CN207721796U - A kind of nonlinear optics flexible endoscope imaging device - Google Patents
A kind of nonlinear optics flexible endoscope imaging device Download PDFInfo
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- CN207721796U CN207721796U CN201721307804.1U CN201721307804U CN207721796U CN 207721796 U CN207721796 U CN 207721796U CN 201721307804 U CN201721307804 U CN 201721307804U CN 207721796 U CN207721796 U CN 207721796U
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Abstract
A kind of nonlinear optics flexible endoscope imaging device, it includes one group of coupled lens, multigroup relay lens, a piece of dichroscope, a piece of speculum, one group of fiber coupling lens, one group of object lens and an optical fiber.The ultrafast laser of two-dimensional scan is imported first group of relay lens by external two-dimensional scanner by coupled lens, and so on, N groups relay lens continues two-dimensional scan plane in the air gap being imaged between N groups relay lens and dichroscope, ultrafast laser is focused on by dichroscope and by objective scan in external sample, it is collected by object lens in the non linear optical signal that focal point inspires, after dichroscope reflects 90 degree, 90 degree are reflected by speculum again, optical fiber is coupled by fiber coupling lens and is finally transmitted to external photoelectric detector.The utility model is simple in structure, small, at low cost, can be used in combination with commercial gastroscope, can TPEAF, a variety of nonlinear properties such as SHG, CARS be carried out while be detected, and realizes realization live body, and functional imaging in situ is expected to realize the detection of early-stage cancer.
Description
Technical field
The utility model is related to a kind of nonlinear optics flexible endoscope imaging devices, saturating especially with the miniature relaying of multi-disc
The distal end of the minor diameter flexible imaging light path that mirror is realized, the light path has miniature apochromatic objective, can sweep external two dimension
The multi-wavelength's ultrashort pulse retouched can be poly- with the instrument channel for the commercial endoscope that small-bend radius is bent by distal end
Coke is to human internal organs, to inspire the various non linear optical signals with diagnostic significance, and will be various by optical fiber
Non linear optical signal is transmitted to external nonlinear optics detection device.The utility model can be used for clinical realization early-stage cancer
Non-invasive detection.
Background technology
Realization uses ultra-short pulse laser for excitation light source, enters human consumption by the instrument channel of commercial electronic gastroscope
The scanning imaging system that road carries out nonlinear optics imaging is very difficult.Nonlinear optics scans endoscopic imaging system first
General technological difficulties be：1. how completely the ultrashort laser pulse as exciting light, it is transferred into not broadening
It goes：Common nonlinear optical effect includes that double/three-photon excites fluorescence（Two/Third-photon Excited
Fluorescence, TPEF/Third PEF）, two-photon excitation autofluorescence（Two-photon Excited
Autofluorescence,TPEAF）, the generation of two/triple-frequency harmonics（Second/Third Harmonic Generation,SHG/
THG）, coherent anti-stokes raman scattering (Coherent Anti-Strokes Raman Scattering, CARS) etc..
In addition to needing double/three-photon excitation fluorescence of fluorochrome label not to be suitable for human body in these nonlinear optical effects, other
It is suitable for unmarked（Label free）In vivo detection.These nonlinear optical effect generally use femtosecond lasers（Double/tri- light
Son excitation fluorescence, two-photon excitation autofluorescence, two/triple-frequency harmonics occur）Or picosecond laser（Coherent anti-Stokes Raman dissipates
It penetrates）As excitation light source.The ultrashort laser pulse that light source is sent out transmitted in the optical elements such as ordinary optic fibre and lens mainly by
To Self-phase modulation（Self Phase Modulation, SPM）With group velocity delay (Group Velocity Delay,
GVD) both effects and broaden.Consider there is flexible optical fiber first：Photonic crystal hollow optic fibre can
Low-loss transmits ultrashort laser pulse with not broadening, therefore has been applied to nonlinear optics scanning endoscopic imaging system；Imaging
Fiber optic bundle is made of thousands of to tens thousand of single mode optical fibers, since the diameter of every single mode optical fiber is only a few micrometers, pulsewidth 100fs
The laser pulse of energy 10nJ is in single mode optical fiber by the length of 1cm since self phase modulation is just stretched to 1-
10ps, peak energy substantially reduce.Energy is stronger, and self phase modulation is more apparent, and is difficult compensation.Laser arteries and veins after broadening
Punching continues to propagate in light can be based on broadening that group velocity delay effect is brought, and this broadening can be compensated.
