CN207913280U - Chromatographic isolation resin column group - Google Patents
Chromatographic isolation resin column group Download PDFInfo
- Publication number
- CN207913280U CN207913280U CN201721842972.0U CN201721842972U CN207913280U CN 207913280 U CN207913280 U CN 207913280U CN 201721842972 U CN201721842972 U CN 201721842972U CN 207913280 U CN207913280 U CN 207913280U
- Authority
- CN
- China
- Prior art keywords
- resin column
- chromatographic isolation
- resin
- column
- discharge port
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000011347 resin Substances 0.000 title claims abstract description 100
- 229920005989 resin Polymers 0.000 title claims abstract description 100
- 238000007445 Chromatographic isolation Methods 0.000 title claims abstract description 27
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract description 20
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 abstract description 10
- 229930003268 Vitamin C Natural products 0.000 abstract description 10
- 235000019154 vitamin C Nutrition 0.000 abstract description 10
- 239000011718 vitamin C Substances 0.000 abstract description 10
- 239000012452 mother liquor Substances 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 7
- 239000004480 active ingredient Substances 0.000 description 3
- 238000005265 energy consumption Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000013375 chromatographic separation Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Landscapes
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The utility model discloses a kind of chromatographic isolation resin column groups, including the first resin column, the second resin column and third resin column, the discharge port of first resin column is connected to the feed inlet of the second resin column, the discharge port of second resin column is connected to the feed inlet of third resin column, the discharge port of third resin column is connected with discharge pipe, there are two valves for setting above discharge pipe, and the first pump is equipped between the first resin column and the second resin column, and the second pump is equipped between the second resin column and third resin column；The specification all same of first resin column, the second resin column and third resin column, it is 3~4m that the specification of the first resin column, which is length, and internal diameter is 0.8~1.2m.The chromatographic isolation resin column group can effectively reduce the length of single resin column, improve the separating effect of vitamin C refinement mother liquor.
Description
Technical field
The utility model belongs to separating-purifying equipment technical field, and in particular to a kind of chromatographic isolation resin column group.
Background technology
In chemical industry, pharmaceutical engineering, in order to make product purity higher, quality is more excellent, often uses chromatographic isolation tree
Fat column, i.e. column chromatography, main function are exactly the active ingredient in separation and Extraction mixed liquor, and main operation principle is exactly：
Chromatographic isolation resin needed for being filled in resin column, mixed liquor flow into when in resin column active ingredient and impurity in the promotion of mobile phase
Under effect, relative motion is carried out with resin in column, it is repeated multiple times to utilize contained each component partition equilibrium property in mixed liquor
Difference finally reaches the purpose for being separated from each other purification, to obtain the high active ingredient product of purity.
At present during vitamin C refinement mother liquor remanufacture, the vitamin C refinement mother liquor underflow that will be handled well is needed
Chromatographic isolation is carried out, the higher vitamin C chromatographic isolation liquid of purity is respectively obtained and purity is higher is not converted into vitamin C
2KGA-Na chromatographic isolation liquid.To reach raising separating effect, the length for improving chromatographic isolation resin column is needed
Degree.The vitamin C refinement mother liquor underflow handled well is sent into chromatography by used chromatographic isolation resin pillar height 10m, internal diameter 1m with pump
Separation resin column upper end controls chromatographic velocity by adjusting upper end charging rate and lower end discharging speed, reaches predetermined
Chromatographic isolation effect.Used chromatographic isolation resin column lower end is single valve control.Current equipment has as follows in actual production
Disadvantage：(1) resin column is excessively high, cannot directly utilize sold resin column, need voluntarily to process construction, increase manpower, material resources and financial resources
Input；(2) personnel will often make an inspection tour upper resin column top operating platform, and security risk increases；(3) pump refines vitamin C
Mother liquor underflow is transported to the resin top feed mouth of 10m high, and to the more demanding of pump, while energy consumption also increases；(4) resin column bottom
Single valve coutroi velocity, when adjusting, be not easy to operate, and flow velocity is not easy to control.
Utility model content
The utility model proposes a kind of chromatographic isolation resin column group, which can effectively reduce single tree
The length of fat column improves the separating effect of vitamin C refinement mother liquor.
What the technical solution of the utility model was realized in：
A kind of chromatographic isolation resin column group, including the first resin column, the second resin column and third resin column, first tree
The discharge port of fat column is connected to the feed inlet of second resin column, the discharge port of second resin column and the third resin
The feed inlet of column is connected to, and the discharge port of the third resin column is connected with discharge pipe, two are provided with above the discharge pipe
A valve is equipped with the first pump, second resin column and the third between first resin column and second resin column
The second pump is equipped between resin column；The specification of first resin column, second resin column and the third resin column is homogeneous
Together, it is 3~4m that the specification of first resin column, which is length, and internal diameter is 0.8~1.2m.
