CN208013058U - Glycolated hemoglobin analysis detector - Google Patents

Glycolated hemoglobin analysis detector Download PDF

Info

Publication number
CN208013058U
CN208013058U CN201820442945.2U CN201820442945U CN208013058U CN 208013058 U CN208013058 U CN 208013058U CN 201820442945 U CN201820442945 U CN 201820442945U CN 208013058 U CN208013058 U CN 208013058U
Authority
CN
China
Prior art keywords
lens
collimation lens
collimation
light
achromatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201820442945.2U
Other languages
Chinese (zh)
Inventor
侯茂元
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201820442945.2U priority Critical patent/CN208013058U/en
Application granted granted Critical
Publication of CN208013058U publication Critical patent/CN208013058U/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Landscapes

  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A kind of glycolated hemoglobin analysis detector, including light emitting source and sample flow cell;It further includes the first collimation lens, the first achromatic lens and the second collimation lens;First collimation lens, the first achromatic lens and the second collimation lens are sequentially located between light emitting source and sample flow cell and in the emitting light path in light emitting source;First collimation lens can collimate the light that light emitting source is sent out;First achromatic lens can carry out achromatism and focusing to the light by the first collimation lens collimation;Second collimation lens is located at the focal position of the emergent ray of the first achromatic lens, can collimate the first achromatic lens emergent ray;Sample flow cell is located in the emitting light path of the second collimation lens, to realize glycosylated hemoglobin analysis detection, the utility model so that collimation is far and near consistent with the first optical focus after colour killing, hot spot is evenly distributed, light beam irradiates sample flow cell on sample so that testing result is very accurate and stablizes.

