CN208161513U - A kind of compounding medicine tank - Google Patents
A kind of compounding medicine tank Download PDFInfo
- Publication number
- CN208161513U CN208161513U CN201820340367.1U CN201820340367U CN208161513U CN 208161513 U CN208161513 U CN 208161513U CN 201820340367 U CN201820340367 U CN 201820340367U CN 208161513 U CN208161513 U CN 208161513U
- Authority
- CN
- China
- Prior art keywords
- tank body
- tank
- bottom cover
- agitating shaft
- end socket
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 43
- 238000013329 compounding Methods 0.000 title claims abstract description 18
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 42
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 22
- 239000007788 liquid Substances 0.000 claims abstract description 15
- 230000000930 thermomechanical effect Effects 0.000 claims abstract description 8
- 239000003638 chemical reducing agent Substances 0.000 claims abstract description 5
- 239000012530 fluid Substances 0.000 claims description 13
- 238000004140 cleaning Methods 0.000 claims description 6
- 238000001514 detection method Methods 0.000 claims description 6
- 239000007789 gas Substances 0.000 claims description 6
- 238000004321 preservation Methods 0.000 claims description 5
- 230000010354 integration Effects 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 230000008676 import Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 abstract description 14
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract description 10
- 239000001301 oxygen Substances 0.000 abstract description 10
- 229910052760 oxygen Inorganic materials 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 6
- 238000002156 mixing Methods 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000005266 casting Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000010411 cooking Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 238000007493 shaping process Methods 0.000 description 2
- 235000014347 soups Nutrition 0.000 description 2
- 241000282994 Cervidae Species 0.000 description 1
- 206010054949 Metaplasia Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 240000005373 Panax quinquefolius Species 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 241000270295 Serpentes Species 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 241000271897 Viperidae Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 210000003056 antler Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 230000015689 metaplastic ossification Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 150000002829 nitrogen Chemical class 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Mixers Of The Rotary Stirring Type (AREA)
Abstract
A kind of compounding medicine tank including driving motor, gear reducer component, agitating shaft, tank body and is mounted on the end socket of top of the tank and by the closed bottom cover of tank base, offers liquid outlet on the bottom cover;The driving motor is fixed on the top of end socket, and the driving motor is connect with the input terminal of deceleration thermomechanical components, and the output end and agitating shaft of the deceleration thermomechanical components are drivingly connected;The agitating shaft is deep into tank interior from end socket vertically, and center axis thereof is not overlapped with the central axis of tank body;The outside of the agitating shaft is provided with helical blade, and the bottom of agitating shaft is installed with multiple agitating paddles;The utility model can make by nitrogen preferably contacted with product, be discharged tank body residual oxygen, thus achieve the effect that protect product, and can make drug prepare in-tank mixing it is more uniform.
Description
Technical field
The utility model belongs to field of biological pharmacy, more particularly, to a kind of compounding medicine tank.
Background technique
The operations such as normal pressure, decocting, the fragrant oil extract of the industries such as Chinese medicine, food generally will use extractor, and Chinese medicine refers to
For preventing, diagnosing, treating disease or adjusting the drug of function of human body under instruction of Chinese Medicine theory.Mostly botanical medicine also has
Object medicine, mineral drug and part chemistry, biological drug.Chinese medicine is divided into Chinese patent drug, Chinese medicine by processing technology.Chinese medicine is main
Originating from China, other than botanical medicine, animal drugs such as snake gall, bear gall, long-noded pit viper, pilose antler, deer horn etc.;Shell class such as pearl,
Concha meretricis seu cylinae;Mineral substance such as keel, magnetite etc. are all the Chinese medicine for curing the disease.A small number of Chinese medicines are derived from foreign country, such as American Ginseng.Now I
Relatively common Chinese medicine be generally referred to as Chinese medicine soup agent, have various soup agents on the market now, in present industry
The decoction of medicinal ingredients that metaplasia produces, usually medicinal material are put together cooking, then it is cold go it is filling, but due to the pharmacological property of various medicinal materials
Difference carries out separating cooking, and together, the dosing apparatus that present this kind of production method is used compares last mixed configuration
It is few.