The laser pulse of broadening can be such that the launching efficiency of nonlinear effect substantially reduces.Therefore imaging optical fiber bundle has been used in copolymerization coke
Imaging is peeped, and is not used to nonlinear optics imaging.Secondly, up to the present, no any research is realized ultrashort sharp using lens
Light pulse completely, does not broaden ground in the instrument channel of the electronic gastroscope of curved narrow（Or broadening can compensate for）Transmission.This is
One of innovative point of the utility model.2. as how formed two dimensional image：Nonlinear optics imaging need using inner scanning or
External scan is come the method that forms two dimensional image, and cannot use whole audience imaging.Inner scanning is used in the distal end of endoscope
Piezo-electric micro driver drives simple optical fiber vibration to carry out two-dimensional scan or realizes two-dimensional scan using MEMS microdrive.
The benefit of inner scanning is that single photonic crystal fiber transmission ultrashort laser pulse can be used, the disadvantage is that either using piezoelectric micromotor
Driver or MEMS microdrive, the volume of assembled endoscope is excessive, and especially distal end rigid element is long,
The physiological bending portion of human body alimentary canal and the bendable portion of commercial electronic gastroscope can not be passed through.External scan is by outside
Scanning device is responsible for ultrashort laser pulse being coupled into the two dimension biography optical element such as imaging optical fiber bundle, to pass exciting light from distal end
It is defeated to arrive sample, then the image of sample is passed back to distal end.The advantages of external scan is convenient and commercial microscopes, without another
Build imaging system outside.The disadvantage is that imaging optical fiber bundle seriously broadens ultrashort laser pulse, it is not used to nonlinear optical and studies
Picture.The utility model uses external scan and is combined with lens relay.3. the various non linear optical signals emitted in sample
How expeditiously to be collected：The excitation wavelength of two-photon excitation autofluorescence is 800nm or so, and launch wavelength is the left sides 516nm
It is right.The excitation wavelength that second harmonic occurs is 800nm or so, and launch wavelength is 400nm or so.The excitation wave that triple-frequency harmonics occurs
Length is 1200nm to 1550nm or so, and launch wavelength is 400nm to 500nm or so.Coherent anti-stokes raman scattering is four
The Third-order nonlinearity that photon participates in, it is 817nm, the Stokes generated with optical parametric amplifier to need pump wavelength
The wavelength of light is 1064nm, and the wavelength of anti-Stokes light is 663nm.As it can be seen that in nonlinear optics imaging, excitation wavelength
It differs greatly with nonlinear effect wavelength, this brings conveniently for high s/n ratio detection, but is proposed to the design of optical system
Very high requirement causes optical system detection efficiency and image quality to substantially reduce because will produce apparent aberration.Therefore it examines
The optical system for surveying single nonlinear effect must be achromatic, and the optical system for detecting a variety of nonlinear effects must be
Apochromatic, and peep application in being limited to, the diameter and length to optical system have considerable restraint, design, process and group
It fills very difficult.The utility model uses multi-disc micro lens relay imaging.Single-sheet miniature lens have diameter small, and shape is easy
The advantages that processing, but aberration is larger, numerical aperture is relatively low.Therefore it is ultrafast sharp to use micro lens relay transmission for this project
Light pulse does not transmit non linear optical signal, and uses achromat-design, realizes the simplification of optical system.
