CN207520449U - Negative thread gold mark implant and gold mark emitter - Google Patents
Negative thread gold mark implant and gold mark emitter Download PDFInfo
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- CN207520449U CN207520449U CN201720111365.0U CN201720111365U CN207520449U CN 207520449 U CN207520449 U CN 207520449U CN 201720111365 U CN201720111365 U CN 201720111365U CN 207520449 U CN207520449 U CN 207520449U
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- gold
- sample body
- gold mark
- layer
- negative thread
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Abstract
The utility model discloses a kind of negative thread gold mark implants, and including golden sample body, the gold sample body is equipped with spiral groove；Golden sample body and the tumor tissues of implantation or the stability of surrounding specific soft tissue are increased by spiral groove, golden sample body is made to be not susceptible to move, improve safety and the accuracy for the treatment of, since golden sample body is not easily shifted, reduce makes irradiation position change because movement occurs for golden sample body over the course for the treatment of, may cause the radioactive damage probability that even accident occurs.On this basis, the utility model additionally provides a kind of gold mark emitter.
Description
Technical field
The utility model is related to medical instruments field, more particularly to a kind of negative thread gold mark implant and gold mark emitter.
Background technology
In order to irradiate the tumour in soft tissue in high precision, need within the tumor or other implantation gold is marked, by gold in treatment
The dynamic tracing to tumour is realized in target tracking.
The implantation of gold mark after a week, forms metastable geometrical relationship with tumour, golden cursor position is determined in the treatment
The position of tumour is determined that, golden target degree of moving also just represents the dynamic degree of tumour.
But gold is marked on implantation tumour tissue or around it after specific soft tissue, gold mark thing easily moves, if displacement
Occur before the treatment, risk will not be brought, but the decline of irradiation precision may be caused, can be solved by being implanted into gold mark again
Certainly；If being displaced in the treatment, safety and the accuracy for the treatment of, and the mobile then irradiation position of gold mark may be influenced
It changes, radioactive damage even accident may be caused.Therefore, no matter gold mark displacement occurs before the treatment or in treatment,
It will actively take measures, the safety and accuracy for avoiding treatment are affected.
Utility model content
It is existing to solve the purpose of this utility model is to provide a kind of negative thread gold mark implant and gold mark emitter
Technical problem present in technology.
Negative thread gold mark implant provided by the utility model, including golden sample body, the gold sample body is equipped with spiral
Connected in star.
Further, the golden sample body is cylinder.
Further, the spiral groove is arranged on along center line direction on the cylinder.
Further, the golden sample body is equipped with Nano medication layer.
Further, the Nano medication layer is adhered to by connecting oxidant layer on the golden sample body.
Further, the connection oxidant layer is made a living object adhesive phase.
Further, the bioadhesive oxidant layer for fibrinogen layer, thrombin layer, casein layer, chitin layer or
Chitosan layer.
Further, the golden sample body is made of proof gold.
Further, the golden sample body is made of titanium alloy.
Negative thread gold mark implant provided by the utility model, has the following advantages that：
Golden sample body and the tumor tissues of implantation or the stabilization of surrounding specific soft tissue are increased by spiral groove
Property, golden sample body is made to be not susceptible to move, improves safety and the accuracy for the treatment of, since golden sample body is not easily shifted, is reduced
Irradiation position is made to change because movement occurs for golden sample body over the course for the treatment of, radioactive damage even accident may be caused to go out
Existing probability.
In addition, the utility model additionally provides a kind of gold mark emitter, including injection needle body and above-mentioned negative thread gold mark
Implant, the gold sample body are placed in the injection needle body.
Description of the drawings
It, below will be right in order to illustrate more clearly of specific embodiment of the present invention or technical solution of the prior art
Specific embodiment or attached drawing needed to be used in the description of the prior art are briefly described, it should be apparent that, it is described below
In attached drawing be the utility model some embodiments, for those of ordinary skill in the art, do not paying creativeness
Under the premise of labour, other attached drawings are can also be obtained according to these attached drawings.
