CN208008809U - 1.2 μm of normal pore size liquid medicine filter Candida albicans rejection tests device - Google Patents
1.2 μm of normal pore size liquid medicine filter Candida albicans rejection tests device Download PDFInfo
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- CN208008809U CN208008809U CN201721890197.6U CN201721890197U CN208008809U CN 208008809 U CN208008809 U CN 208008809U CN 201721890197 U CN201721890197 U CN 201721890197U CN 208008809 U CN208008809 U CN 208008809U
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Abstract
1.2 μm of normal pore size liquid medicine filter Candida albicans rejection tests device, including challenging suspension containing reagent bottle, challenge a fittings of the suspension containing reagent bottle by hose and four-way connection, peristaltic pump is set on hose, remaining three connector of four-way connection are connected to one end of first pipe, second pipe and third pipeline respectively, flow valve is respectively mounted on first pipe, second pipe and third pipeline, first pipe and the second pipe other end are respectively connected to an inlet for reagent liquid filter.The utility model has the advantage of：Contrasting detection can be carried out to the Candida albicans rejection effect of liquid medicine filter to be measured, control group is synchronouss with the test process of test group to carry out, and test result is accurate, reliably etc..
Description
Technical field
The utility model is related to a kind of liquid medicine filter detection experimental rig and method, specifically a kind of normal pore sizes
1.2 μm of liquid medicine filter Candida albicans rejection tests device and methods.
Background technology
Currently, the infusion apparatus with the 1.2 μm of liquid medicine filters in normal pore size is mainly used for the total nutrient admixture of fatty breast
（TNA）, the drugs such as Lansoprazole venoclysis.For Fat Emulsion class drug, the main function of liquid medicine filter is to filter out it
In particle and bubble etc..For Lansoprazole drug, the main function of liquid medicine filter is to filter out in infusion process to produce
Raw sediment etc..Total nutrient admixture（TNA）Contain carbohydrate, amino acid, lipid, vitamin, minerals and micro
Element is the good growing environment of microorganism.Although all paying attention to keeping its aseptic during production, preparation and infusion,
Microbial contamination is still even generation.Wherein, candida albicans is contaminating microorganisms the most typical.It is generally believed that being used for full nutrition
Mixed liquor（TNA）1.2 μm of the normal pore size liquid medicine filter of infusion is also answered other than filtering out particle and bubble therein etc.
The candida albicans that may wherein pollute can be effectively filtered out.
Utility model content
The purpose of this utility model is to provide a kind of 1.2 μm of liquid medicine filter Candida albicans rejection tests dresses in normal pore size
It sets and method, it can test the liquid medicine filter of 1.2 μm of normal pore size, detect its effect of shutting off to Candida albicans
Fruit.
The utility model to achieve the above object, is achieved through the following technical solutions：1.2 μm of normal pore size liquid medicine filter
Candida albicans rejection tests device, including challenge suspension containing reagent bottle, challenge suspension containing reagent bottle pass through hose and four
One fittings of pass joint, are arranged peristaltic pump on hose, four-way connection remaining three connector respectively with first pipe,
Two pipelines are connected to one end of third pipeline, and flow valve, first pipe are respectively mounted on first pipe, second pipe and third pipeline
Respectively be connected to an inlet for reagent liquid filter with the second pipe other end, two for reagent liquid filter liquid outlet it is each
It is connected to corresponding filtrate collection reagent bottle by an insertion pipe, the third pipeline other end passes through another insertion pipe
It is connected to positive control agent bottle.The filtrate collection reagent bottle is identical with the structure of positive control agent bottle, includes bottle
Body, bottle side wall install one-way exhaust valve, bottleneck ring are installed at bottle upper opening, installs lid on bottleneck ring, lid passes through
Screw thread and bottleneck ring are connected, and internal projecting ring is arranged in bottleneck ring internal perisporium bottom, are arranged supporting plate on internal projecting ring, supporting plate, lid and
The side wall of bottleneck ring surrounds cavity jointly, the annular liquid capsule of installation in cavity, hydraulically full in annular liquid capsule, annular liquid capsule center of circle position
Set and open up first through hole on the lid of top, open up the second through-hole on the supporting plate below annular liquid capsule center location, insertion pipe according to
It is secondary to pass through first through hole, annular liquid capsule（10）With insertion bottle（300）Inside, supporting plate top surface open up groove, bottom portion of groove installation
Contact switch, contact switch top is arranged movable plate, spring is installed between movable plate and bottom portion of groove, when movable plate moves down, bullet
Spring compresses, and movable plate can press the contact of contact switch, when movable plate moves up, spring-relaxation, movable plate and contact switch
Contact chip is arranged in contact separation, supporting plate bottom surface, and contact chip is connect by circuit with contact switch, and ring is arranged in convex top surface of ring border
Shape contact, when supporting plate is placed on internal projecting ring, contact chip can with annular contact pad and be connected, setting control in bottleneck ring
Device, controller are connect by circuit with annular contact, and controller can detect the open and-shut mode of contact switch, control by circuit
Device is connect with signal transmission line and power circuit.Blind hole is opened up on the bottleneck ring inner wall, and electric pushrod, electricity are installed in blind hole
Dynamic push rod is connect by circuit with controller, and controller can control the flexible of electric pushrod, the movable boom end of electric pushrod
Baffle is installed, baffle can move under the driving of electric pushrod in blind hole, and when electric pushrod extended configuration, baffle is located at blind
The opening in hole is contacted with annular liquid capsule, and when electric pushrod contraction state, baffle can be withdrawn inside blind hole.
