CN207076027U - Titanium alloy gold mark implant and gold mark emitter - Google Patents
Titanium alloy gold mark implant and gold mark emitter Download PDFInfo
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- CN207076027U CN207076027U CN201720114501.1U CN201720114501U CN207076027U CN 207076027 U CN207076027 U CN 207076027U CN 201720114501 U CN201720114501 U CN 201720114501U CN 207076027 U CN207076027 U CN 207076027U
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- titanium alloy
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Abstract
The utility model discloses a kind of titanium alloy gold mark implant, including golden sample body, the golden sample body is made up of titanium alloy, and the golden sample body includes arc-shaped connecting rod, the arc-shaped connecting rod both ends are installed with spheroid respectively, and the diameter of the spheroid is more than the diameter of the arc-shaped connecting rod；The tumor tissues of golden sample body and implantation or the stability of the specific soft tissue around it are increased by the spheroid at arc-shaped connecting rod both ends, golden sample body is set to be not susceptible to move, improve the security and accuracy for the treatment of, because golden sample body is not easily shifted, reduction makes irradiation position change because golden sample body is moved over the course for the treatment of, may cause the radioactive damage probability that even accident occurs.On this basis, the utility model also provides a kind of gold mark emitter using titanium alloy gold mark implant.
Description
Technical field
Medical instruments field is the utility model is related to, more particularly to a kind of titanium alloy gold mark implant and gold mark emitter.
Background technology
The tumour irradiated for high accuracy in soft tissue in intra-tumor or other implantation gold, it is necessary to mark, by gold in treatment
The dynamic tracing to tumour is realized in target tracking.
After gold mark implantation one week, metastable geometrical relationship is formed with tumour, golden cursor position is determined in the treatment
The position of tumour is determined that, the dynamic degree of golden target also just represents the dynamic degree of tumour.
But gold is marked on implantation tumour tissue or around it after specific soft tissue, gold mark thing is easily moved, if displacement
Occur before the treatment, risk will not be brought, but the decline of irradiation precision may be caused, can be solved by being implanted into gold mark again
Certainly；If being shifted in the treatment, the security and accuracy for the treatment of, and the mobile then irradiation position of gold mark may be influenceed
Change, radioactive damage even accident may be caused.Therefore, no matter gold mark displacement occurs before the treatment, or in treatment,
Will actively it take measures, the security and accuracy for avoiding treatment are affected.
Utility model content
The purpose of this utility model is to provide a kind of titanium alloy gold mark implant and gold mark emitter, to solve existing skill
Above-mentioned technical problem present in art.
Titanium alloy gold mark implant provided by the utility model, including golden sample body, the golden sample body is by titanium alloy system
Into the golden sample body includes arc-shaped connecting rod, and the arc-shaped connecting rod both ends are installed with spheroid, the diameter of the spheroid respectively
More than the diameter of the arc-shaped connecting rod.
Further, the golden sample body is provided with projection.
Further, it is described raised for cross projection.
Further, it is described raised for herringbone projection.
Further, it is described raised for V-shaped projection.
Further, the golden sample body is provided with Nano medication layer.
Further, the Nano medication layer is adhered on the golden sample body by connecting oxidant layer.
Further, the connection oxidant layer is made a living thing adhesive phase.
Further, the bioadhesive oxidant layer be fibrinogen layer, thrombin layer, casein layer, chitin layer or
Chitosan layer.
Titanium alloy gold mark implant provided by the utility model, has the following advantages that：
Golden sample body and the tumor tissues or specific soft around it being implanted into are increased by the spheroid at arc-shaped connecting rod both ends
The stability of tissue, make golden sample body be not susceptible to move, improve the security and accuracy for the treatment of, because golden sample body is not easy
Mobile, reduction makes irradiation position change because golden sample body is moved over the course for the treatment of, may cause radioactive damage
The probability that even accident occurs.
In addition, the utility model additionally provides a kind of gold mark emitter, including injection needle body and above-mentioned titanium alloy gold mark
Implant, the golden sample body are placed in the injection needle body.
Brief description of the drawings
, below will be right in order to illustrate more clearly of the utility model embodiment or technical scheme of the prior art
The required accompanying drawing used is briefly described in embodiment or description of the prior art, it should be apparent that, describe below
In accompanying drawing be some embodiments of the present utility model, for those of ordinary skill in the art, do not paying creativeness
On the premise of work, other accompanying drawings can also be obtained according to these accompanying drawings.
