CN207408157U - A kind of micro liquid sampler - Google Patents

Abstract

The application provides a kind of micro liquid sampler, including pinching air bag and capillary, one end of capillary is stretched by pinching the lower part of air bag and pinches inside air bag, pinch air bag lower part and capillary junction it is closed, air bag is pinched equipped with perforate, the inner wall of capillary is coated with internal standard compound.Using the utility model, it is strongly professional to solve the of high cost of present laboratory routine liquid-transfering device, operation, conventional internal standard addition manner increase analysis workload, it is of high cost the problems such as.

Description

A kind of micro liquid sampler

Technical field

The utility model is related to medical instruments field, more particularly, to a kind of micro liquid sampler.

Background technology

Analysis detection field generally involves pipetting for micro liquid sample, and laboratory is generally configured with complete liquid relief dress It puts, mainly micropipette rifle and micro-capillary tubes.The mating disposable plastic pipette tips of micropipette rifle use, and cost is higher, Operation difficulty is high, and since the nonstandard use of operator can cause larger error；Micro-capillary tubes are usually glass material, Length is usually 10cm, and outer wall has 1-2 scale (such as capillary of 20 μ L has two scales of 20 μ L and 10 μ L), utilizes capillary Effect or compound rubber suction nozzle are using the liquid sample that can quantitatively draw several microlitres, but either capillarity or rubber head are inhaled The operation taken is required to certain skill, and since capillary inner diameter is small, it is more difficult to liquid level is just controlled at scale, that is, It says and accurately pipettes quantitative liquid, there are certain errors.

Internal standard method is a kind of analysis method of generally acknowledged accurate quantitative analysis, and conventional way is to pipette certain volume (to be typically Several hectolambdas are to several milliliters) fluid sample in centrifuge tube, artificially add in a certain amount of inner mark solution, it carried out again after mixing He is handled.The deficiency of this method is to add workload, and the especially same position of internal standard compound the step for adding internal standard compound Plain internal standard compound is often expensive, but in testing often inner mark solution it is more, it is necessary to amount it is small, cause very big waste.

With the development of analytical technology, increase of the society to analysis demand, substantial amounts of sample analysis is quickly live to divide Analysis, using the conventional method of sampling is of high cost, operation is strongly professional, using conventional internal standard addition manner increase workload and Analysis cost, these already become new challenge.

Utility model content

In order to overcome the defects of existing, the utility model proposes a kind of micro liquid samplers.

According to the utility model, a kind of micro liquid sampler is provided, as shown in Figure 1, including pinching air bag and capillary, One end of capillary is stretched by pinching air bag lower part and pinches inside air bag, and it is closed to pinch the junction of air bag lower part and capillary, pinches gas There is perforate, for the inner wall of capillary coated with chemicals film, chemicals include but not limited to internal standard compound, derivatization reagent on capsule Or the chemical substances such as anticoagulant.

Wherein, the length of capillary and internal diameter determine the volume for quantitatively pipetting liquid.Preferably, the internal diameter of capillary is 0.1~2mm, length are 5~20mm, can be fabricated to the about quantitative microsampling device of 0.1~20 μ L.

Preferably, pinch air bag to be made of transparent elastoplastic or rubber, capillary is by simple glass or high boron glass, stone English glass or plastics are made.

Pinching the shape of air bag can be：Top is semicircle spherical shape, middle part is cylindrical, lower part is inverted conical and pinches gas The lower part of capsule extends to form extension tube along the axial direction for pinching air bag.

Preferably, perforate is located at the middle part for pinching air bag.

Micro liquid sampler provided by the utility model with internal standard compound, it is easy to use, disposably quantify micro liquid Sampler body is quick and precisely；Internal standard compound has been carried, the work of a line analysis personnel can be saved, and has been reduced to the special of analysis personnel Industry requirement.

Description of the drawings

The above and other aspect and feature of the utility model will be in clearly to the explanation of embodiment from below in conjunction with attached drawing It is existing, wherein：

Fig. 1 is the structure diagram of the sampler of the utility model one embodiment；

Fig. 2 is the structure diagram of the sampler of the utility model another embodiment；

Fig. 3 is the structure diagram of the sampler of the utility model another embodiment.

Specific embodiment

A kind of micro liquid sampler provided by the utility model is carried out in the following with reference to the drawings and specific embodiments detailed Description.It is done herein with explanation simultaneously, in order to make embodiment more detailed, the following examples are optimal, are preferably implemented Example, can also be used other alternatives for some known technologies those skilled in the art and implements；And attached drawing part Merely to more specifically describing embodiment, and it is not intended to specifically limit the utility model.

According to the utility model, a kind of micro liquid sampler is provided, as shown in Figure 1, including pinching air bag 1 and capillary Pipe 4, one end of capillary 4 are stretched by pinching the lower part of air bag 1 and pinch inside air bag, pinch the lower part of air bag and the connection of capillary 4 Locate closed, pinch air bag equipped with perforate 2, the inner wall of capillary 4 can be coated with the changes such as internal standard compound, derivatization reagent or anticoagulant Learn substance.

