CN206777421U - A kind of ejecting device with parcel function - Google Patents
A kind of ejecting device with parcel function Download PDFInfo
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- CN206777421U CN206777421U CN201621170192.1U CN201621170192U CN206777421U CN 206777421 U CN206777421 U CN 206777421U CN 201621170192 U CN201621170192 U CN 201621170192U CN 206777421 U CN206777421 U CN 206777421U
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- ejecting device
- syringe needle
- capillary
- pressure
- nozzle body
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Abstract
The utility model patent discloses a kind of ejecting device with parcel function, and it not only overcomes the problem of cell mortality is too high in existing 3D biometric prints technology, and can realize that biologic grain is uniformly arranged.There is the ejecting device of parcel function mainly to include nozzle body, cone keeper, capillary, syringe needle, locknut, snap joint and sealing screw for this.The characteristics of the utility model is：It is threadably secured between cone keeper and nozzle body and is realized by taper and is positioned；The fixation realized positioning and capillary is realized by cohesive mode is coordinated by gap between capillary and cone keeper；Syringe needle is fixed by locknut and nozzle body, and positioning is realized by the port of export taper of nozzle body, so as to reach the requirement of the axiality of capillary and syringe needle；Two cavitys be present between cone keeper and nozzle body, internal cavity and external cavity are full of different materials, control the pressure of interior exocoel respectively by pressure feedback control loop, and then control in exocoel biomaterial flowing velocity, the parcel and intergranular uniformly arrangement, the shower nozzle for realizing cell or active biomaterial also have the characteristics of easy to process.
Description
Technical field
Patent of the present invention is related to the shower nozzle manufacturing technology in field of tissue engineering technology, is related to one kind and automatically controls biomaterial
The ejecting device of parcel.
Background technology
In recent years, application of the 3D biometric prints technology in terms of bioengineering, it is organ disease patient, skin burn trouble
Person, multiple organ drug screening, the construction etc. of blood vessel bring pleasantly surprised and wished, with the development of 3D biometric print technologies, approach
Disease up to a million will obtain new life by way of 3D biometric prints.However, living cells printing face it is one very big
Problem, i.e., by printing the immunological rejection phenomena of the tissue obtained or organ, this is that whole world scientific research scholar all suffers from urgently
The problem of to be solved.According to statistics, Chinese organ quantity in stock is very low, the demand of not nearly enough organ transplant, China every year because
Uremia must receive about 120,000 of kidney transplant, and only twentieth patient has an opportunity to receive kidney transplant；
And the Disease of liver transplant has 1,000,000 or so, only three or four thousand people have an opportunity to receive liver transplantation every year.On the other hand,
People are solved using the method for traditional organ transplant and the method for animal organ's transplanting, and this all would potentially result in human body and exempts from
Epidemic disease organ rejection's phenomenon, the patient through organ transplant need long-term use of anti-rejection medication, can just Disease is continued
To existence, this has not only aggravated the financial burden of patient, and cannot be guaranteed the health of patient.However, 3D biometric prints
Appearance can solve this problem.
3D biometric prints are substantially by pressure feedback control system, control the active biomaterial and parcel in print cartridge
Material is equably printed upon on biological support, forms the shape of organ, then using somatomedin human body fluid environment
It is lower by printing shaping organ prototype carry out induction be differentiated to form the organ with corresponding function.Complete the most important limit of said process
Factor processed is the design of ejection head control device.How to realize the parcel of cell or active biomaterial, realize biologic grain
Uniformly the problems such as arrangement, accurate control biologic grain arrangement number.
The problem of based on more than to the demands such as organ, skin, drug screening and sprinkler design requirement, patent of the present invention is public
A kind of ejecting device with parcel function of cloth.
The content of the invention
The purpose of patent of the present invention is the shortcomings that presence for the manufacture of existing 3D biometric prints machine shower nozzle and patent
（CN201520289726.1）The practical application the defects of, research and development are applied to the shower nozzle of active biomaterial printing, and the shower nozzle can
The parcel of cell or active biomaterial is realized, being uniformly distributed for parcel particulate is realized, can preferably be protected by the ejecting device
Protect cell or active biomaterial activity.
