CN207605686U - A kind of improved liquid medicine dosing system for setting T-type liquid filter - Google Patents
A kind of improved liquid medicine dosing system for setting T-type liquid filter Download PDFInfo
- Publication number
- CN207605686U CN207605686U CN201720911860.XU CN201720911860U CN207605686U CN 207605686 U CN207605686 U CN 207605686U CN 201720911860 U CN201720911860 U CN 201720911860U CN 207605686 U CN207605686 U CN 207605686U
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- Prior art keywords
- filter
- liquid
- mixing system
- liquid mixing
- pipe
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- 239000007788 liquid Substances 0.000 title claims abstract description 136
- 239000003814 drug Substances 0.000 title claims abstract description 34
- 230000000712 assembly Effects 0.000 claims description 18
- 238000000429 assembly Methods 0.000 claims description 18
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims description 16
- 238000001914 filtration Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 3
- 239000002184 metal Substances 0.000 claims description 3
- 229910001220 stainless steel Inorganic materials 0.000 claims description 3
- 239000010935 stainless steel Substances 0.000 claims description 3
- 238000005516 engineering process Methods 0.000 abstract description 5
- 241000894006 Bacteria Species 0.000 abstract description 4
- 230000001954 sterilising effect Effects 0.000 description 18
- 238000004140 cleaning Methods 0.000 description 10
- 238000010586 diagram Methods 0.000 description 4
- 238000009434 installation Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000003670 easy-to-clean Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The utility model is related to liquid medicine dosing systems technology field, specifically a kind of improved liquid medicine dosing system for setting T-type liquid filter, it is characterised in that：The inlet pressure gauge is set on the liquid mixing system inlet pipe, and the delivery gauge is set in the liquid mixing system outlet pipe；The both ends of bypass line are connected at the input end close at the outlet end of liquid mixing system inlet pipe and close to liquid mixing system outlet pipe, are respectively equipped with a diaphragm valve close at the both ends of bypass pipe on the bypass pipe；The filter inlet on the top of the filter housing is closed using blind plate；The input end of the outlet end and entrance sleeve and discharge connection and liquid mixing system outlet pipe of sanitation-grade clamping joint clamping liquid mixing system inlet pipe is respectively adopted in the both ends of two manual diaphragm valves.The utility model is compared with the existing technology, simple in structure, and the component of dismounting is few；It is easy to operate, there is corresponding bacteria removing measure to exposure portion.
Description
Technical field
The utility model is related to liquid medicine dosing systems technology field, specifically a kind of improved T-type liquid that sets filters
The liquid medicine dosing system of device.
Background technology
In sterile preparation pharmaceutical production, sterilizing filter is the most key one of component, is the sterile important guarantor of liquid
Barrier；Sterilizing filter is divided into hydrophilic liquid filtering and hydrophobic gas filtering, and hydrophilic liquid filter is for sterile
The filtration sterilization task that liquid undertakes drug is in direct contact in preparation liquid mixing system；Its filter is from the dismounting in pipe-line system
Installation action is related to whether liquid can be secondarily contaminated.
Referring to Fig. 1, currently, in liquid medicine dosing system, the T-type liquid filter of usually set degerming include filter housing 1,
Filter core 2, filter housing pedestal 3, entrance sleeve 31, discharge connection 32.T-type liquid filter is installed on the liquid medicine dosing system of sterile preparation
In the liquid transfer pipeline of system, the top inlet end of T-type liquid filter is equipped with inlet pressure gauge 41, for detecting T-type liquid
The inlet liquid pressure of body filter is installed in the liquid mixing system outlet pipe 52 that the discharge connection 32 of T-type liquid filter is connected
There is delivery gauge 42 for detecting a mouthful fluid pressure, needs to carry out the component of liquid contact site before compounding medicine production
Cleaning and sterilizing, make system be in cleaning, gnotobasis.And T-type liquid filter is cleaned offline using dismounting, sterilizing, generally
Steps are as follows for technological operation：
1. removing inlet pressure gauge 41, filter core 2, filter housing 1；
2. by closing is connect using blind cover 33 with the filter housing pedestal 3 of 1 junction of filter housing, and ensure the reliable sealing of connection,
Referring to Fig. 2；
3. liquid medicine dosing system is passed through cleansing medium and carries out on-line cleaning, abbreviation CIP, while the inlet pressure gauge 41 removed
Interface, filter core 2, filter housing 1 is using offline cleaning；Cleansing medium selected by certain on-line cleaning and offline cleaning, needs root
It is selected according to different liquid physicochemical properties；
4. liquid medicine dosing system is passed through SIP sterile mediums and is sterilized online again, abbreviation SIP, while the filter core 2 of dismounting,
Filter housing 1 is put into sterilizing cabinet to be sterilized offline；
5. the filter core 2 and filter housing 1 after offline sterilizing are removed by sterilizing cabinet is packed into hermetic bag interior sealing, liquid medicine dosing system is moved to
Road installation position under the overall leadership；
6. rapid to take out filter core 2, filter housing 1 and be installed on after removing the blind cover being connect with filter housing pedestal 3, removing hermetic bag
On filter housing pedestal 3, and inlet pressure gauge 41 is installed, makes filter core 2, filter housing 1, liquid medicine dosing after sterilizing due to dismounting action at this time
Interface position in system, that is, liquid mixing system inlet pipe 51, liquid mixing system outlet pipe 52, T-type liquid filter import and export take over
31,32, it is exposed in non-sterile air a period of time, the gnotobasis of liquid medicine dosing system of destroyed at this time, liquid
Liquid mixing system, which is contaminated degree, to be influenced the operating time by personnel；
7. installing rear system purge pressurize in place, component is for use after qualification.
