CN207872061U - A kind of cross-current type super-gravity device preparing white-oil adjuvant vaccine emulsions - Google Patents
A kind of cross-current type super-gravity device preparing white-oil adjuvant vaccine emulsions Download PDFInfo
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- CN207872061U CN207872061U CN201721781151.0U CN201721781151U CN207872061U CN 207872061 U CN207872061 U CN 207872061U CN 201721781151 U CN201721781151 U CN 201721781151U CN 207872061 U CN207872061 U CN 207872061U
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- Prior art keywords
- cross
- flow
- hypergravity
- oil adjuvant
- mixing apparatus
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Abstract
The utility model discloses a kind of cross-current type super-gravity devices preparing white-oil adjuvant vaccine emulsions, including heat preservation pre-mixing apparatus and hypergravity cross-flow filling device, water phase and oil phase are stirred in heat preservation pre-mixing apparatus by fully premix, enter in hypergravity cross-flow filler device from premixed liquid outlet pump, it is directly entered super gravity field, in centrifugal chamber through high speed centrifugation, due to centrifugal action, it enters back into the cricoid cross-flow packing cavity in outside, it is mixed by the efficient mass transfer and liquid liquid of filling system, after forming stable lotion, then it is discharged from fluid hole；The device of the utility model can improve the stability of the vaccine emulsions of white-oil adjuvant, considerably reduce emulsification times, and emulsifying power is substantially improved, and occupation area of equipment is greatly decreased, and reduces investment outlay.
Description
Technical field
The utility model belongs to Petrochemical Production Technologies field or bioengineering and biomaterial preparation engineering field, relates to
And a kind of super-gravity device more particularly to a kind of cross-current type super-gravity device preparing white-oil adjuvant vaccine emulsions.
Background technology
In petrochemical industry or in bioengineering field, white-oil adjuvant emulsification has a direct impact the quality of vaccine,
And then directly affect the validity of Animal diseases prevention.The performance of the vaccine emulsions of white-oil adjuvant is removed and white oil type, emulsifier
Type and formula are outer, and performance and stability of lotion etc. and emulsifying manner have close relationship, prepare white-oil adjuvant epidemic disease at present
The common emulsifying manner of seedling has stirring and emulsifying device and high-shear homogenizing machine, while needing that stabilizer is added, and tackifier etc. are protected
The stability of the viscosity of lotion after card emulsification, major defect is the high energy consumption of equipment, and temperature is unstable in emulsion process, consumption
When about 1-2 hours, the uniform force degree of fluid differs, and causes the vaccine emulsions grain size of Water-In-Oil uneven, is easily demulsified, while water
The loss amount of antigen is also larger in phase.Ultrasonic emulsification also has an application, advantage be it is small, light-weight while efficient, still
Equipment energy consumption is high, for less in big production application.
In addition, often all there is the lotion of different batches in existing emulsification method, due to emulsifying process it cannot be guaranteed that completely
Unanimously, same raw material, it may appear that emulsion viscosity different problems, viscosity stability are poor.
The filler of existing super-gravity device is usually reverse-flow or deflector type, mainly has the function that efficient mass transfer, inverse
Although the filler of streaming and deflector type is simple, processing is easy to use, and the liquid holdup of device is larger, and liquid liquid contact area is small,
Time of contact is short, is not suitable for the emulsification processing of vaccine adjuvant.
Utility model content
The purpose of this utility model is that in view of the deficiencies of the prior art, a kind of white-oil adjuvant vaccine emulsions that prepare are provided
Cross-current type super-gravity device can improve the stability of the vaccine emulsions of white-oil adjuvant using the device, considerably reduce breast
Change the time, emulsifying power is substantially improved, and occupation area of equipment is greatly decreased, and reduces investment outlay.The required reduction of production is reached
Energy consumption improves safety, shortens the requirement of production time.Equipment can be installed horizontally or vertically, unrestricted to occasion, repair
Simply.
The cross-current type super-gravity device for preparing white-oil adjuvant vaccine emulsions of the utility model, including heat preservation pre-mixing apparatus and
Hypergravity cross-flow filling device is provided with water phase import, oil phase import, exhaust outlet and premixed liquid on the heat preservation pre-mixing apparatus and goes out
Mouthful, it is equipped with agitating shaft in heat preservation pre-mixing apparatus, inlet opening, gas vent is provided on hypergravity cross-flow filling device and goes out liquid
The entire cavity in hole, hypergravity cross-flow filling device is separated into center centrifugal chamber and outside ring-type cross-flow chamber, center centrifugal chamber
It is interior to be equipped with central rotating shaft, the full cross-flow filler material of outside ring-type cross-flow intracavitary filling；Premixed liquid outlet passes through pipeline and pump and feed liquor
Hole is connected, and premixed liquid is introduced directly into the centrifugal chamber of center, gas vent and fluid hole may be contained within hypergravity cross-flow filling device
Side wall.