To the method that 1.2 μm of normal pore size liquid medicine filter carries out Candida albicans rejection tests, include the following steps：
1. 2400mL total nutrient admixtures are injected in challenge suspension containing reagent bottle；
2. by the Candida albicans ATCC10231 of deposit from streak inoculation on work bacterial strain inclined-plane to Sabouraud's dextrose agar
On culture medium flat plate, 48h is cultivated at 25 DEG C；
3. the picking single bacterium colony on the culture medium flat plate 2. step is cultivated after is seeded to and fills 100 mL Sabouraud dextrose liquid
In the 250mL conical flasks of body culture medium, 160rpm shaken cultivations for 24 hours, obtain culture solution at 25 DEG C ± 1 DEG C；
4. 3. culture solution that step obtains is inoculated in 1. reagent bottle that step fills total nutrient admixture, mixing is equal
It is even, obtain the challenge suspension containing reagent bottle equipped with challenge suspension；
Challenge suspension is equipped with 5. taking a four-way connection, 4. a connector of the four-way connection by hose and step
The connection of suspension containing reagent bottle is challenged, peristaltic pump is installed on hose, by four-way connection remaining three connector respectively with first
Pipeline, second pipe are connected to one end of third pipeline, and flow is respectively mounted on first pipe, second pipe and third pipeline
First pipe and the second pipe other end are respectively connected to an inlet for reagent liquid filter by valve, and two for reagent liquid mistake
The liquid outlet of filter is respectively connected to by an insertion pipe with corresponding filtrate collection reagent bottle, by the third pipeline other end
It is connected to positive control agent bottle；
6. starting peristaltic pump, adjustment flow will challenge the challenge suspension in suspension containing reagent bottle to each to 100 mL/h
It is pumped for 24 hours in filtrate collection reagent bottle and positive control agent bottle；
7. taking the whole filter liquors and challenge suspension in each filtrate collection reagent bottle and positive control agent bottle, ginseng respectively
According to《Chinese Pharmacopoeia》Version the 4th 1105 in 2015《Non-sterile product limit test of microbe：Microorganism count method》In film
Filtration method is counted.
The utility model has the advantage of：The Candida albicans rejection effect of liquid medicine filter to be measured can be compared
Detection, control group is synchronouss with the test process of test group to carry out, and test result is accurate, reliably etc..
Description of the drawings
Fig. 1 is the structural schematic diagram of the utility model；
Fig. 2 is the portions I enlarged structure schematic diagram in Fig. 1；
Fig. 3 is that insertion pipe is not inserted into the structural schematic diagram in bottle in structure shown in Fig. 2.
