CN208493847U - A kind of vaccine emulsifying device - Google Patents
A kind of vaccine emulsifying device Download PDFInfo
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- CN208493847U CN208493847U CN201820130762.7U CN201820130762U CN208493847U CN 208493847 U CN208493847 U CN 208493847U CN 201820130762 U CN201820130762 U CN 201820130762U CN 208493847 U CN208493847 U CN 208493847U
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Abstract
The utility model relates to production of vaccine fields, in particular to a kind of vaccine emulsifying device.The equipment includes tank body；The top of the tank is provided with spray head；The tank interior is additionally provided with agitating device and shear.When being emulsified, water phase is handled through spray head and is added dropwise in oily phase with pole fine droplets, water phase is increased to be in contact with oil surface area, it is dispersed in water phase in oily phase, so as to which influence of the temperature to effective component in antigen caused by the damage and mechanical force of mechanical force is reduced to antigen under lower speed of agitator, it reduces under conditions of not influencing integrated artistic and does time in advance, improve working efficiency and improve product total quality.The scrap build is at low cost, is easy to rectify and improve.
Description
Technical field
The present invention relates to production of vaccine fields, in particular to a kind of vaccine emulsifying device.
Background technique
Oil emulsion vaccine is common vaccine dosage, with the long feature of its immune stimulation lasts, immune period in vaccine
Application aspect have irreplaceable role.
With the continuous development of biovaccine industry, people gradually deepen the understanding of safety and the side effect of vaccine,
Requirement to oil emulsion vaccine quality is also gradually increased.
Oil emulsion vaccine has biggish oil-water interfaces, belongs to thermodynamic unstable system, unstability mainly shows
There are layering, demulsification, make the transition and ruin, it is most commonly seen to be layered, be demulsified, it is the long-standing problem of vaccine producers.Such as
The bad stability and immunizing potency that will seriously affect vaccine of the emulsifying effectiveness of fruit vaccine.Influence oil emulsion vaccine quality because
In element, the effect of emulsification plays conclusive effect.Therefore, existing emulsifying process is optimized, is had very important
Realistic meaning.
It is emulsified in the prior art to oil emulsion vaccine, when the water phase containing vaccine is added dropwise into oily phase tank, often
Frequently with the mode of vertical dropwise addition or adherent dropwise addition.
Rectilinear dropwise addition refers to that pipeline vertically instills in oily phase perpendicular to when water phase being added dropwise in tank body, by stirring dynamics with
And rate of addition is to make Aqueous dispersions in oily phase.During being slowly added dropwise water phase flowed into oily phase with vertical direction rather than
It is instilled in oily phase with pole fine droplets, it is small to contact oily phase surface product, it is necessary to by improving mixing speed and sufficient time
It can be uniformly dispersed to reach water phase in oily phase, in lower mixing speed and cannot achieve in the shorter time by water phase
(Fig. 1) is dispersed in oily phase, so too relying on stirring dynamics and increasing the production work time, mixing power spends height
Mechanical damage is generated to water phase endoantigen, and as the raising temperature of revolving speed also increases, effective component-sugar of vaccine
Proteantigen meeting accelerated decomposition, effect also just decrease.
Wall-attaching type dropwise addition refer to pipeline be affixed on tank interior tank skin buffered by tank skin, stirring dynamics and rate of addition from
And it is scattered in water phase slowly in oily phase.Water phase is flowed slowly into oily phase rather than with micro- during being slowly added dropwise with adherent manner
Droplet mode is dripped in oily phase, in lower mixing speed and water phase can not be dispersed in oily phase in the shorter time
Interior (Fig. 2), the oily phase surface product of contact is too small to be reached water phase by improving mixing speed and sufficient time and can uniformly divide
Dissipate in oily phase, mixing power spend it is high mechanical damage generated to water phase endoantigen, and also therewith with the raising temperature of revolving speed
It increases, effective component-glycoprotein antigen meeting accelerated decomposition of vaccine, effect also just decreases.If realizing adherent dropwise addition
Tank interior conduit, which must increase curvature, can be only achieved adherent effect, so excessively cumbersome in disassembly process.
