CN207640822U - Neutron capture treatment system and target for particle beam generating apparatus - Google Patents
Neutron capture treatment system and target for particle beam generating apparatus Download PDFInfo
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- CN207640822U CN207640822U CN201720599511.9U CN201720599511U CN207640822U CN 207640822 U CN207640822 U CN 207640822U CN 201720599511 U CN201720599511 U CN 201720599511U CN 207640822 U CN207640822 U CN 207640822U
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Abstract
The utility model provides a kind of neutron capture treatment system and the target for particle beam generating apparatus, can promote the heat dissipation performance of target, reduces blistering, increases target life.The neutron capture treatment system of the utility model, including neutron generation device and beam-shaping body, neutron generation device includes accelerator and target, sub-line during accelerator accelerates the charged particle line generated to be generated with target effect, target includes active layer, pedestal layer and heat dissipating layer, sub-line during active layer is generated with the effect of charged particle line, pedestal layer supporting role layer, heat dissipating layer includes the tube-like piece being made of multiple tube side-by-sides.
Description
Technical field
The utility model relates in one aspect to a kind of irradiation with radiation system more particularly to a kind of neutron capture treatment system；
On the other hand the utility model is related to a kind of target for irradiation with radiation system, more particularly to a kind of for particle line generation
The target of device.
Background technology
As the radiation cures such as the development of atomics, such as cobalt 60, linear accelerator, electron beam have become cancer
One of the main means of disease treatment.However conventional photonic or electronic therapy are limited by radioactive ray physical condition itself, are being killed
While dead tumour cell, a large amount of normal structure in beam approach can also be damaged；Additionally, due to tumour cell to putting
The difference of radiation-sensitive degree, traditional radiation therapy is for relatively having the malignant tumour of radiation resistance (such as：Multirow glioblast
Tumor (glioblastoma multiforme), melanocytoma (melanoma)) treatment effect it is often bad.
In order to reduce the radiation injury of tumour surrounding normal tissue, the target therapy in chemotherapy (chemotherapy)
Concept is just applied in radiation cure；And for the tumour cell of radiation resistance, also actively development has high phase at present
To the radiation source of biological effect (relative biological effectiveness, RBE), as proton therapeutic, heavy particle are controlled
Treatment, neutron capture treatment etc..Wherein, neutron capture treatment is to combine above two concept, if boron neutron capture is treated, by
Boracic drug gathers in the specificity of tumour cell, and accurately neutron beam regulates and controls for cooperation, provides more better than conventional radiation
Treatment of cancer selects.
In the treatment of accelerator boron neutron capture, the treatment of accelerator boron neutron capture by accelerator by proton accelerate (beamacceleration),
Proton beam accelerates to the energy for being enough to overcome target atom core coulomb repulsion, and nuclear reaction occurs to generate neutron, therefore with target
Target can be irradiated by the accelerating proton beam of very same high-energy level during generating neutron, and the temperature of target can be substantially
Rise, while the metal part of target is easy blistering, to influence the service life of target.
Therefore, it is necessary to propose a kind of new technical solution to solve the above problems.
Utility model content
To solve the above-mentioned problems, on the one hand the utility model provides a kind of neutron capture treatment system, including neutron
Generation device and beam-shaping body, the neutron generation device include accelerator and target, and the accelerator accelerates the band generated
Sub-line during electrochondria sub-line is generated with target effect, the beam-shaping body includes reflector, slow body, neutron absorption
Body, radiation shield and beam outlet, the slow body will be from the neutron degradation that the target generates to epithermal neutron energy area, institute
State reflector surround the slow body and the neutron that will deviate from back to the slow body to improve epithermal neutron intensity of beam, institute
When stating thermal neutron absorber for absorbing thermal neutron to avoid treatment multi-dose, the radiation shield were caused with shallow-layer normal structure
Body is covered around beam outlet to be arranged at the reflector rear portion for shielding the neutron leaked and photon to reduce non-irradiated
The normal tissue dose in area, the target include active layer, pedestal layer and heat dissipating layer, and the active layer is acted on charged particle line
Sub-line in generation, the pedestal layer support the active layer, and the heat dissipating layer includes the tube-like piece being made of multiple tube side-by-sides.It adopts
With the radiator structure of tube-like piece, heat-delivery surface is increased, improves heat dissipation effect, contributes to the service life for extending target.
Preferably as one kind, the neutron capture treatment system further includes instrument table and collimator, and the neutron generates
The middle sub-line that device generates irradiates the patient on the instrument table, the patient and beam outlet by the beam-shaping body
Between setting radiation shield device to shield radiation of the beam for exporting out from the beam to patient's normal structure, the standard
Straight device is arranged goes out metastomium with sub-line in converging in the beam.First, second cooling tube, institute are set in the beam-shaping body
Stating target has cooling import, coolant outlet and a cooling duct being arranged between cooling import and coolant outlet, described first,
The cooling import with the target and coolant outlet are connect respectively for one end of second cooling tube, and the other end is connected to external cooling
Source, each pipe inside of the tube-like piece form at least part of the cooling duct, further enhance heat dissipation effect, prolong
Long target life.
Further, the target is located in the beam-shaping body, and the accelerator, which has, carries out charged particle line
The accelerating tube of acceleration, the accelerating tube stretch into the beam-shaping body along charged particle line direction and sequentially pass through the reflector
With slow body, the target is arranged described slowly in vivo and positioned at the acceleration tube end, to obtain preferable neutron beam
Quality, first, second cooling tube are arranged between the accelerating tube and the reflector and slow body.
