CN208218851U - A kind of tumour cell capture device - Google Patents
A kind of tumour cell capture device Download PDFInfo
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- CN208218851U CN208218851U CN201820198265.0U CN201820198265U CN208218851U CN 208218851 U CN208218851 U CN 208218851U CN 201820198265 U CN201820198265 U CN 201820198265U CN 208218851 U CN208218851 U CN 208218851U
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- film layer
- closed container
- capture device
- tumour cell
- filtering film
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Abstract
The utility model discloses a kind of tumour cell capture devices, it is related to the field of medical instrument technology, including closed container, chamber resettling is formed with inside it, the closed container is disposed with the retention unit for being located at the chamber resettling into blood mouth and blood outlet, the retention unit includes at least one layer of filtering film layer, and each filter membrane layer arrangement has multiple retention micropores.The utility model is provided with the closed container of one layer or more filtering film layer by design, and the retention micropore in filtering film layer retains blood circulation tumour cell, reliable, objective reality Data Detection source object is provided for subsequent detection, pass through the back flush capture device simultaneously, elute catch, the capture device easy removal is easily changed, and can be connect with conduit, is applied on various blood catheter accesses.
Description
Technical field
The utility model relates to the field of medical instrument technology, in particular to a kind of tumour cell capture device.
Background technique
Although currently, having the equipment for carrying out Cell capture to blood circulation tumour in medical field, and being captured
Tumour cell is used for downstream analysis, still, on the one hand, the tumour cell captured still has careless omission, can not reflect to objective reality
The truth of patient, on the other hand, catch is eluted out from existing tumour cell capture device it is relatively difficult, simultaneously
It is easy to damage when eluting catch or damaged portion catch, objective reality can not be provided to the tumour cell detection of next step
Detectable substance.Obviously, a kind of tumour cell that can be captured to greatest extent in blood is needed for detecting, and reflects to objective trouble
The interior tumor cell situation of person provides instruction for doctor's clinical diagnosis.
Utility model content
The purpose of this utility model is to provide a kind of tumour cell capture device, can intercept in blood to greatest extent
Tumour cell.
Used technical solution to solve above-mentioned technical problem:
A kind of tumour cell capture device, including
Closed container, inside be formed with chamber resettling, which is disposed with into blood mouth and blood outlet
Positioned at the retention unit of the chamber resettling, which includes at least one layer of filtering film layer, each filtering
Film layer is disposed with multiple retention micropores.
As a further improvement of the above technical scheme, the inner wall at the edge and the closed container of each filtering film layer
It is tightly connected, there is the interconnecting piece connecting with each filtering film layer in the closed container.
As a further improvement of the above technical scheme, it is described enter blood mouth be connected with the entrance connecting pin of hollow tube-shape, institute
State the outlet connecting pin that blood outlet is connected with hollow tube-shape.By in the capture device inlet porting connecting pin and outlet connection
End, so that the capture device can be connect with conduit, and be applied on various blood catheter accesses, in addition, the capture device has
Easy removal, the features such as being easily changed.
As a further improvement of the above technical scheme, at least three layers of the filtering film layer, including the first film layer, the second film
Layer and third membrane layer are disposed with the clearance space of transition between each filtering film layer.
As a further improvement of the above technical scheme, the retention micropore size of first film layer is 45 μm to 80 μm institutes
The retention micropore size for stating the second film layer is 25 μm to 50 μm, and the retention micropore size of the third membrane layer is 10 μm to 35 μm.
As a further improvement of the above technical scheme, the closed container is in pie, and each filtering film layer is in flat
The side of planar, each filtering film layer towards the blood outlet is disposed with the bracket of reticular structure.