Description

Glycolated hemoglobin analysis detector
Technical field
The utility model is related to glycosylated hemoglobin analytical equipment fields, and in particular to a kind of glycolated hemoglobin analysis Detector.
Background technology
Glycolated hemoglobin analysis is that a kind of accurate and micro detecting instrument, wherein fluorescence detector are most important Core component.The principle of its fluorescence detector is:The sample flow cell of detector is flowed through in sample by light emitting source Continuous irradiation On, and acquisition absorbance value completes the detection of sample in real time.
The volume of sample flowed through in sample flow cell in real time is very micro, to irradiating the sample flowed through in sample flow cell Light beam requirement is high, requires higher more particularly to the multiple wavelength illumination light beams of application, is mainly influenced by following several respects:1, The light that light emitting source is sent out is scattering;2, due to the influence of aberration, the first optical focus thickens with circle of least confusion, aberration It is that there is the light of different refractive index by different wave length by lens and generated, and the aberration of each wavelength is different, after focusing Respective first optical focus distance is different;3, applicable cases are irradiated in the light source of multi-wavelength, the light source of multi-wavelength is in the first light There can be serious off-axis property in focus;Factors above understands the accuracy that this detects instrument and stability brings serious shadow It rings, testing requirements are not achieved in measurement accuracy so that testing result is inaccurate, and unstable.
Utility model content
The utility model provides the sugar that a kind of testing result is accurate and stablizes to overcome the above-mentioned deficiency of the prior art Change hemoglobin analyser detector, solves the measurement accuracy of the fluorescence detector of existing glycolated hemoglobin analysis up to not To the purpose of testing requirements.
To achieve the above object, the utility model provides a kind of glycolated hemoglobin analysis detector, including shines Source and sample flow cell;Further include the first collimation lens, the first achromatic lens and the second collimation lens;First collimation lens, First achromatic lens and the second collimation lens are sequentially located between light emitting source and sample flow cell and the outgoing in light emitting source In light path;
First collimation lens can collimate the light that light emitting source is sent out;First achromatic lens can be to accurate by first The light of straight collimated carries out achromatism and focusing;Second collimation lens is located at the poly- of the emergent ray of the first achromatic lens Burnt position can collimate the first achromatic lens emergent ray;Sample flow cell is located at going out for the second collimation lens It penetrates in light path.
As the optimal technical scheme of the utility model, the center of the central optical axis and light emitting source of first collimation lens Ray position overlaps, and the central optical axis of first achromatic lens coincides with the central optical axis position of the first collimation lens; The central optical axis of second collimation lens and the position of the central optical axis of the first achromatic lens coincide.
As the optimal technical scheme of the utility model, first collimation lens, the first achromatic lens and second are accurate Straight lens for two surface shapes of centring optical axis are spherical surface, aspherical or cylinder or two surface shapes be spherical surface, The combination of arbitrary the two aspherical, in cylinder three.
As the optimal technical scheme of the utility model, the quantity of first collimation lens and the second collimation lens is extremely It is one less.
As the optimal technical scheme of the utility model, first achromatic lens is reflected by two or more than two The different lens gluing of rate, dispersive power forms.
As the optimal technical scheme of the utility model, first achromatic lens is that air-gap achromatism closes thoroughly more Mirror.
As the optimal technical scheme of the utility model, first achromatic lens can send out at least light emitting source The light of 2 wavelength is focused coincidence at the first optical focus.
As the optimal technical scheme of the utility model, also set in the light path between the light emitting source and the first collimation lens There are the second achromatic lens, the focal position of the saturating emergent ray of the second achromatism and the center weight of the first collimation lens It closes, the second achromatic lens can be focused coincidence to the light at least two wavelength that light emitting source is sent out at the second optical focus.
The glycolated hemoglobin analysis detector of the utility model can reach following advantageous effect:
The glycolated hemoglobin analysis detector of the utility model, by including light emitting source and sample flow cell;It is also Including the first collimation lens, the first achromatic lens and the second collimation lens;First collimation lens, the first achromatic lens and Two collimation lenses are sequentially located between light emitting source and sample flow cell and in the emitting light path in light emitting source;First collimation lens The light that light emitting source is sent out can be collimated;First achromatic lens can carry out the light by the first collimation lens collimation Achromatism and focusing;Second collimation lens is located at the focal position of the emergent ray of the first achromatic lens, can be by first Achromatic lens emergent ray is collimated;Sample flow cell is located in the emitting light path of the second collimation lens, to realize sugar Change hemoglobin analysis detection so that the light that the utility model first issues light emitting source carry out collimation and colour killing, collimation and The first optical focus after colour killing is far and near consistent, and hot spot is evenly distributed, and the collimated light beam after collimation is finally irradiated sample flow cell In on sample, very perfect effect can be reached in this way so that testing result is very accurate and stablizes.
Description of the drawings
Utility model will be further described in detail below with reference to the attached drawings and specific embodiments.
Fig. 1 is the light path principle figure for the first example that the utility model glycolated hemoglobin analysis detector provides;
Fig. 2 is the light path principle figure for the second example that the utility model glycolated hemoglobin analysis detector provides.
In figure:1, light emitting source, the 2, first collimation lens, the 3, first achromatic lens, the 4, second collimation lens, 5, sample stream Logical pond, 6, sample, the 7, first optical focus, 8, central optical axis, the 9, second achromatic lens, the 10, second optical focus.
The utility model aim is realized, the embodiments will be further described with reference to the accompanying drawings for functional characteristics and advantage.
Specific implementation mode
It should be appreciated that specific embodiment described herein is only used to explain the utility model, it is not used to limit this Utility model.
Fig. 1 is the light path principle figure for the first example that the utility model glycolated hemoglobin analysis detector provides, such as Glycolated hemoglobin analysis detector shown in FIG. 1 comprising light emitting source 1 and sample flow cell 5;It further includes the first collimation Lens 2, the first achromatic lens 3 and the second collimation lens 4;First collimation lens 2, the first achromatic lens 3 and second collimation Lens 4 are sequentially located between light emitting source 1 and sample flow cell 5 and in the emitting light path in light emitting source 1;First collimation lens 2 The light that can be sent out to light emitting source 1 collimates;First achromatic lens 3 can be to the light by the first collimation lens 2 collimation Carry out achromatism and focusing;Second collimation lens 4 is located at the focal position of the emergent ray of the first achromatic lens 3, can be with First achromatic lens, 3 emergent ray is collimated;Sample flow cell 5 is located in the emitting light path of the second collimation lens 4, obtains It can be irradiated on the sample 6 of sample flow cell 5 to collimated light beam, to realize glycosylated hemoglobin analysis detection, wherein shine The light that source 1 issues carries out collimation and colour killing by the first collimation lens 2, the first achromatic lens 3 and the second collimation lens 4, Collimation is far and near consistent with the first optical focus 7 after colour killing, and hot spot is evenly distributed, and the collimated light beam after collimation irradiates sample flow cell 5 on sample 6, can reaching very perfect effect so that testing result is very accurate and stablizes.