In addition, this field it is common the usual volume of emulsion tank it is smaller, and according to big volume emulsion tank (such as 6000L~
8000L), the shortcomings that undoubtedly amplifying vertical dropwise addition or adherent dropwise addition.Therefore, this field urgently provides one kind and can reach
The emulsifying device and emulsification method of more preferable emulsifying effectiveness, to adapt to the requirement of big volume emulsion tank.
In view of this, the present invention is specifically proposed.
Summary of the invention
The first object of the present invention is to provide vaccine emulsifying device, which increases water phase by changing dropwise addition mode and drip
Be in contact during adding with oil surface area, and water phase can be uniformly distributed in oily phase by shortening mixing time and reducing mixing speed
To reach expected results.
The second object of the present invention is to provide the application method of equipment described in one kind, and this method passes through preferred operations item
Part can reach optimal emulsifying effectiveness.
In order to realize above-mentioned purpose of the invention, the following technical scheme is adopted:
The present invention relates to a kind of vaccine emulsifying devices, including tank body；The top of the tank is provided with spray head；
The tank interior is additionally provided with agitating device and shear.
According to an aspect of the present invention, the invention further relates to the vaccine emulsification methods for using equipment as described above, comprising:
Oil is mutually contained in the tank body, the spray head extracts water phase and sprays in the tank body, sprays process
The middle unlatching agitating device is stirred, and the agitating device is opened after spray and the shear is emulsified.
Compared with prior art, the invention has the benefit that
When being emulsified, water phase is handled through spray head and is added dropwise in oily phase with pole fine droplets, increase water phase with
Oil is in contact surface area, is dispersed in water phase in oily phase, so as to reduce machine to antigen under lower speed of agitator
Influence of the temperature to effective component in antigen caused by the damage and mechanical stirring of tool power, in the item for not influencing integrated artistic
It reduces under part and does time in advance, improve working efficiency and improve product total quality.The scrap build is at low cost, is easy to rectify and improve.
Detailed description of the invention
It, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical solution in the prior art
Embodiment or attached drawing needed to be used in the description of the prior art be briefly described, it should be apparent that, it is described below
Attached drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not making the creative labor
It puts, is also possible to obtain other drawings based on these drawings.
Fig. 1 is vertical dropwise addition method schematic diagram in the prior art；
Fig. 2 is adherent dropwise addition method schematic diagram in the prior art；
Fig. 3 is that method schematic diagram is added dropwise in spray of the present invention；
Fig. 4 is the structural schematic diagram of vaccine emulsifying device provided by one embodiment of the invention；
Fig. 5 is the structural schematic diagram of spray head provided by one embodiment of the invention；
Fig. 6 is the schematic diagram of the section structure of spray head rotating part provided by one embodiment of the invention.
Appended drawing reference:
Spray head 1；Fixed part 101；Rotating part 102；Small liquid outlet 103；Big liquid outlet 104；
Agitating device 2；Agitating shaft 201；Agitating paddle 202；
Shear 3；
Baffle 4；
Power device 5.
Specific embodiment
Technical solution of the present invention is clearly and completely described below in conjunction with the drawings and specific embodiments, but
Be it will be understood to those of skill in the art that it is following described embodiments are some of the embodiments of the present invention, rather than it is whole
Embodiment is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.Based on the embodiments of the present invention, ability
Domain those of ordinary skill every other embodiment obtained without making creative work, belongs to guarantor of the present invention
The range of shield.The person that is not specified actual conditions in embodiment, carries out according to conventional conditions or manufacturer's recommended conditions.Agents useful for same
Or production firm person is not specified in instrument, is the conventional products that can be obtained by commercially available purchase.
