CN106691393A - Malaria detector - Google Patents

Malaria detector Download PDF

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Publication number
CN106691393A
CN106691393A CN201710085204.3A CN201710085204A CN106691393A CN 106691393 A CN106691393 A CN 106691393A CN 201710085204 A CN201710085204 A CN 201710085204A CN 106691393 A CN106691393 A CN 106691393A
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CN
China
Prior art keywords
laser
malaria
raman
spectroscope
detector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710085204.3A
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Chinese (zh)
Inventor
郑斐钟
朱沛林
李士新
庄向阳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Leihao Optoelectronics Co Ltd
Original Assignee
Shanghai Leihao Optoelectronics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Leihao Optoelectronics Co Ltd filed Critical Shanghai Leihao Optoelectronics Co Ltd
Priority to CN201710085204.3A priority Critical patent/CN106691393A/en
Publication of CN106691393A publication Critical patent/CN106691393A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062Arrangements for scanning
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/74Details of notification to user or communication with user or patient ; user input means
    • A61B5/742Details of notification to user or communication with user or patient ; user input means using visual displays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/74Details of notification to user or communication with user or patient ; user input means
    • A61B5/746Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

The invention relates to a malaria detector. The malaria detector comprises a support, a positioning device for positioning an arm is arranged on the support, a placement table is arranged at the front end of the positioning device, a detection device is arranged on the placement table and comprises a laser device, a laser fiber collimator, a spectroscope, a Raman fiber collimator, a light beam analysis detector, a database, a display, a power supply appliance and a controller, output of the laser device is connected with the input end of the laser fiber collimator, the output end of the laser fiber collimator is connected with the spectroscope, the output end of the spectroscope butts against the waist on the inner side of the arm of a detected person connectively, the input end of the Raman fiber collimator is arranged on the spectroscope and is perpendicularly connected with the spectroscope, the other end of the Raman fiber collimator is connected with the light beam analysis detector through a Raman fiber probe, and the controller is connected with the light beam analysis detector, the database and the display. The malaria detector is capable of diagnosing malaria symptoms quickly without blood sampling, so that detection precision and detection efficiency are improved finally.