Specific implementation mode
1.2 μm of liquid medicine filter Candida albicans rejection tests devices in normal pore size described in the utility model include challenge
Suspension containing reagent bottle 101, challenge suspension containing reagent bottle 101 are connected by a connector of hose 102 and four-way connection 104
It is logical, peristaltic pump 103 is set on hose 102, four-way connection 104 remaining three connector respectively with first pipe 105, second pipe
106 are connected to one end of third pipeline 107, and flow valve is respectively mounted on first pipe 105, second pipe 106 and third pipeline 107
108, first pipe 105 and 106 other end of second pipe are respectively connected to an inlet for reagent liquid filter 109, and two supply
The liquid outlet of reagent liquid filter 109 is respectively connected by an insertion pipe 112 and corresponding filtrate collection reagent bottle 110
Logical, 107 other end of third pipeline is connected to by another insertion pipe 112 with positive control agent bottle 111.Before test, challenging
Injection challenge suspension in suspension containing reagent bottle 101, install in first pipe 105 and second pipe 106 for trying medical filtration
Device 109 selects the liquid medicine filter of the liquid medicine filter and a known good batch of a batch to be measured respectively, compacted when test
Dynamic pump 103 starts, and the challenge suspension challenged in suspension containing reagent bottle 101 is slowly pumped out, through four-way connection 104 respectively into
Enter first pipe 105, second pipe 106 and third pipeline 107, the challenge suspension in first pipe 105 and second pipe 106 point
It is not filtered by the liquid medicine filter of batch to be measured and the liquid medicine filter of known good batch, filter liquor enters corresponding
Filtrate collection reagent bottle 110 is collected, and the challenge suspension in third pipeline 107 is directly entered positive control agent bottle without filtering
111 collect, then in two filtrate collection reagent bottles 110 and positive control agent bottle 111 whole filter liquors and challenge
Suspension is counted using membrane-filter procedure, you can judges whether the liquid medicine filter of batch to be measured has Candida albicans retention
Whether effect, and effect of shutting off comply with standard.The utility model can retain the Candida albicans of liquid medicine filter to be measured
Effect carries out contrasting detection, and control group is synchronous with the test process of test group to carry out, and test result is accurate, reliable.
Since the test process of the present apparatus is longer, peristaltic pump 103 is usually not required to staff after starting and aside observes, this
Utility model is in order to avoid the microorganism in environment is from insertion pipe and filtrate collection reagent bottle 110 or positive control agent bottle
Enter in bottle between 111, influences test result, following structures can be used：The filtrate collection reagent bottle 110 and positive control
The structure of reagent bottle 111 is identical, includes bottle 300, and 300 side wall of bottle installs one-way exhaust valve 303, and 300 top of bottle is opened
Bottleneck ring 1 is installed at mouthful, lid 2 is installed on bottleneck ring 1, lid 2 is connected by screw thread and bottleneck ring 1,1 inner circumferential of bottleneck ring
Internal projecting ring 7 is arranged in wall bottom, and supporting plate 8 is arranged on internal projecting ring 7, and the side wall of supporting plate 8, lid 2 and bottleneck ring 1 surrounds cavity 9 jointly,
The annular liquid capsule 10 of installation in cavity 9, it is hydraulically full in annular liquid capsule 10, it is opened on the lid 2 above 10 center location of annular liquid capsule
If first through hole 301, the second through-hole 302 is opened up on the supporting plate 8 below 10 center location of annular liquid capsule, insertion pipe 112 passes through successively
Cross first through hole 301, annular 10 and second through-hole 302 of liquid capsule is inserted into inside bottle 300,8 top surface of supporting plate opens up groove 11, groove
Contact switch 12 is installed in 11 bottoms, and movable plate 23 is arranged in 12 top of contact switch, and movable plate 23 and groove are installed between 11 bottom
Spring 24, when movable plate 23 moves down, spring 24 compresses, and movable plate 23 can press the contact of contact switch 12, on movable plate 23
When shifting, 24 diastole of spring, the contact separation of movable plate 23 and contact switch 12, contact chip 13, contact chip 13 is arranged in 8 bottom surface of supporting plate