In the description of the present invention, it should be noted that term " center ", "upper", "lower", "left", "right", "vertical",
The orientation or positional relationship of the instructions such as "horizontal", "inner", "outside" be based on the orientation or positional relationship shown in the drawings, merely to
Convenient for description the present invention and simplify description, rather than the device or element of indication or suggestion meaning must have a particular orientation,
It is constructed and operated in a specific orientation, therefore is not considered as limiting the invention.In addition, term " first ", " second ",
" third " is used for descriptive purposes only and cannot be understood as indicating or suggesting relative importance.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " installation ", " phase
Even ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or be integrally connected；It can
To be mechanical connection, it is also possible to be electrically connected；It can be directly connected, can also can be indirectly connected through an intermediary
Connection inside two elements.For the ordinary skill in the art, above-mentioned term can be understood at this with concrete condition
Concrete meaning in invention.
The present invention relates to a kind of vaccine emulsifying devices, as shown in figure 3, by using sprinkling equipment, it can be quickly by water phase
Atomization, water phase are added dropwise in oily phase with pole fine droplets, and big water phase is in contact surface area with oil, cooperation agitating device with shear
Water phase quickly can be mixed quickly with incense oil, preferably to reach homogeneous state, be emulsified by machine.
Specifically, as shown in figure 4, the equipment includes tank body；The top of the tank is provided with spray head 1；
The tank interior is additionally provided with agitating device 2 and shear 3.
Preferably, the shear 3 is set to tank base, and off-centered position.
Wherein, shear 3 be emulsification shearing equipment commonly used in the art, can efficiently, rapidly and uniformly by a phase
Or multiple phases are distributed in another continuous phase.The high tangential velocity as caused by rotor high speed rotation and high frequency mechanical effect band
The powerful kinetic energy come squeezes material in the narrow gap of stator and rotor by strong machinery and aquashear, centrifugation, liquid
The comprehensive functions such as tearing and turbulent flow are hit in layer friction, thus make immiscible liquid phase under the action of corresponding mature technology, moment
The dispersion and emulsion of uniform, fine finally obtains stable high-quality product by moving in circles for high frequency.
Preferably, the device bottom is additionally provided with leakage fluid dram, it is furthermore preferred that leakage fluid dram setting is in bottom centre position
It sets.
Preferably, the side wall of the tank body is long tubular, and tank base is arc-shaped to arch upward outward.
Preferably, where the spray head 1 is set to long tubular tank body cross section near the center of circle of circle, specially distance is round
1/10~1/5 radius of the heart.
Preferably, as shown in figure 5, the spray head 1 is made of hollow fixed part 101 and rotating part 102, the fixation
Portion 101 is the cylindrical body of lower part tightening, and there are circular open at the tightening of lower part, the circle is inserted at the top of the rotating part 102
Shape is open and is flexibly connected with the fixed part 101；
102 surface of rotating part is provided at least two liquid outlets of different sizes, so that different in spray go out
The pressure that liquid mouth sprays water is different, and the rotating part can rotate under the action of pressure difference.
Wherein, the top of the rotating part 102 can be the structure expanded, so as to be stuck at circular open, and round
The junction of opening and rotating part 102 be it is more relaxed, rotated conducive to rotating part 102.
The water of high pressure is sent into fixed part 101, water can there are circular opens to be flowed into from 101 lower part tightening place of fixed part
It in rotating part 102, is sprayed along the water outlet of rotating part 102, spraying the torsion that the pressure difference that water generates generates can to revolve
Transfer part 102 is with the rotation of 101 place axle center of fixed part.The rotating part 102 can be to be cylindrical, the various shapes such as rectangular, as long as from
The reaction force that water is sprayed in the rotary body can generate the torsion relative to support base, which can be with support base
Axis rotation.
Preferably, vaccine emulsifying device as described above, the rotating part 102 are sphere；
Preferably, diameter >=42mm of the sphere.The diameter of sphere is adapted with the size of tank body, diameter 42mm
Above sphere is suitable for the tank body of 6000L~8000L.
Preferably, vaccine emulsifying device as described above, the liquid outlet are two, respectively small liquid outlet 103 and big
Liquid outlet 104, the liquid outlet and is respectively positioned on the rotating part vertically where the circular open in the great circle of plane；
Preferably, as shown in fig. 6, the small liquid outlet 103 and big liquid outlet 104 are along the long and narrow of great circle setting
Shaped opening；It is furthermore preferred that one end of the small liquid outlet 103 and big liquid outlet 104 abuts the fixed part and the rotation
The junction of transfer part；It is furthermore preferred that the 2/10~4/10 of a length of great circle arc length of small liquid outlet 103, it is described to go out liquid greatly
The 4/10~6/10 of 104 a length of great circle arc length of mouth.