In specific implementation, the central optical axis 8 of first collimation lens is overlapped with the central ray position of light emitting source, described The central optical axis 8 of first achromatic lens and 8 position of central optical axis of the first collimation lens coincide;In second collimation lens Heart optical axis 8 and the position of the central optical axis 8 of the first achromatic lens 3 coincide, the center line of central optical axis, that is, light beam, this implementation Central optical axis 8 in example is with light emitting source 1 for unlimited central point, and light penetrates the first collimation lens from the central point straight line 2, the first achromatic lens 3 and the second collimation lens 4, and the optical axis being irradiated on the sample 6 of sample flow cell 5, i.e., first is accurate Straight lens 2, the first achromatic lens 3 and the second collimation lens 4 are between light emitting source 1 and sample flow cell 5, along light emitting source 1 Light source exit direction successively combination settings on same central optical axis 8.
In specific implementation, during first collimation lens 2, the first achromatic lens 3 and the second collimation lens 4 are for being aligned Two surface shapes of heart optical axis 8 are spherical surface, both arbitrary face between aspherical or cylinder or spherical surface, aspherical or cylinder Combination.
Preferably, the first collimation lens 2, the first achromatic lens 3 and the second collimation lens 4 are used for centring optical axis 8 Two surface shapes be non-spherical lens or spherical surface and both aspherical combination.
Preferably, the quantity of first collimation lens, 2 and second collimation lens 4 is at least one, when the first collimation When the quantity of lens 2 or the second collimation lens 4 is multiple, installation site and quantity do not require, as long as can send out light emitting source 1 The light gone out is collimated.
In specific implementation, first achromatic lens 3 is the different lens of two or more than two refractive index, dispersive power Gluing forms, or closes lens for air-gap achromatism more, and the light of at least two wavelength for being used to send out light emitting source 1 is in the It is focused coincidence at one optical focus 7.
Preferably, first achromatic lens 3 can be that air-gap achromatism closes lens more.
Preferably, the first achromatic lens 3 can also be multiple, multiple when the quantity of the first achromatic lens 3 is multiple The installation site and quantity of first achromatic lens 3 do not require, as long as can send out the carry out achromatism of light to light emitting source 1 and make The light of at least two wavelength focuses coincidence at the first optical focus 7, or standard again after the light progress achromatism sent out to light emitting source 1 It is straight.
Fig. 2 is the light path principle figure for the second example that the utility model glycolated hemoglobin analysis detector provides, such as Glycolated hemoglobin analysis detector shown in Fig. 2 comprising light emitting source 1 and sample flow cell 5;It further includes the first collimation Lens 2, the first achromatic lens 3, the second achromatic lens 9 and the second collimation lens 4;Second achromatic lens 9, first collimates Lens 2, the first achromatic lens 3 and the second collimation lens 4 are sequentially located between light emitting source 1 and sample flow cell 5 and in hairs In the emitting light path of light source 1;Second achromatic lens 9 can carry out the light of incident light emitting source 1 achromatism and focusing, and second Achromatic lens(9)Emergent ray focal position and the first collimation lens(2)Center overlap, the second achromatic lens (9)It can be to light emitting source(1)The light of at least two wavelength sent out is in the second optical focus(10)Place is focused coincidence;First is accurate Straight lens 2 can be to the second achromatic lens(9)Emergent ray collimated;First achromatic lens 3 can be to accurate by first The light that straight lens 2 collimate carries out achromatism and focusing;Second collimation lens 4 is located at the emergent ray of the first achromatic lens 3 Focal position, 3 emergent ray of the first achromatic lens can be collimated;It is saturating that sample flow cell 5 is located at the second collimation In the emitting light path of mirror 4, obtaining collimated light beam can be irradiated on the sample 6 of sample flow cell 5, to realize glycosylated hemoglobin Analysis detection.
In the embodiment, the light that light emitting source 1 issues is first into the second achromatic lens excessively(9)It carries out achromatism and gathers Coke, the light after by first time achromatism and focusing is collimated by the first collimation lens 2, using the first achromatic lens 3 achromatism and focusing again are irradiated to after being collimated finally by the second collimation lens 4 on the sample 6 of sample flow cell 5, are passed through Repeatedly collimation is far and near consistent with the light of multiple wavelength of the first optical focus 7 after colour killing, and hot spot is evenly distributed, by the second collimation Lens 4 collimate after collimated light beam irradiation sample flow cell 5 in very perfect effect on sample 6, can be reached so that detection As a result very accurate and stable.
In specific implementation, the central optical axis 8 of first collimation lens is overlapped with the central ray position of light emitting source, described The central optical axis 8 of first achromatic lens 3 and the second achromatic lens 9 with 8 position phase of the central optical axis of the first collimation lens It overlaps;The central optical axis 8 of second collimation lens and the position of the central optical axis 8 of the first achromatic lens coincide, central optical axis That is the center line of light beam, the central optical axis 8 in the present embodiment are with light emitting source 1 for unlimited central point, and light is from the center Point straight line penetrates the first collimation lens 2, the first achromatic lens 3 and the second collimation lens 4, and is irradiated in sample flow cell 5 Optical axis on sample 6, i.e. the second achromatic lens 3, the first collimation lens 2, the first achromatic lens 3 and the second collimation lens 4 Between light emitting source 1 and sample flow cell 5, along light emitting source 1 light source exit direction successively combination settings in same central optical axis 8 On.
In specific implementation, second achromatic lens 3, the first collimation lens 2, the first achromatic lens 3 and second are accurate Straight lens 4 for two surface shapes of centring optical axis 8 are spherical surface, aspherical or cylinder or spherical surface, aspherical or column The combination in both arbitrary face between face.
Preferably, the second achromatic lens 9, the first collimation lens 2, the first achromatic lens 3 and the second collimation lens 4 are used It is that non-spherical lens or spherical surface and aspherical the two combine in two surface shapes of centring optical axis 8.
Preferably, the quantity of first collimation lens, 2 and second collimation lens 4 is at least one, when the first collimation When the quantity of lens 2 or the second collimation lens 4 is multiple, installation site and quantity do not require, as long as can send out light emitting source 1 The light gone out is collimated.
In specific implementation, first achromatic lens 3 is the different lens of two or more than two refractive index, dispersive power Gluing forms, or closes lens for air-gap achromatism more, and the light of at least two wavelength for being used to send out light emitting source 1 is in the It is focused coincidence at one optical focus 7.
Preferably, first achromatic lens, 3 and second achromatic lens 9 all can be close thoroughly more air-gap achromatism Mirror.
Although the foregoing describe specific embodiment of the present utility model, those skilled in the art should manage Solution, these are merely examples, various changes or modifications can be made to present embodiment, without departing from the original of the utility model Reason and essence, the scope of protection of the utility model are only limited by the claims that follow.