It is connect with contact switch 12 by circuit, the annular contact 14 of 7 top surface border of internal projecting ring setting, supporting plate 8 is placed on internal projecting ring 7
When, contact chip 13 can contact and be connected with annular contact 14, and controller 15 is arranged in bottleneck ring 1, and controller 15 passes through circuit
It is connect with annular contact 14, controller 15 can detect the open and-shut mode of contact switch 12, controller 15 and signal by circuit
Transmission line is connected with power circuit.After insertion pipe 112 is inserted into 300 inside of bottle, the softness and elasticity of annular liquid capsule 10 itself
Feature can be such that itself and 112 outer wall of insertion pipe is fitted close, and realize good sealing, one-way exhaust valve 303 be used in filter liquor or
Challenge suspension enters the gas that 300 heel row of bottle goes out in bottle 300, and the side wall of insertion pipe 112 is from 10 inside of annular liquid capsule to ring
Shape liquid capsule 10, which is formed, to be squeezed, and annular liquid capsule 10 protrudes Compressive activities plate 23 from groove 11, and movable plate 23 overcomes the bullet of spring 24
Power is moved to 12 side of contact switch, presses the contact of moving contact switch 12, and controller 15 detects the tactile of contact switch 12 at this time
Point be pressed, judge 112 side wall of insertion pipe with 10 tight fit inside of annular liquid capsule, favorable sealing property.It was testing
If insertion pipe 112 is pulled out or the unexpected abjection inside bottle 300 in journey, 10 inside of annular liquid capsule loses pressure, liquid capsule
The pressure of 10 pairs of movable plates 23 reduces, and movable plate 23 leaves contact switch 12 under the elastic force effect of spring 24, and controller 15 is examined
The contact for measuring contact switch 12 is bounced, and judges that the sealing at annular liquid capsule 10 is destroyed, the accuracy of this test data without
Method ensures, not can be used as Appreciation gist, controller 15 can send out alarm signal and record warning message.Such as entire test process
The sealing that middle controller 15 is not detected at annular liquid capsule 10 goes wrong, then the result reliability of the secondary test is higher, can
To be evaluated the Candida albicans rejection effect of the liquid medicine filter of the batch according to the test result.Lid 2 passes through spiral shell
Line and bottleneck ring 1 are connected, and the rotatable lid of staff 2 adjusts the elastic of lid 2 and bottleneck ring 1, to annular liquid capsule
10 pressure sizes are adjusted, and realize the adjusting for the sensitivity that contact switch 12 is triggered to annular liquid capsule 10.
The utility model avoids warning function failure from leading to bottle in order to carry out self-test to the warning function of controller 15
Fail to find, to influence test result, blind hole 19, blind hole can be opened up on 1 inner wall of the bottleneck ring in time when body seal failure
Electric pushrod 20 is installed, electric pushrod 20 is connect by circuit with controller 15, and controller 15 can control electric pushrod in 19
20 it is flexible, the movable boom end of electric pushrod 20 installs baffle 21, and baffle 21 can be under the driving of electric pushrod 20 blind
It is moved in hole 19, when 20 extended configuration of electric pushrod, the opening that baffle 21 is located at blind hole 19 is contacted with annular liquid capsule 10, electronic
When 20 contraction state of push rod, baffle 21 can be withdrawn inside blind hole 19.Electric pushrod 20 is in extended configuration usually, needs self-test
When, staff can be shunk by signal line remote control electric pushrod 20, so that baffle 21 is retracted to inside blind hole 19, at this time
The annular liquid capsule 10 of 19 opening of blind hole can be to prominent, 23 pressure of the movable plate reduction in groove 11 inside blind hole 19, movable plate
23 leave contact switch 12 under the elastic force effect of spring 24, and such as controller 15 normally sends out alarm at this time, then judges work(of alarming
It can be working properly.After self-test, remote control electric push rod 20 restores extended configuration, and baffle 21 will blast the annular liquid capsule 10 of blind hole 19
The opening of blind hole 19 is pushed back, 23 pressure of movable plate in groove 11 increases, and movable plate 23 overcomes the elastic force of spring 24 to contact
12 side of switch is moved, and the contact of contact switch 12 is pressed.Controller 15 does not send out alarm normally when such as self-test, then judges to alarm
Functional status is abnormal, this test result not can be used as Appreciation gist.