In conclusion peeping scanning imaging system presently, there are in, there are two main classes：One kind is to use piezo-electric micro driver
Or MEMS microdrive carries out the non-linear optical endoscope of inner scanning, it is main to realize scan forward imaging, still
Distal end rigid element is too long, cannot be introduced into the alimentary canal of people.Another kind of is the copolymerization for being carried out using imaging optical fiber bundle external scan
Burnt endoscope can enter the alimentary canal of people, but since imaging optical fiber bundle broadens seriously ultra-short pulse laser, can not excite non-
Linear effect.
The utility model proposes peeped in the multi-mode nonlinear optics scanning for transmitting light path with minor diameter flexible imaging
Imaging system uses, and the noninvasive biopsy of realization early carcinoma of stomach can be combined with electronic gastroscope.
Invention content
The utility model is related to a kind of nonlinear optics flexible endoscope imaging devices, saturating especially with the miniature relaying of multi-disc
The distal end of the minor diameter flexible imaging light path that mirror is realized, the light path has miniature apochromatic objective, can sweep external two dimension
The multi-wavelength's ultrashort pulse retouched can be poly- with the instrument channel for the commercial endoscope that small-bend radius is bent by distal end
Coke is to human internal organs, to inspire the various non linear optical signals with diagnostic significance, and will be various by optical fiber
Non linear optical signal is transmitted to external nonlinear optics detection device.The utility model can be used for clinical realization early-stage cancer
Non-invasive detection.
To achieve the above object, the utility model is using technical solution：It includes one group of coupled lens, and multigroup relaying is saturating
Mirror, a piece of dichroscope, a piece of speculum, one group of fiber coupling lens, one group of object lens and an optical fiber.The input of coupled lens
End is connected with the external elements such as two-dimensional scanner and its attached lenses；The output end of coupled lens is defeated with first group of relay lens
Enter end to be connected；The output end of first group of relay lens is connected with the input terminal of second group of relay lens；And so on, N-1 groups
The output end of relay lens is connected with the input terminal of N group relay lens；The output end of N group relay lens and dichroscope
Input terminal is connected；One output end of dichroscope is connected with the input terminal of object lens；The output end of object lens is connected with external sample；
Another output end of dichroscope is connected with the input terminal of speculum；The input of the output end and fiber coupling lens of speculum
End is connected；The output end of fiber coupling lens is connected with the input terminal of optical fiber；The output end of optical fiber and external photoelectric detector and
Its attached lenses, dichroscope, the elements such as optical filter are connected；The elements such as external two-dimensional scanner and its attached lenses sweep two dimension
The ultrafast laser retouched imports first group of relay lens by coupled lens, and first group of relay lens exists two-dimensional scan planar imaging
In the air gap between first group of relay lens and second group of relay lens, second group of relay lens by two-dimensional scan plane after
It is continuous to be imaged in the air gap between second group of relay lens and third group relay lens, and so on, N group relay lens
Two-dimensional scan plane is continued in the air gap being imaged between N groups relay lens and dichroscope, ultrafast laser passes through
Dichroscope is simultaneously focused on by objective scan in external sample, is received by object lens in the non linear optical signal that focal point inspires
Collection reflects 90 degree after dichroscope reflects 90 degree, then by speculum, is coupled into optical fiber by fiber coupling lens and is finally passed
Transport to external photoelectric detector and its attached lenses, dichroscope, the elements such as optical filter.