The chemical substance of coating can be drawn by the form of solution into capillary 4, and hair is covered in by evaporation drying formation The stabilization chemicals film of 4 inner wall of tubule.

Air bag 1 is pinched to be more conform with and micro pipette having for operation there are many shape：As shown in Figure 1, top is semi-round ball Shape pipe, middle part are cylindrical tube, and lower part is inverted conical pipe and extension tube 3, and perforate 2 is located at the middle part for pinching air bag 1；Such as Fig. 2 institutes Show, top is spherical, lower part is cylindrical, and perforate 2 is located at the top for pinching air bag 1；As shown in figure 3, air bag is pinched as cylinder.

Fig. 2 and Fig. 3 is the structure diagram of the utility model other embodiment, and elongated pore 3 can with 4 contact position of capillary There is redundant space, when using sampler active pipette samples, when such as sucking is beyond the excess sample of capillary volume, sample can Redundant space is flowed into, to ensure to collect sample size in capillary 3 as setting volume.

When needing to analyze fluid sample, different samplings can be directed to and chosen with different chemical substances (such as Internal standard compound, derivative reagent, anticoagulant) and different capabilities sampler, so not only operation facility while saves internal standard compound, It is cost-effective.

The length and internal diameter of capillary 4 determine the volume for quantitatively pipetting liquid.About 0.1~20 μ L can be fabricated to Quantitative microsampling device.The sampler of different capabilities contributes to the liquid sample needed for medical worker's Quick Acquisition.Capillary 4 Internal diameter can be that 0.1~2mm, length be 5~20mm.

One embodiment is given below to illustrate：

Capillary inner diameter is 0.86mm, and length 10mm, volume is 5.8 μ L, and inside is coated with by absorption-drying process The common deuterated internal standard Imatinib-D8 of 2.9ng quantify microsampling device using this and take blood sample, when air bag is pinched in extruding, internal standard Object is discharged together with blood.

Pinching air bag 1 can be made of transparent elastoplastic or rubber, capillary 4 can by simple glass, high boron glass, Quartz glass or plastics are made.

The occupation mode of the utility model is as follows：

(1) automatic mode：During sampling, forefinger is gently held with thumb pinches 1 middle part of air bag, is careful not to be covered out with finger Sampler is placed in fluid sample surface by hole 2, and by capillarity, sample instants are full of capillary 4, and coating chemistry is multiple in advance It is molten into sample.

(2) aggressive mode：As shown in Figure 2,3, block perforate 2 and clutch air bag, and capillary 4 is contacted into sample.When After air bag is pinched in release, sample will be sucked because of air pressure difference in capillary, and coating chemicals is made to redissolve in sample, redundant sample stream Enter at 3 and 4 connection structure, to ensure that sampling quantity is consistent in capillary 4.Therefore with the utility model without skill, anyone It can be carried out operating, the result of sampling is the same and accurately (the internal diameter volume of capillary).

(3) during stock layout, forefinger pinches 1 middle part of air bag with thumb squeezes, pays attention to covering perforate 2, sample and internal standard compound with finger It can discharge moment.

Using the utility model, it is strongly professional to solve the of high cost of present laboratory routine liquid-transfering device, operation, The chemical substances addition manners such as conventional derivating agent, internal standard increase analysis workload, it is of high cost the problems such as, and it is easy to operate, Speed is fast.

Certainly, the utility model also has various other embodiments, in the situation without departing substantially from the utility model spirit and essence Under, those skilled in the art can make various corresponding changes according to the utility model, but this change should all belong to Scope of the claims appended by the utility model.

Claims (8)

1. a kind of micro liquid sampler, including pinching air bag (1) and capillary (4), one end of the capillary (4) passes through described Pinch air bag (1) lower part stretch into it is described pinch inside air bag, the junction of the lower part for pinching air bag and the capillary (4) is close It closes, described pinch has perforate (2) on air bag, which is characterized in that the inner wall of the capillary (4) is coated with chemicals film, institute Stating chemicals includes internal standard compound, derivatization reagent or anticoagulant.

2. micro liquid sampler according to claim 1, which is characterized in that the internal diameter of the capillary (4) for 0.1~ 2mm, length are 5~20mm.

3. micro liquid sampler according to claim 1, which is characterized in that the air bag (1) of pinching is by transparent elasticity Plastics or rubber are made.

4. micro liquid sampler according to claim 1, which is characterized in that the capillary (4) is by simple glass, height Boron glass, quartz glass or plastics are made.

5. micro liquid sampler according to claim 1, which is characterized in that semi-round ball is in described air bag (1) top of pinching Shape, middle part are cylinder, and lower part extends to form extension tube for inverted conical and along the axial method for pinching air bag (1) (3)。

6. micro liquid sampler according to claim 1, which is characterized in that described air bag (1) top of pinching is spherical shape, under Portion is cylinder.

7. micro liquid sampler according to claim 5 or 6, which is characterized in that the perforate (2), which is located at, pinches air bag (1) middle part.

8. micro liquid sampler according to claim 1, which is characterized in that the air bag (1) of pinching is cylinder.