CN207856685U - A kind of device of Antibody Concentration - Google Patents
A kind of device of Antibody Concentration Download PDFInfo
- Publication number
- CN207856685U CN207856685U CN201721807528.5U CN201721807528U CN207856685U CN 207856685 U CN207856685 U CN 207856685U CN 201721807528 U CN201721807528 U CN 201721807528U CN 207856685 U CN207856685 U CN 207856685U
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- Prior art keywords
- enriched chamber
- bottom end
- enrichment facility
- return
- valve
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Abstract
The utility model discloses a kind of devices of Antibody Concentration, including enrichment facility shell, it is provided with feed pipe nozzle in the left side upper end of the enrichment facility shell, the feed pipe passes through enrichment facility shell, and the right end of feed pipe stretches into upper end on the left of enriched chamber, the enriched chamber is mounted in enrichment facility shell on bottom end, the inside of enriched chamber is equipped with agitating device, the bottom end of enriched chamber is provided with waste liquid tank, it is provided with ultrafiltration membrane between the waste liquid tank upper end and enriched chamber, return tank is connected by pipeline on the right side of enriched chamber bottom end, return tank bottom end two sides are connected separately with return duct and discharge nozzle, the discharge nozzle left end connects return tank, right end is connected to the left side upper end of storage compartment, described return duct one end is connected to return tank, the other end is connected to enriched chamber right side upper end.The device of the Antibody Concentration, conveniently moving, concentration speed is fast, and is concentrated by recycling, and concentrating degree is high.
Description
Technical field
The utility model belongs to biological equipment technical field, and in particular to a kind of device of Antibody Concentration.
Background technology
Antibody is a kind of immunoglobulin that can be combined with antigentic specificity.Antibody by its reaction formation be divided into agglutinin,
Precipitin, antitoxin, dissolving element, opsonin, neutralizing antibody, complement fixation antibody etc..The source generated by antibody is divided into normally
Antibody (natural antibody), such as example antimicrobial antibody of antibody and immune antiboidy of the anti-A and anti-B in blood group ABO type.By anti-
The source of antigen is answered to be divided into xenoantibody, heterophile antibody, allo-antibody and autoantibody.By antigen reactive state of aggregation point
For complete antibody IgM and incomplete antibody IgG etc..Antibody is in medical practice using very extensively.Such as be used for disease prevention,
It all has certain effect in terms of diagnosing and treating.Clinically use gamma globulin preventing viral hepatitis, measles, rubella etc., state
Prevent the hemolytic disease caused by Rh blood group incompatibilities with anti Rh immunoglobulin on border.
Current antibody when in use, needs the requirement for having certain to the concentration of antibody, and at this stage antibody in concentration
Often concentration speed is excessively slow in the process, and some waste liquor contamination devices are easy tod produce after concentrating, while the antibody concentration after concentration
It is impossible to ensure that reaching demand.
Utility model content
It is mentioned above in the background art to solve the purpose of this utility model is to provide a kind of device of Antibody Concentration
Problem.
To achieve the above object, the utility model provides the following technical solutions：A kind of device of Antibody Concentration, including concentration
Device case, feed pipe nozzle is provided in the left side upper end of the enrichment facility shell, and the feed pipe passes through enrichment facility
Shell, and the right end of feed pipe stretches into upper end on the left of enriched chamber, the enriched chamber is mounted in enrichment facility shell on bottom end, dense
The inside of contracting room is equipped with agitating device, and the bottom end of enriched chamber is provided with waste liquid tank, between the waste liquid tank upper end and enriched chamber
It is provided with ultrafiltration membrane, enriched chamber bottom end right side connects return tank by pipeline, and pacifies on the pipeline between enriched chamber and return tank
Equipped with the 5th valve, return tank bottom end two sides are connected separately with return duct and discharge nozzle, the discharge nozzle left end connection
Return tank, right end are connected to the left side upper end of storage compartment, and described return duct one end is connected to return tank, and the other end is connected to concentration
Room right side upper end.
