CN206893310U - A kind of controllable Optical Tweezers Array device of three-dimensional position - Google Patents
A kind of controllable Optical Tweezers Array device of three-dimensional position Download PDFInfo
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Abstract
It the utility model is related to a kind of controllable Optical Tweezers Array device of three-dimensional position, the laser of laser emitting is successively through pinhole filter, after collimating mirror, reflexed to through polarizing beam splitter mirror on Wave-front phase adjuster, reflected through Wave-front phase adjuster, through polarizing beam splitter mirror, pass sequentially through quarter-wave plate, first Fourier changes lens, wave filter, second Fourier changes lens, incided after dichroscope reflects in the first object lens, the controllable array hot spot in position is produced after the focusing of the first object lens, realize that light manipulates to sample in sample cell, light emitting diode is as lighting source, the light wave of outgoing passes through the second object lens successively, sample cell, first object lens, dichroscope, speculum, imaging len, after optical filter, into sensor devices.The utility model has the advantages of realizing sample position controllable precise in cubical array optical tweezer.
Description
Technical field
It the utility model is related to a kind of controllable Optical Tweezers Array device of three-dimensional position.
Background technology
Optical tweezer technology is the mechanics effect using laser, and gradient force ligh trap is formed by the laser of high concentration, is reached pair
The effect that micron or sub-micrometer scale particle are captured.The advantages of optical tweezer capture particulate, has：Non-contact, manipulation work with no damage
Body material, particulate can be captured rapidly and sensitively, can apply to the manipulation of living biological cell.In recent years, the research of optical tweezer technology
Rapid development is obtained with application, particularly in life science, optical tweezer has turned into research individual cells and biology is big
The indispensable effective tool of molecule.
Traditional single beam optical tweezer, can only control single particle, and in biomedical research, it is often necessary to multiple thin
Born of the same parents or particle are sorted and purified, and are at this moment just needed Optical Tweezers Array while are manipulated multiple cells or particle.Array is produced at present
The method of optical tweezer have it is a variety of, wherein conventional has：Time-sharing multiplex method, interferometric method, vertical cavity surface method, fibre bundle method and holography method,
These methods are also all there is the considerably complicated costliness of hardware configuration used in shortcoming, such as time-sharing multiplex method, and due to laser wheel
Stream is radiated in every bit optical tweezer, and the chance away from binding site is provided for particulate；Interference formula Optical Tweezers Array can not realize battle array
The adjustable and real-time dynamic of row number of spots manipulates；What vertical cavity surface method and fibre bundle method equally existed array number of spots can not
The shortcomings that any regulation；Holography method forms array optical tweezers, this is just by modulating the amplitude and phase of each light beam on focal plane
It is the general principle of holographic formula optical tweezer, but the method needs complicated algorithm to carry out computed hologram, thus realize that high precision position is grasped
Computationally intensive, calculating cost time length is needed during control.
The content of the invention
The utility model is in order to solve the deficiency of above technology, there is provided one kind realizes that array number of spots is adjustable, array
In each hot spot the accurate adjustable Three-Dimensional Dynamic Optical Tweezers Array device in position.