The coupled lens are achromat-design, and design wavelength is 600nm to arbitrary 2 wavelength between 1700nm,
Usually 817nm and 1064nm, but the two wavelength are not limited to, material is optical glass or high molecular polymer, and there is increasing on surface
The optical coating of strong transmissivity, is used for the ultrafast laser of the two-dimensional scan of the elements such as external two-dimensional scanner and its attached lenses
Import multigroup relay lens；
The relay lens is achromat-design, and design wavelength is 600nm to arbitrary 2 wavelength between 1700nm,
Usually 817nm and 1064nm, but the two wavelength are not limited to, material is optical glass or high molecular polymer, and there is increasing on surface
The optical coating of strong transmissivity, the two-dimensional scan plane for ultrafast laser carry out relay imaging, have between multigroup relay lens
There are the air gap, the two-dimensional scan plane of ultrafast laser to be focused in the air gap, two adjacent groups relay lens is by that can turn
Dynamic mechanical structure is connected；
The dichroscope is cube structure, and material is optical glass or high molecular polymer, and surface has enhancing saturating
The optical coating of rate is penetrated, it is in the optical thin film of 45 degree of angles that inside, which has with incident light axis, for transmiting near infrared band
（700nm-1300nm）Ultrafast laser and reflect visible light wave range（350nm-700nm）Non linear optical signal；
The object lens be achromat-design, design wavelength be 600nm to arbitrary 2 wavelength between 1700nm, usually
For 817nm and 1064nm, but the two wavelength are not limited to, material is optical glass or high molecular polymer, and surface has enhancing saturating
The optical coating for penetrating rate inspires non linear optical signal for focusing on incident ultrafast laser in external sample, and with
It falls the mode that formula of penetrating detects and collects non linear optical signal；
The material of the speculum is optical glass or high molecular polymer, and there is the optics plating of enhancing reflectivity on surface
Film, design wavelength are 350nm to 700nm, for it will be seen that the non linear optical signal of optical band reflects 90 degree；
The fiber coupling lens are achromat-design, and design wavelength is 350nm to arbitrary 2 waves between 700nm
It grows, usually 400nm and 633nm, but is not limited to the two wavelength, material is optical glass or high molecular polymer, and surface has
The optical coating for enhancing transmissivity, for will be seen that the non linear optical signal of optical band focuses and is coupled into optical fiber；
The optical fiber is multimode fibre, and transmission wavelength is 350nm to 700nm.
The operation principle of the utility model is such：It is external ultrafast sharp in order to realize the detection of TPEAF, SHG and CARS
Radiant needs to provide the femtosecond laser of 817nm and the picosecond laser of 1064nm.The two is accurate coaxial conllinear, wherein 817nm
Femtosecond laser is used for TPEAF, and the exciting light of SHG generates the SHG signals of the TPEAF and 400nm of 500nm, also serves as the pump of CARS
Pu light generates the CARS signals of 633nm；The picosecond laser of 1064nm is used as the stokes light of CARS.Include the femtosecond of 817nm
The ultrashort pulse of the picosecond laser of laser and 1064nm（Hereinafter referred to as ultrashort pulse）By external two-dimensional scan
Device carries out two-dimensional scan, passes through scanning lens, a series of scanning optical paths such as sleeve lens and micro objective, by coupling later
It closes object lens and enters the utility model.It is the achromat-design for 817nm and 1064nm wavelength to couple object lens.Multigroup relay lens
For the achromat-design for 817nm and 1064nm wavelength, the two-dimensional scan plane for ultrafast laser carries out relay imaging, more
Between group relay lens there is the air gap, the two-dimensional scan plane of ultrafast laser to be focused in the air gap, avoids nothing
The ultrashort pulse broadening that the self phase modulation of method compensation is brought, and the group delay color brought by medium in excitation light path
Precommpression can be carried out to compensate by external pulse shortener to ultrashort pulse by dissipating.Two adjacent groups relay lens passes through rotatable
Mechanical structure be connected, to realize two-dimensional scan ultrafast laser bending transmission.N groups relay lens is by two-dimensional scan
Plane continues in the air gap being imaged between N groups relay lens and dichroscope, and ultrafast laser passes through dichroscope
（Transmit 700nm-1300nm；Reflect 350nm-700nm）And focused in external sample by objective scan, it is inspired in focal point
TPEAF, SHG, CARS non linear optical signals are collected by object lens again.Object lens are the colour killing for 817nm and 1064nm wavelength
Difference design, it means that for object lens for the SHG of 400nm, the CARS signals of the TPEAF and 633nm of 500nm have larger color
Difference, and this part aberration will carry out part compensation by fiber coupling lens.Non linear optical signal is reflected by dichroscope
After 90 degree, then by 90 degree of speculum reflection, it is coupled into optical fiber by fiber coupling lens and is finally transmitted to external photoelectric detector
And its attached lenses, dichroscope, the elements such as optical filter.Fiber coupling lens are the achromatism for 400nm and 633nm wavelength
Design, although there is certain aberration for 500nm wavelength, since wavelength is at a distance of relatively close, it should influence little.This practicality is new
Type realizes excitation light path and collects the separate design of light path, avoids that volume is big, and complicated multi-wavelength apochromatism is saturating
Mirror designs, and is directed to 817nm and 1064nm in excitation light path, is collecting light path for 400nm and 633nm using small, knot
The simple achromatic lens design of structure.Optical fiber is major diameter multimode fibre.External photoelectric detector be multiple photomultipliers or
Avalanche diode.Non linear optical signal is by dichroscope outside multi-disc by the Signal separator of different wave length out by different
Photomultiplier or avalanche diode are detected.