Preferably, it is 3.5m, internal diameter 1m that the specification of first resin column, which is length,.
Preferably, the distance between two described valves are 60cm.
The beneficial effects of the utility model：
It, can be with using the chromatographic isolation resin column group of the utility model in vitamin C refinement mother liquor chromatographic separation process
The height for reducing chromatographic isolation resin column efficiently separates length without reduction resin column, can not influence chromatographic isolation effect,
And energy consumption is reduced, reduce safe operation risk, keeps operation more convenient effectively, improve production efficiency, reduce and set
Standby operation cost.
Description of the drawings
In order to illustrate the embodiment of the utility model or the technical proposal in the existing technology more clearly, below will be to embodiment
Or attached drawing needed to be used in the description of the prior art is briefly described, it should be apparent that, the accompanying drawings in the following description is only
It is some embodiments of the utility model, for those of ordinary skill in the art, in the premise not made the creative labor
Under, other drawings may also be obtained based on these drawings.
Fig. 1 is the structural schematic diagram of the utility model chromatographic isolation resin column group.
Attached drawing indicates：1, the first resin column, the 2, second resin column, 3, third resin column, 4, discharge pipe, the 5, first pump,
6, the second pump, 7, valve.
Specific implementation mode
The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model
Clearly and completely describe, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than whole
Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art are without making creative work
The every other embodiment obtained, shall fall within the protection scope of the present invention.
Referring to Fig.1, a kind of chromatographic isolation resin column group, including the first resin column 1, the second resin column 2 and third resin column
3, the discharge port of the first resin column 1 is connected to the feed inlet of the second resin column 2, discharge port and the third resin of the second resin column 2
The feed inlet of column 3 is connected to.The discharge port of third resin column 3 is connected with discharge pipe 4, and there are two valves for the setting above of discharge pipe 4
Door 7, the distance between two valves are 60cm.The first pump 5, the second resin are equipped between first resin column 1 and the second resin column 2
The second pump 6 is equipped between column 2 and third resin column 3；The specification of first resin column 1, the second resin column 2 and third resin column 3 is equal
Identical, it is 3.5m, internal diameter 1m that the specification of the first resin column 1, which is length,.
It, can be with using the chromatographic isolation resin column group of the utility model in vitamin C refinement mother liquor chromatographic separation process
The height for reducing chromatographic isolation resin column efficiently separates length without reduction resin column, can not influence chromatographic isolation effect,
And energy consumption is reduced, reduce safe operation risk, keeps operation more convenient effectively, improve production efficiency, reduce and set
Standby operation cost.
The above is only the preferred embodiment of the utility model only, is not intended to limit the utility model, all at this
Within the spirit and principle of utility model, any modification, equivalent replacement, improvement and so on should be included in the utility model
Protection domain within.
Claims (3)
1. a kind of chromatographic isolation resin column group, which is characterized in that including the first resin column, the second resin column and third resin column,
The discharge port of first resin column is connected to the feed inlet of second resin column, the discharge port of second resin column and institute
State the feed inlet connection of third resin column, the discharge port of the third resin column is connected with discharge pipe, on the discharge pipe
There are two valves for face setting, and the first pump, second resin column are equipped between first resin column and second resin column
The second pump is equipped between the third resin column；First resin column, second resin column and the third resin column
Specification all same, the specification of first resin column is that length is 3~4m, and internal diameter is 0.8~1.2m.
2. chromatographic isolation resin column group according to claim 1, which is characterized in that the specification of first resin column is length
Degree is 3.5m, internal diameter 1m.
3. chromatographic isolation resin column group according to claim 1, which is characterized in that the distance between two described valves are
60cm。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721842972.0U CN207913280U (en) | 2017-12-25 | 2017-12-25 | Chromatographic isolation resin column group |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721842972.0U CN207913280U (en) | 2017-12-25 | 2017-12-25 | Chromatographic isolation resin column group |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207913280U true CN207913280U (en) | 2018-09-28 |
Family
ID=63607535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721842972.0U Active CN207913280U (en) | 2017-12-25 | 2017-12-25 | Chromatographic isolation resin column group |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207913280U (en) |
-
2017
- 2017-12-25 CN CN201721842972.0U patent/CN207913280U/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20240117 Address after: 458000 No.9 Muping Road, Shancheng District, Hebi City, Henan Province Patentee after: Xintuoyang Bioengineering Co.,Ltd. Address before: No. 76 Science Avenue, Development Zone, Zhengzhou High tech Zone, Zhengzhou City, Henan Province, 450001 Patentee before: ZHENGZHOU TUOYANG INDUSTRIAL CO.,LTD. |
|
| TR01 | Transfer of patent right |