6 of upper cover 2 and tooth shape lower cover 1, reaction film 7 are fixed on the bottom of tooth shape upper cover 2 and tooth shape lower cover 1
Notch 6 in；The edge of the notch 6 of tooth shape lower cover 1 is equipped with welding groove 9, and the edge of the notch 6 of tooth shape upper cover 2 is arranged
Fuse 4 is led, when leading the dissolution of fuse 4, welding is carried out with welding groove 9, so that reaction film 7 is fixed on tooth shape upper cover 2 and tooth
Between the notch of shape lower cover 1；The top of tooth shape upper cover 2 and tooth shape lower cover 1 is equipped with front and back sides mark recess 5, works as tooth
When shape upper cover 2 and tooth shape 1 welding of lower cover, the front and back sides mark recess 5 of tooth shape upper cover 2 and tooth shape lower cover 1 is mutually aligned,
Front and back sides mark recess 5 is used to distinguish the front and back sides of reaction film 7；Retention bead, the setting of tooth shape upper cover is arranged in tooth shape lower cover
Limit hole 3 is limited so that the retention bead of tooth shape lower cover is placed in the limit hole 3 of tooth shape upper cover.
Further, the projective structure that fuse 4 is triangle is led.
Wherein, the effect of the projective structure of triangle is focused energy, makes it possible to the temperature for reaching melting as early as possible, thus
Obtain better welding effect.
Further, reaction film is fixed at least one antibody or antigen.
Further, when tooth shape upper cover and tooth shape lower cover carry out welding according to ultrasonic fusing technology.
Further, tooth shape upper cover, tooth shape lower cover, lead fuse and welding groove is that thermoplastic is prepared.
Embodiment 2 carries out welding using ultrasonic fusing technology, and the fuse 4 of leading of thermoplastic absorbs ultrasonic energy, surpasses
The time of sound wave welding is set as leading fuse 4 and when welding groove 9 contacts with each other, and stops ultrasonic fusing at once, so that leading molten
Line 4 reaches instantaneous high-temperature, and is in contact with welding groove 9, and high temperature is avoided to pass on reaction film.
The top view of the full-automatic protein chip of schematic diagram and Fig. 3 is it is found that tooth after the full-automatic protein chip welding of Fig. 2
The edge of the notch of shape lower cover 1 is equipped with welding groove 9, and the edge setting of the notch of tooth shape upper cover 2 leads fuse 4, it is molten to lead fuse 4
Xie Shi carries out welding with welding groove 9, so that reaction film 7 is fixed between tooth shape upper cover 2 and the notch of tooth shape lower cover 1,
Fusion process occurs at the edge of tooth shape upper cover 2 and the notch of tooth shape lower cover 1, and the high temperature of welding will not pass on chip；
For the detailed process of welding as shown in figure 4, Fig. 4 is full-automatic protein chip fusion process schematic diagram, A is molten for full-automatic protein chip
Pre-structure figure is connect, B, C, D are respectively structure chart between full-automatic protein chip welding, when E is that full-automatic protein chip welding is completed
Structure chart, it is known that make tooth shape upper cover 2 and tooth shape lower cover 1 closely be fixed together after welding, and firmly clamp anti-
Answer film 7.
Embodiment 3
Fig. 1 to Fig. 7 is please referred to, embodiment 1 provided by the present application is a kind of full-automatic protein chip detection system, embodiment
3 include: tooth shape lower cover 1, tooth shape upper cover 2, lead fuse 4, front and back sides mark recess 5, limit hole 3, reaction cup 8, position-limited edge 11,
Limiting groove 10, reaction film 7 and welding groove 9；The bottom jagged 6 of tooth shape upper cover 2 and tooth shape lower cover 1, reaction film 7
It is fixed in the notch 6 of the bottom of tooth shape upper cover 2 and tooth shape lower cover 1；The edge of the notch 6 of tooth shape lower cover 1 is equipped with molten
Groove 9 is connect, the edge setting of the notch 6 of tooth shape upper cover 2 is led fuse 4, when leading the dissolution of fuse 4, melted with welding groove 9
It connects, so that reaction film 7 is fixed between tooth shape upper cover 2 and the notch of tooth shape lower cover 1；Under tooth shape upper cover 2 and tooth shape
The top of lid 1 is equipped with front and back sides mark recess 5, when tooth shape upper cover 2 and tooth shape 1 welding of lower cover, 2 He of tooth shape upper cover
The front and back sides mark recess 5 of tooth shape lower cover 1 is mutually aligned, and front and back sides mark recess 5 is used to distinguish the front and back sides of reaction film 7；
Retention bead is arranged in tooth shape lower cover, and limit hole 3 is arranged in tooth shape upper cover, so that the retention bead of tooth shape lower cover is placed in tooth
It is limited in the limit hole 3 of shape upper cover；Reaction cup 8 includes cup body, and full-automatic protein chip is socketed in the cup body of reaction cup 8
Portion；Position-limited edge 11 is set to the two sides of tooth shape upper cover and tooth shape lower cover, so that the position-limited edge 11 and tooth shape of tooth shape upper cover
The position-limited edge 11 of lower cover is mutually aligned；Limiting groove 10 is arranged in the opening of cup body, so that under tooth shape upper cover and tooth shape
The position-limited edge 11 of the two sides of lid is placed in limiting groove 10 and is limited.