On the other hand the utility model provides a kind of target for particle beam generating apparatus, the target includes effect
Layer, pedestal layer and heat dissipating layer, for the active layer for generating the particle line, the pedestal layer supports the active layer, described
Heat dissipating layer includes the tube-like piece being made of multiple tube side-by-sides.Using the radiator structure of tube-like piece, heat-delivery surface is increased, is improved
Heat dissipation effect contributes to the service life for extending target.
Preferably as one kind, the particle beam generating apparatus is neutron beam generating apparatus, and the material of the active layer is
Li or its alloy, the active layer and incident proton Shu Fasheng7Li(p,n)7Be nuclear reactions generate neutron；Or the active layer
Material be Be or its alloy, the active layer and incident proton Shu Fasheng9Be(p,n)9B nuclear reactions generate neutron.
Preferably as one kind, the target further includes anti oxidation layer, for preventing active layer from aoxidizing, the anti oxidation layer
Material include Al, Ti, Be and its at least one of alloy or stainless steel, be not easy to be applied layer corrosion and can reduce into
Penetrate loss and the caused fever of proton beam of proton beam；Adhesive layer, the material of adhesive layer are set between the active layer and pedestal layer
Material includes at least one of Cu, Al, Mg or Zn, improves the adhesion of pedestal layer and active layer；The heat dissipating layer is by heat conduction material
Material or can heat conduction again inhibition foam material be made；The pedestal layer is by inhibiting the material of foaming to be made；Inhibit foaming
Material or can heat conduction but inhibit foaming material include at least one of Fe, Ta or V, Heat Conduction Material includes Cu, Fe, Al
At least one of, the heat dissipating layer is connected with the pedestal layer by HIP techniques, and the active layer passes through with the pedestal layer
Casting, vapor deposition or sputtering technology connection.
Preferably as another kind, the tube-like piece is used as the pedestal layer simultaneously, and the material of the tube-like piece is Ta, institute
Active layer is stated to connect by vapor deposition or sputtering technology with the tube-like piece.
Preferably as one kind, the active layer on each pipe of the tube-like piece at least covers the 1/4 of pipe periphery, active layer
It is at least 45 degree in the angle of circumferencial direction and tube hub line, the tube-like piece forms interconnecting piece between adjacent pipe, described
Interconnecting piece is made of pedestal layer, active layer and anti oxidation layer.
Preferably as one kind, the heat dissipating layer further includes support element, and the material of the support element is Cu, supports positioning
Play additional cooling effect simultaneously；The tube-like piece is welded, is pressed or is detachably connected with the support element, using detachable
Connection target can carry out part replacement, extend target service life, reduce patient's treatment cost；The support element and/or pipe
Shape part has cooling duct, further enhances heat dissipation effect, extends target life.
Further, the support element includes the first support portion and the second support portion being arranged at the tube-like piece both ends,
There is first support portion cooling import and the first cooling duct, second support portion to have coolant outlet and the second cooling
Channel, cooling medium enter through first cooling duct from the cooling import and enter in each pipe of the tube-like piece
Then portion is come out by second cooling duct from the coolant outlet, the cooling medium is water, and the support element includes
The third support portion of first, second support portion is connected, the third support portion connect the active layer with the tube-like piece
The opposite another side contacts in side, the third support portion has a cooling duct, cooling medium only by the support element or
Person not only by the tube-like piece each pipe inside but also pass through the support element third support portion or not only pass through pipe inside but also
By the first, second, and third support portion of support element.
Target radiator portion described in the utility model use tube-like piece, can increasing heat radiation area, promoted target heat dissipation
Effect increases target life, reduces patient's treatment cost；The material of pedestal layer uses Ta, can reduce blistering；Inside tube-like piece
As cooling duct, heat dissipation effect can be further increased.
Description of the drawings
Fig. 1 is the neutron capture treatment system schematic diagram in the utility model embodiment；
Fig. 2 is the schematic diagram of the target in the utility model embodiment；
Fig. 3 is the close-up schematic view of the target in Fig. 2；
Fig. 4 is the schematic diagram that the heat dissipating layer of the target in Fig. 2 is looked over from direction A；
Fig. 5 a are the schematic diagram of the first embodiment of the heat dissipation channel inner wall of the target in Fig. 2；
Fig. 5 b are the schematic diagram along axis B-B of the first embodiment of the heat dissipation channel inner wall of the target in Fig. 2；
Fig. 6 a are the schematic diagram of the second embodiment of the heat dissipation channel inner wall of the target in Fig. 2；
Fig. 6 b are the schematic diagram along axis C-C of the second embodiment of the heat dissipation channel inner wall of the target in Fig. 2；
Fig. 7 is the schematic diagram of the 3rd embodiment of the heat dissipation channel inner wall of the target in Fig. 2.
Specific implementation mode
The following describes the utility model in further detail with reference to the accompanying drawings, to enable those skilled in the art with reference to explanation
Book word can be implemented according to this.