The utility model is by adopting the above-described technical solution, have the following advantages that：
1, two-dimensional scan ultrafast laser is realized using the multigroup relay lens connected by rotatable mechanical structure
Bending transmission；
2, it excitation light path and collects the separate design of light path and avoids that volume is big, and complicated multi-wavelength apochromatism is saturating
Mirror designs, and is directed to 817nm and 1064nm in excitation light path, is collecting light path for 400nm and 633nm using small, knot
The simple achromatic lens design of structure；
3, by the way that the focus of two-dimensional scan plane to be placed in the air gap between multigroup relay lens, avoiding can not
The ultrashort pulse broadening that the self phase modulation of compensation is brought；And the group delay dispersion brought by medium in excitation light path
Precommpression can be carried out to ultrashort pulse by external pulse shortener to compensate；
4, simple in structure, it is small, it is at low cost, it can be used in combination with commercial gastroscope, it can be to TPEAF, SHG, CARS etc.
A variety of nonlinear properties are carried out while being detected, and realize realization live body, and functional imaging in situ is expected to realize early-stage cancer
Detection.
Description of the drawings
Fig. 1 is the structure diagram of the utility model；
Fig. 2 is the connection diagram with external optical imaging device of the utility model；
Fig. 3 is the geometric optics simulation result that multigroup relay lens is bent optical axis.
Specific implementation mode
The utility model is described in further detail with reference to the accompanying drawings and examples：As shown in Figs. 1-3, it includes one group of coupling
Close lens 1, multigroup relay lens 2, a piece of dichroscope 3, a piece of speculum 5, one group of fiber coupling lens 6, one group of 4 He of object lens
A piece optical fiber 7.The input terminal of coupled lens 1 is connected with the external elements such as two-dimensional scanner and its attached lenses；Coupled lens 1
Output end is connected with the input terminal of first group of relay lens 2.1；The output end of first group of relay lens 2.1 and second group of relaying are saturating
The input terminal of mirror 2.2 is connected；And so on, the output end of N-1 group relay lens 2.N-1 is defeated with N group relay lens 2.N's
Enter end to be connected；The output end of N group relay lens 2.N is connected with the input terminal of dichroscope 3；One output of dichroscope 3
End is connected with the input terminal of object lens 4；The output end of object lens 4 is connected with external sample；Another output end of dichroscope 3 with it is anti-
The input terminal for penetrating mirror 5 is connected；The output end of speculum 5 is connected with the input terminal of fiber coupling lens 6；Fiber coupling lens 6
Output end is connected with the input terminal of optical fiber 7；The output end of optical fiber 7 and external photoelectric detector and its attached lenses, dichroscope,
The elements such as optical filter are connected；The ultrafast laser of two-dimensional scan is passed through coupling by the elements such as external two-dimensional scanner and its attached lenses
Lens 1 enter first group of relay lens 2.1, and first group of relay lens 2.1 is by two-dimensional scan planar imaging in the first set after lens
In the air gap between 2.1 and second group of relay lens 2.2, second group of relay lens 2.2 by two-dimensional scan plane continue at
As in the second set after in the air gap between lens 2.2 and third group relay lens 2.3, and so on, N groups relaying is thoroughly
Mirror 2.N continues two-dimensional scan plane in the air gap being imaged between N group relay lens 2.N and dichroscope 3, surpasses
Fast laser is by dichroscope 3 and scanning focused in external sample by object lens 4, in the nonlinear optics letter that focal point inspires
It number is collected by object lens 4, after dichroscope 3 reflects 90 degree, then by 90 degree of the reflection of speculum 5, is coupled by fiber coupling lens 6
Enter optical fiber 7 and is finally transmitted to external photoelectric detector and its attached lenses, dichroscope, the elements such as optical filter.