Fig. 1 is the structural front view of negative thread gold mark implant that the utility model embodiment one provides；
Fig. 2 is the structural front view of negative thread gold mark implant that the utility model embodiment two provides；
Fig. 3 is the partial enlarged view A of Fig. 2；
Fig. 4 is the front view of gold mark emitter that the utility model embodiment three provides；
Fig. 5 is the partial enlarged view B of Fig. 4；
Reference numeral：
1- gold sample bodies；11- spiral grooves；2- Nano medication layers；
3- connection oxidant layer；4- injects needle body；41- casings；
42- hollow handles；43- propellers；44- push rod；
45- pushes and pulls head；411- tips.
Specific embodiment
The technical solution of the utility model is clearly and completely described below in conjunction with attached drawing, it is clear that described
Embodiment is the utility model part of the embodiment, instead of all the embodiments.Based on the embodiment in the utility model, sheet
Field those of ordinary skill all other embodiments obtained without making creative work, belong to this practicality
Novel protected range.
In the description of the present invention, it should be noted that term " " center ", " on ", " under ", it is "left", "right", " perpendicular
Directly ", the orientation of the instructions such as " level ", " interior ", " outer " or position relationship are based on orientation shown in the drawings or position relationship, are only
The utility model must have specific with the device or element for simplifying description rather than instruction or hint meaning for ease of description
Orientation, with specific azimuth configuration and operation, therefore it is not intended that limitation to the utility model.In addition, term " the
One ", " second ", " third " are only used for description purpose, and it is not intended that instruction or hint relative importance.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " is pacified
Dress ", " connected ", " connection " should be interpreted broadly, for example, it may be being fixedly connected or being detachably connected or integrally
Connection；Can be mechanical connection or electrical connection；It can be directly connected, can also be indirectly connected by intermediary,
It can be the connection inside two elements.For the ordinary skill in the art, on can understanding as the case may be
State concrete meaning of the term in the utility model.
Embodiment one：
Fig. 1 is the structural front view of negative thread gold mark implant provided by the utility model；As shown in Figure 1, this practicality is new
The negative thread gold mark implant that type provides, including golden sample body 1, the gold sample body 1 is equipped with spiral groove 11.
The gold sample body 1 is cylinder, and the spiral groove 11 is arranged on the circle along center line direction
On cylinder.
Negative thread gold mark implant provided by the utility model, has the following advantages that：
By spiral groove 11 increase golden sample body 1 and implantation tumor tissues or surrounding specific soft tissue it is steady
It is qualitative, golden sample body 1 is made to be not susceptible to move, improves safety and the accuracy for the treatment of, since golden sample body 1 is not easily shifted,
Reduce makes irradiation position change because movement occurs for golden sample body 1 over the course for the treatment of, may cause radioactive damage even
The probability that accident occurs.
Embodiment two：
Fig. 2 is the structural front view of negative thread gold mark implant that the utility model embodiment two provides, and Fig. 3 is Fig. 2's
Partial enlarged view A；As shown in Fig. 2-Fig. 3, negative thread gold mark implant provided by the utility model is described including golden sample body 1
Golden 1 outer wall of sample body is equipped with spiral groove 11.
The gold sample body 1 is cylinder, and the spiral groove 11 is arranged on the circle along center line direction
On cylinder, the length of golden sample body 1 is 0.1mm-10mm, a diameter of 0.1mm-1.5mm.
The gold sample body 1 is equipped with Nano medication layer 2.
The Nano medication layer 2 is adhered to by connecting oxidant layer 3 on the golden sample body 1.
The connection oxidant layer 3 is biological adhesive phase.
The bioadhesive oxidant layer is fibrinogen layer, thrombin layer, casein layer, chitin layer or chitosan layer.