The reaction film of full-automatic protein chip is fixed at least one antibody or antigen.
Different solution can be added in the reaction cup 8 of embodiment 3, full-automatic protein chip can pass through full-automatic machine
Suspended in midair and be transferred in reaction cup 8 so that full-automatic protein chip reacts from different solution, tooth shape upper cover with
The position-limited edge 11 of the two sides of tooth shape lower cover is placed on the limiting groove 10 of the opening of cup body, allows reaction film preferably and reaction cup
Solution contact in 8 reacts.
Embodiment 4
Referring to Fig. 8, Fig. 8 is the application of the full-automatic protein chip detection system of the application, embodiment 4 includes following step
It is rapid:
S101: sample to be tested or sample to be tested and dilution are added in reaction cup；
S102: full-automatic protein chip is placed in the reaction cup of S101 and occur Ag-Ab specific binding；
S103: it specifically binds in Ag-Ab after reaction, by the way that full-automatic protein chip is washed and used
After the secondary antibody of enzyme label is incubated for, testing result reading is carried out by detection readout instrument.
Full-automatic protein chip is passed through full-automatic machine by the application of the full-automatic protein chip analysis system of embodiment 4
Chip is suspended in midair and is shifted by the top of this protein chip of the crawl of device, is allowed to be placed in the reaction cup containing sample and containing useful enzyme mark
In the reaction cup of the secondary antibody of note, Ag-Ab specific binding reaction occurs, to quantify simultaneously to various disease
Or/and qualitative detection, this full-automatic protein chip is used in full-automatic machine.
The above is only the preferred embodiment of the application, it is noted that for the ordinary skill people of the art
For member, under the premise of not departing from the application principle, several improvements and modifications can also be made, these improvements and modifications are also answered
It is considered as the protection scope of the application.
Claims (5)
1. a kind of full-automatic protein chip characterized by comprising tooth shape upper cover, tooth shape lower cover, to lead fuse, welding recessed
Slot, front and back sides mark recess and reaction film；
The bottom of the tooth shape upper cover and the tooth shape lower cover is jagged, and the reaction film is fixed on the tooth shape
In the notch of the bottom of lid and the tooth shape lower cover；
The edge of the notch of the tooth shape lower cover is equipped with welding groove, and the edge setting of the notch of the tooth shape upper cover is led molten
Line, it is described lead fuse dissolution when, with the welding groove carry out welding so that the reaction film is fixed on the tooth shape upper cover
Between the notch of the tooth shape lower cover；
The top of the tooth shape upper cover and the tooth shape lower cover is equipped with front and back sides mark recess, when the tooth shape upper cover
When with the tooth shape lower cover welding, the front and back sides mark recess of the tooth shape upper cover and the tooth shape lower cover is mutually right
Together, the front and back sides mark recess is used to distinguish the front and back sides of the reaction film；
Wherein, the fuse of leading is bulge-structure.
2. full-automatic protein chip according to claim 1, which is characterized in that described when the tooth shape upper cover and described
Tooth shape lower cover carries out welding according to ultrasonic fusing technology.
3. full-automatic protein chip according to claim 1 or 2, which is characterized in that further include limit hole and retention bead；
The retention bead is arranged in the tooth shape lower cover, and the limit hole is arranged in the tooth shape upper cover, so that the tooth
The retention bead of shape lower cover is placed in the limit hole of the tooth shape upper cover and is limited.