To reach above purpose of design, patent of the present invention takes following design：
A kind of ejecting device with parcel function, it is characterised in that shower head mechanism includes nozzle body, cone positioning, pin
Head, locknut, the first snap joint, the second snap joint, sealing screw and capillary.Bore between keeper and nozzle body
It is threadably secured and is realized by taper and is positioned；Coordinated between capillary and cone keeper by gap and realize positioning, passed through
Cohesive mode realizes fixation；Syringe needle is fixed by locknut and nozzle body, passes through the outlet end cone of nozzle body
Degree realizes positioning, so as to reach the requirement of the axiality of cone keeper and syringe needle；Print cartridge equipped with biomaterial and equipped with parcel material
The print cartridge of material is connected with snap joint respectively；The shower nozzle control system also includes air pressure automatic control loop, the pneumatic circuit by
Proportioning valve, pressure-reducing valve, controller, filter, source of the gas etc. form, the pressure control loop can the control of passing ratio valve connected
Continuous pressure and discontinuous pressure, so as to realize different parcel effects.
A kind of operation principle with the ejecting device for wrapping up function：First, the pressure for adjusting pressure-reducing valve is 1MPa, is kept
Airline pressure before proportioning valve is 1MPa, and proportioning valve is closed；Secondly, controller controls the opening degree of proportioning valve,
Make between pressure 0-1MPa to change in packing pressure loop；Finally, by biomaterial flow in Stress control print cartridge, and then control
The flow velocity of biomaterial and lapping in shower nozzle processed, realize biomaterial parcel and uniform extrusion.
In the above-mentioned ejecting device with parcel function, capillary need to meet axiality requirement with syringe needle.
In the above-mentioned ejecting device with parcel function, the convenient installation of cone keeper and quick detachable, by changing hair
The diameter of tubule, the output speed and diameter of cell or active biomaterial are controlled, and fine holes need not reprocess, in addition,
The outlet diameter of cone keeper can be adjusted, and so as to change the extrusion capacity of inner chamber biomaterial, further control outer layer covers
The thickness of material.
In the above-mentioned ejecting device with parcel function, the convenient installation of syringe needle and quick detachable, and change can be passed through
The diameter of syringe needle, control the extrusion diameter of biomaterial.
In the above-mentioned ejecting device with parcel function, the device, which has, fabricates the characteristics of simple, syringe needle and
Capillary is obtained by way of outsourcing, and the fixed capillary by the way of cohesive, syringe needle is fixed by the way of locknut,
The device overcomes patent（CN201520289726.1）The problem of middle inner cylinder and outer barrel tradition micro- long hole machined, and effectively subtract
The overall size of small shower nozzle and process-cycle, the overall installation accuracy of shower nozzle and significantly cost-effective is improved, and can controlled
The diameter range of capillary processed is between 0.05mm ~ 0.8mm.
In the above-mentioned ejecting device with parcel function, the nozzle system include controller, proportioning valve, magnetic valve,
Sensor etc. collectively forms air pressure feedback regulation loop, makes the pressure remained steady in pneumatic circuit.
Compared with existing shower nozzle technology, the ejecting device for originally automatically controlling biomaterial parcel has advantages below：
1）The device can realize the parcel of cell and active biomaterial, realize the particle after parcel by uniform point at equal intervals
Cloth.
2）By automatically controlling the opening degree of proportioning valve, the pressure continuous-stable in print cartridge and noncontinuity change are kept,
Realize biomaterial parcel and be uniformly distributed at equal intervals.
3）There is the design of parcel multifunctional spray head structure by this, the death rate of cell and active biomaterial can be reduced,
And improve the adhesion rate of biomaterial.
Brief description of the drawings
Fig. 1 ejecting device schematic diagrames
The diagrammatic cross-section of Fig. 2 ejecting devices
Fig. 3 automatic air pressure regulating loop schematic diagrames
Fig. 4 pressure adjusts schematic diagram
1, first snap joint in figure；2nd, the second snap joint；3rd, keeper is bored；4th, nozzle body；5th, locknut；6、
Syringe needle, 7, sealing screw；8th, capillary；9th, source of the gas；10th, pressure-reducing valve；11st, two part；12nd, proportioning valve；13rd, magnetic valve；14、
Pressure sensor；15th, print cartridge；16th, ejecting device；17th, controller.
Embodiment
For the feasibility of patent of the present invention, practicality and type easy to operate is expanded on further, the present invention will combine signal
Patent of invention is described in detail figure.