Description

A kind of malaria detector
Technical field
The present invention relates to a kind of technical field of malaria detection, particularly a kind of malaria detector.
Background technology
Malaria is the mosquito matchmaker disease that the Parasitic protozoa belonged to by deformable body (Plasmodium) causes.Five kinds of deformable bodys can To infect the mankind-plasmodium falciparum (P .falciparum), Plasmodium vivax (P .vivax), ovale malaria protozoon (P .ovale), malariae (P .malariae) and Plasmodium knowlesi (P .knowlesi)-but most of death are to dislike Plasmodium causes property.Plasmodium falciparum causes up to 1,200,000 death every year.Infection it is accurate and early diagnosis after With treat immediately be reduce the death rate and prevent excessively use anti-malaria medicaments it is essential.
Malaria wreaks havoc prevalence in Africa, Southeast Asia, per year over million people's infection.At present, sediments microscope inspection (thick blood film, Thin smear film) be still malaria diagnosis goldstandard.But sediments microscope inspection there are problems that as a kind of diagnostic method again.Due to Plasmodium body is small, and form is similar, it is difficult to dyeing and detection, experienced person just to accomplish correct diagnosis;While mirror Inspection is wasted time and energy, and is not suitable for the detection of extensive sample.
Ramam effect can produce the spectrum different from incident wavelength after referring to laser irradiation medium, so as to obtain molecular vibration Relevant information, information in terms of molecular vibration, rotation is provided by analyzing Raman spectrum characteristic peak position, intensity and line width, according to This can reflect different chemical bond or functional groups in molecule, therefore Raman spectrum turns into the effective of research material molecular structure Means.
The content of the invention
One kind is provided the invention aims to solve above-mentioned the deficiencies in the prior art by using a certain certain wave Laser long, is irradiated through skin to the blood of human body, the malarial pigment that the malaria plasmodium in blood is produced in human body, by Raman scattering is produced in laser is absorbed, is detected by a kind of Raman spectrum analysis malaria that just whether energy quick diagnosis are infected with malaria Instrument.
To achieve these goals, a kind of malaria detector designed by the present invention, including support, is provided with use on support In the positioner for being positioned arm, mounting table is provided with the front end of positioner, detection means is provided with mounting table, The detection means includes:
Laser with optical fiber output;
For the laser fiber collimater that the optical fiber for exporting laser is calibrated;
For by laser and the separate spectroscope of Raman spectrum for producing;
For the Raman fiber collimater for being calibrated Raman light;
Collecting the light beam for returning by Raman fiber optic probe carries out spectrally resolved beam analysis detector;
Database for placing the known spectra feature of malarial parasite related lipid;
For the display for being shown data;
And charger for being powered to whole device and one are used to that raman spectral signal will to be detected and are carried out with database The controller for comparing;
Wherein:The output of the laser is connected with the input of laser fiber collimater;The output end of laser fiber collimater It is connected with spectroscope, spectroscopical output end apical grafting is in the inboard arm wrist of testing staff, and described Raman fiber is accurate Straight device input is on spectroscope and vertical with spectroscope is connected;The other end of the Raman fiber collimater passes through Raman light Fibre probe is connected with beam analysis detector;The controller is connected with beam analysis detector, database and display.
In order to realize that the hand in detection to any size is positioned, so that accuracy of detection is improved, the positioner Including a downward opening upper semi-circle positioning seat and an opening up lower half circle fixing groove, the upper semi-circle positioning seat and The opening of lower half circle fixing groove cooperates, and the first horizontal-extending delay number is provided with the both sides of upper semi-circle positioning seat, under The both sides of semicircle fixing groove are provided with the second horizontal-extending delay number, the first mounting hole are provided with the second delay number, first Delay number is provided with the second installation peace hole coordinated with the first mounting hole, and first mounting hole and second set between installing peace hole There is the screw rod that can make to be open between upper semi-circle positioning seat and lower half circle fixing groove and become big, clamping screw is provided with screw rod.
In order to further realize that bluetooth is transmitted to data, and realize that Realtime Alerts are acted on, connected on the controller There are Bluetooth transmission equipment and LED alarm lamp, the Bluetooth transmission equipment is connected with receiving terminal.
In order to improve accuracy of detection, the wave-length coverage that the laser is used is 532-671nm, and uses pulse laser.
A kind of malaria detector that the present invention is obtained, using malarial pigment and hemoglobin in the case where the laser of specific wavelength irradiates The different Raman spectrums of generation this features, and Raman spectrum will be produced through the illuminated blood of skin, compare normal blood red The characteristic spectrum of albumen and malarial pigment, it is easy to show whether tested person is infected, so as to realize without going through blood sampling, it is not necessary to Large-scale microscope or other equipment just can be final to improve accuracy of detection and detection efficiency with quick diagnosis malaria symptoms.
Brief description of the drawings
Fig. 1 is a kind of structural representation of malaria detector of embodiment 1;
Fig. 2 is the structural representation of detection means in Fig. 1;
Fig. 3 is the structural representation of positioner in embodiment 2;
Fig. 4 is the structural representation of detection means in embodiment 3.
In figure:1. support;2. positioner;3. mounting table;4. detection means;5. laser;6. laser fiber Collimater;7. spectroscope;8. Raman fiber collimater;9. beam analysis detector;10. charger;11. controllers; 12. upper semi-circle positioning seats;13. upper semi-circle positioning seats;14. first delay numbers;15. second delay numbers;16. Bluetooth transmissions Equipment;17. LED alarm lamps;18. first mounting holes;19. second install peace hole;20. screw rods;21. clamping screws;22. Database;23. displays;24. arms.