As a further improvement of the above technical scheme, the closed container includes the first gland and close with first gland
The second gland of connection is sealed, the lateral wall of first gland has the holding section extended radially out, second gland
Inner sidewall has the snap fit portion radially-inwardly stretched out.Further, each interconnecting piece is circular retainer ring, each institute
It states retainer ring upper and lower end faces and is arranged with pressure touching in the accordingly sealing ring of filtering film layer or closed container inner side end.By using
The technical solution of the structure can be improved the producing efficiency of capture device, first each filtering film layer is mounted in the first gland, so
After cover the second gland, the second gland by holding section auxiliary section thereon it is seizing live the first gland on holding section, and pass through
Sealing ring on each retainer ring forms chamber resettling described in inside.
As an alternative to the above-described technical solution, the closed container is cylindrical in shape, the upper surface of the closed container
Be arranged with multiple annular flanges being sequentially increased on the inside of inside and lower end surface, the annular flange of the closed container upper surface and
The corresponding annular flange in lower end surface forms the interconnecting piece, and each filtering film layer is cylindrical in shape, each described filtering film layer one end
It is embedded in the annular flange of the closed container upper surface, it is annular accordingly that the other end is embedded in the closed container lower end surface
In flange.
As a further improvement of the above technical scheme, first film layer, the second film layer and third membrane layer by outer and
Inside be sequentially arranged in the closed container, it is described enter blood mouth at be disposed with flow-guiding channel to the outside of first film layer.
The beneficial effects of the utility model are: the utility model is provided with the closed of at least one layer of filtering film layer by design
Container, and by filtering film layer on retention micropore by blood tumour cell retain, for it is subsequent detection provide reliably,
The Data Detection source object of objective reality, while by the back flush capture device, catch is eluted, and the capture fills
It sets easy removal, be easily changed, can be connect with conduit, is applied on various blood catheter accesses.
Detailed description of the invention
It, below will be to required in embodiment description in order to illustrate more clearly of the technical scheme in the embodiment of the utility model
Attached drawing to be used is briefly described.Obviously, described attached drawing is a part of the embodiment of the utility model, rather than complete
Portion's embodiment, those skilled in the art without creative efforts, can also be obtained according to these attached drawings it
His design scheme and attached drawing.
Fig. 1 is the structural schematic diagram of the first embodiment of the utility model；
Fig. 2 is the structural schematic diagram of second of embodiment of the utility model.
Specific embodiment
It is carried out below with reference to technical effect of the embodiment and attached drawing to the design of the utility model, specific structure and generation
It clearly and completely describes, to be completely understood by the purpose of this utility model, feature and effect.Obviously, described embodiment
It is a part of the embodiment of the utility model, rather than whole embodiments, it is based on the embodiments of the present invention, the skill of this field
Art personnel other embodiments obtained without creative efforts belong to the model of the utility model protection
It encloses.In addition, all connection/connection relationships being previously mentioned in text, not singly refer to that component directly connects, and referring to can be according to specific reality
Situation is applied, by adding or reducing couple auxiliary, to form more preferably coupling structure.
Referring to Fig.1, a kind of tumour cell capture device, including closed container 1 and retention unit, inside closed container 1 at
Xing You chamber resettling, retention unit are located at chamber resettling, and retention unit includes at least one layer of filtering film layer, and each film layer that filters is gathered
Multiple retention micropores.The closed container 1 of present embodiment is in pie, and each film layer that filters is in planar, and preferably three layers,
Respectively the first film layer 4, the second film layer 5 and third membrane layer 6, it is each to filter the clearance space that transition is disposed between film layer,
In the first embodiment, the clearance space of transition is round pie, and each side for filtering film layer towards blood outlet is disposed with netted
The bracket 7 of structure, wherein there are two brackets 7 to be located at the clearance space between two filtering film layers, another bracket 7 is located at tertiary membrane
Between layer 6 and 1 inner wall of closed container, in blood stream after previous filtering film layer, by clearance space, next mistake is passed through
Filter membranous layer, by the transition of clearance space, makes blood at the case where being easy to appear blocking after can preventing the stacking of two layers filter membrane from closing
The retention micropore in each filtering film layer can uniformly be reached.Meanwhile first film layer 4 retention micropore size be 45 μm to 80 μm,
The retention micropore size of second film layer 5 is 25 μm to 50 μm, and the retention micropore size of third membrane layer 6 is 10 μm to 35 μm.At this
In embodiment, the retention micropore size of the first film layer 4 is preferably 60 μm, and the retention micropore size of the second film layer 5 is preferably 41 μ
M, the retention micropore size of third membrane layer 6 are preferably 30 μm, and the inner wall of each edge for filtering film layer and closed container 1, which seals, to be connected
It connects, there is the interconnecting piece 8 connecting with each filtering film layer in closed container 1.