Such as the 3/10 of a length of great circle arc length of small liquid outlet 103, the 5/10 of a length of great circle arc length of big liquid outlet 104,
Not opening part accounts for 1/10, accounts for 1/10 with 101 junctions.
Spray head provided by the present invention can rotate sprinkling liquid by hydraulic pressure impact automatically, not need additional power dress
It sets, and structure is simple, it is easy to maintain.
Preferably, vaccine emulsifying device as described above, the agitating device are upper agitating device；
Preferably, the agitating device 2 includes agitating shaft 201 and agitating paddle 202；
The agitating shaft 201 is perpendicular to horizontal plane and is fixed on tank deck, the top of the agitating shaft 201 and power device 5
It is connected；The agitating paddle is set on the agitating shaft 201.
Preferably, the power device 5 is magnetic power machine.
Preferably, vaccine emulsifying device as described above, there are three the agitating paddles 202；
Preferably, the agitating paddle 202 is turbine type agitating paddle or pusher agitating paddle；
It is furthermore preferred that the agitating paddle 202 is four leaf push type agitating paddles.
Preferably, vaccine emulsifying device as described above is additionally provided with baffle 4, the gear inside the tank skin of the tank body
Plate 4 is perpendicular to horizontal plane；
It is furthermore preferred that the baffle 4 has 3~5, more preferably 4, and it is uniformly distributed on the tank skin of the tank body；
It is furthermore preferred that the baffle 4 is perpendicular to tank skin.
Preferably, vaccine emulsifying device as described above, the tank volume are 6000L~10000L.
According to an aspect of the present invention, the invention further relates to the vaccine emulsification methods for using equipment as described above, comprising:
Oil is mutually contained in the tank body, the spray head extracts water phase and sprays in the tank body, sprays process
The middle unlatching agitating device is stirred, and the agitating device is opened after spray and the shear is emulsified.
It is oily mutually and after water phase mixing to obtain oil emulsion vaccine；Preferably, the oil mutually and the water phase be by volume 1~
2:1 mixing and emulsifying, more preferably 1.5:1.
Preferably, the oil mutually includes following raw material: 93~95 parts of white oil, 5~7 parts of lipophilic surfactant
With 0~0.5 part of aluminum stearate；
The water phase includes vaccine antigen aqueous solution and hydrophilic surfactant active, the vaccine antigen aqueous solution with it is described
The volume ratio of hydrophilic surfactant active is 95~96:4~5.
Compared with conventional oil emulsion vaccine, oil emulsion vaccine of the present invention greatly reduces the dosage of aluminum stearate,
Aluminum stearate is even omitted, meanwhile, the method for the invention also reduces the dosage of vaccine antigen aqueous solution in water phase.Thus
To oil emulsion vaccine viscosity reduce, be not easy to be layered, the stability of vaccine it is high, the immunizing potency of vaccine is high, reduces vaccine note
Side effect after penetrating, and the decline of vaccine antigen amount of aqueous solution used can reduce vaccine preparation cost.
In some specific embodiments, the parts by weight of the white oil are 93 parts, 93.5 parts, 94 parts, 94.5 parts or 95
Part；Preferably, the parts by weight of the white oil are 94 parts.
In some specific embodiments, the parts by weight of the lipophilic surfactant are 5 parts, 5.5 parts, 6 parts,
6.5 parts or 7 parts；Preferably, the parts by weight of the lipophilic surfactant are 6 parts.
In some specific embodiments, the volume parts of the vaccine antigen aqueous solution are 95 parts, 95.5 parts or 96
Part；Preferably, the volume parts of the vaccine antigen aqueous solution are 96 parts.
In some specific embodiments, the volume parts of the hydrophilic surfactant active are 4 parts, 4.5 parts or 5
Part；Preferably, the volume parts of the hydrophilic surfactant active are 4 parts.