The method described in the utility model that Candida albicans rejection tests are carried out to 1.2 μm of normal pore size liquid medicine filter,
It is characterized in that：Include the following steps：
1. 2400mL total nutrient admixtures are injected in challenge suspension containing reagent bottle 101；
2. by the Candida albicans ATCC10231 of deposit from streak inoculation on work bacterial strain inclined-plane to Sabouraud's dextrose agar
On culture medium flat plate, 48h is cultivated at 25 DEG C；
3. the picking single bacterium colony on the culture medium flat plate 2. step is cultivated after is seeded to and fills 100 mL Sabouraud dextrose liquid
In the 250mL conical flasks of body culture medium, 160rpm shaken cultivations for 24 hours, obtain culture solution at 25 DEG C ± 1 DEG C；
4. 3. culture solution that step obtains is inoculated in 1. reagent bottle that step fills total nutrient admixture, mixing is equal
It is even, obtain the challenge suspension containing reagent bottle 101 equipped with challenge suspension；
5. taking a four-way connection 104,4. a connector of the four-way connection 104 is equipped with by hose 102 with step
Challenge suspension challenge suspension containing reagent bottle 101 be connected to, on hose 102 install peristaltic pump 103, by four-way connection 104 its
Three remaining connectors are connected to one end of first pipe 105, second pipe 106 and third pipeline 107 respectively, in first pipe
105, it is respectively mounted flow valve 108 on second pipe 106 and third pipeline 107, first pipe 105 and second pipe 106 is another
End is respectively connected to an inlet for reagent liquid filter 109, and two respectively pass through one for the liquid outlet of reagent liquid filter 109
Insertion pipe 112 is connected to corresponding filtrate collection reagent bottle 110, and 107 other end of third pipeline and positive control are tried
Agent bottle 111 is connected to；
6. starting peristaltic pump 103, adjustment flow to 100 mL/h hangs the challenge challenged in suspension containing reagent bottle 101
Liquid pumps for 24 hours into each filtrate collection reagent bottle 110 and positive control agent bottle 111；
7. taking whole filter liquors in each filtrate collection reagent bottle 110 and positive control agent bottle 111, reference respectively
《Chinese Pharmacopoeia》Version the 4th 1105 in 2015《Non-sterile product limit test of microbe：Microorganism count method》In film mistake
Filter method is counted.
Above-mentioned steps can to the Candida albicans rejection effect of liquid medicine filter to be measured carry out contrasting detection, control group and
The test process of test group, which synchronizes, to carry out, and test result is accurate, reliable.
1. 1.2 μm of normal pore size liquid medicine filter Candida albicans rejection tests device, it is characterised in that：Including challenge
Suspension containing reagent bottle（101）, challenge suspension containing reagent bottle（101）Pass through hose（102）With four-way connection（104）One
Fittings, hose（102）Upper setting peristaltic pump（103）, four-way connection（104）Remaining three connector respectively with first pipe
（105）, second pipe（106）With third pipeline（107）One end connection, first pipe（105）, second pipe（106）With
Three pipelines（107）On be respectively mounted flow valve（108）, first pipe（105）And second pipe（106）The other end is respectively with one for examination
Liquid medicine filter（109）Inlet connection, two for reagent liquid filter（109）Liquid outlet respectively pass through an insertion pipe
（112）With corresponding filtrate collection reagent bottle（110）Connection, third pipeline（107）The other end passes through another grafting
Pipe（112）With positive control agent bottle（111）Connection.
2. 1.2 μm of liquid medicine filter Candida albicans rejection tests devices in normal pore size according to claim 1,
It is characterized in that：The filtrate collection reagent bottle（110）With positive control agent bottle（111）Structure it is identical, include bottle
Body（300）, bottle（300）Side wall installs one-way exhaust valve（303）, bottle（300）Bottleneck ring is installed at upper opening（1）, bottle
Mouth circle（1）Upper installation lid（2）, lid（2）Pass through screw thread and bottleneck ring（1）It is connected, bottleneck ring（1）Internal perisporium bottom is set
Set internal projecting ring（7）, internal projecting ring（7）Upper setting supporting plate（8）, supporting plate（8）, lid（2）And bottleneck ring（1）Side wall surround sky jointly
Chamber（9）, cavity（9）The annular liquid capsule of interior installation（10）, annular liquid capsule（10）It is interior hydraulically full, annular liquid capsule（10）On center location
The lid of side（2）On open up first through hole（301）, annular liquid capsule（10）Supporting plate below center location（8）On to open up second logical
Hole（302）, insertion pipe（112）Pass through first through hole successively（301）, annular liquid capsule（10）With the second through-hole（302）It is inserted into bottle
（300）Inside, supporting plate（8）Top surface opens up groove（11）, groove（11）Bottom is installed by contact switch（12）, contact switch（12）On
Side's setting movable plate（23）, movable plate（23）With groove（11）Spring is installed between bottom（24）, movable plate（23）When moving down, bullet
Spring（24）Compression, movable plate（23）Contact switch can be pressed（12）Contact, movable plate（23）When moving up, spring（24）It relaxes
, movable plate（23）With contact switch（12）Contact separation, supporting plate（8）Contact chip is arranged in bottom surface（13）, contact chip（13）It is logical
Oversampling circuit and contact switch（12）Connection, internal projecting ring（7）The annular contact of top surface border setting（14）, supporting plate（8）It is placed on convex
Ring（7）When upper, contact chip（13）It can be with annular contact（14）It contacts and is connected, bottleneck ring（1）Interior setting controller（15）, control
Device processed（15）Pass through circuit and annular contact（14）Connection, controller（15）Contact switch can be detected by circuit（12）Open
Closed state, controller（15）It is connect with signal transmission line and power circuit.
