CN208414449U - A kind of stirring-type bioreactor - Google Patents
A kind of stirring-type bioreactor Download PDFInfo
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- CN208414449U CN208414449U CN201820407825.9U CN201820407825U CN208414449U CN 208414449 U CN208414449 U CN 208414449U CN 201820407825 U CN201820407825 U CN 201820407825U CN 208414449 U CN208414449 U CN 208414449U
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- partition
- tracheae
- tank
- sterilization tank
- sterilization
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Abstract
The utility model discloses a kind of stirring-type bioreactors, including tank body, control cabinet and sterilization tank, air inlet and air outlet are provided on the sterilization tank, the air inlet is connected with the first tracheae, first partition and second partition are provided in the sterilization tank, the first partition is connected with the bottom and side wall of sterilization tank, the second partition is connected with the top of sterilization tank with side wall, between the first partition and second partition, ultraviolet radiator is provided between first partition or second partition and tank wall, the first partition and second partition are electric boiling plate；The utility model is provided with sterilization tank, and sterilization tank is internally provided with electric boiling plate and ultraviolet radiator, and ultraviolet radiator carries out sterilization to the gas that will be delivered in agitator tank, avoids the cell cultivated in agitator tank by the infection of external germ；Electric boiling plate heats the gas that will be delivered in agitator tank, and gas is made to reach consistent with the culture-liquid temp in agitator tank.
Description
Technical field
The utility model relates to technical field of cell culture, specifically a kind of stirring-type bioreactor.
Background technique
Cell culture technology can become simple unicellular or seldom breaking up more by mass propgation by a cell
Cell obtains a large amount of cell or its metabolite by cell culture.Because biological product is got from cell, can
To say that cell culture technology is most crucial, most basic technology in biotechnology.Cell culture work has been widely used in giving birth to
The every field such as object, medicine, new drug development become one of most important basic science.The growth of cell is needed in sealing
It is carried out in culture tank, extraneous bacterium dirt is avoided to infect；In order to provide oxygen necessary to cell is grown, the training into culture tank is needed
Oxygen is provided in nutrient solution, but when providing oxygen into culture solution, extraneous disinfect pathogen can be delivered in culture tank simultaneously,
And be delivered to the culture-liquid temp difference in the gas temperature and culture tank in culture tank also can to cell culture generate it is unfavorable
It influences.
Utility model content
The purpose of this utility model is to provide a kind of stirring-type bioreactors, to solve providing oxygen into culture solution
When gas, extraneous disinfect pathogen can be delivered in culture tank simultaneously, and be delivered to the gas temperature in culture tank and culture
Culture-liquid temp difference in tank leads to the problem of having an adverse effect to cell culture.
To achieve the above object, the utility model provides the following technical solutions: a kind of stirring-type bioreactor, including tank
Body, control cabinet and sterilization tank are provided with blender and the first temperature sensor in the tank body, be provided on the sterilization tank into
Port and gas outlet, the air inlet and air outlet are respectively arranged on the opposite side wall of sterilization tank, and the air inlet is connected with
First tracheae is equipped with pipeline fan on first tracheae, is provided with Air Filter at the air inlet of first tracheae, described
First partition and second partition are provided in sterilization tank, the first partition is connected with the bottom and side wall of sterilization tank, and described
Two partitions are connected with the top of sterilization tank with side wall, the first partition and second partition circuit sequentially be provided with it is multiple, it is described
Between first partition and second partition, it is provided with ultraviolet radiator between first partition or second partition and tank wall, described first
Partition and second partition are electric boiling plate, are located at gas outlet on the sterilization tank and are provided with second temperature sensor, described
Gas outlet is connected with one end of the second tracheae, and the other end of second tracheae stretches to bottom in tank body, second tracheae
On be provided with the first electrically operated valve.
Preferably, third gas is connected on the side wall on second tracheae between the first electrically operated valve and gas outlet
One end of pipe, the third tracheae are connected with the second tracheae, are provided with the second electrically operated valve on the third tracheae.
Preferably, the tank body is internally provided with air-dispersing plate, and the air-dispersing plate is hollow structure, the plate of the air-dispersing plate
Throughout there is micro-through-hole on wall, second tracheae protrudes into the intracorporal one end of tank and stretches in the inner cavity of air-dispersing plate.
Compared with prior art, the utility model has the beneficial effects that being provided with sterilization tank, sterilization tank is internally provided with electricity
Heating plate and ultraviolet radiator, ultraviolet radiator carry out sterilization to the gas that will be delivered in agitator tank, avoid in agitator tank
Infection of the cell of culture by external germ；Electric boiling plate heats the gas that will be delivered in agitator tank, makes gas
Body reaches consistent with the culture-liquid temp in agitator tank, and temperature difference is avoided to generate unfavorable shadow to the cell cultivated in agitator tank
It rings.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the utility model.