The technical scheme that the utility model solves above-mentioned technical problem is a kind of controllable Optical Tweezers Array device of three-dimensional position,
Including in laser, pinhole filter, collimating mirror, polarizing beam splitter mirror, Wave-front phase adjuster, quarter-wave plate, first Fu
It is leaf lens, wave filter, the second fourier lense, dichroscope, the first object lens, sample cell, the second object lens, light emitting diode, anti-
Penetrate mirror, imaging len, optical filter and sensor devices, the laser of the laser emitting by the pinhole filter that is arranged in order and
After collimating mirror, reflexed to through polarizing beam splitter mirror on Wave-front phase adjuster, it is parallel after Wave-front phase adjuster modulation
Light reflexes on the polarizing beam splitter mirror again, after the polarizing beam splitter mirror, then pass sequentially through the quarter-wave plate,
First Fourier transform lens, wave filter, the second Fourier transform lens and the dichroscope, after dichroscope reflects,
Incide in first object lens, the controllable array hot spot in position is produced after the focusing of the first object lens, it is real to sample in sample cell
Now light manipulates；The light emitting diode is lighting source, and the light wave of outgoing is successively by second object lens, sample cell, first
Object lens and dichroscope, after speculum reflects, successively after imaging len and optical filter, into sensor devices, photoreceptor
Part constantly records the dynamic change situation of capture sample；The Wave-front phase adjuster is that the Wave-front phase with segmented phase is adjusted
Device is saved, the parameter of the segmented phase for the different zones inserted and the first object lens is closely related, and its value meets following formula：
Wherein, Δ x, Δ y and Δ z be spatial position change of the focus on focal plane, and R is the radius of entrance pupil, NA
For the numerical aperture of object lens, ntFor the refractive index of oil immersion material, λ is the wavelength for focusing on light.Therefore, by caused by formula (1)
Phase distribution can be used for modulating the back focal plane of object lens, accurately control its position of caused focus on focal plane.
The beneficial effects of the utility model are：It is distributed by modulating the Wave-front phase on object lens back focal plane so that object lens gather
Jiao produces array hot spot, and the number of array hot spot is adjustable, and the position of each hot spot accurately controls, and realizes that the three-dimensional of optical tweezer is moved
State is adjustable；In addition, do not have to use constructively complex as well as expensive hardware in the device, it is not required that calculated with the algorithm of complexity complete
Breath figure, amount of calculation are small.
Further, the described Wave-front phase adjuster segmented phase with segmented phase includes radial direction subregion or angular point
Area.
It is using the above-mentioned further beneficial effect of technical scheme：Segmented phase is radial direction subregion, and it is by radially
A large amount of concentric annular structure compositions of equal in width, different phase distributions are inserted the concentric ring of diverse location, and be filled with difference
The concentric ring of phase distribution is alternately present at equal intervals, and the number of out of phase distribution determines of caused focus
Number, the value of phase determine the locus of each focus；
Segmented phase is angular subregion, and it is by the equal angular a large amount of sector structure structure compositions in angularly direction, by difference
Phase distribution insert in the sector of diverse location, and be filled with out of phase distribution sector region be equal angular be alternately present
, the number for the out of phase distribution equally inserted determines the number of caused focus, and the value of phase determines each Jiao
The locus of point；
The number of focus and locus are easy to determine.
Further, the described Wave-front phase adjuster with segmented phase is programmable reflective pure phase bit space light
Modulator.
Further, described Wave-front phase adjuster is located at the front focal plane of the first Fourier transform lens, and wave filter is same
When at the back focal plane and the second Fourier transform lens front focal plane of the first Fourier transform lens, the back focal plane of the first object lens
Overlapped with the second Fourier transform lens back focal plane, the wave filter is high-pass filter, and front focal plane refers to what light first passed through
Focal plane, back focal plane refer to after light by focal plane.
Using the beneficial effect of above-mentioned further technical scheme：The influence of the zero level bias light of modulation light beam can be reduced.
Further, the focal length f1 of the first described Fourier transform lens, the second Fourier transform lens focal length f2 with
Minimum length of side l, the entrance pupil diameter d of the first object lens of effective modulation areas of Wave-front phase adjuster match, and meet f1/
F2=l/d or approximation meet f1/f2=l/d.
It is using the above-mentioned further beneficial effect of technical scheme：Effective picture of Wave-front phase adjuster can be made full use of
Vegetarian noodles accumulates.
Further, the laser, pinhole filter, collimating mirror center line overlap, the polarizing beam splitter mirror and collimating mirror
Center line it is at 45 °.
It is using the above-mentioned further beneficial effect of technical scheme：Facilitate the regulation of light path.
