CN207012179U - A kind of malaria detector - Google Patents
A kind of malaria detector Download PDFInfo
- Publication number
- CN207012179U CN207012179U CN201720142550.6U CN201720142550U CN207012179U CN 207012179 U CN207012179 U CN 207012179U CN 201720142550 U CN201720142550 U CN 201720142550U CN 207012179 U CN207012179 U CN 207012179U
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- Prior art keywords
- laser
- raman
- spectroscope
- malaria
- detector
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 201000004792 malaria Diseases 0.000 title claims abstract description 26
- 239000000835 fiber Substances 0.000 claims abstract description 34
- 238000001069 Raman spectroscopy Methods 0.000 claims abstract description 28
- 238000001514 detection method Methods 0.000 claims abstract description 26
- 238000004458 analytical method Methods 0.000 claims abstract description 16
- 239000000523 sample Substances 0.000 claims abstract description 10
- 210000000707 wrist Anatomy 0.000 claims abstract description 4
- 238000001237 Raman spectrum Methods 0.000 claims description 12
- 230000005540 biological transmission Effects 0.000 claims description 9
- 239000013307 optical fiber Substances 0.000 claims description 9
- 238000009434 installation Methods 0.000 claims description 8
- 238000001228 spectrum Methods 0.000 claims description 8
- 238000007689 inspection Methods 0.000 claims description 5
- 150000002632 lipids Chemical class 0.000 claims description 3
- 244000045947 parasite Species 0.000 claims description 3
- 230000003595 spectral effect Effects 0.000 claims description 3
- 240000004343 Indigofera suffruticosa Species 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 abstract description 5
- 238000010241 blood sampling Methods 0.000 abstract description 3
- 208000024891 symptom Diseases 0.000 abstract description 3
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 239000000049 pigment Substances 0.000 description 6
- 102000001554 Hemoglobins Human genes 0.000 description 4
- 108010054147 Hemoglobins Proteins 0.000 description 4
- 241000224016 Plasmodium Species 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 241000223960 Plasmodium falciparum Species 0.000 description 2
- 241000223801 Plasmodium knowlesi Species 0.000 description 2
- 206010035502 Plasmodium ovale infection Diseases 0.000 description 2
- 241000223810 Plasmodium vivax Species 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000013049 sediment Substances 0.000 description 2
- UPLPHRJJTCUQAY-WIRWPRASSA-N 2,3-thioepoxy madol Chemical compound C([C@@H]1CC2)[C@@H]3S[C@@H]3C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@](C)(O)[C@@]2(C)CC1 UPLPHRJJTCUQAY-WIRWPRASSA-N 0.000 description 1
- 241000255925 Diptera Species 0.000 description 1
- 241001062009 Indigofera Species 0.000 description 1
- 102000010445 Lactoferrin Human genes 0.000 description 1
- 108010063045 Lactoferrin Proteins 0.000 description 1
- 206010035500 Plasmodium falciparum infection Diseases 0.000 description 1
- 241000223821 Plasmodium malariae Species 0.000 description 1
- 206010035501 Plasmodium malariae infection Diseases 0.000 description 1
- 241001505293 Plasmodium ovale Species 0.000 description 1
- 201000009705 Plasmodium ovale malaria Diseases 0.000 description 1
- 206010035503 Plasmodium vivax infection Diseases 0.000 description 1
- 230000000078 anti-malarial effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 1
- 229940078795 lactoferrin Drugs 0.000 description 1
- 235000021242 lactoferrin Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
It the utility model is related to a kind of malaria detector, including support, the positioner for being used for being positioned arm is provided with support, mounting table is provided with the front end of positioner, detection means is provided with mounting table, the detection means includes laser, laser fiber collimater, spectroscope, Raman fiber collimater, beam analysis detector, database, display, charger and controller；The output of laser is connected with the input of laser fiber collimater；The output end of laser fiber collimater is connected with spectroscope, spectroscopical output end apical grafting in the inboard arm wrist of testing staff, Raman fiber collimater input on the spectroscope and with spectroscope vertical connection；The other end of Raman fiber collimater is connected by Raman fiber optic probe with beam analysis detector；Controller is connected with beam analysis detector, database and display.The utility model is realized without going through blood sampling, it is possible to quick diagnosis malaria symptoms, it is final to improve accuracy of detection and efficiency.