Claims (8)

1. a kind of glycolated hemoglobin analysis detector, including light emitting source(1)With sample flow cell(5);It is characterized in that:Its It further include the first collimation lens(2), the first achromatic lens(3)With the second collimation lens(4);First collimation lens(2), first Achromatic lens(3)With the second collimation lens(4)It is sequentially located at light emitting source(1)With sample flow cell(5)Between and in shine Source(1)Emitting light path in;
First collimation lens(2)It can be to light emitting source(1)The light sent out is collimated;First achromatic lens(3)It can be to passing through First collimation lens(2)The light of collimation carries out achromatism and focusing;Second collimation lens(4)Positioned at the first achromatic lens (3)Emergent ray focal position, can be by the first achromatic lens(3)Emergent ray is collimated;Sample flow cell (5)Positioned at the second collimation lens(4)Emitting light path in.
2. glycolated hemoglobin analysis detector described in accordance with the claim 1, which is characterized in that first collimation lens (2)Central optical axis and light emitting source(1)Central ray position overlap, first achromatic lens(3)Central optical axis with First collimation lens(2)Central optical axis position coincide;Second collimation lens(4)Central optical axis and the first achromatic lens (3)The position of central optical axis coincide.
3. glycolated hemoglobin analysis detector according to claim 2, which is characterized in that first collimation lens (2), the first achromatic lens(3)With the second collimation lens(4)For centring optical axis(8)Two surface shapes be ball Face, aspherical or cylinder or two surface shapes are the combination of spherical surface, aspherical, in cylinder three arbitrary the two.
4. glycolated hemoglobin analysis detector described in accordance with the claim 3, which is characterized in that first collimation lens (2)With the second collimation lens(4)Quantity be at least one.
5. glycolated hemoglobin analysis detector according to claim 4, which is characterized in that first achromatism is saturating Mirror(3)It is formed by the different lens gluing of two or more than two refractive index, dispersive power.
6. glycolated hemoglobin analysis detector according to claim 5, which is characterized in that first achromatism is saturating Mirror(3)Lens are closed for air-gap achromatism more.
7. according to claim 6 or the glycolated hemoglobin analysis detector, which is characterized in that first achromatism Lens(3)It can be to light emitting source(1)The light of at least two wavelength sent out is in the first optical focus(7)Place is focused coincidence.
8. according to claim 1 to 7 any one of them glycolated hemoglobin analysis detector, which is characterized in that the hair Light source(1)With the first collimation lens(2)Between light path in be additionally provided with the second achromatic lens(9), second achromatism is saturating Mirror(9)Emergent ray focal position and the first collimation lens(2)Center overlap, the second achromatic lens(9)It can be to hair Light source(1)The light of at least two wavelength sent out is in the second optical focus(10)Place is focused coincidence.
CN201820442945.2U 2018-03-30 2018-03-30 Glycolated hemoglobin analysis detector Expired - Fee Related CN208013058U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201820442945.2U CN208013058U (en) 2018-03-30 2018-03-30 Glycolated hemoglobin analysis detector