Further, in the Wave-front phase adjuster, quarter-wave plate, the first fourier lense, wave filter, second Fu
Leaf lens, dichroscope are arranged side by side successively in the horizontal, Wave-front phase adjuster, quarter-wave plate, the first fourier lense,
Wave filter, the second fourier lense center line overlap, and polarizing beam splitter mirror and Wave-front phase adjuster center line are at 45 °, wavefront phase
Position adjuster and dichroscope center line are at 45 °.
It is using the above-mentioned further beneficial effect of technical scheme：Facilitate the regulation of light path.
Further, described speculum, dichroscope, the first object lens, sample cell, the second object lens, light emitting diode be successively
Vertically side by side from the bottom up, the first object lens, the second object lens, light emitting diode center line overlap, dichroscope and first
Object lens center line angle at 45 °, with mirror center line at an angle of 90.
It is using the above-mentioned further beneficial effect of technical scheme：Facilitate the regulation of light path.
Further, the speculum, imaging len, optical filter and sensor devices are arranged side by side successively in the horizontal, and imaging is saturating
Mirror and sensor devices center line overlap.
Further, described imaging len longitudinal separation is adjustable, and the sample that optical tweezer captures clearly is imaged on photosensitive by it
On device.
It is using the above-mentioned further beneficial effect of technical scheme：The sample of capture can be imaged on photoreceptor exactly
Part.
Brief description of the drawings
Fig. 1 is structural representation of the present utility model；
Fig. 2 is the utility model radial direction segmented phase schematic diagram；
Fig. 3 is the angular segmented phase schematic diagram of the utility model.
Embodiment
The utility model is further described below in conjunction with accompanying drawing, example is served only for explaining the utility model, and
It is non-to be used to limit the scope of the utility model.
As shown in figure 1, the Optical Tweezers Array device of the present utility model for realizing that a kind of three-dimensional position is controllable is by laser 1, pin
Hole wave filter 2, collimating mirror 3, polarizing beam splitter mirror 4, Wave-front phase adjuster 5, quarter-wave plate 6, the first fourier lense 7,
Wave filter 8, the second fourier lense 9, dichroscope 10, the first object lens 11, sample cell 12, the second object lens 13, light emitting diode
14th, speculum 15, imaging len 16, optical filter 17 and sensor devices 18 form, wherein：Laser 1 used is Solid State Laser
Device, a length of 532nm of its caused light wave, power 2W；Wave front phase modulator 5 used is adjusted for reflective pure phase bit space light
Device processed；Light-Emitting Diode 14 is red-light LED, centre wavelength 620nm；Dichroscope 10 is that cutoff wavelength 567nm long wave leads to
Dichroscope, its transmission bandwidth are 584-700nm, reflection bandwidth 380-550nm；Optical filter 17 is that 610 nanometers of long waves are connected with color
Glass filter；First object lens 11 are the high-NA oil immersion objective of numerical aperture 1.4；Second object lens 13 are numerical aperture
0.25 low NA objective；Imaging len 16 is focal length 100mm convex lens；Sensor devices 18 are CCD sensor devices.
The laser being emitted from solid state laser 1, clean diffusion light beam is produced after pinhole filter 2, passes through collimating mirror 3
After produce collimated light beam, the spot diameter of collimated light beam is more than the effective sensitization area of pure phase spatial light modulator 5, through polarization
Beam splitter 4 is reflexed on pure phase spatial light modulator 5, the polarization direction of the directional light reflected through polarizing beam splitter mirror 4 and pure phase
The polarization direction that bit space optical modulator 5 requires incident is identical, and the directional light after the modulation of pure phase spatial light modulator 5 is again
Reflect, successively through polarizing beam splitter mirror 4 and quarter-wave plate 6, the optical axis direction and incident parallel of quarter-wave plate 6
The polarization direction angle at 45 ° of light, now the directional light through quarter-wave plate 6 is circularly polarized light, then passes through first successively
After Fourier transform lens 7, wave filter 8, the second Fourier transform lens 9, high numerical aperture is incided through the reflection of dichroscope 10
In the oil immersion objective of footpath, the controllable array hot spot in position is produced after the focusing of high-NA oil immersion objective, array hot spot can be to sample
Sample realizes that light manipulates in product pond 12, and red light-emitting diode 14 is used as lighting source, and the light wave of outgoing is through too low numerical aperture
Object lens are injected in sample cell 12 after focusing on, and sample is realized and illuminated, and high-NA oil is passed through successively through the illumination light of sample
After soaking object lens, dichroscope 10, reflected through speculum 15, it is photosensitive into CCD successively after imaged lens 16 and optical filter 17
In device 18, CCD sensor devices constantly record the dynamic change situation of capture sample.