3. 1.2 μm of liquid medicine filter Candida albicans rejection tests devices in normal pore size according to claim 2,
It is characterized in that：The bottleneck ring（1）Blind hole is opened up on inner wall（19）, blind hole（19）Interior installation electric pushrod（20）, electronic to push away
Bar（20）Pass through circuit and controller（15）Connection, controller（15）Electric pushrod can be controlled（20）Flexible, electric pushrod
（20）Movable boom end install baffle（21）, baffle（21）It can be in electric pushrod（20）Driving under in blind hole（19）Interior shifting
It is dynamic, electric pushrod（20）When extended configuration, baffle（21）Positioned at blind hole（19）Opening and annular liquid capsule（10）Contact, it is electronic
Push rod（20）When contraction state, baffle（21）Blind hole can be withdrawn（19）It is internal.
4. carrying out Candida albicans to 1.2 μm of normal pore size liquid medicine filter using the experimental rig as described in claim 1-3
The method of bacterium rejection tests, it is characterised in that：Include the following steps：
1. 2400mL total nutrient admixtures are injected challenge suspension containing reagent bottle（101）In；
2. by the Candida albicans ATCC10231 of deposit from streak inoculation on work bacterial strain inclined-plane to Sabouraud's dextrose agar
On culture medium flat plate, 48h is cultivated at 25 DEG C；
3. the picking single bacterium colony on the culture medium flat plate 2. step is cultivated after is seeded to and fills 100 mL Sabouraud dextrose liquid
In the 250mL conical flasks of body culture medium, 160rpm shaken cultivations for 24 hours, obtain culture solution at 25 DEG C ± 1 DEG C；
4. 3. culture solution that step obtains is inoculated in 1. reagent bottle that step fills total nutrient admixture, mixing is equal
It is even, obtain the challenge suspension containing reagent bottle equipped with challenge suspension（101）；
5. taking a four-way connection（104）, by the four-way connection（104）A connector pass through hose（102）With step
4. the challenge suspension containing reagent bottle equipped with challenge suspension（101）Connection, in hose（102）Upper installation peristaltic pump（103）, by four
Pass joint（104）Remaining three connector respectively with first pipe（105）, second pipe（106）With third pipeline（107）One
End connection, in first pipe（105）, second pipe（106）With third pipeline（107）On be respectively mounted flow valve（108）, by first
Pipeline（105）And second pipe（106）The other end is respectively with one for reagent liquid filter（109）Inlet connection, two for examination
Liquid medicine filter（109）Liquid outlet respectively pass through an insertion pipe（112）With corresponding filtrate collection reagent bottle（110）
Connection, by third pipeline（107）The other end and positive control agent bottle（111）Connection；
6. starting peristaltic pump（103）, adjustment flow to 100 mL/h will challenge suspension containing reagent bottle（101）Interior chooses
Suspension fight to each filtrate collection reagent bottle（110）With positive control agent bottle（111）Interior pumping is for 24 hours；
7. taking each filtrate collection reagent bottle respectively（110）With positive control agent bottle（111）Interior whole filter liquors, ginseng
According to《Chinese Pharmacopoeia》Version the 4th 1105 in 2015《Non-sterile product limit test of microbe：Microorganism count method》In film
Filtration method is counted.
Claims (3)
1. 1.2 μm of normal pore size liquid medicine filter Candida albicans rejection tests device, it is characterised in that：It is contained including challenge suspension
Put reagent bottle（101）, challenge suspension containing reagent bottle（101）Pass through hose（102）With four-way connection（104）A connector connect
It is logical, hose（102）Upper setting peristaltic pump（103）, four-way connection（104）Remaining three connector respectively with first pipe（105）,
Second pipe（106）With third pipeline（107）One end connection, first pipe（105）, second pipe（106）With third pipeline
（107）On be respectively mounted flow valve（108）, first pipe（105）And second pipe（106）The other end is respectively with one for reagent liquid mistake
Filter（109）Inlet connection, two for reagent liquid filter（109）Liquid outlet respectively pass through an insertion pipe（112）With it is each
Self-corresponding filtrate collection reagent bottle（110）Connection, third pipeline（107）The other end passes through another insertion pipe（112）With
Positive control agent bottle（111）Connection.