Such as Fig. 1, the neutron capture treatment system in the present embodiment is preferably boron neutron capture treatment system 100, including in
Sub- generation device 10, beam-shaping body 20, collimator 30 and instrument table 40.Neutron generation device 10 includes accelerator 11 and target
T, accelerator 11 accelerate charged particle (such as proton, deuteron), generate the charged particle line P such as proton line, band electrochondria
Sub-line (neutron beam) N, target T is preferably metal targets during sub-line P is irradiated to target T and is generated with target T effects.According to needed for
Neutron yield rate and energy, available the characteristics such as charged particle energy and the materialization of size of current, metal targets is accelerated
Suitable nuclear reaction is selected, the nuclear reaction being often discussed has7Li(p,n)7Be and9Be(p,n)9B, both reactions are all heat absorption
Reaction.The energy threshold of two kinds of nuclear reactions is respectively 1.881MeV and 2.055MeV, due in the ideal of boron neutron capture treatment
Component is the epithermal neutron of keV energy grades, if being theoretically only slightly taller than the proton bombardment lithium metal target of threshold values using energy,
The neutron that opposite low energy can be generated, clinic can be used for by being not required to too many slow handle, however lithium metal (Li) and beryllium metal
(Be) the proton-effect section of two kinds of targets and threshold values energy is not high, for the neutron flux for generating sufficiently large, usually selects higher
The proton of energy causes nuclear reaction.Ideal target should have high neutron yield rate, the neutron energy of generation is distributed close to superthermal
Neutron energy range (will be described in more detail below) wears by force the characteristics such as radiation generation, the cheap easily operated and high temperature resistant of safety without too many,
But actually and it can not find and meet required nuclear reaction.It is well known to those skilled in the art, target T can also by Li,
Metal material except Be is made, such as by formation such as Ta or W and its alloys.Accelerator 11 can be linear accelerator, convolution
Accelerator, synchrotron, synchrocyclotron.
The neutron beam N that neutron generation device 10 generates passes sequentially through beam-shaping body 20 and collimator 30 is irradiated to instrument table
Patient 200 on 40.Beam-shaping body 20 can adjust the beam quality of the neutron beam N of the generation of neutron generation device 10, collimation
Device 30 makes neutron beam N have higher targeting during being treated to converge neutron beam N.Beam-shaping body 20
Further comprise reflector 21, slow body 22, thermal neutron absorber 23, radiation shield 24 and beam outlet 25, neutron generates
The neutron that device 10 generates other than epithermal neutron meets treatment needs, needs to reduce it as far as possible since power spectrum is very wide
The neutron and photon content of his type damage to avoid to operating personnel or patient, therefore are come out from neutron generation device 10
Neutron need fast neutron energy adjusting therein to epithermal neutron energy area by slow body 22, slow body 22 by with fast neutron
The material that action section is big, epithermal neutron action section is small is made, and in the present embodiment, slow body 22 is by D2O、AlF3、
Fluental、CaF2、Li2CO3、MgF2And Al2O3At least one of be made；Reflector 21 surrounds slow body 22, and will pass through
The neutron reflection that slow body 22 is spread around returns neutron beam N to improve the utilization rate of neutron, by with neutron reflection ability
Strong material is made, and in the present embodiment, reflector 21 is made of at least one of Pb or Ni；There are one heat at slow 22 rear portion of body
Neutron absorber 23 is made of the material big with thermal neutron action section, and in the present embodiment, thermal neutron absorber 23 is by Li-6 systems
At thermal neutron absorber 23 is avoided for absorbing the thermal neutron across slow body 22 to reduce the content of thermal neutron in neutron beam N
When treatment multi-dose was caused with shallow-layer normal structure；Radiation shield 24 is arranged around beam outlet 25 at reflector rear portion,
For shielding the neutron and photon that are leaked from beam outlet 25 with outer portion, the material of radiation shield 24 includes photon shielding material
At least one of material and neutron shielding material, in the present embodiment, the material of radiation shield 24 includes photon shielding material lead
(Pb) and neutron shielding material polyethylene (PE).It is appreciated that beam-shaping body 20 can also have other constructions, as long as can
Obtain epithermal neutron beam needed for treatment.The setting of collimator 30 exports 25 rear portions in beam, is come out from collimator 30 superthermal
Neutron beam is irradiated to patient 200, is slowly that thermal neutron reaches tumour cell M after shallow-layer normal structure, it will be understood that collimation
Device 30 can also be cancelled or be replaced by other structures, and neutron beam is out directly irradiated to patient 200 from beam outlet 25.This implementation
In example, it is also provided with radiation shield device 50 between patient 200 and beam outlet 25, shields the beam out from beam outlet 25
Radiation to patient's normal structure, it will be understood that radiation shield device 50 can not also be set.
After patient 200 takes or inject boracic (B-10) drug, it is gathered in tumour cell M to boracic drug selectivity,
Then utilize boracic (B-10) drug that there is the characteristic of high capture cross section to thermal neutron, by10B(n,α)7Li neutron captures and core
Dissociative reaction generates4He and7Two heavy burden charged particle of Li.The average energy of two charged particles is about 2.33MeV, has High Linear
(Linear Energy Transfer, LET), short range feature are shifted, the linear energy transfer of the short particles of α is respectively with range
150keV/ μm, 8 μm, and7Li heavy burdens particle is then 175keV/ μm, 5 μm, and it is big that the integrated range of two particle is approximately equivalent to a cell
It is small, therefore radiation injury can be confined to cell level for caused by organism, just can cause too big wound in not normal tissue
Under the premise of evil, achieve the purpose that tumour cell is killed in part.
The structure of target T is described in detail with reference to Fig. 2, Fig. 3 and Fig. 4.
Target T is arranged between accelerator 11 and beam-shaping body 20, and accelerator 11, which has, adds charged particle line P
The accelerating tube 111 of speed, in the present embodiment, accelerating tube 111 stretches into beam-shaping body 20 along the directions charged particle line P, and wears successively
Reflector 21 and slow body 22 are crossed, target T is arranged in slow body 22 and positioned at the end of accelerating tube 111, preferable to obtain
Neutron beam quality.