In some specific embodiments, the lipophilic surfactant be selected from sorbester p18, sorbester p38, sorbester p17,
At least one of sapn 83, span 85, lecithin, Fabaceous Lecithin, glycerin monostearate or glyceryl monooleate；
Preferably, the lipophilic surface-active is sorbester p17.
In some specific embodiments, it is logical that the hydrophilic surfactant active is selected from polysorbas20, Tween 80 or Qula；
Preferably, the hydrophilic surfactant active is Tween 80.
In some specific embodiments, the antigen is selected from avian influenza virus antigen, foot-and-mouth disease virus antigen, new city
One of epidemic disease viral antigen, bronchitis virus antigen, Egg Drop syndrome virus antigen and bursal disease poison antigen are a variety of；
Preferably, the antigen is avian influenza virus antigen；
It is highly preferred that the avian influenza virus antigen is cell source avian influenza virus antigen.
Preferably, method as described above, the water phase are stored in water phase tank, and the water phase pressure tank 0.10Mpa ±
0.02Mpa, the tank body pressure 0.02Mpa ± 0.002Mpa；The water phase enters the spray head under the action of pressure difference
It is sprayed；
Under this pressure difference, the spray rate of spray head is probably 3000-3500kg/h.
Preferably, the revolving speed of the agitating device is 130~150r/min during spray；More preferably 140r/min；
Preferably, the revolving speed of the agitating device is 130~150r/min, more preferably 140r/min after spray；
The revolving speed of the shear is 1800~2200r/min, handles 40~60min；More preferably 2000r/min, processing
50min。
Embodiment
In the present embodiment, vaccine emulsifying device includes the oily phase tank body of 8000L；The side wall of the tank body is long tubular, tank
Body bottom is arc-shaped to arch upward outward；The top of the tank is provided with spray head；The tank interior be additionally provided with agitating device and
Shear.
Where the spray head is set to long tubular tank body cross section near the center of circle of circle, specially apart from the center of circle 1,/10 half
At diameter.
The spray head is made of hollow fixed part and rotating part, and the fixed part is the cylindrical body of lower part tightening, under
There are circular open at portion's tightening, the top of the rotating part is inserted into the circular open and is flexibly connected with the fixed part；
The rotating part is the sphere of diameter 42mm, surface setting there are two liquid outlet of different sizes, respectively it is small go out
Liquid mouth and big liquid outlet, the liquid outlet and are respectively positioned on the rotating part vertically where the circular open in the great circle of plane；
Small liquid outlet and big liquid outlet be along the great circle setting narrow shaped opening, the 3/ of a length of great circle arc length of small liquid outlet
10, the 5/10 of a length of great circle arc length of big liquid outlet, not opening part accounts for 1/10, accounts for 1/10 with fixed plate junction.Liquid outlet
Width be 2mm~4mm.
The agitating device includes agitating shaft and agitating paddle；The agitating shaft is perpendicular to horizontal plane and is fixed on tank deck, institute
The top for stating agitating shaft is connected with power device；The agitating paddle is set on the agitating shaft.There are three the agitating paddles, and
It is four leaf push type agitating paddles.
Baffle is additionally provided with inside the tank skin of the tank body, baffle there are 4, and is uniformly distributed in the tank skin of the tank body
On；The baffle is perpendicular to tank skin.
Baffle can avoid generating generation whirlpool in pot liquid center when stirring, and stirring efficiency is caused to reduce.
The spray head is connected by conveyance conduit with 6000L water phase tank.
Water phase and oily phase the preparation method comprises the following steps:
Oily phase: 95 parts and 5 parts of sorbester p17 of white oil are weighed, sorbester p17 is added in white oil, stirs evenly, by the temperature of oily phase
Degree is adjusted to 25 DEG C；
Water phase: taking H5 type avian influenza virus antigen (cell of infection H5 type avian influenza virus) aqueous solution, mixed with Tween 80
It closes uniformly, wherein the volume ratio of the H5 type avian influenza virus antigen aqueous solution and Tween 80 is 95.5:4.5, it later, will be described
The temperature of water phase is adjusted to 25 DEG C.