4. a kind of full-automatic protein chip detection system, is characterized in that, comprising: complete as described in claims 1 to 3 any one
Automatic protein chip and reaction cup；
The reaction cup includes cup body；
The full-automatic protein chip is socketed in inside the cup body of the reaction cup.
5. full-automatic protein chip detection system according to claim 4, which is characterized in that the two of the tooth shape upper cover
Side is additionally provided with position-limited edge；The two sides of the tooth shape lower cover are additionally provided with position-limited edge so that the position-limited edge of the tooth shape upper cover and
The position-limited edge of the tooth shape lower cover is mutually aligned；
The reaction cup further includes limiting groove, and the limiting groove is arranged in the opening of the cup body of the reaction cup, so that
The position-limited edge of the two sides of the tooth shape lower cover and tooth shape upper cover is placed in the limiting groove and is limited.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821138657.4U CN208568804U (en) | 2018-07-18 | 2018-07-18 | A kind of full-automatic protein chip and its detection system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821138657.4U CN208568804U (en) | 2018-07-18 | 2018-07-18 | A kind of full-automatic protein chip and its detection system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208568804U true CN208568804U (en) | 2019-03-01 |
Family
ID=65446437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821138657.4U Active CN208568804U (en) | 2018-07-18 | 2018-07-18 | A kind of full-automatic protein chip and its detection system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN208568804U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108593939A (en) * | 2018-07-18 | 2018-09-28 | 广州瑞博奥生物科技有限公司 | A kind of full-automatic protein chip and its application |
-
2018
- 2018-07-18 CN CN201821138657.4U patent/CN208568804U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108593939A (en) * | 2018-07-18 | 2018-09-28 | 广州瑞博奥生物科技有限公司 | A kind of full-automatic protein chip and its application |
| CN108593939B (en) * | 2018-07-18 | 2023-11-14 | 瑞博奥(广州)生物科技股份有限公司 | Full-automatic protein chip and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103954751B (en) | Immunoassay platform is detected at the micro-fluidic immunosensor chip of paper substrate and scene in time | |
| CN103201628B (en) | For the immunoassay test strip used in diagnostic system | |
| US8586347B2 (en) | System and method for detecting multiple molecules in one assay | |
| JP6267650B2 (en) | Signal amplification in lateral flow and related immunoassays | |
| JP3299271B2 (en) | Capillary blood antigen tester | |
| CN101821620B (en) | Microfluidic sensor complex structure | |
| TWI335430B (en) | Directed-flow assay device | |
| US8303910B2 (en) | Biosensor | |
| JPWO2003014740A1 (en) | Biosensor and measurement method | |
| JP2008304477A (en) | Accessible assay system and its usage | |
| JPH03223674A (en) | Reaction vessel | |
| JP2014077801A (en) | Immunodiagnostic test card having indicia to be indicated | |
| JP2008522169A (en) | Lateral flow test device provides improved test result effectiveness | |
| JP4699840B2 (en) | Biochip and immunoassay method | |
| CN103140292B (en) | Sample plate | |
| JP2005257337A (en) | Inspection object receiver, inspection device, and inspection method | |
| WO2016084491A1 (en) | Inspection kit | |
| CN208568804U (en) | A kind of full-automatic protein chip and its detection system | |
| JPWO2009136476A1 (en) | Biosensor manufacturing method and biosensor | |
| CN106226540A (en) | Full-automatic protein chip analyzer | |
| WO2019124532A1 (en) | Immunochromatography device | |
| CN108593939A (en) | A kind of full-automatic protein chip and its application | |
| EP3872490A1 (en) | Cup for immunoassay, method for producing same, and immunoassay method | |
| CN104897654B (en) | A kind of microflow controlled biochip detection device and preparation method | |
| JP2018526625A (en) | Method for evaluating cell surface receptors of blood cells |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 510530 No. 79 Ruihe Road, Science City, Guangzhou High-tech Industrial Development Zone, Guangdong Province Patentee after: Reboo (Guangzhou) Biotechnology Co.,Ltd. Address before: 510530 No. 79 Ruihe Road, Science City, Guangzhou High-tech Industrial Development Zone, Guangdong Province Patentee before: RAYBIOTECH, Inc. |