The coupled lens 1 are achromat-design, and design wavelength is 600nm to arbitrary 2 wavelength between 1700nm,
Usually 817nm and 1064nm, but the two wavelength are not limited to, material is optical glass or high molecular polymer, and there is increasing on surface
The optical coating of strong transmissivity, is used for the ultrafast laser of the two-dimensional scan of the elements such as external two-dimensional scanner and its attached lenses
Import multigroup relay lens 2；
The relay lens 2 is achromat-design, and design wavelength is 600nm to arbitrary 2 wavelength between 1700nm,
Usually 817nm and 1064nm, but the two wavelength are not limited to, material is optical glass or high molecular polymer, and there is increasing on surface
The optical coating of strong transmissivity, the two-dimensional scan plane for ultrafast laser carry out relay imaging, have between multigroup relay lens 2
There are the air gap, the two-dimensional scan plane of ultrafast laser to be focused in the air gap, two adjacent groups relay lens 2 is by that can turn
Dynamic mechanical structure is connected；
The dichroscope 3 is cube structure, and material is optical glass or high molecular polymer, and surface has enhancing saturating
The optical coating of rate is penetrated, it is in the optical thin film of 45 degree of angles that inside, which has with incident light axis, for transmiting 600nm-1700nm's
Ultrafast laser simultaneously reflects visible light wave range（350nm-700nm）Non linear optical signal；
The object lens 4 be achromat-design, design wavelength be 600nm to arbitrary 2 wavelength between 1700nm, usually
For 817nm and 1064nm, but the two wavelength are not limited to, material is optical glass or high molecular polymer, and surface has enhancing saturating
The optical coating for penetrating rate inspires non linear optical signal for focusing on incident ultrafast laser in external sample, and with
It falls the mode that formula of penetrating detects and collects non linear optical signal；
The material of the speculum 5 is optical glass or high molecular polymer, and there is the optics plating of enhancing reflectivity on surface
Film, design wavelength are 350nm to 700nm, for it will be seen that the non linear optical signal of optical band reflects 90 degree；
The fiber coupling lens 6 are achromat-design, and design wavelength is 350nm to arbitrary 2 waves between 700nm
It grows, usually 400nm and 633nm, but is not limited to the two wavelength, material is optical glass or high molecular polymer, and surface has
The optical coating for enhancing transmissivity, for will be seen that the non linear optical signal of optical band focuses and is coupled into optical fiber 7；
7 multimode fibre of optical fiber, transmission wavelength are 350nm to 700nm.