Specific embodiment
The present invention is further described with reference to the accompanying drawings and examples.
Embodiment 1:
As shown in Figure 1 and Figure 2, a kind of malaria detector that the present embodiment is provided, including support 1, are provided with support 1 for inciting somebody to action The positioner 2 that arm 24 is positioned, mounting table 3 is provided with the front end of positioner 2, and detection dress is provided with mounting table 3 4 are put, the detection means 4 includes:
Laser 5 with optical fiber output;
For the laser fiber collimater 6 for being calibrated the optical fiber that laser 5 is exported;
For by laser and the separate spectroscope 7 of Raman spectrum for producing;
For the Raman fiber collimater 8 for being calibrated Raman light;
Collecting the light beam for returning by Raman fiber optic probe carries out spectrally resolved beam analysis detector 9;
Database 22 for placing the known spectra feature of malarial parasite related lipid;
For the display 23 for being shown data;
And for the charger 10 powered to whole device and one be used to that raman spectral signal and database 22 will to be detected The controller 11 being compared;
Wherein:The output of the laser 5 is connected with the input of laser fiber collimater 6;The output of laser fiber collimater 6 End be connected with spectroscope 7, the output end apical grafting of spectroscope 7 in the inner side wrist of arm 24 of testing staff, described Raman The input of optical fiber collimator 8 is on the spectroscope 7 and vertical with spectroscope 7 is connected;The other end of the Raman fiber collimater 8 It is connected with beam analysis detector 9 by Raman fiber optic probe;The controller 11 and beam analysis detector 9, database 22 And display 23 is connected.
In order to improve accuracy of detection, the wave-length coverage that the laser 5 is used is 532-671nm, and uses pulse laser.
By said structure, positioned by the way that arm 24 is fixed on positioner 2, then by detection means 4 pairs The inner side of quasi- arm 24, now by the output fiber light beam of laser 5, and is entered to be about to the biography in optical fiber by laser fiber collimater 6 Lose and be transformed into collimated light (directional light), be then irradiated in vivo by spectroscope 7, due to irradiation is that scope is 532- The light beam of 671nm wavelength, so that and because malarial pigment and hemoglobin are produced in the wave-length coverage under the laser irradiation of wavelength Raw this feature of different Raman spectrums, therefore the Raman spectrum returns to spectroscope 7 and then by Raman fiber collimater 8 After transmission light just in optical fiber is transformed into collimated light (directional light), by the Raman fiber optic probe on beam analysis detector 9 The signal is detected, and beam analysis detector 9 transmits a signal to controller 11, now controller 11 is by the drawing that will detect Graceful spectrum is compared with database 22, finally judges whether tested person is infected.Therefore the present embodiment utilizes malarial pigment and blood Lactoferrin this feature of the different Raman spectrums of generation under the laser irradiation of specific wavelength, and through the illuminated blood of skin Raman spectrum will be produced, the characteristic spectrum of Hb A hemoglobin adult and malarial pigment will be compared, it is easy to show whether tested person is infected, So as to realize without going through blood sampling, it is not necessary to which large-scale microscope or other equipment just can be with quick diagnosis malaria symptoms, finally Improve accuracy of detection and detection efficiency.
The present embodiment has advantages below:
1st, need not take a blood sample, add other chemical reagent, simple to operate, the dependence reduction to personnel;
2nd, the judgement by equipment to characteristic spectrum, improves the sensitivity of detection, reduces artificial erroneous judgement;
3rd, unstressed configuration interference and decomposition risk, it is adaptable to the application of biologic medical;
4th, a whole set of instrument is light, compact, easy to carry, can be with field operation;
5th, low cost, easily realizes that batch is equipped.
Embodiment 2:
As shown in figure 3, a kind of general configuration of malaria detector of the present embodiment offer is same as Example 1, unlike, it is Realize that the hand in detection to any size is positioned, so as to improve accuracy of detection, the positioner 2 is opened including one The upper semi-circle positioning seat 12 of mouth down and an opening up lower half circle fixing groove 13, the upper semi-circle positioning seat 12 and lower half The opening of circle fixing groove 13 is cooperated, and the first horizontal-extending delay number 14 is provided with the both sides of upper semi-circle positioning seat 12, The both sides of lower half circle fixing groove 13 are provided with the second horizontal-extending delay number 15, and the first mounting hole is provided with the second delay number 15 18, be provided with the first delay number 14 with the first mounting hole 18 coordinate second installation peace hole 19, first mounting hole 18 with The screw rod that can make to be open between upper semi-circle positioning seat 12 and lower half circle fixing groove 13 and become big is provided between second installation peace hole 19 20, clamping screw 21 is provided with screw rod 20.
By said structure, fixed with lower half circle when upper semi-circle positioning seat 12 is adjusted according to the size of human arm 24 The distance between groove 13, so as to preferably be positioned to different size of people, finally improves accuracy of detection;And clamping screw 21 For carrying out positioning and locking effect to upper and lower upper semi-circle positioning seat 12 and lower half circle fixing groove 13.
Embodiment 3:
As shown in figure 4, a kind of general configuration of malaria detector of the present embodiment offer is same as Example 1, unlike, it is Further realize that bluetooth is transmitted to data, and realize that Realtime Alerts are acted on, bluetooth biography is connected with the controller 11 Transfer device 16 and LED alarm lamp 17, the Bluetooth transmission equipment 16 are connected with receiving terminal.To be controlled by Bluetooth transmission equipment 16 The data that device processed 11 is eventually detected are transferred to other acceptable terminals and carry out statistics and the calculating of data, while passing through LED alarm lamp 17 is realized once it is malarial pigment carrier that controller 11 detects human body, is carried out the prompting alarm of LED alarm lamp 17 and is made With.