Target T includes heat dissipating layer 12, pedestal layer 13 and active layer 14, during active layer 14 is generated with the P effects of charged particle line
Sub-line, 13 supporting role layer 14 of pedestal layer.In the present embodiment, the material of active layer 14 is Li or its alloy, and charged particle line P is
Proton line, target T further include the anti oxidation layer 15 for being located at 14 side of active layer and being used to prevent active layer from aoxidizing, and pedestal layer 13 can be same
When inhibit foam caused by incident proton line, charged particle line P sequentially passes through anti oxidation layer 15, active layer 14 along incident direction
With pedestal layer 13.The material of anti oxidation layer 15 considers to be not easy to be applied layer corrosion simultaneously and can reduce the loss of incident proton beam
And fever caused by proton beam, such as include Al, Ti and its at least one of alloy or stainless steel.In the present embodiment, antioxygen
It is the material that nuclear reaction can occur with proton simultaneously to change layer 15, can further increase neutron production while functioning as described above
Rate such as uses Be or its alloy at this point, anti oxidation layer is simultaneously a part for active layer, the energy of incident proton beam be higher than with
The energy threshold of nuclear reaction occurs for Li and Be, generates two different nuclear reactions respectively,7Li(p,n)7Be and9Be(p,n)9B；Separately
Outside, it is 1287 DEG C that Be, which has high-melting-point and good thermal conduction characteristic, fusing point, and pyroconductivity is 201W/ (m K), relative to Li
The high temperature resistant and heat dissipation performance of (fusing point is 181 DEG C, and pyroconductivity is 71W/ (m K)) have great advantage, further increase
The service life of target, and its reaction threshold values that (p, n) nuclear reaction occurs with proton is about 2.055MeV, and majority uses proton beamlets
Accelerator neutron generator, energy is all higher than the reaction threshold values, and beryllium target is also the optimal selection other than lithium target.With using other
Material, such as Al, anti oxidation layer compare, due to the presence of Be, neutron yield rate is improved.In the present embodiment, proton line energy
Amount is 2.5MeV-5MeV, can generate higher action section with lithium target, while not will produce excessive fast neutron, obtain compared with
Good beam quality；The thickness of active layer 14 is 80 μm -240 μm, can occur adequately to react with proton, blocked up will not cause
Energy deposits, and influences target heat dissipation performance；Ensure lower manufacturing cost while reaching said effect, anti oxidation layer 15
Thickness is 5 μm -25 μm.In contrast test, using Mondicaro software emulate respectively 2.5MeV, 3MeV, 3.5MeV, 4MeV,
The proton beam of 4.5MeV, 5MeV inject anti oxidation layer 15, active layer 14 successively by the direction of the action face perpendicular to target T
(Li) and pedestal layer 13 (Ta will be described in detail later), the material of anti oxidation layer 15 is compared with Al and Be, and anti oxidation layer 15 is thick
Degree is respectively 5 μm, 10 μm, 15 μm, 20 μm, 25 μm, and 14 thickness of active layer is respectively 80 μm, 120 μm, 160 μm, 200 μm, 240 μ
M, 12 thickness of pedestal layer have little effect visual actual conditions to neutron yield rate and adjust, obtained neutron yield rate (i.e. each matter
The neutron number that son generates) result is as shown in table 1, table 2.Neutron yield rate using Be as lithium target anti oxidation layer relative to Al carries
It is as shown in table 3 to rise ratio result of calculation, is known by result, when using Be as anti oxidation layer material, neutron yield rate has relative to Al
It is obviously improved, the neutron yield rate that can be obtained is 7.31E-05n/proton-5.61E-04n/proton.
Table 1, neutron yield rate (n/proton) .E using Al as lithium target anti oxidation layer are incident proton heat input
Table 2, neutron yield rate (n/proton) .E using Be as lithium target anti oxidation layer are incident proton heat input
Table 3 promotes ratio .E as incident proton line energy using Be as lithium target anti oxidation layer relative to the neutron yield rate of Al
Amount
Heat dissipating layer 12 by Heat Conduction Material (such as material of Cu, Fe, Al good heat conductivity) or can heat conduction but also inhibit send out
The material of bubble is made；Pedestal layer 13 is by inhibiting the material of foaming to be made；The material of inhibition foaming can heat conduction but also inhibition hair
The material of bubble includes at least one of Fe, Ta or V.Heat dissipating layer can there are many constructions, are such as tabular, in the present embodiment,
Heat dissipating layer 12 includes tube-like piece 121 and support element 122, and the material of tube-like piece 121 and support element 122 is all Cu, is had preferable
Heat dissipation performance and cost is relatively low, tube-like piece 121 are made of multiple tube side-by-sides and carry out location and installation, support by support element 122
Part 122 is fixed in slow body 22 by connectors such as bolt or screws or 111 end of accelerating tube, it will be understood that can also adopt
With other dismountable connections, it is conveniently replaceable target.The construction of pipe increases heat dissipation area, improves heat dissipation effect, contributes to
Extend the service life of target.Heat dissipating layer 12 also has a cooling duct P for cooling flow of media, and in the present embodiment, cooling medium is
Water forms and is at least a partially formed cooling duct P inside the pipe of tube-like piece 121, its heat is taken away in inside of the cooling medium stream through pipe,
It is used as cooling duct inside pipe, further enhances heat dissipation effect, extends target life.Shape, number and the size of pipe according to
The size of practical target determines, only symbolically depicts 4 pipes in figure, it will be understood that it may be square tube, polygon
Pipe, elliptical tube etc. and combinations thereof；Adjacent pipe can be closely so that its outer surface is contacted with each other, can also be spaced apart；
The endoporus cross-sectional shape of pipe can also be various, such as circle, polygon, ellipse, and different cross sections can also have
There is different shapes.Since the diameter of tube-like piece each pipe in actually manufacturing is smaller, and there are cooling duct, conventional life in inside
Production. art difficulty is larger, and tube-like piece is obtained using increasing material manufacturing in the present embodiment, facilitate micro-structure and labyrinth at
Type.Three-dimensional modeling is carried out to tube-like piece first, the three-dimensional modeling data of tube-like piece is input in computer system, and is separated into
Two dimensional slice data, the increasing material manufacturing system controlled by computer is successively manufactured raw material (such as copper powder), after superposition
It is final to obtain three-dimensional objects.