In above-mentioned technical proposal, the cross-flow filler material is ceramics or molecular sieve with irregular holes.Described
The unordered mixed and disorderly filling of cyclic annular cross-flow intracavitary on the outside of cross-flow filler material.
Water phase import and oil phase import are opened in device lower part, exhaust outlet and premixed liquid on the heat preservation pre-mixing apparatus
Outlet is opened at the top of device.
The cross-flow hypergravity emulsifier unit of the white-oil adjuvant vaccine emulsions of the utility model is that one kind continuously preparing white oil
Lotion preparation facilities of the aqueous solution as water phase as oil phase, containing inactivation antigen.White oil adds corresponding emulsification as oil phase
After agent, and the aqueous solution containing antigen enters in the heat preservation pre-mixing apparatus of constant temperature simultaneously, can first premix 2-3min, subsequently into
In hypergravity cross-flow filling device, the high speed convection by 1-3min and cross-flow mass transfer emulsion process are drawn white from fluid hole
Oil-adjuvant vaccine lotion finished product.Relative to existing standard machinery emulsifying manner, the cross-flow hypergravity emulsification of the utility model passes through
It is combined using heat preservation pre-mixing apparatus and hypergravity cross-flow filling device, can obviously reduce the loss of antigen, keep the inactivation of antigen,
And the control temperature that can stablize；And the stability of emulsion enhancing between different batches, the viscosity of lotion is accurately controlled, is only needed
It is added a small amount of or is added without tackifier and stabilizer, the stability requirement of product emulsion can be reached.In addition, the present apparatus is using wrong
The mode of streaming filler material, mass transfer is not limited to baffling or adverse current, will produce rotating flow or vortex, increased mass transfer mode can be very big
Increase the area that is in contact, provide the sufficient time for phase mass transfer, and then mass-transfer efficiency can be improved, and liquid holdup is smaller, production adds
Work is easy.
Description of the drawings
Fig. 1 is a kind of structural schematic diagram of utility model device.
Fig. 2 is schematic diagram of the lotion through cross-flow filler material in centrifugal process.
In figure：1, water phase import, 2, agitating shaft, 3, oil phase import, 4, exhaust outlet, 5, premixed liquid outlet, 6, inlet opening, 7,
Gas vent, 8, fluid hole.
Specific implementation mode
The utility model is described further below in conjunction with the accompanying drawings.
As shown in Figure 1, the super-gravity device of the utility model includes two parts, first part is the heat preservation of water phase and oil phase
Pre-mixing apparatus, water phase and oil phase are entered by water phase import and oil phase import in heat preservation pre-mixing apparatus respectively, by 2-3min's
Premix stirring, enters from premixed liquid outlet pump in hypergravity cross-flow filler device.Hypergravity cross-flow filler device uses in this example
Horizontally disposed, i.e., central rotating shaft is horizontal, and liquid is directly entered super gravity field from left side inlet opening, centrifugal chamber through high speed from
The heart is entered back into due to centrifugal action in the cricoid cross-flow packing cavity in outside, mixed by the efficient mass transfer and liquid liquid of filling system
It closes, after forming stable lotion, then stable, the satisfactory white-oil adjuvant vaccine emulsions from fluid hole discharge.
As shown in Fig. 2, water phase and oil phase mixed liquor enter filler part through rotating centrifugal, filler is with irregular hole
Irregular shape ceramic material with holes, sintering silicate material with holes, mesoporous or big specifically may be used in ceramics or molecular sieve
Porous molecular sieve material, the unordered accumulation of filler, when mixed liquor enters filler, through modes such as reflux, shock, cross-flow, bafflings
Mass transfer makes oil phase and water phase adequately be contacted, and then obtains stable lotion.Since cross-flow filler aperture is complex,
Under the effect of centrifugation, lotion is constantly crashed to pieces, and is come out by the aperture of material, and the lotion of excessive grain size is rolled over again
It returns, is dispersed into low particle size emulsion, ensure that the homogeneity of the grain size of lotion.In super-gravity device, common is rotary packed bed
For deflector type and reverse-flow, it is therefore an objective to extend the mass transfer time, improve mass-transfer efficiency, both packed beds be more suitable for mass transfer or point
From the filling for needing the contact mass transfer time longer the preparation of lotion is equipped, and substance separation is chosen without utilizing.This reality
With new design cross-current type packed bed, since the bending and design in duct are completely random, when increasing the contact of liquid liquid in this way
Between, but not feed liquid is caused to detach, cause water phase and oil phase to contact well, emulsion dispersion is uniform.