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201820442945.2U CN208013058U (en) 2018-03-30 2018-03-30 Glycolated hemoglobin analysis detector

Publications (1)

Publication Number Publication Date
CN208013058U true CN208013058U (en) 2018-10-26

Family

ID=63891321

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201820442945.2U Expired - Fee Related CN208013058U (en) 2018-03-30 2018-03-30 Glycolated hemoglobin analysis detector

Country Status (1)

Country Link
CN (1) CN208013058U (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112683937A (en) * 2019-10-18 2021-04-20 北航(四川)西部国际创新港科技有限公司 Multi-source ray integration device

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112683937A (en) * 2019-10-18 2021-04-20 北航(四川)西部国际创新港科技有限公司 Multi-source ray integration device
CN112683937B (en) * 2019-10-18 2024-05-10 北航(四川)西部国际创新港科技有限公司 Multisource ray integration device

Similar Documents

Publication Publication Date Title
CN107462405B (en) Broadband differential confocal Infrared Lens element refractive index measurement method and device
JP6352713B2 (en) Flow cytometer, particle analyzer and flow cytometry method
CN101153868B (en) Stream type cell analyzer
JP4713037B2 (en) Fluorescent capillary interface with laser excitation
CN105705932B (en) Improvement related with particle characterization
CN108709858A (en) Glycolated hemoglobin analysis detector
JP7429643B2 (en) Optical flow cytometer for epifluorescence measurements
US5446532A (en) Measuring apparatus with optically conjugate radiation fulcrum and irradiated area
CN106997091B (en) A kind of laser angular measurement lens optical system
CN106019608A (en) Gaussian-like flat-topped beam laser system
CN207408305U (en) A kind of multichannel fluorescence detecting system
CN106841014A (en) Flow cytometer gathers the optical system of camera lens and two-color laser flow cytometer
CN105223137B (en) A kind of optical measuring device for detection of biological samples
CN106017673A (en) MEMS-scanning-micromirror-based double-pass grating monochrometer optical path structure
CN208013058U (en) Glycolated hemoglobin analysis detector
CN108646422B (en) Multi-laser beam shaping system and method for stream detection
KR20220159975A (en) Configuring an optical spectroscopy probe to focus light onto a portion of the sample
CN107782697A (en) The confocal Infrared Lens element refractive index measurement method of broadband and device
GB2125181A (en) Flow cells for particle study
CN110411933B (en) Forward scattering light detection system, flow cytometer, and method for measuring cell diameter
CN207215699U (en) A kind of universal spectroscopic analysis system
CN104019893B (en) Offner structure imaging spectrogrph
CN205898637U (en) A catoptric system for flow cytometer polychrome laser focusing
US20120243567A1 (en) Laser irradiation device and microparticle measuring device
CN206489074U (en) A kind of fluorescence detecting system for cytoanalyze

Legal Events

Date Code Title Description
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20181026

Termination date: 20210330