Preferably, the bottom end quadrangle of the enrichment facility shell, which is respectively provided with, is equipped with universal wheel, the return duct and discharging
Pipe is separately installed with the second valve and the 4th valve in the upper end at the return tank, and return duct on enriched chamber junction
End is provided with the 6th valve, and infusion pump is communicated on return duct and discharge nozzle.
Preferably, the agitating device includes stirring motor and stirring rod, and the stirring motor is mounted on the upper of enriched chamber
It is square, booster pump is also equipped in the rear side enriched chamber of stirring motor, the bottom end of stirring motor is rotatablely connected the stirring rod, and stirs
Bar is mixed to be arranged in enriched chamber.
Preferably, the waste liquid tank is cone tank, and the bottom end of waste liquid tank is connected with sewer pipe, and the sewer pipe connection is set dense
Compression apparatus shell Basolateral, and sewer pipe is equipped with the first valve outside enrichment facility shell.
Preferably, the storage compartment is mounted on bottom end on the right side of enrichment facility enclosure interior, and storage compartment is in enrichment facility shell
Outside, which is arranged, is communicated with discharge pipe, the bottom end installation pressure sensor of storage compartment, outside the pressure sensor electrical connection device
Third valve is installed in display, the discharge pipe upper end outside enrichment facility shell.
Preferably, the ultrafiltration membrane is polypropylene PP or polythene PE material ultrafiltration membrane.
The technique effect and advantage of the utility model：The device of the Antibody Concentration, by being equipped with stirring in enriched chamber
The bottom end of device, enriched chamber is provided with ultrafiltration membrane, makes material accelerate to concentrate by agitating device in enriched chamber, improves material
The efficiency of concentration, while being detected according to enriched chamber in return tank, when detectable concentration is reasonable between stored by discharge nozzle
To storage compartment, concentration room is needed when concentration is less than, by return duct to concentration indoor return, ensure that the concentration of concentration reaches institute
Concentration is needed, while being discharged by the waste liquid that sewer pipe generates concentration, waste liquor contamination is prevented, achievees the effect that environmental protection, finally lead to
Cross universal wheel, device easy to remove.
Description of the drawings
Fig. 1 is the front view of the utility model；
Fig. 2 is the return tank structural schematic diagram of the utility model.
In figure：1 enrichment facility ontology, 2 feed pipes, 3 universal wheels, 4 enriched chambers, 5 agitating devices, 51 stirring motors, 52 are stirred
Mix bar, 6 pressure sensors, 7 ultrafiltration membranes, 8 sewer pipes, 9 first valves, 10 waste liquid tanks, 11 return ducts, 12 return tanks, 13 dischargings
Pipe, 14 second valves, 15 storage compartments, 16 discharge pipes, 17 third valves, 18 the 4th valves, 19 the 5th valves, 20 infusion pumps, 21
6th valve.
Specific implementation mode
The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model
Clearly and completely describe, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than whole
Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art are without making creative work
The every other embodiment obtained, shall fall within the protection scope of the present invention.
The utility model provides a kind of device of Antibody Concentration as shown in Figs. 1-2, including enrichment facility shell 1, institute
It states and is provided with 2 nozzle of feed pipe in the left side upper end of enrichment facility shell 1, the feed pipe 2 passes through enrichment facility shell 1, and
The right end of feed pipe 2 stretches into 4 left side upper end of enriched chamber, and the enriched chamber 4 is mounted in enrichment facility shell 1 on bottom end, concentration
The inside of room 4 is equipped with agitating device 5, and the bottom end of enriched chamber 4 is provided with waste liquid tank 10,10 upper end of the waste liquid tank and enriched chamber
Be provided with ultrafiltration membrane 7 between 4, return tank 12 connected by pipeline on the right side of 4 bottom end of enriched chamber, and enriched chamber 4 and return tank 12 it
Between pipeline on the 5th valve 19 is installed, 12 bottom end two sides of the return tank are connected separately with return duct 11 and discharge nozzle
13,13 left end of the discharge nozzle connects return tank 12, and right end is connected to the left side upper end of storage compartment 15,11 one end of the return duct
It is connected to return tank 12, the other end is connected to 4 right side upper end of enriched chamber.