Fig. 1 is the structural front view for the titanium alloy gold mark implant that the utility model embodiment one provides；
Fig. 2 is the structural front view for the titanium alloy gold mark implant that the utility model embodiment two provides；
Fig. 3 is the structural front view for the titanium alloy gold mark implant that the utility model embodiment three provides；
Fig. 4 is the structural front view for the titanium alloy gold mark implant that the utility model embodiment four provides；
Fig. 5 is the structural front view for the titanium alloy gold mark implant that the utility model embodiment five provides；
Fig. 6 is the partial enlarged drawing at A in Fig. 5；
The structural front view for the gold mark emitter that Fig. 7 the utility model embodiments six provide；
Fig. 8 is the partial enlarged drawing at B in Fig. 7.
Reference：
1- gold sample bodies；11- arc-shaped connecting rods；12- spheroids；
13- is raised；2- Nano medication layers；3- connection oxidant layer；
4- injects needle body；41- sleeve pipes；42- hollow handles；
43- propellers；411- tips；44- push rod；
45- push-and-pull heads.
Embodiment
The technical solution of the utility model is clearly and completely described below in conjunction with accompanying drawing, it is clear that described
Embodiment is the utility model part of the embodiment, rather than whole embodiments.Based on the embodiment in the utility model, sheet
The every other embodiment that field those of ordinary skill is obtained under the premise of creative work is not made, belongs to this practicality
Novel protected scope.
, it is necessary to explanation in description of the present utility model, term " " center ", " on ", " under ", it is "left", "right", " perpendicular
Directly ", the orientation of the instruction such as " level ", " interior ", " outer " or position relationship are based on orientation shown in the drawings or position relationship, are only
Described for the ease of description the utility model and simplifying, rather than instruction or imply signified device or element must have it is specific
Orientation, with specific azimuth configuration and operation, therefore it is not intended that to limitation of the present utility model.In addition, term " the
One ", " second ", " the 3rd " are only used for describing purpose, and it is not intended that instruction or hint relative importance.
, it is necessary to which explanation, unless otherwise clearly defined and limited, term " are pacified in description of the present utility model
Dress ", " connected ", " connection " should be interpreted broadly, for example, it may be fixedly connected or be detachably connected, or integratedly
Connection；Can be mechanical connection or electrical connection；Can be joined directly together, can also be indirectly connected by intermediary,
It can be the connection of two element internals.For the ordinary skill in the art, on can understanding as the case may be
State concrete meaning of the term in the utility model.
Embodiment one：
Fig. 1 is the structural front view for the titanium alloy gold mark implant that the utility model embodiment one provides；As shown in figure 1,
Titanium alloy gold mark implant provided by the utility model, including golden sample body 1, the golden sample body 1 is made up of titanium alloy, described
Golden sample body 1 includes arc-shaped connecting rod 11, and the both ends of arc-shaped connecting rod 11 are installed with spheroid 12 respectively, the spheroid 12
Diameter is more than the diameter of the arc-shaped connecting rod 11.
Titanium is a kind of important structural metal to grow up the 1950s, and titanium alloy is because high, anti-corrosion with intensity
The features such as property is good, heat resistance is high and be widely used in every field.Many countries all recognize the weight of titanium alloy material in the world
The property wanted, it is researched and developed in succession, and be applied.50~sixties of 20th century, mainly develop aviation hair
The high-temperature titanium alloy of motivation and the structural titanium alloy of body, develop a collection of corrosion resistant Ti alloy the seventies, since the eighties,
Corrosion resistant Ti alloy and high-strength titanium alloy are further developed.Titanium alloy is mainly used in making aircraft engine compressor part,
Secondly it is the structural member of rocket, guided missile and high-speed aircraft.
Titanium alloy gold mark implant provided by the utility model, has the following advantages that：
The tumor tissues of golden sample body and implantation or the spy around it are increased by the spheroid 12 at the both ends of arc-shaped connecting rod 11
Determine the stability of soft tissue, make golden sample body be not susceptible to move, improve the security and accuracy for the treatment of, due to golden sample body
Not easily shifted, reduction makes irradiation position change because golden sample body is moved over the course for the treatment of, may cause radioactivity
The damage probability that even accident occurs.
Embodiment two：
Fig. 2 is the structural front view for the titanium alloy gold mark implant that the utility model embodiment two provides；As shown in Fig. 2
Titanium alloy gold mark implant provided by the utility model, including golden sample body 1, the golden sample body 1 is made up of titanium alloy, described
Golden sample body 1 includes arc-shaped connecting rod 11, and the both ends of arc-shaped connecting rod 11 are installed with spheroid 12 respectively, the spheroid 12
Diameter is more than the diameter of the arc-shaped connecting rod 11.