Description
Technical field
It the utility model is related to a kind of technical field of malaria detection, particularly a kind of malaria detector.
Background technology
Malaria is mosquito matchmaker disease caused by the Parasitic protozoa belonged to as deformable body (Plasmodium).Five kinds of deformable bodys can
To infect the mankind-plasmodium falciparum (P .falciparum), Plasmodium vivax (P .vivax), ovale malaria protozoon (P
.ovale), malariae (P .malariae) and Plasmodium knowlesi (P .knowlesi)-but most of death are to dislike
Caused by property plasmodium.Plasmodium falciparum causes up to 1,200,000 death every year.Infection it is accurate and early diagnosis after
Be to reduce the death rate and to prevent from excessively using anti-malaria medicaments essential to treat immediately.
Malaria wreaks havoc prevalence in Africa, Southeast Asia, is infected per year over million people.At present, sediments microscope inspection (thick blood film,
Thin smear film) be still malaria diagnosis goldstandard.But sediments microscope inspection there are problems that again as a kind of diagnostic method.Due to
Plasmodium body is small, and form is similar, it is difficult to dyeing and detection, experienced person just to accomplish correctly to diagnose；Mirror simultaneously
Inspection is wasted time and energy, and is not suitable for the detection of extensive sample.
Ramam effect can produce the spectrum different from incident wavelength after referring to laser irradiation medium, so as to obtain molecular vibration
Relevant information, by analyzing Raman spectrum characteristic peak position, intensity and line width information in terms of molecular vibration, rotation is provided, according to
This can reflect chemical bond different in molecule or functional group, therefore Raman spectrum turns into the effective of research material molecular structure
Means.
Utility model content
The purpose of this utility model is to provide one kind by using a certain spy to solve above-mentioned the deficiencies in the prior art
The laser of standing wave length, is irradiated, the caused malaria color in human body of the malaria plasmodium in blood through skin to the blood of human body
Element, Raman scattering is produced due to absorbing laser, pass through a kind of Raman spectrum analysis malaria that just whether energy quick diagnosis is infected with malaria
Disease detector.
To achieve these goals, a kind of malaria detector designed by the utility model, including support, set on support
There is the positioner for arm to be positioned, mounting table is provided with the front end of positioner, detection is provided with mounting table
Device, the detection means include：
Laser with optical fiber output；
The laser fiber collimater calibrated for the optical fiber for exporting laser；
For by the separated spectroscope of laser and caused Raman spectrum；
For the Raman fiber collimater for being calibrated Raman light；
The light beam returned is collected by Raman fiber optic probe and carries out spectrally resolved beam analysis detector；
For the database for the known spectra feature for placing malarial parasite related lipid；
For the display for being shown data；
And the charger for being powered to whole device and one are used to that raman spectral signal and database will to be detected
The controller being compared；
Wherein：The output of the laser is connected with the input of laser fiber collimater；Laser fiber collimater it is defeated
Go out end to be connected with spectroscope, spectroscopical output end apical grafting is in the inboard arm wrist of testing staff, described Raman light
Fine collimater input on the spectroscope and with spectroscope vertical connection；The other end of the Raman fiber collimater passes through drawing
Graceful fibre-optical probe is connected with beam analysis detector；The controller connects with beam analysis detector, database and display
Connect.