Currently, in order to ensure the stabilization of drug quality, in the production process of drug, it is necessary to take all means and method
To improve the stability of drug, such as sterile powder injection can be made, for oxidizable than more sensitive drug to water and soda acid
, then reduce time that drug contacts oxygen to the greatest extent and may.
Pulvis or injection container in use, need to be filled with nitrogen into container be discharged in container other mix gas
Body, alleviates the variation of drug color grade according to the inertia of nitrogen, to achieve the effect that improve stability of drug products, reaches protection product
Purpose.Existing nitrogen charging device is delivered to preparing tank by stainless steel closed conduit, is filled with nitrogen protection production to reach
The purpose of product.But the main ingredient of residual air in preparing tank, air is nitrogen and oxygen, but oxygen density is big, closed
Sink in container, this nitrogen is filled with mode, is not avoided that in product and is mixed with remaining oxygen.
Utility model content
In order to overcome the deficiencies of the prior art, the utility model proposes a kind of compounding medicine tank, can make by nitrogen
It is preferably contacted with product, tank body residual oxygen is discharged, to achieve the effect that protect product, and drug can be made to exist
It is more uniform to prepare in-tank mixing.
The technical solution adopted in the utility model is:
A kind of compounding medicine tank, including driving motor, gear reducer component, agitating shaft, tank body and it is mounted on top of the tank
End socket and by the closed bottom cover of tank base, offer liquid outlet on the bottom cover;It is connected on the tank body and bottom cover
The heat preservation cylinder that size and tank body and bottom cover size are adapted, keeps the temperature the inner surface of cylinder and the appearance face interval of tank body and bottom cover
Setting is filled with insulating layer between heat preservation cylinder and tank body and the bottom cover, the side of the tank body is equipped with steam inlet, described
Steam (vapor) outlet is provided on bottom cover;
The driving motor is fixed on the top of end socket, and the driving motor is connect with the input terminal of deceleration thermomechanical components, institute
The output end and agitating shaft for stating deceleration thermomechanical components are drivingly connected;The agitating shaft is deep into tank interior, and its from end socket vertically
Central axis is not overlapped with the central axis of tank body;
The outside of the agitating shaft is provided with helical blade, and the bottom of agitating shaft is installed with multiple agitating paddles;
The upper end of the tank body is additionally provided with the pneumostome and extend functional group for connecting for guaranteeing that tank body is communicated with the atmosphere
The spare mouth of part;
Nitrogen blanketing valve is also equipped on the end socket, the nitrogen blanketing valve is deep into the bottom of tank body and its lower end is equipped with and it
The lateral escape pipe of connection, the transverse direction escape pipe are arranged lower than stirring blade, and the right end closing of lateral escape pipe laterally goes out
Multiple gas outlets are provided on tracheae;
The side of the tank body is provided with the sample tap for medical fluid in extractor body;
Tank bottom diaphragm valve is provided on the liquid outlet;
It is additionally provided with the detection mouth for detecting fluid temperature in tank body on the bottom cover, temperature is installed in the detection mouth
Spend sensor.
Preferably, the tank bottom diaphragm valve includes valve seat, outlet tube, valve deck, valve rod, operation handwheel, the valve seat
The connection of the liquid outlet of side and tank body, other side setting pipe joint are fixedly connected with outlet tube, and the valve deck passes through locking
Bolt is fixed on the lateral wall of valve seat pipe joint, forms valve chamber, and the valve rod is arranged in valve chamber, and the valve rod is connected with
Handwheel is operated, is provided with skid resistance strip on the operation handwheel.
Preferably, the compounding medicine tank further includes the frequency converter that can adjust driving motor output power, the change
Frequency device is electrically connected with driving motor.
Preferably, the end socket is equipped with the manhole that can quickly open and close;The manhole is located in tank body
The side of mandrel line, the central axis of the agitating shaft are located at the other side of the central axis of tank body.