Wave-front phase adjuster 5 is the Wave-front phase adjuster with segmented phase, as shown in Fig. 2 segmented phase is footpath
To subregion, different phase distributions is inserted different positions by it by a large amount of concentric annular structure compositions of radially equal in width
In the concentric ring put, and the concentric ring for being filled with out of phase distribution is alternately present at equal intervals, the number of out of phase distribution
Mesh determines the number of caused focus, and the value of phase determines the locus of each focus.
As shown in figure 3, segmented phase is angular subregion, it is by the equal angular a large amount of sector structure structure groups in angularly direction
Into, different phase distributions is inserted in the sector of diverse location, and be filled with out of phase distribution sector region be angularly
Be alternately present, the number of the out of phase distribution equally inserted determine caused by focus number, the value of phase determines
The locus of each focus is determined.
Wherein, the parameter of the segmented phase for the different zones inserted and the first object lens 11 is closely related, and its value is true by following formula
It is fixed
Wherein, Δ x, Δ y and Δ z be spatial position change of the focus on focal plane, and R is the radius of entrance pupil, NA
For the numerical aperture of object lens, ntFor the refractive index of oil immersion material, λ is the wavelength for focusing on light.Therefore, by caused by formula (1)
Phase distribution can be used for modulating the back focal plane of object lens, accurately control its position of caused focus on focal plane.
In order to reduce the influence of the zero level bias light of modulation light beam, it is necessary to which Wave-front phase adjuster 5 is placed in first Fu
At the front focal plane of leaf transformation lens 7, wave filter 8 is a high-pass filter, and it is located at the first Fourier transform lens 7 simultaneously
At the front focal plane of back focal plane and the second Fourier transform lens 9, while ensure back focal plane and the second Fourier of the first object lens 11
The back focal plane of transform lenses 9 overlaps.
In order to make full use of the effective pixel area of Wave-front phase adjuster, it is necessary to Jiao of the first Fourier transform lens 7
Away from f1, the minimum length of side l of effective modulation areas of focal length f2 and the Wave-front phase adjuster 5 of the second Fourier transform lens 9, the
The entrance pupil diameter d of one object lens 11 matches, and meets that f1/f2=l/d or approximation meet f1/f2=l/d；
For easy to adjust, laser 1, pinhole filter 2, the coincidence of the center line of collimating mirror 3 of light path, polarizing beam splitter mirror 4
With the center line angle at 45 ° of collimating mirror 3；Wave-front phase adjuster 5, quarter-wave plate 6, the first fourier lense 7, wave filter
8th, the center line of the second fourier lense 9 overlaps, the angle at 45 ° with the center line of Wave-front phase adjuster 5 of polarizing beam splitter mirror 4 and same
In horizontal plane, Wave-front phase adjuster 5 is with the center line of dichroscope 10 angle at 45 ° and in same vertical plane；First object lens 11,
Second object lens 13, the center line of light emitting diode 14 overlap, the center line angle at 45 ° of 10 and first object lens of dichroscope 11, with reflection
The center line of mirror 15 is at an angle of 90；Imaging len 16 and the center line of sensor devices 18 overlap；
, can in order to accurately the sample of capture is imaged on sensor devices, it is necessary to the longitudinal separation of imaging len 16 is adjustable
The sample that optical tweezer captures clearly is imaged on sensor devices 18.