The length of golden sample body 1 is 0.1mm-10mm, a diameter of 0.1mm-1.5mm.
The golden sample body 1 is provided with projection 13.
Described raised 13 be that cross is raised.
Pass through the further tumor tissues for increasing and being implanted into of projection 13 on golden sample body 1 or the specific soft tissue around it
Stability.
Embodiment three：
Fig. 3 is the structural front view for the titanium alloy gold mark implant that the utility model embodiment three provides；As shown in figure 3,
Titanium alloy gold mark implant provided by the utility model, including golden sample body 1, the golden sample body 1 is made up of titanium alloy, described
Golden sample body 1 includes arc-shaped connecting rod 11, and the both ends of arc-shaped connecting rod 11 are installed with spheroid 12 respectively, the spheroid 12
Diameter is more than the diameter of the arc-shaped connecting rod 11.
The golden sample body 1 is provided with projection 13.
Described raised 13 be that herringbone is raised.
Example IV：
Fig. 4 is the structural front view for the titanium alloy gold mark implant that the utility model embodiment four provides；As shown in figure 4,
Titanium alloy gold mark implant provided by the utility model, including golden sample body 1, the golden sample body 1 is made up of titanium alloy, described
Golden sample body 1 includes arc-shaped connecting rod 11, and the both ends of arc-shaped connecting rod 11 are installed with spheroid 12 respectively, the spheroid 12
Diameter is more than the diameter of the arc-shaped connecting rod 11.
The golden sample body 1 is provided with projection 13.
Described raised 13 be that V-shaped is raised.
It should be noted that the shape and structure of projection 13 can also use in addition to cross, herringbone and V fonts
Other shapes, just differ a citing herein.
Embodiment five：
Fig. 5 is the structural front view for the titanium alloy gold mark implant that the utility model embodiment five provides, and Fig. 6 is A in Fig. 5
The partial enlarged drawing at place, as seen in figs. 5-6, titanium alloy gold mark implant provided by the utility model, including golden sample body 1, institute
State golden sample body 1 to be made up of titanium alloy, the golden sample body 1 includes arc-shaped connecting rod 11, the both ends of arc-shaped connecting rod 11 point
Spheroid 12 is not installed with, and the diameter of the spheroid 12 is more than the diameter of the arc-shaped connecting rod 11.
The golden sample body 1 is provided with Nano medication layer 2.
The Nano medication layer 2 is adhered on the golden sample body 1 by connecting oxidant layer 3.
The connection oxidant layer 3 is biological adhesive phase.
The bioadhesive oxidant layer is fibrinogen layer, thrombin layer, casein layer, chitin layer or chitosan layer.
Collagen is boiomacromolecule, the main component in animal connective tissue, and mammal in-vivo content is most
Functional protein more, distribution is most wide, accounts for the 25%~30% of total protein, some organisms are even as high as more than 80%.
Collagen species is more, and common type is I type, II type, III type, V type and Ⅺ type.
Collagen is because having good biocompatibility, biodegradable and a bioactivity, therefore in food, doctor
The fields such as medicine, organizational project, cosmetics are widely applied.Such as the collagen health products " donkey-hide gelatin " of Chinese tradition, mainly
Using donkey hide as raw material (being exactly contained collagen in donkey hide in fact), there is higher nourishing health function, have Chinese medicine Triratna it
One good reputation.
Fibrin ferment：It is a kind of in human body anti-freezing, promotees the bioactivity egg of important role in solidifying coagulation cascade reaction
In vain.
Casein layer：Casein is a kind of associated proteins of phosphorous calcium, acid labile, can be precipitated when pH is relatively low.
Casein is that mammal includes cow, the main protein in sheep and people's milk, also known as：Casein, casein, cheese
Element.
Chitin layer：Chitin (chitin) is also known as chitin.The knot being polymerized for N-acetyl-glucosamine by β connections
Structure homopolysaccharide.It is widely present in the cell wall of the shell of shellfish, the crust of insect and fungi, exists in some green algas
In；It is primarily used to as support body skeleton, and plays protection to body.
Chitosan layer：Chitosan (chitosan) is also known as chitosan, is the chitin being widely present by nature
(chitin) obtained by deacetylation, chemical name is Chitosan (1-4) -2- amino-B-D glucose.