Claims (5)

1. a kind of malaria detector, including support (1), is provided with the positioning for arm (24) to be positioned on support (1) Device (2), mounting table (3) is provided with the front end of positioner (2), and detection means (4), the inspection are provided with mounting table (3) Surveying device (4) includes:
Laser (5) with optical fiber output;
For the laser fiber collimater (6) for being calibrated the optical fiber that laser (5) is exported;
For by laser and the separate spectroscope (7) of Raman spectrum for producing;
For the Raman fiber collimater (8) for being calibrated Raman light;
Collecting the light beam for returning by Raman fiber optic probe carries out spectrally resolved beam analysis detector (9);
Database (22) for placing the known spectra feature of malarial parasite related lipid;
For the display (23) for being shown data;
And for the charger (10) powered to whole device and one be used to that raman spectral signal and database will to be detected (22) controller (11) being compared;
Wherein:The output of the laser (5) is connected with the input of laser fiber collimater (6);Laser fiber collimater (6) Output end be connected with spectroscope (7), arm (24) the inner side wrist of the output end apical grafting of spectroscope (7) in testing staff On, described Raman fiber collimater (8) input is on spectroscope (7) and vertical with spectroscope (7) is connected;The Raman The other end of optical fiber collimator (8) is connected by Raman fiber optic probe with beam analysis detector (9);The controller (11) with The connection of beam analysis detector (9), database (22) and display (23).
2. a kind of malaria detector according to claim 1, it is characterized in that:The positioner (2) is opened including one The upper semi-circle positioning seat (12) of mouth down and an opening up lower half circle fixing groove (13), the upper semi-circle positioning seat (12) Opening with lower half circle fixing groove (13) cooperates, and is provided with horizontal-extending first in the both sides of upper semi-circle positioning seat (12) and prolongs Period (14), horizontal-extending the second delay number (15) is provided with the both sides of lower half circle fixing groove (13), in the second delay number (15) the first mounting hole (18) is provided with, the second installation coordinated with the first mounting hole (18) is provided with the first delay number (14) Peace hole (19), first mounting hole (18) with second install peace hole (19) between be provided with can make upper semi-circle positioning seat (12) and Be open the screw rod (20) for becoming big between lower half circle fixing groove (13), and clamping screw (21) is provided with screw rod (20).
3. a kind of malaria detector according to claim 1 and 2, it is characterized in that:Indigo plant is connected with the controller (11) Tooth transmission equipment (16) and LED alarm lamp (17), the Bluetooth transmission equipment (16) are connected with receiving terminal.
4. a kind of malaria detector according to claim 1 and 2, it is characterized in that:The wavelength model that the laser (5) uses It is 532-671nm to enclose, and uses pulse laser.
5. a kind of malaria detector according to claim 3, it is characterized in that:The wave-length coverage that the laser (5) uses It is 532-671nm, and uses pulse laser.
CN201710085204.3A 2017-02-17 2017-02-17 Malaria detector Pending CN106691393A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710085204.3A CN106691393A (en) 2017-02-17 2017-02-17 Malaria detector

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710085204.3A CN106691393A (en) 2017-02-17 2017-02-17 Malaria detector

Publications (1)

Publication Number Publication Date
CN106691393A true CN106691393A (en) 2017-05-24

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Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5615673A (en) * 1995-03-27 1997-04-01 Massachusetts Institute Of Technology Apparatus and methods of raman spectroscopy for analysis of blood gases and analytes
CN101042348A (en) * 2006-03-24 2007-09-26 中国科学院长春光学精密机械与物理研究所 Device for nondestructively detecting carotenoid concentration in human body
CN101600962A (en) * 2006-11-10 2009-12-09 埃克塞特大学 A kind of apparatus and method that detect β-protoheme and malarial pigment
CN104267015A (en) * 2014-07-09 2015-01-07 香港应用科技研究院有限公司 Optical Signal Detection Device For Physiological Detection And Method For Analyzing Sample Components
CN204318754U (en) * 2014-12-15 2015-05-13 孟庆慧 A kind of electrode clip of electrocardiogram
CN104897644A (en) * 2015-06-05 2015-09-09 深圳国际旅行卫生保健中心 Detection method and detection system for plasmodium
CN205866754U (en) * 2016-05-10 2017-01-11 潘茹会 Clinical laboratory uses arm positioner
CN207012179U (en) * 2017-02-17 2018-02-16 上海镭昊光电股份有限公司 A kind of malaria detector

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5615673A (en) * 1995-03-27 1997-04-01 Massachusetts Institute Of Technology Apparatus and methods of raman spectroscopy for analysis of blood gases and analytes
CN101042348A (en) * 2006-03-24 2007-09-26 中国科学院长春光学精密机械与物理研究所 Device for nondestructively detecting carotenoid concentration in human body
CN101600962A (en) * 2006-11-10 2009-12-09 埃克塞特大学 A kind of apparatus and method that detect β-protoheme and malarial pigment
CN104267015A (en) * 2014-07-09 2015-01-07 香港应用科技研究院有限公司 Optical Signal Detection Device For Physiological Detection And Method For Analyzing Sample Components
CN204318754U (en) * 2014-12-15 2015-05-13 孟庆慧 A kind of electrode clip of electrocardiogram
CN104897644A (en) * 2015-06-05 2015-09-09 深圳国际旅行卫生保健中心 Detection method and detection system for plasmodium
CN205866754U (en) * 2016-05-10 2017-01-11 潘茹会 Clinical laboratory uses arm positioner
CN207012179U (en) * 2017-02-17 2018-02-16 上海镭昊光电股份有限公司 A kind of malaria detector

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