As it can be seen that this traditional liquid medicine dosing system for setting T-type liquid filter needs more dismounting installing component, this is dynamic
Filter core 2 in work, filter housing 1, liquid medicine dosing system interface position be exposed in non-sterile air a period of time then again without it
Its bacteria removing measure, then our technical issues that need to address include：
1, it reduces the dismounting process of component to the greatest extent, avoid interior fittings from being exposed in non-sterile air as possible；
2, the inevitable accessory interface being exposed in non-sterile air, needs corresponding bacteria removing measure.
Utility model content
The purpose of the utility model is to overcome the deficiencies in the prior art, provide a kind of simple in structure, easy to use, reduction portion
The liquid medicine dosing system for setting T-type liquid filter of part dismounting avoids secondary pollution with easy to clean.
To achieve the above object, a kind of improved liquid medicine dosing system for setting T-type liquid filter, including T-type liquid are designed
Body filter and liquid transfer pipeline, the T-type liquid filter includes filter housing, the filter housing that is connected at filter housing bottom end opening
The top of pedestal, the filter core being fixed in filter housing, inlet pressure gauge, delivery gauge, the filter housing is equipped with filter inlet；
The bottom end of the filter housing pedestal set there are two mutually backwards to setting L-shaped entrance sleeve and L-shaped discharge connection；Described
Liquid transfer pipeline includes liquid mixing system inlet pipe and liquid mixing system outlet pipe, it is characterised in that：
The inlet pressure gauge is set on the liquid mixing system inlet pipe, and the outlet pressure is set in the liquid mixing system outlet pipe
Power table；The both ends of bypass line be connected to close at the outlet end of liquid mixing system inlet pipe and close to liquid mixing system outlet pipe into
At mouth end, a diaphragm valve is respectively equipped with close at the both ends of bypass pipe on the bypass pipe；
The filter inlet on the top of the filter housing is closed using blind plate；
Be separately connected on the entrance sleeve and discharge connection of the filter housing pedestal of the T-type liquid filter one manually every
One end of film valve forms filter assemblies；
The other end of two manual diaphragm valves of filter assemblies be connected respectively liquid mixing system inlet pipe outlet end and
The input end of liquid mixing system outlet pipe；
The outlet of sanitation-grade clamping joint clamping liquid mixing system inlet pipe is respectively adopted in the both ends of two manual diaphragm valves
The input end at end and entrance sleeve and discharge connection and liquid mixing system outlet pipe.
The blind plate uses stainless steel.
The manual diaphragm valve uses metal valve handle.
The utility model is compared with the existing technology, simple in structure, and the component directly dismantled from liquid medicine dosing system is few, only
Need overall pulling down filter assemblies；It is easy to operate, the local spool of two manual diaphragm valves only on filter assemblies with it is non-
Sterile air contact, and after filter assemblies are connect with liquid transfer pipeline, which can convey again with liquid
System is carried out at the same time SIP, realizes bacteria removing.
Description of the drawings
Fig. 1 is the partial schematic diagram at connecting T-shaped liquid filter in original liquid medicine dosing system.
Fig. 2 is that original liquid medicine dosing system removes the partial schematic diagram after T-type liquid filter.