2. 1.2 μm of liquid medicine filter Candida albicans rejection tests devices in normal pore size according to claim 1, feature
It is：The filtrate collection reagent bottle（110）With positive control agent bottle（111）Structure it is identical, include bottle
（300）, bottle（300）Side wall installs one-way exhaust valve（303）, bottle（300）Bottleneck ring is installed at upper opening（1）, bottleneck
Circle（1）Upper installation lid（2）, lid（2）Pass through screw thread and bottleneck ring（1）It is connected, bottleneck ring（1）Internal perisporium bottom is arranged
Internal projecting ring（7）, internal projecting ring（7）Upper setting supporting plate（8）, supporting plate（8）, lid（2）And bottleneck ring（1）Side wall surround cavity jointly
（9）, cavity（9）The annular liquid capsule of interior installation（10）, annular liquid capsule（10）It is interior hydraulically full, annular liquid capsule（10）Above center location
Lid（2）On open up first through hole（301）, annular liquid capsule（10）Supporting plate below center location（8）On open up the second through-hole
（302）, insertion pipe（112）Pass through first through hole successively（301）, annular liquid capsule（10）With the second through-hole（302）It is inserted into bottle
（300）Inside, supporting plate（8）Top surface opens up groove（11）, groove（11）Bottom is installed by contact switch（12）, contact switch（12）On
Side's setting movable plate（23）, movable plate（23）With groove（11）Spring is installed between bottom（24）, movable plate（23）When moving down, bullet
Spring（24）Compression, movable plate（23）Contact switch can be pressed（12）Contact, movable plate（23）When moving up, spring（24）It relaxes
, movable plate（23）With contact switch（12）Contact separation, supporting plate（8）Contact chip is arranged in bottom surface（13）, contact chip（13）It is logical
Oversampling circuit and contact switch（12）Connection, internal projecting ring（7）The annular contact of top surface border setting（14）, supporting plate（8）It is placed on convex
Ring（7）When upper, contact chip（13）It can be with annular contact（14）It contacts and is connected, bottleneck ring（1）Interior setting controller（15）, control
Device processed（15）Pass through circuit and annular contact（14）Connection, controller（15）Contact switch can be detected by circuit（12）Open
Closed state, controller（15）It is connect with signal transmission line and power circuit.
3. 1.2 μm of liquid medicine filter Candida albicans rejection tests devices in normal pore size according to claim 2, feature
It is：The bottleneck ring（1）Blind hole is opened up on inner wall（19）, blind hole（19）Interior installation electric pushrod（20）, electric pushrod（20）
Pass through circuit and controller（15）Connection, controller（15）Electric pushrod can be controlled（20）Flexible, electric pushrod（20）'s
Movable boom end installs baffle（21）, baffle（21）It can be in electric pushrod（20）Driving under in blind hole（19）Interior movement, electricity
Dynamic push rod（20）When extended configuration, baffle（21）Positioned at blind hole（19）Opening and annular liquid capsule（10）Contact, electric pushrod
（20）When contraction state, baffle（21）Blind hole can be withdrawn（19）It is internal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721890197.6U CN208008809U (en) | 2017-12-29 | 2017-12-29 | 1.2 μm of normal pore size liquid medicine filter Candida albicans rejection tests device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721890197.6U CN208008809U (en) | 2017-12-29 | 2017-12-29 | 1.2 μm of normal pore size liquid medicine filter Candida albicans rejection tests device |
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| Publication Number | Publication Date |
|---|---|
| CN208008809U true CN208008809U (en) | 2018-10-26 |
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ID=63882121
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110317715A (en) * | 2019-08-16 | 2019-10-11 | 贵州大学 | A kind of mixed fermentation device for laboratory liquid state fermentation |
-
2017
- 2017-12-29 CN CN201721890197.6U patent/CN208008809U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110317715A (en) * | 2019-08-16 | 2019-10-11 | 贵州大学 | A kind of mixed fermentation device for laboratory liquid state fermentation |
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