The operation principle of the utility model is such：It is external to illustrate for realizing the detection of TPEAF, SHG and CARS
Ultrafast laser light source needs to provide the femtosecond laser of 817nm and the picosecond laser of 1064nm.The two is accurate coaxial conllinear, wherein
817nm femtosecond lasers are used for TPEAF, and the exciting light of SHG generates the SHG signals of the TPEAF and 400nm of 500nm, also serves as
The pump light of CARS generates the CARS signals of 633nm；The picosecond laser of 1064nm is used as the stokes light of CARS.Including
The ultrashort pulse of the femtosecond laser of 817nm and the picosecond laser of 1064nm（Hereinafter referred to as ultrashort pulse）By outer
Portion's two-dimensional scanner carries out two-dimensional scan, passes through scanning lens, a series of scanning light such as sleeve lens and micro objective later
Road is entering the utility model by coupling object lens 1.Coupling object lens 1 set for the achromatism for 817nm and 1064nm wavelength
Meter.Multigroup relay lens 2 is the achromat-design for 817nm and 1064nm wavelength, and the two-dimensional scan for ultrafast laser is flat
Face carries out relay imaging, between multigroup relay lens 2 there is the air gap, the two-dimensional scan plane of ultrafast laser to be focused on sky
In gas gap, the ultrashort pulse broadening that self phase modulation that avoiding can not compensate is brought, and by excitation light path
The group delay dispersion that medium belt comes can carry out precommpression to compensate by external pulse shortener to ultrashort pulse.Two adjacent groups
Relay lens 2 is connected by rotatable mechanical structure, to realize the bending transmission of two-dimensional scan ultrafast laser.N
Group relay lens 2.N continues two-dimensional scan plane between the air being imaged between N group relay lens 2.N and dichroscope 3
In gap, ultrafast laser passes through dichroscope 3（Transmit 600nm-1700nm；Reflect 350nm-700nm）And it is scanned by object lens 4 poly-
Coke is in external sample, and in the TPEAF that focal point inspires, SHG, CARS non linear optical signals are collected by object lens 4 again.Object lens
4 be the achromat-design for 817nm and 1064nm wavelength, it means that object lens 4 are for the SHG of 400nm, the TPEAF of 500nm
Larger aberration is had with the CARS signals of 633nm, and this part aberration will carry out part compensation by fiber coupling lens 6.
Non linear optical signal reflects 90 degree after dichroscope 3 reflects 90 degree, then by speculum 5, is coupled by fiber coupling lens 6
Enter optical fiber 7 and is finally transmitted to external photoelectric detector and its attached lenses, dichroscope, the elements such as optical filter.Fiber coupling
Lens 6 are the achromat-design for 400nm and 633nm wavelength, although there is certain aberration for 500nm wavelength, by
In wavelength at a distance of relatively close, it should influence little.The utility model realizes excitation light path and collects the separate design of light path, avoids
Volume is big, complicated multi-wavelength apochromatic lens design, and is directed to 817nm and 1064nm in excitation light path, is receiving
Collect light path for 400nm and 633nm using small, simple in structure achromatic lens design.Optical fiber is major diameter multimode light
It is fine.External photoelectric detector is multiple photomultipliers or avalanche diode.Non linear optical signal by outside multi-disc two to
The Signal separator of different wave length is out detected by different photomultiplier or avalanche diode by Look mirror.
Claims (8)
1. a kind of nonlinear optics flexible endoscope imaging device, it is characterised in that：It includes one group of coupled lens, and multigroup relaying is saturating
Mirror, a piece of dichroscope, a piece of speculum, one group of fiber coupling lens, one group of object lens and an optical fiber；The input of coupled lens
End is connected with the external elements such as two-dimensional scanner and its attached lenses；The output end of coupled lens is defeated with first group of relay lens
Enter end to be connected；The output end of first group of relay lens is connected with the input terminal of second group of relay lens；And so on, N-1 groups
The output end of relay lens is connected with the input terminal of N group relay lens；The output end of N group relay lens and dichroscope
Input terminal is connected；One output end of dichroscope is connected with the input terminal of object lens；The output end of object lens is connected with external sample；
Another output end of dichroscope is connected with the input terminal of speculum；The input of the output end and fiber coupling lens of speculum
End is connected；The output end of fiber coupling lens is connected with the input terminal of optical fiber；The output end of optical fiber and external photoelectric detector and
Its attached lenses, dichroscope, the elements such as optical filter are connected；The elements such as external two-dimensional scanner and its attached lenses sweep two dimension
The ultrafast laser retouched imports first group of relay lens by coupled lens, and first group of relay lens exists two-dimensional scan planar imaging
In the air gap between first group of relay lens and second group of relay lens, second group of relay lens by two-dimensional scan plane after
It is continuous to be imaged in the air gap between second group of relay lens and third group relay lens, and so on, N group relay lens
Two-dimensional scan plane is continued in the air gap being imaged between N groups relay lens and dichroscope, ultrafast laser passes through
Dichroscope is simultaneously focused on by objective scan in external sample, is received by object lens in the non linear optical signal that focal point inspires
Collection reflects 90 degree after dichroscope reflects 90 degree, then by speculum, is coupled into optical fiber by fiber coupling lens and is finally passed
Transport to external photoelectric detector and its attached lenses, dichroscope, the elements such as optical filter.