It is of the present utility model it is crucial that wavefront phase with the Wave-front phase adjuster modulating lasering beam with segmented phase
Position, and the locus of the parameter of segmented phase and the first object lens 11, array hot spot is closely related, realizes and forms array hot spot number
The purpose for the cubical array optical tweezer that mesh is adjustable, the position of each hot spot accurately controls.It is every to use similar knot of the present utility model
Structure, method and its similar change, all should be included in the scope of protection of the utility model.
Claims (10)
- A kind of 1. controllable Optical Tweezers Array device of three-dimensional position, it is characterised in that including laser (1), pinhole filter (2), Collimating mirror (3), polarizing beam splitter mirror (4), Wave-front phase adjuster (5), quarter-wave plate (6), the first fourier lense (7), Wave filter (8), the second fourier lense (9), dichroscope (10), the first object lens (11), sample cell (12), the second object lens (13), light emitting diode (14), speculum (15), imaging len (16), optical filter (17) and sensor devices (18), the laser The laser of device (1) outgoing reflexes to after the pinhole filter (2) and collimating mirror (3) that are arranged in order through polarizing beam splitter mirror (4) On Wave-front phase adjuster (5), it is re-reflected into afterwards on the polarizing beam splitter mirror (4), after the polarizing beam splitter mirror (4), The quarter-wave plate (6), the first Fourier transform lens (7), wave filter (8), the second Fourier transformation are passed sequentially through again Lens (9) and the dichroscope (10), after dichroscope (10) reflection, incide in first object lens (11), through the One object lens (11) produce the controllable array hot spot in position after focusing on, realize that light manipulates to sample in sample cell (12)；It is described luminous Diode (14) is lighting source, the light wave of outgoing successively by the second object lens (13), sample cell (12), the first object lens (11) and Dichroscope (10), after speculum (15) reflection, successively after imaging len (16) and optical filter (17), into photoreceptor Part (18)；The Wave-front phase adjuster (5) is the Wave-front phase adjuster with segmented phase.
- 2. the controllable Optical Tweezers Array device of three-dimensional position according to claim 1, it is characterised in that described carries subregion The segmented phase of the Wave-front phase adjuster of phase includes radial direction subregion or angular subregion.
- 3. the controllable Optical Tweezers Array device of three-dimensional position according to claim 1, it is characterised in that described carries subregion The Wave-front phase adjuster of phase is programmable reflective pure phase spatial light modulator.
- 4. the controllable Optical Tweezers Array device of three-dimensional position according to claim 1, it is characterised in that the Wave-front phase is adjusted Section device (5) is located at the front focal plane of first Fourier transform lens (7), and the wave filter (8) is located in first Fu At the back focal plane of leaf transformation lens (7), and at the second Fourier transform lens (9) front focal plane, first object lens (11) back focal plane overlaps with the second Fourier transform lens (9) back focal plane, and the wave filter (8) is high-pass filter.
- 5. the controllable Optical Tweezers Array device of three-dimensional position according to claim 1, it is characterised in that in first described Fu The focal length f1 of leaf transformation lens (7), the focal length f2 of second Fourier transform lens (9), the Wave-front phase adjuster (5) Modulation areas minimum length of side l, the entrance pupil diameter d of first object lens (11), meet formula f1/f2=l/d.
- 6. the controllable Optical Tweezers Array device of three-dimensional position according to claim 1, it is characterised in that the laser (1), Pinhole filter (2) and collimating mirror (3) center line overlap, and the polarizing beam splitter mirror (4) and the center line of collimating mirror (3) are at 45 °.
- 7. the controllable Optical Tweezers Array device of three-dimensional position according to claim 1, it is characterised in that the Wave-front phase is adjusted Save the center of device (5), quarter-wave plate (6), the first fourier lense (7), wave filter (8) and the second fourier lense (9) Line overlaps, and the polarizing beam splitter mirror (4) and the center line of Wave-front phase adjuster (5) are at 45 °, the Wave-front phase adjuster (5) with the center line angle at 45 ° of the dichroscope (10).