Lamp is visited preferably, being additionally provided on the end socket convenient for the visor of observation tank interior liquid case and integration.
Preferably, being provided at least one on the end socket convenient for the cleaning interface of cleaning tank interior.
Preferably, the tank body, end socket and bottom cover integrally casting shaping.
Preferably, the bottom of bottom cover is connected at least three support legs.
The beneficial effects of the utility model are:1, agitating shaft is not overlapped with the central axis of tank body, agitating shaft and fixation
Helical blade on agitating shaft is located at the side of tank body, and driving motor is through speed reducer Component driver agitating shaft in the side of tank body
When rotation, since solution cannot be symmetrical around agitating shaft, that is, it is unfavorable for forming stable vortex shape, therefore, solution and tune
Preparaton it is more fully mixed and efficient, can be improved the efficiency of process;2, nitrogen blanketing valve is directly deep into the bottom of tank body, and sets
It is equipped with lateral escape pipe, nitrogen can be made to mix with medical fluid more uniform, remaining oxygen in tank body is more quickly replaced, makes
Product is prepared to be protected;3, it is provided with tank bottom diaphragm valve, when tank bottom carries out media discharge, medium can be directly through going out liquid
Mouthful drain tank is external, makes to retain in tank body without medium, guarantees that tank body meets the sanitation-grade of pharmacy, food or bioengineering field and makes
With requiring.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the utility model;
Fig. 2 is the top view of Fig. 1;
Fig. 3 is the enlarged drawing in Fig. 1 at A.
Specific embodiment
The embodiments of the present invention is illustrated by particular specific embodiment below, those skilled in the art can be by this
Content disclosed by specification understands other advantages and effect of the utility model easily.
It please refers to Fig.1 to Fig.3.It should be clear that this specification structure depicted in this specification institute accompanying drawings, ratio, size etc., only to
Cooperate the revealed content of specification, so that those skilled in the art understands and reads, is not intended to limit the utility model
Enforceable qualifications, therefore do not have technical essential meaning, the modification of any structure, the change of proportionate relationship or size
Adjustment, in the case where not influencing the effect of the utility model can be generated and the purpose that can reach, should all fall in the utility model institute
In the range of the technology contents of announcement can be covered.Meanwhile in this specification it is cited as "upper", "lower", "left", "right", " in
Between " and " one " etc. term, be merely convenient to being illustrated for narration, rather than to limit the enforceable range of the utility model,
Relativeness is altered or modified, under the content of no substantial changes in technology, when being also considered as the enforceable scope of the utility model.
A kind of compounding medicine tank, including driving motor 1, deceleration thermomechanical components 2, agitating shaft 3, tank body 4 and it is mounted on tank body 4
The end socket 5 at top and by the closed bottom cover 6 in 4 bottom of tank body, offers liquid outlet 7 on bottom cover 6;It is solid on tank body 4 and bottom cover 6
It is connected to size and tank body 4 and the adaptable heat preservation cylinder 8 of 6 size of bottom cover, keeps the temperature the inner surface and tank body 4 and bottom cover 6 of cylinder 8
The setting of appearance face interval keeps the temperature and is filled with insulating layer 9 between cylinder 8 and tank body 4 and bottom cover 6, the side of tank body 4 be equipped with steam into
Mouthfuls 10, steam (vapor) outlet 11 is provided on bottom cover 6;
Driving motor 1 is fixed on the top of tank body 4, and driving motor 1 is connect with the input terminal of deceleration thermomechanical components 2, speed reducer
The output end and agitating shaft 3 of component 2 are drivingly connected;Agitating shaft 3 is deep into inside tank body 4 vertically from end socket 5, and center axis thereof
It is not overlapped with the central axis of tank body 4;
The outside of agitating shaft 3 is provided with helical blade 12, and the bottom of agitating shaft 3 is installed with multiple agitating paddles 13;
The upper end of tank body 4 is additionally provided with the pneumostome 14 and extend functional group for connecting for guaranteeing that tank body 4 is communicated with the atmosphere
The spare mouth 15 of part;
Nitrogen blanketing valve 16 is also equipped on end socket 5, nitrogen blanketing valve 16 is deep into the bottom of tank body 4 and its lower end and is equipped with and connects with it
Logical lateral escape pipe 17, lateral escape pipe 17 are arranged lower than agitating paddle 13, and the right end closing of lateral escape pipe 17 laterally goes out
Multiple gas outlets 18 are provided on tracheae 17;
The side of tank body 4 is provided with the sample tap 19 for extracting medical fluid in tank body 4;
Tank bottom diaphragm valve 20 is provided on liquid outlet 7;
It is additionally provided with the detection mouth 21 for detecting fluid temperature in tank body 4 on bottom cover 6, temperature is installed in detection mouth 21
Sensor 22.