Closed container 1, which is disposed with, simultaneously enters the entrance connecting pin that blood mouth is connected with hollow tube-shape into blood mouth and blood outlet
2, blood outlet is connected with the outlet connecting pin 3 of hollow tube-shape.Blood enters the capture device of the utility model through entering blood mouth, successively
It is flowed out after flowing through the first film layer 4, the second film layer 5 and third membrane layer 6 through blood outlet.It, can maximum limit by filtering film layer three times
It spends the tumour cell captured in blood and catch is eluted by the back flush capture device, provided for subsequent detection
Reliably, the Data Detection source object of objective reality, and the capture device easy removal, be easily changed, it can be with conduit
Connection, and be applied on various blood catheter accesses.
As the further improvement of the first embodiment, closed container 1 include the first gland 11 and with first gland
11 the second glands 12 being tightly connected, the lateral wall of the first gland 11 have the holding section extended radially out, the second gland 12
Inner sidewall there is the snap fit portion radially-inwardly stretched out.Further, each interconnecting piece 8 is circular retainer ring, each to block
Circle upper and lower end faces are arranged with pressure touching in the accordingly sealing ring of filtering film layer or closed container inner side end.First by each filter membrane
Layer is mounted in the first gland 11, then covers the second gland 12, and the second gland 12 is seizing by holding section auxiliary section thereon
The firmly holding section on the first gland 11, and by the sealing ring on each retainer ring, form the internal chamber resettling.
Fig. 2 illustrates second of embodiment of the utility model, with the first embodiment difference, is: close
It closes container 1 to be cylindrical in shape, is arranged with multiple convex annulars being sequentially increased on the inside of the upper surface of closed container 1 and on the inside of lower end surface
Edge, the corresponding annular flange of the annular flange of 1 upper surface of closed container and lower end surface form interconnecting piece 8, and filtering film layer is cylindrical in shape,
In the second embodiment, respectively the clearance space of transition is in hollow tube-shape between filtering film layer, each to filter the insertion of film layer one end
In the annular flange of 1 upper surface of closed container, the other end is embedded in the corresponding annular flange in 1 lower end surface of closed container.The
One film layer 4, the second film layer 5 and third membrane layer 6 are sequentially arranged in from outside to inside in closed container 1, i.e., each filtering film layer has
Effect retention area is different, meanwhile, enter to be disposed with the outside of 9 to the first film layer 4 of flow-guiding channel at blood mouth.Blood be entered blood mouth into
Enter capture device, the outside of the first film layer 4 is then flowed to by flow-guiding channel 9, it is specific inside tubular closed container 1
Flow direction, be from flowing to blood outlet inward outside, i.e., followed by the first film layer 4, the second film layer 5 and the third membrane layer 6 in Fig. 2,
After flowing through previous filtering film layer, by the clearance space in hollow tube-shape, next filtering film layer is passed through, it can be effective
The case where avoiding filtering film block.In the second embodiment, the retention micropore size of the first film layer 4 is preferably 70 μm,
The retention micropore size of second film layer 5 is preferably 50 μm, and the retention micropore size of third membrane layer 6 is preferably 30 μm.
The embodiments of the present invention is explained in detail above in conjunction with attached drawing, but the utility model is not limited to
State embodiment, within the scope of knowledge possessed by those of ordinary skill in the art, can also do not depart from it is practical
Various changes can be made under the premise of novel objective.