- 8. the controllable Optical Tweezers Array device of three-dimensional position according to claim 1, it is characterised in that first object lens (11), the second object lens (13), the center line of light emitting diode (14) overlap, the dichroscope (10) and first object lens (11) center line angle at 45 °, with speculum (15) center line at an angle of 90.
- 9. the controllable Optical Tweezers Array device of three-dimensional position according to claim 1, it is characterised in that the speculum (15), imaging len (16), optical filter (17) and sensor devices (18) are arranged side by side successively in the horizontal, imaging len (16) and sense Optical device (18) center line overlaps.
- 10. the controllable Optical Tweezers Array device of three-dimensional position according to claim 1, it is characterised in that described imaging is saturating Mirror (16) longitudinal separation is adjustable.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109147983A (en) * | 2018-09-18 | 2019-01-04 | 湖北第二师范学院 | One kind is based on just setting microscopical single beam laser light forceps device |
| CN109802287A (en) * | 2019-03-20 | 2019-05-24 | 中国人民解放军国防科技大学 | Three-dimensional self-cooling laser optical tweezers device and method based on lens combination |
| CN110471187A (en) * | 2019-08-20 | 2019-11-19 | 济南大学 | Generate the apparatus and method of the cubical array ampuliform light beam in Hexagonal Close-packed distribution |
| CN111337712A (en) * | 2020-04-10 | 2020-06-26 | 清华大学 | Coupling system of vacuum atomic force microscope and vacuum atomic force microscope |
| CN111381357A (en) * | 2018-12-29 | 2020-07-07 | 中国科学院深圳先进技术研究院 | Image three-dimensional information extraction method, object imaging method, device and system |
| CN113409980A (en) * | 2021-07-07 | 2021-09-17 | 鲁东大学 | Dynamic multi-focus optical tweezers generating device and using method |
| CN114062346A (en) * | 2021-11-08 | 2022-02-18 | 吉林大学 | In-situ high-pressure laser heating system |
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2017
- 2017-03-30 CN CN201720324318.4U patent/CN206893310U/en not_active Expired - Fee Related
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109147983A (en) * | 2018-09-18 | 2019-01-04 | 湖北第二师范学院 | One kind is based on just setting microscopical single beam laser light forceps device |
| CN111381357A (en) * | 2018-12-29 | 2020-07-07 | 中国科学院深圳先进技术研究院 | Image three-dimensional information extraction method, object imaging method, device and system |
| CN111381357B (en) * | 2018-12-29 | 2021-07-20 | 中国科学院深圳先进技术研究院 | Image three-dimensional information extraction method, object imaging method, device and system |
| CN109802287A (en) * | 2019-03-20 | 2019-05-24 | 中国人民解放军国防科技大学 | Three-dimensional self-cooling laser optical tweezers device and method based on lens combination |
| CN109802287B (en) * | 2019-03-20 | 2020-02-07 | 中国人民解放军国防科技大学 | Three-dimensional self-cooling laser optical tweezers device and method based on lens combination |
| CN110471187A (en) * | 2019-08-20 | 2019-11-19 | 济南大学 | Generate the apparatus and method of the cubical array ampuliform light beam in Hexagonal Close-packed distribution |
| CN110471187B (en) * | 2019-08-20 | 2021-07-30 | 济南大学 | Device and method for generating three-dimensional array bottle-shaped light beams in hexagonal close-packed distribution |
| CN111337712A (en) * | 2020-04-10 | 2020-06-26 | 清华大学 | Coupling system of vacuum atomic force microscope and vacuum atomic force microscope |
| CN113409980A (en) * | 2021-07-07 | 2021-09-17 | 鲁东大学 | Dynamic multi-focus optical tweezers generating device and using method |
| CN114062346A (en) * | 2021-11-08 | 2022-02-18 | 吉林大学 | In-situ high-pressure laser heating system |
| CN114062346B (en) * | 2021-11-08 | 2024-03-26 | 吉林大学 | In-situ high-pressure laser heating system |
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