A kind of ejecting device with parcel function, as illustrated in fig. 1 and 2, including the first snap joint 1, the second fast quick access
First 2, keeper 3, nozzle body 4, locknut 5, syringe needle 6, sealing screw 7, capillary 8 are bored.Nozzle body 4 and cone keeper
It is threadably secured between 3 and keeps axiality requirement by boring to position, the structure can prevents lapping from leaking；Syringe needle 6 is logical
Cross locknut 5 to fix with nozzle body 4, realize that syringe needle 6 positions by the taper design of nozzle body 4 and wanted so as to reach axiality
Ask；Sealing screw 7 plays a part of sealing, prevents lapping or active biomaterial from leaking, in addition, cone keeper（3）'s
Outlet diameter can be adjusted, and so as to change the extrusion capacity of inner chamber biomaterial, further control the thickness of outer layer covers material.
Fig. 3 is the air pressure automatic feedback adjustment control loop of shower nozzle, and source of the gas 9 passes through pressure-reducing valve 10, two parts 11, proportioning valve
12nd, magnetic valve 13, pressure sensor 14, print cartridge 15, ejecting device 16, controller 17 etc., the air pressure feedback control loop can be real
Existing pressure continuously and discontinuous regulation, as shown in figure 4, and the stabilization of pressure in loop can be maintained.
First snap joint 1 and the second snap joint 2 are respectively biomaterial and lapping entrance, biomaterial and bag
Wrap up in material and nozzle body 4 is entered by entrance at various pressures, by controlling proportioning valve 12 to realize lapping and biology
Material is uniformly discharged.When external magnetic valve 13 is controlled using noncontinuity, in pressure change such as Fig. 4（2）It is shown, when output
When pressure is p1, cell or active biomaterial numerical density are smaller, and particle will not be extruded；When the pressure of output is p2
（p2>p1）, extrusion that the extrusion force suffered by cell or active biomaterial particle will overcome resistance to realize particle, so as to realize life
Thing material is uniformly arranged at equal intervals.
When magnetic valve 13 is controlled using continuity, in pressure change such as Fig. 4（1）It is shown.If the pressure of cavity fluid is big
In the pressure of exocoel fluid, i.e. p1>P2, cell or active biomaterial continuously flow after being wrapped up by outer layer covers material
Go out；If the pressure of cavity fluid is less than the pressure of exocoel fluid, i.e. p1<P2, the pressure of exocoel is larger, then is produced in inner chamber negative
Pressure, with the continuous flowing of exocoel lapping, biomaterial will be sucked out, and uniformly be arranged according to certain size.
Ejecting device designed by patent of the present invention carries out the specific steps of cell or biomaterial parcel：
1）Build air pressure feedback control loop system, the air-path control system mainly include source of the gas, pressure-reducing valve, proportioning valve,
Magnetic valve, controller etc., continual and steady pressure is provided for print cartridge by the gas circuit；
2）Air pressure feedback regulation device is coupled with proportioning valve, so as to control proportioning valve opening degree, realized in pneumatic circuit
Pressure regulation；
3）By 1）In the pneumatic circuit reponse system mentioned couple with print cartridge, print cartridge is coupled with ejecting device, is checked
Loop avoids gas leakage；
4）Pass through 2）Middle feedback regulation device, control 1）Middle magnetic valve for continuous control, keep different cavitys respectively
The stabilization of interior pressure, realize that biomaterial is continuously extruded；
5）Pass through 2）Middle air pressure feedback regulation device, control 1）Middle magnetic valve for Noncontinuous control, so as to control cell
Or active biomaterial is evenly distributed according to a determining deviation in granular form.
Between the present invention realizes that cell or active biomaterial are wrapped up and waited by ejecting device and air pressure feedback control loop
Away from evenly distributed, gas circuit feedback control system is connected with print cartridge, and print cartridge is connected with ejecting device, ejecting device and pressure sensor
Connection, pressure sensor are connected with signal processor, and signal processor is connected with analyzer, and analyzer is connected with controller, control
Device processed is connected with proportioning valve.
Analyzer receives the information from pressure sensor and makes feedback, controller control proportioning valve opening degree, pressure
Sensor obtains pressure value by analog-signal transitions into data signal, is then delivered to analyzer, analyzer is computer, to pressure
Force data is analyzed, and forms feedback control instruction.
Patent of the present invention is not limited to appeal embodiment, if the various changes and modification to patent of the present invention do not take off
From the spirit and scope of patent of the present invention, if these changes and modification belong to the claim and equivalent technologies of patent of the present invention
Within the scope of, then patent of the present invention is also intended to comprising these changes and modification.