Fig. 2 is the structural schematic diagram of air-dispersing plate in the utility model.
In figure: 1- tank body, 2- control cabinet, 3- sterilization tank, 301- air inlet, the gas outlet 302-, the first tracheae of 4-, 5- pipe
Road blower, 6- first partition, 7- second partition, 8- ultraviolet radiator, 9- blender, the first temperature sensor of 10-, the second temperature of 11-
Spend sensor, the second tracheae of 12-, the first electrically operated valve of 13-, 14- air-dispersing plate, 15- Air Filter, 16- third tracheae, 17- second
Electrically operated valve.
Specific embodiment
The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model
Clearly and completely describe, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than whole
Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art are without making creative work
Every other embodiment obtained, fall within the protection scope of the utility model.
Referring to Fig. 1, in the utility model embodiment, a kind of stirring-type bioreactor, including tank body 1,2 and of control cabinet
Sterilization tank 3 is provided with blender 9 and the first temperature sensor 10 in tank body 1, and the first temperature sensor 10 is for detecting tank body
The temperature of cell culture fluid in 1 is provided with air inlet 301 and gas outlet 302, air inlet 301 and gas outlet 302 on sterilization tank 3
It is respectively arranged on the opposite side wall of sterilization tank 3, air inlet 301 is connected with the first tracheae 4, is equipped with pipeline on the first tracheae 4
Blower 5 is provided with Air Filter 15 at the air inlet of first tracheae 4, prevents the dust being mingled in gas from entering in sterilization tank 3, go out
First partition 6 and second partition 7 are provided in bacterium case 3, first partition 6 is connected with the bottom and side wall of sterilization tank 3, second every
Plate 7 is connected with the top of sterilization tank 3 with side wall, and first partition 6 and second partition 7 circuit sequentially and be provided with multiple, first partition 6
Between second partition 7, ultraviolet radiator 8, multiple first partitions 6 are provided between first partition 6 or second partition 7 and tank wall
The inner cavity of sterilization tank 3 is divided into the multiple air ducts being sequentially connected with second partition 7, gas is extended and is stopped in sterilization tank 3
Time, gas has the irradiation of ultraviolet radiator 8 when by each air duct, extends the irradiation time of ultraviolet radiator 8, sterilizing is killed
Poison is more thorough；First partition 6 and second partition 7 are electric boiling plate, for being heated to by the gas of sterilization tank 3, sterilization tank 3
It is upper to be provided with second temperature sensor 11 at gas outlet 302, for detecting the temperature that gas is discharged by sterilization tank 3；Outlet
Mouth 302 is connected with one end of the second tracheae 12, and the other end of the second tracheae 12 stretches to bottom in tank body 1, and sterilization tank 3 is discharged
Gas by the second tracheae 12 enter tank body 1 in, the supplemental oxygen into tank body 1；The first motor-driven valve is provided on second tracheae 12
Door 13 when being not required to the supplemental oxygen into tank body 1, closes the first electrically operated valve 13, when needing the supplemental oxygen into tank body 1, opens
First electrically operated valve 13；Is connected on side wall on second tracheae 12 between the first electrically operated valve 13 and gas outlet 302
One end of three tracheaes 16, third tracheae 16 are connected with the second tracheae 12, and the second electrically operated valve is provided on third tracheae 16
17, when closing the first electrically operated valve 13, opening the second electrically operated valve 17, the inappropriate gas of temperature that will be discharged by gas outlet 302
Body is discharged by third pipeline 16；Pipeline fan 5, first partition 6, second partition 7, ultraviolet radiator 8, the first temperature sensor 10,
Second temperature sensor 11, the first electrically operated valve 13 and the second electrically operated valve 17 are electrically connected with control cabinet 2, set in control cabinet 2
It is equipped with intelligent temperature controller and control switch, the input of the first temperature sensor 10, second temperature sensor 11 and intelligent temperature controller
End is electrically connected, and the output end of intelligent temperature controller and the input terminal of control switch are electrically connected, pipeline fan 5, first partition 6, second
Partition 7, ultraviolet radiator 8, the first electrically operated valve 13 and the second electrically operated valve 17 are electrically connected with the output end of control switch.