Spray rate control is carried out by forming relative pressure difference between two connected tank bodies, water phase pressure tank
0.10Mpa ± 0.02Mpa, oily phase pressure tank 0.02Mpa ± 0.002Mpa, rate of addition normal control is in 3000-3500kg/h
?.
Pressure difference decides spray range.If spraying, range is excessive, and emulsion drips everywhere to be caused to hanging on tank skin
The oily phase emulsifying power of this part of tank skin reduces；And if will lead to oil apart from too small and be mutually unevenly distributed.
Agitating paddle speed during water phase is added dropwise in tank should be controlled in 140r/min.After completion of dropwise addition, adjust
In whole good tank in agitating paddle and tank cutter revolving speed, rotating speed of agitator control in 140r/min, shear 2000r/min,
Pre- cream 50min.
Comparative example 1
It being emulsified referring to the method for experimental example, difference is only that, spray head is not used, and use is vertical in the prior art
The mode of dropwise addition adds water phase；Rate of addition is similarly controlled in 3000-3500kg/h.
Comparative example 2
It being emulsified referring to the method for experimental example, difference is only that, spray head is not used, and use is adherent in the prior art
The mode of dropwise addition adds water phase；Rate of addition is similarly controlled in 3000-3500kg/h.
The oil emulsion vaccine that 1 distinct methods of table are prepared compares
Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Present invention has been described in detail with reference to the aforementioned embodiments for pipe, but those skilled in the art should understand that: its
It is still possible to modify the technical solutions described in the foregoing embodiments, or to some or all of the technical features
It is equivalently replaced；And these are modified or replaceed, various embodiments of the present invention skill that it does not separate the essence of the corresponding technical solution
The range of art scheme.
Claims (9)
1. a kind of vaccine emulsifying device, which is characterized in that including tank body；The top of the tank is provided with spray head；
The tank interior is additionally provided with agitating device and shear；
The spray head is made of hollow fixed part and rotating part, and the fixed part is the cylindrical body of lower part tightening, and lower part is received
There are circular open, the tops of the rotating part to be inserted into the circular open and be flexibly connected with the fixed part at tight place；
The rotating part surface is provided at least two liquid outlets of different sizes, so that the liquid outlet different in spray sprays
The pressure of water is different, and the rotating part can rotate under the action of pressure difference.
2. vaccine emulsifying device according to claim 1, which is characterized in that the rotating part is sphere.
3. vaccine emulsifying device according to claim 2, which is characterized in that the liquid outlet be two, respectively it is small go out
Liquid mouth and big liquid outlet, the liquid outlet and are respectively positioned on the rotating part vertically where the circular open in the great circle of plane.
4. vaccine emulsifying device according to claim 3, which is characterized in that the small liquid outlet and big liquid outlet are edge
The narrow shaped opening of the great circle setting.
5. vaccine emulsifying device according to claim 1, which is characterized in that the agitating device is upper agitating device；
The agitating device includes agitating shaft and agitating paddle；
The agitating shaft is perpendicular to horizontal plane and is fixed on tank deck, and the top of the agitating shaft is connected with power device；It is described to stir
Paddle is mixed to be set on the agitating shaft.
6. vaccine emulsifying device according to claim 5, which is characterized in that there are three the agitating paddles.
7. vaccine emulsifying device according to claim 1, which is characterized in that be additionally provided with gear inside the tank skin of the tank body
Plate, the baffle is perpendicular to horizontal plane.
8. vaccine emulsifying device according to claim 7, which is characterized in that the baffle has 3~5, and is uniformly distributed
In on the tank skin of the tank body；
The baffle is perpendicular to tank skin.
9. described in any item vaccine emulsifying devices according to claim 1~8, which is characterized in that the tank volume is 6000L
~10000L.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108126545A (en) * | 2018-01-25 | 2018-06-08 | 吉林冠界生物技术有限公司 | A kind of vaccine emulsifying device and its application method |
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| CN108126545A (en) * | 2018-01-25 | 2018-06-08 | 吉林冠界生物技术有限公司 | A kind of vaccine emulsifying device and its application method |
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