2. a kind of nonlinear optics flexible endoscope imaging device as described in claim 1, it is characterised in that：The coupling is saturating
Mirror is achromat-design, and design wavelength is 600nm to arbitrary 2 wavelength between 1700nm, usually 817nm and 1064nm,
But the two wavelength are not limited to, material is optical glass or high molecular polymer, and there is the optical coating of enhancing transmissivity on surface.
3. a kind of nonlinear optics flexible endoscope imaging device as described in claim 1, it is characterised in that：The relaying is saturating
Mirror is achromat-design, and design wavelength is 600nm to arbitrary 2 wavelength between 1700nm, usually 817nm and 1064nm,
But the two wavelength are not limited to, material is optical glass or high molecular polymer, and there is the optical coating of enhancing transmissivity on surface, uses
Relay imaging is carried out in the two-dimensional scan plane of ultrafast laser, there is the air gap between multigroup relay lens, ultrafast laser
Two-dimensional scan plane is focused in the air gap, and adjacent two groups of relay lens are connected by rotatable mechanical structure.
4. a kind of nonlinear optics flexible endoscope imaging device as described in claim 1, it is characterised in that：The dichroic
Mirror is cube structure, and material is optical glass or high molecular polymer, and there are the optical coating of enhancing transmissivity, inside tool in surface
There is the optical thin film in 45 degree of angles with incident light axis.
5. a kind of nonlinear optics flexible endoscope imaging device as described in claim 1, it is characterised in that：The object lens are
Achromat-design, design wavelength are 600nm to arbitrary 2 wavelength between 1700nm, usually 817nm and 1064nm, but not
It is limited to the two wavelength, material is optical glass or high molecular polymer, and there is the optical coating of enhancing transmissivity on surface, and being used for will
Incident ultrafast laser focuses in external sample, inspires non linear optical signal, and collected in a manner of falling and penetrate formula detection
Non linear optical signal.
6. a kind of nonlinear optics flexible endoscope imaging device as described in claim 1, it is characterised in that：The speculum
Material be optical glass or high molecular polymer, surface have enhancing reflectivity optical coating, design wavelength be 350nm extremely
700nm。
7. a kind of nonlinear optics flexible endoscope imaging device as described in claim 1, it is characterised in that：The optical fiber coupling
Conjunction lens are achromat-design, and design wavelength is 350nm to arbitrary 2 wavelength between 700nm, usually 400nm and
633nm, but the two wavelength are not limited to, material is optical glass or high molecular polymer, and there is the optics of enhancing transmissivity on surface
Plated film, for will be seen that the non linear optical signal of optical band focuses and is coupled into optical fiber.
8. a kind of nonlinear optics flexible endoscope imaging device as described in claim 1, it is characterised in that：The optical fiber is
Multimode fibre, transmission wavelength are 350nm to 700nm.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107456202A (en) * | 2017-10-01 | 2017-12-12 | 凝辉(天津)科技有限责任公司 | A kind of nonlinear optics flexible endoscope imaging device |
| CN114689095A (en) * | 2021-08-13 | 2022-07-01 | 清华大学 | Ultrahigh-speed all-fiber imaging system and method based on multimode fiber |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107456202A (en) * | 2017-10-01 | 2017-12-12 | 凝辉(天津)科技有限责任公司 | A kind of nonlinear optics flexible endoscope imaging device |
| CN114689095A (en) * | 2021-08-13 | 2022-07-01 | 清华大学 | Ultrahigh-speed all-fiber imaging system and method based on multimode fiber |
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