When pedestal layer 13 is made of Ta, there is certain heat dissipation effect can reduce blistering simultaneously, inhibits proton and Li
Inelastic scattering occurs and discharges γ, and extra proton is prevented to pass through target；In the present embodiment, the material of pedestal layer 13 is
Ta-W alloys can significantly improve the disadvantage that pure tantalum intensity is low, heat conductivity is poor while keeping the excellent performance of above-mentioned Ta,
Active layer 14 that the heat that nuclear reaction generates occurs to be conducted in time by pedestal layer, at this point, heat dissipating layer can also be at least
Part uses identical material or Construction integration with pedestal layer.The weight percent of W is 2.5%-20% in Ta-W alloys, to protect
The characteristic that pedestal layer inhibits foaming is demonstrate,proved, while pedestal layer has higher intensity and heat conductivity, further extends target and use
Service life.Using powder metallurgy, forging, compacting etc. by Ta-W alloys (such as Ta-2.5wt%W, Ta-5.0wt%W, Ta-7.5wt%
W, Ta-10wt%W, Ta-12wt%W, Ta-20wt%W etc.) pedestal layer 13 of plate is made, be in proton heat input
The thickness of 1.881MeV-10MeV, pedestal layer are at least 50 μm, to fully absorb extra proton.
In the present embodiment, the manufacturing process of target T is as follows：
S1：The lithium metal of liquid is poured into formation active layer 14 on pedestal layer 13, vapor deposition or sputtering etc. can also be used
Processing, can also be arranged very thin adhesive layer 16 between lithium and tantalum, the material of adhesive layer 16 include in Cu, Al, Mg or Zn extremely
Few one kind, equally can be used the processing such as vapor deposition or sputtering, improve the adhesion of pedestal layer and active layer；
S2：The tube-like piece 121 of pedestal layer 13 and heat dissipating layer 12 is subjected to HIP (Hot Isostatic Pressing：Heat etc.
Static pressure) processing；
S3：Anti oxidation layer 15, which is carried out at the same time HIP processing or is closed pedestal layer 13 by other techniques, forms a vessel
And/or active layer 14 is surrounded；
S4：Support element 122 and tube-like piece 121 are attached by the modes such as welding, being pressed.
Above-mentioned steps S1, S2, S3 and S4 in no particular order, such as can first carry out anti oxidation layer 15 and pedestal layer 13 at HIP
Pedestal layer 13 is closed one vessel of formation by reason by other techniques, then the lithium metal of liquid is poured into the vessel and is formed
Active layer 14.It is appreciated that support element 122 can also omit, multiple pipes are sequentially connected fixation by welding or other modes
It is integrated.Pedestal layer 13, active layer 14, anti oxidation layer 15 on each pipe are separately formed, then by tube-like piece and support element
122 are located by connecting, the pedestal layer 13 that is formed on each pipe after connection, active layer 14, anti oxidation layer 15 entirety may be not connect
Continuous, then it needs to form interconnecting piece 17 between adjacent pipe, interconnecting piece 17 is also by pedestal layer 13, active layer 14 and anti oxidation layer
15 compositions, entire target are divided into multiple individual effect partials, further reduced the foaming phenomena of metal oxidation resistance layer, this
When, in S4 support element 122 and the connection of tube-like piece 121 dismountable mode can also be used, then target T can carry out part more
It changes, extends target service life, reduce patient's treatment cost；It is appreciated that pedestal layer 13, active layer 14 on each pipe, anti-
Oxide layer 15 can also global formation be connected to tube-like piece, the active layer of target T is integrally continuous after connecting in this way, for
Charged particle line P has an effect with target T and is advantageous, and support element 122 can also be with tube-like piece 121 at this time integrally passes through increasing
Material manufacture obtains, and reduces processing, assembly difficulty.Pedestal layer 13, active layer 14, anti oxidation layer 15 formed it is whole perpendicular to
The shape of the section of tube hub line can also be various, and pedestal layer 13, active layer 14, anti oxidation layer 15 are such as connect with tube-like piece
The outer surface profile of side is consistent, is arc-shaped in the present embodiment, increase target T and charged particle line P effects area and
Heat dissipating layer 12 contacts with pedestal layer 13 and conducts the area of heat；Active layer 14 on each pipe at least covers the 1/4 of pipe periphery,
I.e. active layer is at least 45 degree in the angle α of circumferencial direction and tube hub line.
In the present embodiment, support element 122 includes the first support portion 1221 and the second support portion 1222, is symmetricly set on tubulose
The both ends of part 121 are respectively provided with cooling import IN and coolant outlet OUT, the cooling import IN of cooling duct P connections and coolant outlet
OUT.Cooling duct P include the first cooling duct P1 on the first support portion, the second cooling duct P2 on the second support portion and
Form the third cooling duct P3 formed inside the pipe of tube-like piece 121.Cooling medium from the cooling on the first support portion 1221 into
Mouth IN enters, and is entered inside each pipe of composition tube-like piece 121 simultaneously by the first cooling duct P1, then passes through second and support
The second cooling duct P2 in portion comes out from coolant outlet OUT.Target T by same high-energy level accelerating proton beam irradiation temperature
Fever is increased, heat derives are passed through the cooling medium in tube-like piece and support element that circulates by the pedestal layer and heat dissipating layer
Heat is taken out of, to be cooled down to target T.