The filler of equipment is simple in the device of the utility model, and mass-transfer efficiency significantly improves, and can reduce emulsification times, and steady
Determine emulsifying temperature so that emulsion particle diameter size is concentrated, and stability greatly improves.
Claims (4)
1. a kind of cross-current type super-gravity device preparing white-oil adjuvant vaccine emulsions, which is characterized in that including keeping the temperature pre-mixing apparatus
With hypergravity cross-flow filling device, water phase import, oil phase import, exhaust outlet and premixed liquid are provided on the heat preservation pre-mixing apparatus
Outlet is equipped with agitating shaft in heat preservation pre-mixing apparatus, is provided with inlet opening, gas vent on hypergravity cross-flow filling device and goes out liquid
The entire cavity in hole, hypergravity cross-flow filling device is divided into center centrifugal chamber and outside ring-type cross-flow chamber two parts, center centrifugation
Intracavitary is equipped with central rotating shaft, the full cross-flow filler material of outside ring-type cross-flow intracavitary filling；Premixed liquid outlet by pipeline and pump with into
Fluid apertures is connected and premixed liquid is introduced directly into the centrifugal chamber of center, and gas vent and fluid hole may be contained within hypergravity cross-flow filling dress
The side wall set.
2. the cross-current type super-gravity device according to claim 1 for preparing white-oil adjuvant vaccine emulsions, which is characterized in that institute
The cross-flow filler material stated is ceramics or molecular sieve with irregular holes.
3. the cross-current type super-gravity device according to claim 2 for preparing white-oil adjuvant vaccine emulsions, which is characterized in that institute
The cross-flow filler material the stated unordered mixed and disorderly filling of cyclic annular cross-flow intracavitary on the outside.
4. the cross-current type super-gravity device according to claim 1 for preparing white-oil adjuvant vaccine emulsions, which is characterized in that institute
Water phase import and oil phase import are opened in device lower part on the heat preservation pre-mixing apparatus stated, and exhaust outlet and premixed liquid outlet open up
At the top of device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721781151.0U CN207872061U (en) | 2017-12-19 | 2017-12-19 | A kind of cross-current type super-gravity device preparing white-oil adjuvant vaccine emulsions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721781151.0U CN207872061U (en) | 2017-12-19 | 2017-12-19 | A kind of cross-current type super-gravity device preparing white-oil adjuvant vaccine emulsions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207872061U true CN207872061U (en) | 2018-09-18 |
Family
ID=63501516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721781151.0U Expired - Fee Related CN207872061U (en) | 2017-12-19 | 2017-12-19 | A kind of cross-current type super-gravity device preparing white-oil adjuvant vaccine emulsions |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207872061U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110449051A (en) * | 2019-07-03 | 2019-11-15 | 全球能源互联网欧洲研究院 | A kind of continuous production system and method for phase transformation lotion |
| CN110671193A (en) * | 2019-09-26 | 2020-01-10 | 武汉理工大学 | Nano additive fuel supergravity mixing device of marine engine |
-
2017
- 2017-12-19 CN CN201721781151.0U patent/CN207872061U/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110449051A (en) * | 2019-07-03 | 2019-11-15 | 全球能源互联网欧洲研究院 | A kind of continuous production system and method for phase transformation lotion |
| CN110449051B (en) * | 2019-07-03 | 2022-08-23 | 全球能源互联网欧洲研究院 | Continuous production system and method of phase-change emulsion |
| CN110671193A (en) * | 2019-09-26 | 2020-01-10 | 武汉理工大学 | Nano additive fuel supergravity mixing device of marine engine |
| CN110671193B (en) * | 2019-09-26 | 2021-12-17 | 武汉理工大学 | Nano additive fuel supergravity mixing device of marine engine |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180918 Termination date: 20191219 |
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| CF01 | Termination of patent right due to non-payment of annual fee |