The hand of any size is positioned in detection in order to realize, so as to improve accuracy of detection, the positioner
Including a downward opening upper semi-circle positioning seat and an opening up lower half circle fixing groove, the upper semi-circle positioning seat and
The opening of lower half circle fixing groove cooperates, and the first horizontal-extending delay number is provided with the both sides of upper semi-circle positioning seat, under
The both sides of semicircle fixing groove are provided with the second horizontal-extending delay number, the first mounting hole are provided with the second delay number, first
Delay number is provided with the second installation peace hole coordinated with the first mounting hole, is set between first mounting hole and the second installation peace hole
Having can make opening between upper semi-circle positioning seat and lower half circle fixing groove become big screw rod, and clamping screw is provided with screw rod.
In order to further realize that bluetooth is transmitted to data, and realize that Realtime Alerts act on, connected on the controller
There are Bluetooth transmission equipment and LED alarm lamp, the Bluetooth transmission equipment is connected with receiving terminal.
In order to improve accuracy of detection, the wave-length coverage that the laser uses uses pulse laser for 532-671nm.
A kind of malaria detector that the utility model obtains, shone using malarial pigment and hemoglobin in the laser of specific wavelength
Lower this feature of caused different Raman spectrums is penetrated, and Raman spectrum will be produced through the illuminated blood of skin, is compared normal
The characteristic spectrum of hemoglobin and malarial pigment, it is easy to show whether tested person is infected, so as to realize without going through blood sampling, no
Large-scale microscope or other equipment can quick diagnosis malaria symptoms are needed, it is final to improve accuracy of detection and detection efficiency.
Brief description of the drawings
Fig. 1 is a kind of structural representation of malaria detector of embodiment 1；
Fig. 2 is the structural representation of detection means in Fig. 1；
Fig. 3 is the structural representation of positioner in embodiment 2；
Fig. 4 is the structural representation of detection means in embodiment 3.
In figure：1. support；2. positioner；3. mounting table；4. detection means；5. laser；6. laser fiber
Collimater；7. spectroscope；8. Raman fiber collimater；9. beam analysis detector；10. charger；11. controller；
12. upper semi-circle positioning seat；13. upper semi-circle positioning seat；14. the first delay number；15. the second delay number；16. Bluetooth transmission
Equipment；17. LED alarm lamp；18. the first mounting hole；19. the second installation peace hole；20. screw rod；21. clamping screw；22.
Database；23. display；24. arm.
Embodiment
The utility model is further illustrated with reference to the accompanying drawings and examples.
Embodiment 1：
As shown in Figure 1 and Figure 2, a kind of malaria detector that the present embodiment provides, including support 1, it is provided with and uses on support 1
In the positioner 2 for being positioned arm 24, mounting table 3 is provided with the front end of positioner 2, inspection is provided with mounting table 3
Device 4 is surveyed, the detection means 4 includes：
Laser 5 with optical fiber output；
The laser fiber collimater 6 calibrated for the optical fiber for exporting laser 5；
For by the separated spectroscope 7 of laser and caused Raman spectrum；
For the Raman fiber collimater 8 for being calibrated Raman light；
The light beam returned is collected by Raman fiber optic probe and carries out spectrally resolved beam analysis detector 9；
For the database 22 for the known spectra feature for placing malarial parasite related lipid；
For the display 23 for being shown data；
And for the charger 10 powered to whole device and one it is used to that raman spectral signal and data will to be detected
The controller 11 that storehouse 22 is compared；
Wherein：The output of the laser 5 is connected with the input of laser fiber collimater 6；Laser fiber collimater 6
Output end is connected with spectroscope 7, and the output end apical grafting of spectroscope 7 is described in the inner side wrist of arm 24 of testing staff
The input of Raman fiber collimater 8 on the spectroscope 7 and with the vertical connection of spectroscope 7；The Raman fiber collimater 8 it is another
One end is connected by Raman fiber optic probe with beam analysis detector 9；The controller 11 and beam analysis detector 9, data
Storehouse 22 and display 23 connect.
In order to improve accuracy of detection, the wave-length coverage that the laser 5 uses uses pulse laser for 532-671nm.