Tank bottom diaphragm valve 20 includes valve seat 201, outlet tube 202, valve deck 203, valve rod 204, operation handwheel 205, valve seat 201
Side is connect with the liquid outlet 7 of tank body 4, and other side setting pipe joint is fixedly connected with outlet tube 202, and valve deck 203 passes through lock
Tight bolt is fixed on the lateral wall of 201 pipe joint of valve seat, forms valve chamber, and valve rod 204 is arranged in valve chamber, and valve rod 204 connects
There is operation handwheel 205, operates and be provided with skid resistance strip 206 on handwheel 205.
Compounding medicine tank further includes the frequency converter that can adjust 1 output power of driving motor, 1 electricity of frequency converter and driving motor
Connection.
End socket 5 is equipped with the manhole 23 that can quickly open and close;Manhole 23 is located at the one of the central axis of tank body 4
Side, the central axis of agitating shaft 3 are located at the other side of the central axis of tank body 4.
It is additionally provided on end socket 5 and visits lamp 25 convenient for the visor 24 of observation 4 internal liquid situation of tank body and integration.
At least one is provided on end socket 5 convenient for the cleaning interface 26 inside cleaning tank body 4.
6 integrally casting shaping of tank body 4, end socket 5 and bottom cover.
The bottom of bottom cover 6 is connected at least three support legs 27.
When specific works, agitating shaft 3 is driven to rotate by opening driving motor 1, to make helical blade 12 and stirring
Paddle 13 rotates, and is sufficiently mixed medical fluid in tank body 4, and due to the effect of helical blade 12, the mixing of medical fluid is more uniform, and
Since agitating shaft 13 is not on the shaft core position of tank body 4, so medical fluid cannot be symmetrical around agitating shaft, not will form steady
Fixed eddy-currents, therefore mix more efficiently and uniform.When needing to be passed through nitrogen, nitrogen is poured by nitrogen blanketing valve 16, by
In the presence of lateral escape pipe 17 and gas outlet 18, nitrogen outlet is more uniform, and since lateral escape pipe 17 is located at tank body 4
Lower part, thus the nitrogen sprayed from lateral escape pipe 17 can by medical fluid oxygen and other impurities gas extrusion to tank body 4
Top nitrogen can be made mix with medical fluid more uniform to be discharged from pneumostome 14, more it is quick replace it is residual in tank body
The oxygen stayed reduces the time of contact of medical fluid and oxygen, protects preparation product.
It is obvious to a person skilled in the art that the present invention is not limited to the details of the above exemplary embodiments, and
And without departing substantially from the spirit or essential attributes of the utility model, it can realize that this is practical new in other specific forms
Type.Therefore, in all respects, the present embodiments are to be considered as illustrative and not restrictive, this is practical new
The range of type is indicated by the appended claims rather than the foregoing description, it is intended that containing for the equivalent requirements of the claims will be fallen in
All changes in justice and range are embraced therein.It should not treat any reference in the claims as limiting
Related claim.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiments being understood that.