Fig. 3 is the partial schematic diagram at connecting T-shaped liquid filter in the utility model herb liquid liquid mixing system.
Fig. 4 is the partial schematic diagram that the liquid medicine dosing system after filter assemblies is removed in the utility model.
Specific implementation mode
The utility model is described further with reference to embodiment.
Embodiment 1
Referring to Fig. 3, a kind of improved liquid medicine dosing system for setting T-type liquid filter of the utility model, including T-type liquid
Filter and liquid transfer pipeline, the T-type liquid filter includes filter housing 1, the filter housing that is connected at 1 bottom end opening of filter housing
Pedestal 3, the filter core 2 being fixed in filter housing 1, inlet pressure gauge 41, delivery gauge 42, the top of the filter housing 1 were equipped with
Filter import；The bottom end of the filter housing pedestal 3 set there are two mutually backwards to setting L-shaped entrance sleeve 31 and it is L-shaped go out
Mouth take over 32；The liquid transfer pipeline includes liquid mixing system inlet pipe 51 and liquid mixing system outlet pipe 52, it is characterised in that：
The inlet pressure gauge 41 is set on the liquid mixing system inlet pipe 51, is set in the liquid mixing system outlet pipe 52 described
Delivery gauge 42；The both ends of bypass line 9 are connected to close at the outlet end of liquid mixing system inlet pipe 51 and close to liquid
At the input end of system outlet pipe 52, a diaphragm valve 7 is respectively equipped with close at the both ends of bypass pipe 9 on the bypass pipe 9；
The filter inlet on the top of the filter housing 1 is closed using blind plate 8；
It is separately connected one on the entrance sleeve 31 and discharge connection 32 of the filter housing pedestal 3 of the T-type liquid filter
One end of manual diaphragm valve 6 forms filter assemblies；Brand, which can be selected, in sanitation-grade clamping joint 10 in this example new Lay, A Fala
It cuts down, neumo etc.；
The other end of two manual diaphragm valves 6 of filter assemblies is connected respectively the outlet end of liquid mixing system inlet pipe 51
With the input end of liquid mixing system outlet pipe 52；
The both ends of two manual diaphragm valves 6 are respectively adopted sanitation-grade clamping joint 10 and are clamped liquid mixing system inlet pipe 51
Outlet end and entrance sleeve 31 and the input end of discharge connection 32 and liquid mixing system outlet pipe 52.
Further, the blind plate 8 uses stainless steel.
Further, the manual diaphragm valve 6 uses metal valve handle.
The utility model uses following steps in cleaning：
A1, the other end of two manual diaphragm valves 6 is torn open from liquid mixing system inlet pipe 51 and liquid mixing system outlet pipe 52 respectively
Under, so that filter assemblies is integrally removed from liquid transfer pipeline；
It is close that another blind plate 11 is respectively adopted in the outlet end of a2, the outlet end of liquid mixing system inlet pipe 51 and liquid mixing system outlet pipe 52
Envelope, referring to Fig. 4；
A3, two diaphragm valves 7 on bypass pipe 9 are opened, being then passed through cleansing medium in liquid medicine dosing system carries out
Line cleans；Meanwhile spliting with T-type liquid filter by two manual diaphragm valves 6 in the filter assemblies removed, it tears open
The T-type liquid filter separated and two manual diaphragm valves 6 are reassembled into filter group again after being cleaned offline respectively
Part, in offline cleaning, two manual diaphragm valves 6 are in the open state；
A4, the filter assemblies re-assemblied after cleaning offline are put into sterilizing cabinet and are sterilized offline, offline to sterilize
When, two manual diaphragm valves 6 in filter assemblies are also at opening state, after the completion of offline sterilizing, two manual diaphragm valves 6
It closes, then filter assemblies is moved to the installation position of liquid transfer pipeline, there was only manual diaphragm in filter assemblies at this time
Local spool at the direction external world of valve 6 contacts outside air；
Filter assemblies are sealingly mounted at liquid conveying by two another blind plates 11 on a5, dismounting liquid transfer pipeline
On pipeline；
A6, liquid medicine dosing system are passed through SIP sterile mediums and are sterilized online, online two manual diaphragm valves 6 when sterilizing
It is closed, two diaphragm valves 7 are in opening state, and exposure is aerial manually after originally being removed after line sterilizing
The local spool of diaphragm valve 6 has carried out online sterilizing together with liquid medicine dosing system, ensure that entire liquid medicine dosing system
Germ-free condition；
A7, liquid medicine dosing system carry out purging pressurize, ensure the seal of liquid medicine dosing system；
Two diaphragm valves 7 on a8, closing bypass pipe, open two manual diaphragm valves 6 on filter assemblies, liquid
Liquid mixing system can normal use.