It is appreciated that the first cooling duct P1 and the second cooling duct P2 can also use other settings, such as so that from
The cooling medium that cooling import IN on first support portion 1221 enters passes sequentially through inside each pipe of composition tube-like piece 121,
Finally come out from the coolant outlet OUT on the second support portion；Cooling medium can not also pass through support element, but direct inlet/outlet pipe
Shape part, at this point, cooling import IN and coolant outlet OUT can be arranged on tube-like piece 121, each pipe is sequentially connected composition cooling
Channel P cools down medium followed by the inside of each pipe.
Support element 122 can also include the third support portion 1223 of the first, second support portion 1221,1222 of connection, third
Another side contacts opposite with the side of 121 connection function layer 14 of tube-like piece of support portion 1223, third support portion 1223 can also
The 4th cooling duct with composition cooling duct P, at this point, cooling medium can be only by support element 122 without tubulose
Inside each pipe of part 121, it is not connected to the cooling duct in support element 122 inside each pipe, the cooling in support element 122
Channel can be there are many arrangement mode, such as spiral shape, the region contacted with pipe with processes more as possible；Cooling medium can also be both
By passing through the third support portion of support element inside pipe again or not only having passed through inside pipe but also passed through the first, second and the of support element
Three support portions.
In the present embodiment, first, second cooling tube D1, D2 is set between accelerating tube 111 and reflector 21 and slow body 22,
One end of first, second cooling tube D1, D2 is connect with the cooling import IN of target T and coolant outlet OUT respectively, other end connection
To external cooling source.It is appreciated that the first, second cooling tube can also be otherwise arranged in beam-shaping body, work as target
When material is placed in except beam-shaping body, it can also cancel.
One or more protruding portions 123 with cooling surface S can be set with continued reference to Fig. 5-Fig. 7, in the P of cooling duct,
To increase heat-delivery surface and/or form vortex, enhance heat dissipation effect, cooling surface S is that cooling medium circulates in the P of cooling duct
When the surface that can be contacted with protruding portion 123, protruding portion 123 is from the inner wall W of cooling duct P along leading to direction D with cooling medium stream
Vertical or inclined direction protrudes, it will be understood that protruding portion 123 can also other forms protruded from the inner wall W of cooling duct P.
With the cooling medium stream direction that lead to direction D vertical, the maximum distance L1 that protruding portion 123 extends from cooling duct P inner walls W is less than
The half of the distance L2 of opposite inner wall W is extended in the extending direction, it is cold at this that protruding portion 123 can not influence cooling medium
But the free flow in the P of channel, that is to say, that protruding portion does not have is divided into several substantially independent (coolings by a cooling duct
Medium is independent of each other) cooling duct effect.
In the first embodiment of cooling duct shown in Fig. 5 a and 5b, protruding portion 123 is from the edges inner wall W of cooling duct P
Lead to the vertical directions direction D with cooling medium stream to protrude, the inner wall W of cooling duct P is cylindrical surface, and protruding portion 123 is linear
Shape leads to the strip piece of direction D extensions along cooling medium stream, it will be understood that the inner wall W of cooling duct P can be other shapes, dash forward
Going out portion 123 can also twist or other shapes are led to direction along cooling medium stream from the inner wall W of cooling duct P and extended.In figure
Protruding portion is 10 and to be circumferentially evenly distributed along inner wall W, it will be understood that protruding portion may be other numbers or be provided only on
Active layer or the cooling duct inner wall W of pedestal layer contact, the shape of at least two adjacent protrusions and/or prominent length can also
It is different.Protruding portion 123 can be rectangle, trapezoidal, triangle etc. in the cross-sectional shape for leading to direction D perpendicular to cooling medium stream；
Varying cross-section shape or size can also be different, and such as lead to direction in pulse type, zigzag or wavy in cooling medium stream.It is prominent
Go out on the cooling surface S in portion 123 and sub- protruding portion 1231 is set, in the present embodiment, sub- protruding portion 1231 is perpendicular to cooling medium
The cross-sectional shape of circulating direction D is zigzag, and leads to direction D along cooling medium stream and extend, it will be understood that sub- protruding portion also may be used
With with a variety of different constructions, as long as heat-delivery surface can be increased；In the present embodiment, sub- protruding portion 1231 is only symbolically
It is arranged in one of protruding portion 123 cooling surface, it will be understood that sub- protruding portion 1231 can also be arranged in protruding portion
In 123 other arbitrary cooling surfaces.
Fig. 6 a and 6b show the second embodiment of cooling duct, only describe its ground being different from the first embodiment below
Side, protruding portion 123 are to lead to the ring that direction is spaced apart in cooling medium stream, it is possible to understand that, or at least part of ring.
The number of figure middle ring and the length of cooling duct are only to illustrate, and can be adjusted according to actual conditions.In the present embodiment, the end of ring
Face is the plane for leading to direction D perpendicular to cooling medium stream, it will be understood that it may be to lead to direction D with cooling medium stream to tilt
Plane or for taper surface or curved surface etc..
Refering to Fig. 7, in the 3rd embodiment of cooling duct, at least one second wall of setting 124 will cool down in the P of cooling duct
Channel P point is the mutually independent subchannel P' and P " of at least two, and cooling medium stream leads to direction not in the adjacent subchannel of at least two
Together, increase radiating efficiency.In the present embodiment, the second wall 124 is cylindric on the basis of first embodiment and passes through each protrusion
Portion 123, cylindric 124 inside of the second wall form subchannel P', while in every 2 adjacent protruding portions 123 and the second wall 124
Between form 1 subchannel P ", to form 10 subchannel P ", subchannel P' and at least one subchannel around subchannel P'
Cooling medium stream in P " leads to direction difference, and the cooling medium stream in the adjacent subchannel P " of at least two leads to direction can not also
Together.It is appreciated that the second wall can also have other set-up modes according to the different settings of protruding portion.Protrusion in cooling duct
Portion and sub- protruding portion thereon further increase manufacture difficulty, and therefore, protruding portion and/or the second wall may be used separately formed
It is inserted into pipe and is positioned, or obtained by increasing material manufacturing with pipe one.