Collagen is boiomacromolecule, and the main component and mammal in-vivo content in animal connective tissue are most
Functional protein more, distribution is most wide, accounts for the 25%~30% of total protein, certain organisms are even as high as more than 80%.
Collagen type is more, and common type is I type, II type, III type, V type and Ⅺ type.
Collagen is because with good biocompatibility, biodegradable and bioactivity, therefore in food, doctor
The fields such as medicine, organizational project, cosmetics are widely applied.Such as the collagen health products " donkey-hide gelatin " of Chinese tradition, mainly
Using donkey hide as raw material (being exactly contained collagen in donkey hide in fact), have higher nourishing health function, have Chinese medicine Triratna it
One good reputation.
Fibrin ferment：It is a kind of in human body anti-freezing, promotees the bioactivity egg of important role in solidifying coagulation cascade reaction
In vain.
Casein layer：Casein is a kind of binding protein of phosphorous calcium, and acid labile can precipitate when pH is relatively low.
Casein is that mammal includes cow, the main protein in sheep and people's milk, also known as：Casein, casein, cheese
Element.
Chitin layer：Chitin (chitin) is also known as chitin.The knot being polymerized for N-acetyl-glucosamine by β connections
Structure homopolysaccharide.It is widely present in the cell wall of the shell of shellfish, the crust of insect and fungi, exists in some green algas
In；It is primarily used to as support body skeleton and plays protection to body.
Chitosan layer：Chitosan (chitosan) is also known as chitosan, is the chitin being widely present by nature
(chitin) it is obtained by deacetylation, chemical name is Chitosan (1-4) -2- amino-B-D glucose.
From 1859, after Frenchman Rouget obtains chitosan first, the biological functionality and phase of this natural polymer
The excellent performances such as capacitive, blood compatibility, safety, microbic resolvability by all trades and professions extensive concern, medicine, food,
The application study of the numerous areas such as chemical industry, cosmetics, water process, METAL EXTRACTION and recycling, biochemistry and biomedical engineering obtains
Major progress.For patient, chitosan reducing blood lipid, hypoglycemic effect have research report.Meanwhile chitosan is by as increasing
Thick dose, fruit glaze agent be included in state food additive using standard GB-2760.
Nano medication refers to and directly manipulates atom, molecule or atomic group, micel by certain microfabrication mode, makes
It rearranges combination, forms the new substance or structure with nanoscale, and one kind has with the kin phosphorus of biomembrane
The drug of lipid bilayer structure carrier.
In drug research field, due to nanometer technology continuous infiltration and influence, it is remote to have caused one field depth of drug field
Revolution, so as to Nano medication this new term occur.
Nano medication refers to nanoscale high molecular nanometer grain (nano-particles, NP), nanosphere
(nano.spheres NS), nanocapsule (nano-capsules, NC) etc. are carrier, are combined together in a certain way with drug
Manufactured drug afterwards, grain size can exceed that 100nm, but should be generally less than 500nm.Nano medication can also be directly by raw material
The nanoparticle that drug is processed into.
The application of Nano medication not only improves the physicochemical property of pharmaceutical dosage form, and improves the targeting of drug, delays
Property released etc..It high concentration medicine is directly acted on into cancer cell and avoids the energy of health tissues researches show that nano particle has
Power.
The characteristic of Nano medication：
1) targeting under magnetic fields is combined using nano-carrier with magnetisable material, makes it have magnetism.
Meanwhile by external complementary field or by the materials such as conduit, stent of the implantation with magnetic field effect of performing the operation in body
Interior specific region forms magnetic field.Target organ is exposed in magnetic field, the distribution of magnetic nano-carrier in vivo is controlled with this, makes it
Integrated distribution is in target organ.
Have and concentrate on targeting portion researches show that magnetic nano-carrier orients by magnetic field its chemotherapeutics loaded
Position (tumor tissues), improves drug concentration, the enhancing therapeutic effect of targeting moiety, while reduces the drug concentration at other positions,
Reduce toxicity.