It should be noted that on-line cleaning, online sterilizing, offline sterilizing all use row industry routine in the utility model
Working specification has no special feature in the utility model, so not expansion detailed description.
It can be subtracted in washing and sterilizing using the improved liquid medicine dosing system for setting T-type liquid filter in the utility model
Component and exposure portion are dismantled less, and the two-stage sterilization of exposure portion is handled.
Claims (3)
1. a kind of improved liquid medicine dosing system for setting T-type liquid filter, including T-type liquid filter and liquid delivery pipe
Road, the T-type liquid filter includes filter housing (1), the filter housing pedestal (3) that is connected at filter housing (1) bottom end opening, is fixed on
The top of filter core (2), inlet pressure gauge (41), delivery gauge (42) in filter housing (1), the filter housing (1) is equipped with filtering
Device import；The bottom end of the filter housing pedestal (3) sets that there are two mutually backwards to the L-shaped entrance sleeve (31) and L-shaped of setting
Discharge connection (32)；The liquid transfer pipeline includes liquid mixing system inlet pipe (51) and liquid mixing system outlet pipe (52), feature
It is：
The inlet pressure gauge (41) is set on the liquid mixing system inlet pipe (51), and institute is set in the liquid mixing system outlet pipe (52)
State delivery gauge (42)；The both ends of bypass line (9) be connected to close at the outlet end of liquid mixing system inlet pipe (51) and
Close at the input end of liquid mixing system outlet pipe (52), it is respectively equipped with close at the both ends of bypass pipe (9) on the bypass pipe (9)
One diaphragm valve (7)；
The filter inlet on the top of the filter housing (1) is closed using blind plate (8)；
It is separately connected one on the entrance sleeve (31) and discharge connection (32) of the filter housing pedestal (3) of the T-type liquid filter
One end of a manual diaphragm valve (6) forms filter assemblies；
The other end of two manual diaphragm valves (6) of filter assemblies is connected respectively the outlet end of liquid mixing system inlet pipe (51)
With the input end of liquid mixing system outlet pipe (52)；
Sanitation-grade clamping joint (10) clamping liquid mixing system inlet pipe (51) is respectively adopted in the both ends of two manual diaphragm valves (6)
Outlet end and entrance sleeve (31) and discharge connection (32) and liquid mixing system outlet pipe (52) input end.
2. a kind of improved liquid medicine dosing system for setting T-type liquid filter as described in claim 1, it is characterised in that：Institute
The blind plate (8) stated uses stainless steel.
3. a kind of improved liquid medicine dosing system for setting T-type liquid filter as described in claim 1, it is characterised in that：Institute
The manual diaphragm valve (6) stated uses metal valve handle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720911860.XU CN207605686U (en) | 2017-07-26 | 2017-07-26 | A kind of improved liquid medicine dosing system for setting T-type liquid filter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720911860.XU CN207605686U (en) | 2017-07-26 | 2017-07-26 | A kind of improved liquid medicine dosing system for setting T-type liquid filter |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207605686U true CN207605686U (en) | 2018-07-13 |
Family
ID=62793082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720911860.XU Withdrawn - After Issue CN207605686U (en) | 2017-07-26 | 2017-07-26 | A kind of improved liquid medicine dosing system for setting T-type liquid filter |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207605686U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109304128A (en) * | 2017-07-26 | 2019-02-05 | 上海至纯洁净系统科技股份有限公司 | If the liquid medicine dosing system and its cleaning method of T-type liquid filter |
-
2017
- 2017-07-26 CN CN201720911860.XU patent/CN207605686U/en not_active Withdrawn - After Issue
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109304128A (en) * | 2017-07-26 | 2019-02-05 | 上海至纯洁净系统科技股份有限公司 | If the liquid medicine dosing system and its cleaning method of T-type liquid filter |
| CN109304128B (en) * | 2017-07-26 | 2024-01-23 | 上海至纯洁净系统科技股份有限公司 | Liquid medicine preparation system with T-shaped liquid filter and cleaning method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20180713 Effective date of abandoning: 20240123 |
|
| AV01 | Patent right actively abandoned |
Granted publication date: 20180713 Effective date of abandoning: 20240123 |
|
| AV01 | Patent right actively abandoned | ||
| AV01 | Patent right actively abandoned |