It is appreciated that pedestal layer 13 can also be regard heat dissipating layer 12 as simultaneously, at this point, heat dissipating layer 12 is at least partly by can
Heat conduction can inhibit the material of foaming to be made again, support element made of tube-like piece 121 and Cu as made of using Ta or Ta-W alloys
122, active layer 14 is connect by the techniques such as being deposited or sputtering with Ta or Ta-W compo pipes, Ta or Ta-W compo pipes are used as base simultaneously
Seat layer 12 and heat dissipating layer 13.In the present embodiment, the whole rectangular plates of target T；It is appreciated that target T can also be disk-shaped,
A part for first support portion and the second support portion composition whole circumference or circumference, the length of pipe can be different at this time；Target T
Can be other solid shapes；Target T can also be movable with respect to accelerator or beam-shaping body, change target to facilitate or make
Particle line and target stepless action.Active layer 14 can also use liquid material (liquid metals).
It is appreciated that the target of the utility model can also be applied to other medical treatment and the neutron of non-medical field generates dress
It sets, as long as the generation of its neutron is the nuclear reaction based on particle line and target, then the material of target is also based on different nuclear reactions
Different from；It can also be applied to other particle beam generating apparatus.
" tube-like piece " in the utility model refer to multiple individual pipes arrangements and by connector or Joining Technology into
The entirety of row connection composition, is formed or is combined by one or more plate-like pieces and form the object with hollow portion that hollow portion obtains not
It can be interpreted as the tube-like piece of the utility model.
Although the illustrative specific implementation mode of the utility model is described above, in order to the art
Technical staff understands the utility model, it should be apparent that the utility model is not limited to the range of specific implementation mode, to this technology
For the those of ordinary skill in field, as long as various change is in the essence of the utility model that the attached claims limit and determine
In god and range, these variations are it will be apparent that all within the scope of the requires of the utility model is protected.
Claims (10)
1. a kind of neutron capture treatment system, including neutron generation device and beam-shaping body, the neutron generation device include
Accelerator and target, sub-line during the accelerator accelerates the charged particle line generated to be generated with target effect, the beam
Shaping body includes reflector, slow body, thermal neutron absorber, radiation shield and beam outlet, and the slow body will be described in
The neutron degradation that target generates to epithermal neutron energy area, the reflector surround the slow body and the neutron that will deviate from back to
The slow body to improve epithermal neutron intensity of beam, the thermal neutron absorber for absorb thermal neutron to avoid when treatment with
Shallow-layer normal structure caused multi-dose, the radiation shield to be used at the reflector rear portion around beam outlet setting
The neutron and photon leaked in shielding is to reduce the normal tissue dose in non-irradiated area, which is characterized in that the target includes making
With layer, pedestal layer and heat dissipating layer, sub-line during the active layer is generated with the effect of charged particle line, the pedestal layer supports the work
With layer, the heat dissipating layer includes the tube-like piece being made of multiple tube side-by-sides.
2. neutron capture treatment system as described in claim 1, which is characterized in that the neutron capture treatment system further includes
Instrument table and collimator, the middle sub-line that the neutron generation device generates are irradiated by the beam-shaping body to the instrument table
On patient, the patient and beam outlet between setting radiation shield device to shield the beam for exporting out from the beam
Radiation to patient's normal structure, the collimator is arranged goes out metastomium with sub-line in converging in the beam, and the beam is whole
First, second cooling tube is set in body, and the target has cooling import, coolant outlet and setting in cooling import and cooling
One end of cooling duct between outlet, first, second cooling tube goes out with the cooling import of the target and cooling respectively
Mouth connection, the other end are connected to external cooling source, at least the one of the cooling duct are formed inside each pipe of the tube-like piece
Part.
3. neutron capture treatment system as claimed in claim 2, which is characterized in that the target is located at the beam-shaping body
Interior, there is the accelerator accelerating tube accelerated to charged particle line, the accelerating tube to be stretched into along charged particle line direction
The beam-shaping body simultaneously sequentially passes through the reflector and slow body, and the target setting is described slow in vivo and positioned at institute
Acceleration tube end is stated, first, second cooling tube is arranged between the accelerating tube and the reflector and slow body.
4. a kind of target for particle beam generating apparatus, which is characterized in that the target includes active layer, pedestal layer and heat dissipation
Layer, the active layer support the active layer for generating the particle line, the pedestal layer, and the heat dissipating layer includes by multiple
The tube-like piece of tube side-by-side composition.
5. being used for the target of particle beam generating apparatus as claimed in claim 4, which is characterized in that the particle beam generating apparatus
For neutron beam generating apparatus, the material of the active layer is Li or its alloy, the active layer and incident proton Shu Fasheng7Li
(p,n)7Be nuclear reactions generate neutron；Or the material of the active layer is Be or its alloy, the active layer and incident proton
Shu Fasheng9Be(p,n)9B nuclear reactions generate neutron.