By said structure, positioned by the way that arm 24 is fixed on positioner 2, it is then that detection means 4 is right
The quasi- inner side of arm 24, now by the output fiber light beam of laser 5, and is entered to be about to the biography in optical fiber by laser fiber collimater 6
Lose and be transformed into collimated light (directional light), be then irradiated in vivo by spectroscope 7, what it is due to irradiation is that scope is 532-
The light beam of 671nm wavelength, so as to and due to malarial pigment under the laser irradiation of hemoglobin wavelength in the wave-length coverage with producing
Raw this feature of different Raman spectrums, therefore the Raman spectrum returns to spectroscope 7 and then by Raman fiber collimater 8
After the transmission light in optical fiber is transformed into collimated light (directional light), pass through the Raman fiber optic probe on beam analysis detector 9
The signal is detected, and beam analysis detector 9 transmits a signal to controller 11, now controller 11 passes through the drawing that will detect
Graceful spectrum finally judges whether tested person is infected compared with database 22.Therefore the present embodiment utilizes malarial pigment and blood
Lactoferrin caused this feature of different Raman spectrums under the laser irradiation of specific wavelength, and through the illuminated blood of skin
Raman spectrum will be produced, compares the characteristic spectrum of Hb A hemoglobin adult and malarial pigment, it is easy to show whether tested person is infected,
So as to realize without going through blood sampling, it is not necessary to large-scale microscope or other equipment can quick diagnosis malaria symptoms, finally
Improve accuracy of detection and detection efficiency.
The present embodiment has advantages below：
1st, it need not take a blood sample, add other chemical reagent, simple to operate, the dependence to personnel reduces；
2nd, by judgement of the equipment to characteristic spectrum, the sensitivity of detection is improved, reduces artificial erroneous judgement；
3rd, unstressed configuration interference and decomposition risk, suitable for the application of biologic medical；
4th, a whole set of instrument is light, compact, easy to carry, can be with field operation；
5th, cost is low, easily realizes that batch is equipped.
Embodiment 2：
As shown in figure 3, a kind of general configuration for malaria detector that the present embodiment provides is same as Example 1, it is different
It is the hand of any size to be positioned in detection in order to realize, so as to improve accuracy of detection, the positioner 2 includes
One downward opening upper semi-circle positioning seat 12 and an opening up lower half circle fixing groove 13, the upper semi-circle positioning seat 12
Cooperated with the opening of lower half circle fixing groove 13, the first horizontal-extending delay number is provided with the both sides of upper semi-circle positioning seat 12
14, the second horizontal-extending delay number 15 is provided with the both sides of lower half circle fixing groove 13, first is provided with the second delay number 15
Mounting hole 18, the second installation peace hole 19 coordinated with the first mounting hole 18, first installation are provided with the first delay number 14
Being provided between the installation peace hole 19 of hole 18 and second can make opening between upper semi-circle positioning seat 12 and lower half circle fixing groove 13 become big
Screw rod 20, clamping screw 21 is provided with screw rod 20.
By said structure, fixed when upper semi-circle positioning seat 12 is adjusted according to the size of human arm 24 with lower half circle
The distance between groove 13, so as to preferably be positioned to different size of people, finally improve accuracy of detection；And clamping screw 21
For carrying out positioning and locking effect to upper and lower upper semi-circle positioning seat 12 and lower half circle fixing groove 13.
Embodiment 3：
As shown in figure 4, a kind of general configuration for malaria detector that the present embodiment provides is same as Example 1, it is different
It is in order to further realize that bluetooth is transmitted to data, and to realize that Realtime Alerts act on, indigo plant is connected with the controller 11
Tooth transmission equipment 16 and LED alarm lamp 17, the Bluetooth transmission equipment 16 are connected with receiving terminal.Pass through Bluetooth transmission equipment 16
The data that controller 11 eventually detects are transferred to statistics and the calculating of other acceptable terminals progress data, led to simultaneously
Cross LED alarm lamp 17 and realize that the progress prompting of LED alarm lamp 17 is alarmed once controller 11 detects that human body is malarial pigment carrier
Effect.