Specifically, the bottom end quadrangle of the enrichment facility shell 1, which is respectively provided with, is equipped with universal wheel 3,11 He of the return duct
Discharge nozzle 13 is separately installed with the second valve 14 and the 4th valve 18 in the upper end at return tank 12, and return duct 11 with
4 junction upper end of enriched chamber is provided with the 6th valve 21, and infusion pump 20 is communicated on return duct 11 and discharge nozzle 13.
Specifically, the agitating device 5 includes stirring motor 51 and stirring rod 52, the stirring motor 51 is mounted on concentration
The top of room 4, booster pump is also equipped in the rear side enriched chamber 4 of stirring motor 51, and the bottom end of stirring motor 51 is rotatablely connected institute
Stirring rod 52 is stated, and stirring rod 52 is arranged in enriched chamber 4.
Specifically, the waste liquid tank 10 is cone tank, the bottom end of waste liquid tank 10 is connected with sewer pipe 8, and the sewer pipe 8 connects
It is logical to set 1 Basolateral of enrichment facility shell, and sewer pipe 8 is equipped with the first valve 9 outside enrichment facility shell 1.
Specifically, the storage compartment 15 is mounted on 1 inner right side bottom end of enrichment facility shell, storage compartment 15 is in enrichment facility
1 outside setting of shell is communicated with discharge pipe 16, and pressure sensor 6 is installed in the bottom end of storage compartment 15, and the pressure sensor 6 is electrical
The outer display of attachment device, third valve 17 is installed in 16 upper end of the discharge pipe outside enrichment facility shell 1.
Specifically, the ultrafiltration membrane 7 is polypropylene PP or polythene PE material ultrafiltration membrane.
Specifically, the material with antibody is passed through feed pipe 2 by the device of the Antibody Concentration first in use
Enriched chamber 4 is flowed to, material is stirred in enriched chamber 4 by agitating device 5, is pressurized into enriched chamber 4 by booster pump,
Ensure that material filters hydrone by ultrafiltration membrane 7 and small-molecule substance, waste liquid enter waste liquid tank 10, is discharged by sewer pipe 8, it
The 5th valve 19 is opened afterwards, and the antibody after concentration enters return tank 12, is directly discharged in return tank 12 by discharge pipe 16 at this time
The partial concentration liquid of portion bottom end, and concentrate is sampled, and the detection of concentration is carried out by spectrophotometer, it is eligible
When, the second valve 14 is opened, antibody concentrated solution enters storage compartment 15 by infusion pump 20, does not meet when needing, closes the second valve
Door 14, opens the 4th valve 18 and the 6th valve 21, concentrate reenter enriched chamber 4 by infusion pump from return duct 11, into
Row concentration, until it is eligible, after concentrated antibody enters in storage compartment 15, when anti-in the transmission of pressure sensor 6 storage compartment 15
Body pressure reaches fast when completely closing, and opens third valve 17 and is collected.The device of the Antibody Concentration, conveniently moving concentrate speed
Soon, and by recycling it concentrates, concentrating degree is high.
Finally it should be noted that：The above descriptions are merely preferred embodiments of the present invention, is not limited to this
Utility model, although the utility model is described in detail with reference to the foregoing embodiments, for those skilled in the art
For, it still can be with technical scheme described in the above embodiments is modified, or to which part technical characteristic
Equivalent replacement is carried out, within the spirit and principle of the utility model, any modification, equivalent replacement, improvement and so on,
It should be included within the scope of protection of this utility model.