Fig. 1 and Fig. 2 are please referred to, tank body 1 is internally provided with air-dispersing plate 14, and air-dispersing plate 14 is hollow structure, air-dispersing plate 14
Wooden partition on throughout there is micro-through-hole, one end that the second tracheae 12 protrudes into tank body 1 stretches in the inner cavity of air-dispersing plate 14, second
Tracheae 12 be discharged gas enter in the inner cavity of air-dispersing plate 14, on the wooden partition of air-dispersing plate 14 throughout micro-through-hole under the action of
It scatter, one is the reduction of impact of the gas to culture cell, second is that making the contact for increasing gas with culture solution in tank body 1
The effect of area, supplemental oxygen is more preferable.
When needing the supplemental oxygen into tank body 1, pipeline fan 5 is started by the control switch in control cabinet 2, opens purple
Outside line lamp 8, to 7 electrified regulation of first partition 6 and second partition, while keeping the first electrically operated valve 13 to close, opening the second electricity
The temperature of movable valve 17, the culture solution in tank body 1 that the first temperature sensor 10 will test passes to the intelligence in control cabinet 2
Temperature controller, the temperature at gas outlet 302 that second temperature sensor 11 will test pass to the intelligent temperature control in control cabinet 2
Instrument adjusts the number of first partition 6 and the energization of second partition 7, makes the culture in the gas temperature and tank body 1 at gas outlet 302
The temperature of liquid is identical and is able to maintain after a period of time and opens the first electrically operated valve 13, closes the second electrically operated valve 17, to tank body 1
In culture solution in supplemental oxygen.
It is obvious to a person skilled in the art that the present invention is not limited to the details of the above exemplary embodiments, and
And without departing substantially from the spirit or essential attributes of the utility model, it can realize that this is practical new in other specific forms
Type.Therefore, in all respects, the present embodiments are to be considered as illustrative and not restrictive, this is practical new
The range of type is indicated by the appended claims rather than the foregoing description, it is intended that containing for the equivalent requirements of the claims will be fallen in
All changes in justice and range are embraced therein.It should not treat any reference in the claims as limiting
Related claim.
Claims (3)
1. a kind of stirring-type bioreactor, including tank body (1), control cabinet (2) and sterilization tank (3), the interior setting of the tank body (1)
Have blender (9) and the first temperature sensor (10), which is characterized in that be provided on the sterilization tank (3) air inlet (301) and
Gas outlet (302), the air inlet (301) and gas outlet (302) are respectively arranged on the opposite side wall of sterilization tank (3), described
Air inlet (301) is connected with the first tracheae (4), is equipped with pipeline fan (5) on first tracheae (4), first tracheae
(4) it is provided at air inlet Air Filter (15), is provided with first partition (6) and second partition (7) in the sterilization tank (3),
The first partition (6) is connected with the bottom and side wall of sterilization tank (3), the top of the second partition (7) and sterilization tank (3) and
Side wall is connected, and the first partition (6) and second partition (7) circuit sequentially and be provided with multiple, the first partition (6) and second
Be provided with ultraviolet radiator (8) between partition (7), between first partition (6) or second partition (7) and tank wall, described first every
Plate (6) and second partition (7) are electric boiling plate, are located at gas outlet (302) on the sterilization tank (3) and are provided with second temperature
Sensor (11), the gas outlet (302) are connected with one end of the second tracheae (12), and the other end of second tracheae (12) is stretched
Enter to tank body (1) interior bottom, is provided with the first electrically operated valve (13) on second tracheae (12).
2. a kind of stirring-type bioreactor according to claim 1, which is characterized in that second tracheae (12) is upper
One end of third tracheae (16), the third are connected on side wall between the first electrically operated valve (13) and gas outlet (302)
Tracheae (16) is connected with the second tracheae (12), is provided with the second electrically operated valve (17) on the third tracheae (16).
3. a kind of stirring-type bioreactor according to claim 1, which is characterized in that the inside of the tank body (1) is set
It being equipped with air-dispersing plate (14), the air-dispersing plate (14) is hollow structure, throughout there is micro-through-hole on the wooden partition of the air-dispersing plate (14),
One end that second tracheae (12) is protruded into tank body (1) stretches in the inner cavity of air-dispersing plate (14).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820407825.9U CN208414449U (en) | 2018-03-26 | 2018-03-26 | A kind of stirring-type bioreactor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820407825.9U CN208414449U (en) | 2018-03-26 | 2018-03-26 | A kind of stirring-type bioreactor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208414449U true CN208414449U (en) | 2019-01-22 |
Family
ID=65119069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201820407825.9U Active CN208414449U (en) | 2018-03-26 | 2018-03-26 | A kind of stirring-type bioreactor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN208414449U (en) |
-
2018
- 2018-03-26 CN CN201820407825.9U patent/CN208414449U/en active Active
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