Claims (5)
1. a kind of malaria detector, including support (1), the positioning for being used for being positioned arm (24) is provided with support (1)
Device (2), mounting table (3) is provided with the front end of positioner (2), detection means (4), the inspection are provided with mounting table (3)
Surveying device (4) includes：
Laser (5) with optical fiber output；
The laser fiber collimater (6) calibrated for the optical fiber for exporting laser (5)；
For by the separated spectroscope (7) of laser and caused Raman spectrum；
For the Raman fiber collimater (8) for being calibrated Raman light；
The light beam returned is collected by Raman fiber optic probe and carries out spectrally resolved beam analysis detector (9)；
For the database (22) for the known spectra feature for placing malarial parasite related lipid；
For the display (23) for being shown data；
And the charger for being powered to whole device (10) and one are used to that raman spectral signal and database will to be detected
(22) controller (11) being compared；
Wherein：The output of the laser (5) is connected with the input of laser fiber collimater (6)；Laser fiber collimater (6)
Output end be connected with spectroscope (7), the output end apical grafting of spectroscope (7) wrist on the inside of the arm (24) of testing staff
On, described Raman fiber collimater (8) input on the spectroscope (7) and with spectroscope (7) vertical connection；The Raman
The other end of optical fiber collimator (8) is connected by Raman fiber optic probe with beam analysis detector (9)；The controller (11) with
Beam analysis detector (9), database (22) and display (23) connection.
2. a kind of malaria detector according to claim 1, it is characterized in that：The positioner (2) is opened including one
The upper semi-circle positioning seat (12) of mouth down and an opening up lower half circle fixing groove (13), the upper semi-circle positioning seat (12)
Cooperate with the opening of lower half circle fixing groove (13), prolong in the both sides of upper semi-circle positioning seat (12) provided with horizontal-extending first
Period (14), horizontal-extending the second delay number (15) is provided with the both sides of lower half circle fixing groove (13), in the second delay number
(15) the first mounting hole (18) is provided with, the second installation coordinated with the first mounting hole (18) is provided with the first delay number (14)
Pacify hole (19), first mounting hole (18) with second installation pacify hole (19) between be provided with can make upper semi-circle positioning seat (12) and
Opening becomes big screw rod (20) between lower half circle fixing groove (13), and clamping screw (21) is provided with screw rod (20).
3. a kind of malaria detector according to claim 1 or 2, it is characterized in that：Indigo plant is connected with the controller (11)
Tooth transmission equipment (16) and LED alarm lamp (17), the Bluetooth transmission equipment (16) are connected with receiving terminal.
4. a kind of malaria detector according to claim 1 or 2, it is characterized in that：The wavelength model that the laser (5) uses
Enclose for 532-671nm, and use pulse laser.
5. a kind of malaria detector according to claim 3, it is characterized in that：The wave-length coverage that the laser (5) uses
For 532-671nm, and use pulse laser.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720142550.6U CN207012179U (en) | 2017-02-17 | 2017-02-17 | A kind of malaria detector |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720142550.6U CN207012179U (en) | 2017-02-17 | 2017-02-17 | A kind of malaria detector |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207012179U true CN207012179U (en) | 2018-02-16 |
Family
ID=61461152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720142550.6U Expired - Fee Related CN207012179U (en) | 2017-02-17 | 2017-02-17 | A kind of malaria detector |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207012179U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106691393A (en) * | 2017-02-17 | 2017-05-24 | 上海镭昊光电股份有限公司 | Malaria detector |
-
2017
- 2017-02-17 CN CN201720142550.6U patent/CN207012179U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106691393A (en) * | 2017-02-17 | 2017-05-24 | 上海镭昊光电股份有限公司 | Malaria detector |
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