Claims (6)
1. a kind of device of Antibody Concentration, including enrichment facility shell (1), it is characterised in that：The enrichment facility shell (1)
It is provided with feed pipe (2) nozzle in the upper end of left side, the feed pipe (2) passes through enrichment facility shell (1), and feed pipe (2)
Right end stretches into upper end on the left of enriched chamber (4), and the enriched chamber (4) is mounted on enrichment facility shell (1) interior bottom end, enriched chamber
(4) inside is equipped with agitating device (5), and the bottom end of enriched chamber (4) is provided with waste liquid tank (10), waste liquid tank (10) upper end
Ultrafiltration membrane (7) is provided between enriched chamber (4), enriched chamber (4) bottom end right side connects return tank (12) by pipeline, and concentrates
5th valve (19), return tank (12) the bottom end two sides difference are installed on the pipeline between room (4) and return tank (12)
It is connected with return duct (11) and discharge nozzle (13), discharge nozzle (13) the left end connection return tank (12), right end is connected to storing
The left side upper end of room (15), described return duct (11) one end are connected to return tank (12), and the other end is connected on the right side of enriched chamber (4)
Face upper end.
2. a kind of device of Antibody Concentration according to claim 1, it is characterised in that：The enrichment facility shell (1)
Bottom end quadrangle, which is respectively provided with, is equipped with universal wheel (3), and the return duct (11) and discharge nozzle (13) are at return tank (12)
Upper end is separately installed with the second valve (14) and the 4th valve (18), and return duct (11) with enriched chamber (4) junction upper end
It is provided with the 6th valve (21), infusion pump (20) is communicated on return duct (11) and discharge nozzle (13).
3. a kind of device of Antibody Concentration according to claim 1, it is characterised in that：The agitating device (5) includes stirring
Motor (51) and stirring rod (52) are mixed, the stirring motor (51) is behind the top of enriched chamber (4), stirring motor (51)
Booster pump is also equipped in side enriched chamber (4), the bottom end of stirring motor (51) is rotatablely connected the stirring rod (52), and stirring rod
(52) setting is in enriched chamber (4).
4. a kind of device of Antibody Concentration according to claim 1, it is characterised in that：The waste liquid tank (10) is taper
The bottom end of slot, waste liquid tank (10) is connected with sewer pipe (8), and sewer pipe (8) connection is set outside enrichment facility shell (1) bottom end
Side, and sewer pipe (8) is equipped with the first valve (9) outside enrichment facility shell (1).
5. a kind of device of Antibody Concentration according to claim 1, it is characterised in that：The storage compartment (15) is mounted on dense
Compression apparatus shell (1) inner right side bottom end, storage compartment (15) setting on the outside of enrichment facility shell (1) are communicated with discharge pipe
(16), the bottom end installation pressure sensor (6) of storage compartment (15), the outer display of pressure sensor (6) electrical connection device,
Third valve (17) is installed outside in enrichment facility shell (1) in discharge pipe (16) upper end.
6. a kind of device of Antibody Concentration according to claim 1, it is characterised in that：The ultrafiltration membrane (7) is polypropylene
PP or polythene PE material ultrafiltration membrane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721807528.5U CN207856685U (en) | 2017-12-22 | 2017-12-22 | A kind of device of Antibody Concentration |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721807528.5U CN207856685U (en) | 2017-12-22 | 2017-12-22 | A kind of device of Antibody Concentration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207856685U true CN207856685U (en) | 2018-09-14 |
Family
ID=63465785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721807528.5U Active CN207856685U (en) | 2017-12-22 | 2017-12-22 | A kind of device of Antibody Concentration |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207856685U (en) |
-
2017
- 2017-12-22 CN CN201721807528.5U patent/CN207856685U/en active Active
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address | ||
| CP03 | Change of name, title or address |
Address after: No. 29, Xinye 7th Street, West District, Binhai New Area Economic and Technological Development Zone, Tianjin 300462 Patentee after: Tianjin Texiang Biotechnology Co.,Ltd. Address before: 300000 No.29 Xinye 7th Street, West District, economic and Technological Development Zone, Hexi District, Tianjin Patentee before: TIANJIN DEXIANG BIOTECHNOLOGY Co.,Ltd. |