2) active targeting by monoclonal antibody covalent cross-linking or is adsorbed onto nanoparticle surface, is formed and is received with immunocompetence
The grain of rice, and the research applied to antitumor drug also achieves certain result.
2nd, the controlled capability of Nano medication
Because of many chemotherapeutics half-life shorts, maintain its effective antitumor concentration-time shorter.Some chemotherapeutics are only right
Tumour cell in specific proliferating cycle plays a role, and does not play a role to the cell of other proliferating cycles, however tumour
The cell cycle of cell is typically nonsynchronous, therefore, maintain long period effective blood concentration for oncotherapy nor
It is often important.
3rd, Nano medication absorptivity is high
Nano medication helps to improve the absorptivity of drug, and drug-carrying nanometer particle can change film operative mechanism, increase drug
To the permeability of biomembrane, be conducive to the performance of Drug Percutaneous Absorption and intracellular drug effect.
Such as loading the nanoparticle of antitumor drug adriamycin can make the more common adriamycin of its drug effect increase by 10 times, and reason is
The adhesiveness of drug-carrying nanometer particle and its small grain size can extend the medicine retention time, increase drug and intestinal wall time of contact and
Contact area improves the bioavailability of its oral absorption.
4th, nanometer antitumor drug represents
Liposomal doxorubicin, albumin combination type Japanese yew are represented as currently based on the clinical antitumor agents of nanometer technology
Alcohol.
Wherein liposomal doxorubicin combines the bio distribution for changing drug with lipidic nanoparticles for adriamycin, from
And reducing the cardiac toxic of adriamycin, albumin combination type taxol also eliminates chemotherapeutics and organic solvent polyoxyethylene
The adverse reaction of castor oil, it may not be necessary to directly be applied using any solvent.
The drug being currently in development also has BIND-014, which is targeting prostate-specific membrane antigen (PSMA)
Nanoparticulate drug containing docetaxel.
Have researches show that achieved in the drug late patients with solid tumor good safety, tolerance and effectively
The result of property.
The nano particle of another drug filling gold element is proved the Bb cells leaching in the people's cell that can kill culture
Bar knurl, can inhibit the growth of human B cell lymthoma in Mice Body in the case of non-chemotherapy.
And the targeting particle covered with Bladder cancer specific ligand and load taxol researched and developed is resistance to by 3 times of maximums
The mouse for having transplanted patient tumors is delivered to by the drug of dosage, good disease control is obtained and adverse reaction is resistant to
By.
In terms of the treatment of Huppert's disease, nano particle also shows certain potentiality, how soft overcomes application
Than resistance problems caused by star, one of drug resistance receptor Vla-4-4 (VLA-4) and micro-loop are avoided by nano particle
Border interacts, and more directly, more effectively targeting is in tumour.
The gold sample body 1 is made of proof gold or titanium alloy.
Proof gold refers to 24K gold, that is to say, that its gold content is 100%.But there is no the gold for having 24K in the world.Cause
This, on the market if there is the gold for indicating " 24K gold " or " proof gold " is neither true.
Proof gold content is referred to as " carat (measure of the purity of gold) " in gilding, and English is Karat, therefore referred to as karat gold.Proof gold is generally referred to as 24K, that is, is managed
It is 100% by upper gold content.
Titanium is a kind of important structural metal to grow up the 1950s, and titanium alloy is because high, anti-corrosion with intensity
The features such as property is good, heat resistance is high and be widely used in every field.Many countries all recognize the weight of titanium alloy material in the world
The property wanted in succession researchs and develops it, and is applied.Mainly develop aviation hair 50~sixties of 20th century
The high-temperature titanium alloy of motivation and the structural titanium alloy of body, develop a collection of corrosion resistant Ti alloy the seventies, since the eighties,
Corrosion resistant Ti alloy and high-strength titanium alloy are further developed.Titanium alloy is mainly used for making aircraft engine compressor part,
Secondly it is the structural member of rocket, guided missile and high-speed aircraft.