From 1859, after Frenchman Rouget obtains chitosan first, the biological functionality and phase of this natural polymer
The premium properties such as capacitive, blood compatibility, security, microbic resolvability by all trades and professions extensive concern, medicine, food,
The application study of the numerous areas such as chemical industry, cosmetics, water process, METAL EXTRACTION and recovery, biochemistry and biomedical engineering obtains
Major progress.For patient, chitosan reducing blood lipid, the existing research report of hypoglycemic effect.Meanwhile chitosan is by as increasing
Thick dose, fruit glaze agent is included in state food additive and uses standard GB-2760.
Nano medication, refer to and atom, molecule or atomic group, micel are directly manipulated by certain microfabrication mode, make
It rearranges combination, forms the new material or structure with nanoscale, and one kind has with the kin phosphorus of biomembrane
The medicine of lipid bilayer structure carrier.
In drug research field, due to the continuous infiltration and influence of nanometer technology, trigger the field depth of drug field one remote
Revolution, so as to Nano medication this new term occur.
Nano medication refers to nanoscale high molecular nanometer grain (nano-particles, NP), nanosphere
(nano.spheres NS), nanocapsule (nano-capsules, NC) etc. are carrier, are combined together in a certain way with medicine
Manufactured medicine afterwards, its particle diameter can exceed that 100nm, but should be generally less than 500nm.Nano medication can also be directly by original
The nanoparticle that material medicine is processed into.
The application of Nano medication not only improves the physicochemical property of pharmaceutical dosage form, and improves the targeting of medicine, delays
Property released etc..Research shows that nano particle has and high concentration medicine is directly acted on into cancer cell and avoids the energy of health tissues
Power.
The characteristic of Nano medication：
1) targeting under magnetic fields is combined using nano-carrier with magnetisable material, makes it have magnetic.
Meanwhile by external complementary field, or by the materials such as conduit of the implantation with magnetic field effect, support of performing the operation in body
Interior specific region forms magnetic field.Target organ is exposed in magnetic field, the distribution of magnetic nano-carrier in vivo is controlled with this, makes it
Integrated distribution is in target organ.
There is research to show that magnetic nano-carrier can make its chemotherapeutics orientation loaded concentrate on targeting portion by magnetic field
Position (tumor tissues), improves drug concentration, the enhancing therapeutic effect of targeting moiety, while reduces the drug concentration at other positions,
Reduce toxicity.
2) active targeting by monoclonal antibody covalent cross-linking or is adsorbed onto nanoparticle surface, is formed and is received with immunocompetence
The grain of rice, and also achieve certain result applied to the research of antineoplastic.
2nd, the controlled capability of Nano medication
Because of many chemotherapeutics half-life shorts, maintain its effective antitumor concentration-time shorter.Some chemotherapeutics are only right
Tumour cell in specific proliferating cycle is played a role, and the cell of other proliferating cycles is not played a role, but tumour
The cell cycle of cell is typically nonsynchronous, therefore, maintain long period effective blood concentration for oncotherapy nor
It is often important.
3rd, Nano medication absorptivity is high
Nano medication is favorably improved the absorptivity of medicine, and drug-carrying nanometer particle can change film operative mechanism, increase medicine
To the permeability of biomembrane, be advantageous to the performance of Drug Percutaneous Absorption and intracellular drug effect.
Such as loading the nanoparticle of antineoplastic adriamycin can make the more common adriamycin of its drug effect increase by 10 times, and reason is
The adhesiveness of drug-carrying nanometer particle and its small particle diameter can extend the medicine retention time, increase medicine and intestinal wall time of contact and
Contact area, improve the bioavailability of its oral absorption.
4th, nanometer antineoplastic represents
The clinical antitumor agents for being currently based on nanometer technology are represented as liposomal doxorubicin, albumin combination type Japanese yew
Alcohol.
Wherein liposomal doxorubicin is that adriamycin combines the bio distribution for changing medicine with lipidic nanoparticles, from
And reducing the cardiac toxic of adriamycin, albumin combination type taxol also eliminates chemotherapeutics and organic solvent polyoxyethylene
The adverse reaction of castor oil, it may not be necessary to directly applied using any solvent.
The medicine being currently in development also has BIND-014, and the medicine is targeting PSMA (PSMA)
Nanoparticulate drug containing docetaxel.
Study and shown that the medicine late achieves good security, tolerance and effectively in patients with solid tumor
The result of property.
The nano particle of another medicine filling gold element is proved to kill the Bb cells leaching in the people's cell of culture
Bar knurl, can suppress the growth of human B cell lymthoma in Mice Body in the case of non-chemotherapy.