6. being used for the target of particle beam generating apparatus as claimed in claim 4, which is characterized in that the target further includes antioxygen
Change layer, the material of the anti oxidation layer includes Al, Ti, Be and its at least one of alloy or stainless steel, the active layer
Adhesive layer is set between pedestal layer, and the material of the adhesive layer includes at least one of Cu, Al, Mg or Zn, the heat dissipation
Layer by Heat Conduction Material or can heat conduction again inhibit foaming material be made, the pedestal layer by inhibition foam material be made,
Inhibit foaming material or can heat conduction again inhibition foam material include at least one of Fe, Ta or V, Heat Conduction Material packet
Include at least one of Cu, Fe, Al, the heat dissipating layer is connected with the pedestal layer by HIP techniques, the active layer with it is described
Pedestal layer is connected by casting, vapor deposition or sputtering technology.
7. being used for the target of particle beam generating apparatus as claimed in claim 4, which is characterized in that tube-like piece conduct simultaneously
The material of the pedestal layer, the tube-like piece is Ta, and the active layer is connect with the tube-like piece by vapor deposition or sputtering technology.
8. the target for particle beam generating apparatus as described in any one of claim 4-7, which is characterized in that the tubulose
Active layer on each pipe of part at least covers the 1/4 of pipe periphery, active layer circumferencial direction and the angle of tube hub line at least
It it is 45 degree, the tube-like piece forms interconnecting piece between adjacent pipe, and the interconnecting piece is by pedestal layer, active layer and anti oxidation layer
Composition.
9. the target for particle beam generating apparatus as described in any one of claim 4-7, which is characterized in that the heat dissipation
Layer further includes support element, and the material of the support element is Cu, and the tube-like piece is welded or is detachably connected with the support element, institute
Stating support element and/or tube-like piece has cooling duct.
10. being used for the target of particle beam generating apparatus as claimed in claim 9, which is characterized in that the support element includes setting
The first support portion and the second support portion at the tube-like piece both ends are set, first support portion is cold with cooling import and first
But there is coolant outlet and the second cooling duct, cooling medium to enter from the cooling import logical for channel, second support portion
First cooling duct is crossed into inside each pipe of the tube-like piece, then by second cooling duct from described cold
But it comes out, the cooling medium is water, and the support element further includes the third support for connecting first, second support portion
Portion, the opposite another side contacts in side that the third support portion connects the active layer with the tube-like piece, the third branch
There is cooling duct, cooling medium only by each pipe of tube-like piece inside but also to be passed through by the support element or not only for support part
It crosses the third support portion of the support element or not only passes through inside pipe but also by the first, second, and third support portion of support element.
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720599511.9U CN207640822U (en) | 2017-05-26 | 2017-05-26 | Neutron capture treatment system and target for particle beam generating apparatus |
| EP20197643.8A EP3777976A1 (en) | 2016-12-23 | 2017-07-13 | Neutron capture therapy system and target for particle beam generating device |
| PCT/CN2017/092742 WO2018113274A1 (en) | 2016-12-23 | 2017-07-13 | Neutron capturing therapy system and target material for use in particle beam generating device |
| RU2019121849A RU2727576C1 (en) | 2016-12-23 | 2017-07-13 | Neutron capture therapy system and target for beam particle generation device |
| EP17885357.8A EP3530316B1 (en) | 2016-12-23 | 2017-07-13 | Neutron capturing therapy system and target material for use in particle beam generating device |
| JP2019533000A JP2020513885A (en) | 2016-12-23 | 2017-07-13 | Targets for neutron capture therapy systems and particle beam generators |
| TW106128753A TWI632933B (en) | 2016-12-23 | 2017-08-24 | Neutron capture therapy system and target for particle beam generating device |
| US16/412,762 US20190262632A1 (en) | 2016-12-23 | 2019-05-15 | Neutron capture therapy system and target for particle beam generating device |
| US16/513,956 US11224766B2 (en) | 2016-12-23 | 2019-07-17 | Neutron capture therapy system and target for particle beam generating device |
| US17/539,358 US20220088416A1 (en) | 2016-12-23 | 2021-12-01 | Neutron capture therapy system and target for particle beam generating device |
| JP2022038857A JP7332736B2 (en) | 2016-12-23 | 2022-03-14 | Targets for neutron capture therapy systems and particle beam generators |
| JP2023130566A JP2023162248A (en) | 2016-12-23 | 2023-08-10 | Neutron capture care system and target for particle beam generator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720599511.9U CN207640822U (en) | 2017-05-26 | 2017-05-26 | Neutron capture treatment system and target for particle beam generating apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207640822U true CN207640822U (en) | 2018-07-24 |
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ID=62886273
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720599511.9U Active CN207640822U (en) | 2016-12-23 | 2017-05-26 | Neutron capture treatment system and target for particle beam generating apparatus |
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| Country | Link |
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| CN (1) | CN207640822U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108934120A (en) * | 2017-05-26 | 2018-12-04 | 南京中硼联康医疗科技有限公司 | Target and neutron capture treatment system for neutron beam generating apparatus |
| CN108926784A (en) * | 2017-05-26 | 2018-12-04 | 南京中硼联康医疗科技有限公司 | Neutron capture treatment system and target for particle beam generating apparatus |
-
2017
- 2017-05-26 CN CN201720599511.9U patent/CN207640822U/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108934120A (en) * | 2017-05-26 | 2018-12-04 | 南京中硼联康医疗科技有限公司 | Target and neutron capture treatment system for neutron beam generating apparatus |
| CN108926784A (en) * | 2017-05-26 | 2018-12-04 | 南京中硼联康医疗科技有限公司 | Neutron capture treatment system and target for particle beam generating apparatus |
| CN108934120B (en) * | 2017-05-26 | 2024-04-12 | 南京中硼联康医疗科技有限公司 | Target for neutron ray generating device and neutron capturing treatment system |
| CN108926784B (en) * | 2017-05-26 | 2024-04-16 | 南京中硼联康医疗科技有限公司 | Neutron capture treatment system and target for particle beam generating device |
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