It is only intended to it should be noted that golden sample body 1 is made of proof gold or titanium alloy for example, golden sample body 1 is gone back
It can be made of other materials, just differ a citing herein.
Embodiment three：
Fig. 4 is the structural front view that gold provided by the utility model marks emitter；Fig. 5 is the partial enlarged view B of Fig. 4；Such as
Shown in Fig. 4-Fig. 5, gold mark implanting device provided in this embodiment, including injection needle body 4 and above-mentioned negative thread gold mark implant, institute
Golden sample body 1 is stated to be placed in the injection needle body 4.
The injection needle body 4 includes casing 41, hollow handle 42, propeller 43 and push rod 44, and 41 end of casing is equipped with
Tip 411,41 other end of casing connection hollow handle 42, propeller 43 are arranged in casing 41, and propeller 43 is away from 41 end of casing
There are for placing the gap of golden sample body 1 between portion, 44 one end of push rod is connect with propeller 43, and 44 other end of push rod is worn
It crosses hollow handle 42 and push-and-pull head 45 is installed.
In use, golden sample body 1 is packed into the gap of 41 front end of casing, casing 41 is punctured to the disease for needing to mark
Become in organ, push-and-pull head 45 is pushed to drive push rod 44 so as to drive propeller 43 that golden sample body 1 is released casing and inject disease
Become in organ.
Finally it should be noted that：The above various embodiments is only to illustrate the technical solution of the utility model rather than it is limited
System；Although the utility model is described in detail with reference to foregoing embodiments, those of ordinary skill in the art should
Understand：It can still modify to the technical solution recorded in foregoing embodiments either to which part or whole
Technical characteristic carries out equivalent replacement；And these modifications or replacement, this practicality that it does not separate the essence of the corresponding technical solution are new
The range of each embodiment technical solution of type.
Claims (8)
1. a kind of negative thread gold mark implant, which is characterized in that including golden sample body, it is recessed that the gold sample body is equipped with spiral shape
Slot；
The gold sample body is cylinder；
The spiral groove is arranged on along center line direction on the cylinder.
2. negative thread gold mark implant according to claim 1, which is characterized in that the gold sample body is equipped with nanometer medicine
Nitride layer.
3. negative thread gold mark implant according to claim 2, which is characterized in that the Nano medication layer passes through bridging agent
Layer is adhered on the golden sample body.
4. negative thread gold mark implant according to claim 3, which is characterized in that the connection oxidant layer is made a living object adhesive
Layer.
5. negative thread gold mark implant according to claim 4, which is characterized in that the bioadhesive oxidant layer is fiber egg
White original layer, thrombin layer, casein layer, chitin layer or chitosan layer.
6. negative thread gold mark implant according to claim 2, which is characterized in that the gold sample body is made of proof gold.
7. negative thread gold mark implant according to claim 2, which is characterized in that the gold sample body is by titanium alloy system
Into.
8. a kind of gold mark emitter, which is characterized in that including injection needle body and according to any one of claim 1-7
Negative thread gold mark implant, the gold sample body are placed in the injection needle body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720111365.0U CN207520449U (en) | 2017-02-06 | 2017-02-06 | Negative thread gold mark implant and gold mark emitter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720111365.0U CN207520449U (en) | 2017-02-06 | 2017-02-06 | Negative thread gold mark implant and gold mark emitter |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207520449U true CN207520449U (en) | 2018-06-22 |
Family
ID=62574770
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720111365.0U Active CN207520449U (en) | 2017-02-06 | 2017-02-06 | Negative thread gold mark implant and gold mark emitter |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207520449U (en) |
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2017
- 2017-02-06 CN CN201720111365.0U patent/CN207520449U/en active Active
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