Claims (8)
1. a kind of compounding medicine tank, it is characterised in that:Including driving motor, gear reducer component, agitating shaft, tank body and it is mounted on
The end socket of top of the tank and by the closed bottom cover of tank base, offers liquid outlet on the bottom cover;On the tank body and bottom cover
Be connected with size and tank body and the adaptable heat preservation cylinder of bottom cover size, keep the temperature cylinder inner surface and tank body and bottom cover it is outer
The setting of surface interval, is filled with insulating layer between heat preservation cylinder and tank body and the bottom cover, the side of the tank body is equipped with steam
Import is provided with steam (vapor) outlet on the bottom cover;
The driving motor is fixed on the top of end socket, and the driving motor is connect with the input terminal of deceleration thermomechanical components, described to subtract
The output end and agitating shaft of fast thermomechanical components are drivingly connected;The agitating shaft is deep into tank interior, and its center from end socket vertically
Axis is not overlapped with the central axis of tank body;
The outside of the agitating shaft is provided with helical blade, and the bottom of agitating shaft is installed with multiple agitating paddles;
The upper end of the tank body is additionally provided with the pneumostome and extend functional unit for connecting for guaranteeing that tank body is communicated with the atmosphere
Spare mouth;
Nitrogen blanketing valve is also equipped on the end socket, the nitrogen blanketing valve is deep into the bottom of tank body and its lower end and is equipped with and communicates therewith
Lateral escape pipe, the transverse direction escape pipe is arranged lower than stirring blade, and the right end of lateral escape pipe is closed, lateral escape pipe
On be provided with multiple gas outlets;
The side of the tank body is provided with the sample tap for medical fluid in extractor body;
Tank bottom diaphragm valve is provided on the liquid outlet;
It is additionally provided with the detection mouth for detecting fluid temperature in tank body on the bottom cover, temperature biography is installed in the detection mouth
Sensor.
2. a kind of compounding medicine tank according to claim 1, it is characterised in that:The tank bottom diaphragm valve includes valve seat, goes out
Liquid pipe, valve deck, valve rod, operation handwheel, the liquid outlet of the valve seat side and tank body connect, the other side be arranged pipe joint with
Outlet tube is fixedly connected, and the valve deck is fixed on the lateral wall of valve seat pipe joint by clamping screw, forms valve chamber, described
Valve rod be arranged in valve chamber, the valve rod is connected with operation handwheel, is provided with skid resistance strip on the operation handwheel.
3. a kind of compounding medicine tank according to claim 2, it is characterised in that:The compounding medicine tank further includes that can adjust
The frequency converter of whole driving motor output power, the frequency converter are electrically connected with driving motor.
4. a kind of compounding medicine tank according to claim 3, it is characterised in that:The end socket is equipped with and can quickly open
With the manhole of closing;The manhole is located at the side of the central axis of tank body, and the central axis of the agitating shaft is located at tank body
The other side of central axis.
5. a kind of compounding medicine tank according to claim 4, it is characterised in that:It is additionally provided on the end socket convenient for observation tank
Lamp is visited in the visor of internal portion liquid case and integration.
6. a kind of compounding medicine tank according to any one of claims 1 to 5, it is characterised in that:Be provided on the end socket to
A few cleaning interface convenient for cleaning tank interior.
7. a kind of compounding medicine tank according to claim 6, it is characterised in that:The tank body, end socket and bottom cover are integrally cast
Cause type.
8. a kind of compounding medicine tank according to claim 7, it is characterised in that:The bottom of bottom cover is connected at least three branch
Support foot.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201820340367.1U CN208161513U (en) | 2018-03-13 | 2018-03-13 | A kind of compounding medicine tank |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201820340367.1U CN208161513U (en) | 2018-03-13 | 2018-03-13 | A kind of compounding medicine tank |
Publications (1)
Publication Number | Publication Date |
---|---|
CN208161513U true CN208161513U (en) | 2018-11-30 |
Family
ID=64374612
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201820340367.1U Expired - Fee Related CN208161513U (en) | 2018-03-13 | 2018-03-13 | A kind of compounding medicine tank |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN208161513U (en) |
-
2018
- 2018-03-13 CN CN201820340367.1U patent/CN208161513U/en not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20181130 |
|
CF01 | Termination of patent right due to non-payment of annual fee |