Claims (10)
1. a kind of tumour cell capture device, it is characterised in that: including
Closed container (1), inside be formed with chamber resettling, which is disposed with into blood mouth and blood outlet；
Positioned at the retention unit of the chamber resettling, which includes at least one layer of filtering film layer, each filtering film layer
It is disposed with multiple retention micropores.
2. tumour cell capture device according to claim 1, it is characterised in that: the edge of each filtering film layer and institute
The inner wall for stating closed container (1) is tightly connected, and has the interconnecting piece connecting with each filtering film layer in the closed container (1)
(8)。
3. tumour cell capture device according to claim 2, it is characterised in that: it is described enter blood mouth be connected with hollow tube-shape
Entrance connecting pin (2), the blood outlet is connected with the outlet connecting pin (3) of hollow tube-shape.
4. tumour cell capture device according to claim 2 or 3, it is characterised in that: at least three layers of the filtering film layer,
Including the first film layer (4), the second film layer (5) and third membrane layer (6), the gap of transition is disposed between each filtering film layer
Space.
5. tumour cell capture device according to claim 4, it is characterised in that: the retention of first film layer (4) is micro-
Hole aperture is 45 μm to 80 μm, and the retention micropore size of second film layer (5) is 25 μm to 50 μm, the third membrane layer (6)
Retention micropore size be 10 μm to 35 μm.
6. tumour cell capture device according to claim 4, it is characterised in that: the closed container (1) is in pie, respectively
The filtering film layer be in it is planar, the side of each filtering film layer towards the blood outlet is disposed with the bracket (7) of reticular structure.
7. tumour cell capture device according to claim 6, it is characterised in that: the closed container (1) includes first
Gland (11) and the second gland (12) being tightly connected with first gland (11), the lateral wall of first gland (11) have
The holding section extended radially out, the inner sidewall of second gland (12) have the snap fit portion radially-inwardly stretched out.
8. tumour cell capture device according to claim 7, it is characterised in that: each interconnecting piece (8) is annular shape
Retainer ring, each retainer ring upper and lower end faces be arranged with pressure touching accordingly filtering film layer or closed container inner side end sealing
Circle.
9. tumour cell capture device according to claim 4, it is characterised in that: the closed container (1) is cylindrical in shape, institute
It states on the inside of the upper surface of closed container (1) and is arranged with multiple annular flanges being sequentially increased on the inside of lower end surface, it is described closed
The corresponding annular flange of the annular flange of container (1) upper surface and lower end surface forms the interconnecting piece (8), and the filtering film layer is equal
It is cylindrical in shape, each described filtering film layer one end is embedded in the corresponding annular flange in the closed container (1) upper surface, and the other end is embedding
Enter in the corresponding annular flange in the closed container (1) lower end surface.
10. tumour cell capture device according to claim 9, it is characterised in that: first film layer (4), the second film
Layer (5) and third membrane layer (6) are sequentially arranged in from outside to inside in the closed container (1), it is described enter blood mouth at be disposed with and lead
The outside of circulation road (9) extremely first film layer (4).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820198265.0U CN208218851U (en) | 2018-02-02 | 2018-02-02 | A kind of tumour cell capture device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820198265.0U CN208218851U (en) | 2018-02-02 | 2018-02-02 | A kind of tumour cell capture device |
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| Publication Number | Publication Date |
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| CN208218851U true CN208218851U (en) | 2018-12-11 |
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| CN201820198265.0U Active CN208218851U (en) | 2018-02-02 | 2018-02-02 | A kind of tumour cell capture device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108220137A (en) * | 2018-02-02 | 2018-06-29 | 广州益养生物科技有限公司 | A kind of tumour cell trap setting |
-
2018
- 2018-02-02 CN CN201820198265.0U patent/CN208218851U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108220137A (en) * | 2018-02-02 | 2018-06-29 | 广州益养生物科技有限公司 | A kind of tumour cell trap setting |
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