And the targeting particle covered with Bladder cancer specific ligand and load taxol researched and developed is resistance to by 3 times of maximums
By dosage drug delivery to the mouse for having transplanted patient tumors, obtain good disease control and adverse reaction be resistant to
By.
In terms of the treatment of Huppert's disease, nano particle also show certain potentiality, how soft overcome application
Than resistance problems caused by star, one of resistance acceptor Vla-4-4 (VLA-4) and micro-loop are avoided by nano particle
Border interacts, and more directly, more effectively targeting is in tumour.
Embodiment six：
Fig. 7 is the structural front view for the gold mark emitter that the utility model embodiment six provides, and Fig. 8 is in Fig. 7 at B
Partial enlarged drawing；As shown in Figs. 7-8, gold mark emitter provided by the utility model, including injection needle body 4 and above-mentioned titanium close
Jin Jin marks implant, and the golden sample body 1 is placed in the injection needle body 4.
The injection needle body 4 includes sleeve pipe 41, hollow handle 42, propeller 43 and push rod 44, and the end of sleeve pipe 41 is provided with
Tip 411, the other end of sleeve pipe 41 connection hollow handle 42, propeller 43 are arranged in sleeve pipe 41, and propeller 43 is away from the end of sleeve pipe 41
The space for placing golden sample body 1 is left between portion, the one end of push rod 44 is connected with propeller 43, the other end of push rod 44
Through hollow handle 42 and push-and-pull first 45 is installed.
In use, golden sample body 1 is loaded in the space of the leading section of sleeve pipe 41, sleeve pipe 41, which is punctured to, needs what is marked
In diseased organ, the first 45 drive push rod 44 of push-and-pull is promoted to drive propeller 43 that golden sample body 1 is released into sleeve pipe and inject
In diseased organ.
Finally it should be noted that：Various embodiments above is only to illustrate the technical solution of the utility model, rather than it is limited
System；Although the utility model is described in detail with reference to foregoing embodiments, one of ordinary skill in the art should
Understand：It can still modify to the technical scheme described in foregoing embodiments, either to which part or whole
Technical characteristic carries out equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from this practicality newly
The scope of each embodiment technical scheme of type.
Claims (10)
- A kind of 1. titanium alloy gold mark implant, it is characterised in that including golden sample body, the golden sample body is made up of titanium alloy, The golden sample body includes arc-shaped connecting rod, and the arc-shaped connecting rod both ends are installed with spheroid respectively, and the diameter of the spheroid is big In the diameter of the arc-shaped connecting rod.
- 2. titanium alloy gold mark implant according to claim 1, it is characterised in that the golden sample body is provided with projection.
- 3. titanium alloy gold mark implant according to claim 2, it is characterised in that described raised for cross projection.
- 4. titanium alloy gold mark implant according to claim 2, it is characterised in that described raised for herringbone projection.
- 5. titanium alloy gold mark implant according to claim 2, it is characterised in that described raised for V-shaped projection.
- 6. titanium alloy gold mark implant according to claim 1, it is characterised in that the golden sample body is provided with nanometer medicine Nitride layer.
- 7. titanium alloy gold mark implant according to claim 6, it is characterised in that the Nano medication layer passes through bridging agent Layer is adhered on the golden sample body.
- 8. titanium alloy according to claim 7 gold mark implant, it is characterised in that the connection oxidant layer is made a living thing adhesive Layer.
- 9. titanium alloy gold mark implant according to claim 8, it is characterised in that the bioadhesive oxidant layer is fiber egg White former layer, thrombin layer, casein layer, chitin layer or chitosan layer.
- 10. a kind of gold mark emitter, it is characterised in that including injection needle body and according to any one of claim 1-9 Titanium alloy gold mark implant, the golden sample body is placed in the injection needle body.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201720114501.1U CN207076027U (en) | 2017-02-06 | 2017-02-06 | Titanium alloy gold mark implant and gold mark emitter |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720114501.1U CN207076027U (en) | 2017-02-06 | 2017-02-06 | Titanium alloy gold mark implant and gold mark emitter |
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| CN207076027U true CN207076027U (en) | 2018-03-09 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106693216A (en) * | 2017-02-06 | 2017-05-24 | 中国人民解放军总医院 | Titanium alloy gold label implant and gold label syringe |
-
2017
- 2017-02-06 CN CN201720114501.1U patent/CN207076027U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106693216A (en) * | 2017-02-06 | 2017-05-24 | 中国人民解放军总医院 | Titanium alloy gold label implant and gold label syringe |
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