Although more having used the 1, first snap joint herein, the 2, second snap joint, 3, cone keeper, 4, shower nozzle master
Body, 5, locknut, 6, syringe needle, 7, sealing screw, 8, capillary, 9, source of the gas, 10, pressure-reducing valve, 11, two parts, 12, ratio
Valve, 13, magnetic valve, 14, pressure sensor, 15, print cartridge, 16, ejecting device, 17, the term such as controller, but be not precluded from other
The possibility of term, it is used for the purpose of preferably describing and explaining the essence of the present invention using these terms；It is construed as
The additional limitation of any one is all disagreed with spirit of the present invention.
Claims (7)
1. a kind of ejecting device with parcel function, described ejecting device include the first snap joint（1）, the second fast quick access
Head（2）, cone keeper（3）, nozzle body（4）, locknut（5）, syringe needle（6）, sealing screw（7）, capillary（8）, it is special
Sign is：Snap joint（1）It is connected with inner chamber, snap joint 2 is connected with exocoel, bores keeper（3）And nozzle body（4）Between
It is threadably secured and is realized by taper and is positioned；Capillary（8）With boring keeper（3）Between coordinated by gap realize it is fixed
Position, fixation is realized by cohesive mode；Syringe needle（6）Pass through locknut（5）With nozzle body（4）It is fixed, passes through spray
Head main body（4）Port of export taper realize positioning, so as to reach cone keeper（3）With the axiality requirement of syringe needle；This has bag
Wrapping up in the ejecting device of function also includes source of the gas（9）, pressure-reducing valve（10）, two parts（11）, proportioning valve（12）, magnetic valve（13）, pressure
Force snesor（14）, print cartridge（15）, ejecting device（16）, controller（17）；Described print cartridge（15）With ejecting device（16）Even
Connect, ejecting device（16）With pressure sensor（14）Connection, pressure sensor（14）With controller（17）It is anti-to connect and compose air pressure
Present control loop.
2. ejecting device as claimed in claim 1, it is characterised in that：Described cone keeper（3）Outlet diameter can carry out
Adjustment, so as to change the extrusion capacity of inner chamber biomaterial, further control the thickness of outer layer covers material.
3. ejecting device as claimed in claim 1, it is characterised in that：Syringe needle（6）Installation is simple quick detachable, and can be by changing
Become syringe needle（6）Outlet diameter, change the extrusion diameter of biomaterial.
4. ejecting device as claimed in claim 1, it is characterised in that：Capillary（8）With syringe needle（6）Between assembling meet it is same
The requirement of axle degree.
5. ejecting device as claimed in claim 1, syringe needle（6）And capillary（8）Obtained by way of outsourcing, the device gram
The problem of having taken traditional micro- long hole machined, and the overall size of shower nozzle and process-cycle are effectively reduced, it is whole to improve shower nozzle
The installation accuracy of body is simultaneously significantly cost-effective, and capillary（8）Diameter range between 0.05mm ~ 0.8mm.
6. ejecting device as claimed in claim 1, it is characterised in that：Air pressure feedback control loop is provided with controller（17）, enter
Tracheae and proportioning valve（12）It is connected, proportioning valve（12）With magnetic valve（13）It is connected, described proportioning valve（12）And magnetic valve（13）
Respectively with controller（17）It is connected.
7. ejecting device as claimed in claim 1, it is characterised in that：The continuous of pressure is realized by air pressure feedback control loop
Regulation or discontinuous regulation, realize the continuous extrusion of cell or active biomaterial or equidistantly extrude.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621170192.1U CN206777421U (en) | 2016-11-02 | 2016-11-02 | A kind of ejecting device with parcel function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621170192.1U CN206777421U (en) | 2016-11-02 | 2016-11-02 | A kind of ejecting device with parcel function |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206777421U true CN206777421U (en) | 2017-12-22 |
Family
ID=60703778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621170192.1U Expired - Fee Related CN206777421U (en) | 2016-11-02 | 2016-11-02 | A kind of ejecting device with parcel function |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206777421U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108215157A (en) * | 2018-02-27 | 2018-06-29 | 浙江大学 | The flexible circuit 3 D-printing device that a kind of macromolecule liquid metal prints altogether |
| CN113997527A (en) * | 2021-09-29 | 2022-02-01 | 深圳高性能医疗器械国家研究院有限公司 | Device and method for solidifying two polymer solutions into hollow tubular material |
-
2016
- 2016-11-02 CN CN201621170192.1U patent/CN206777421U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108215157A (en) * | 2018-02-27 | 2018-06-29 | 浙江大学 | The flexible circuit 3 D-printing device that a kind of macromolecule liquid metal prints altogether |
| CN113997527A (en) * | 2021-09-29 | 2022-02-01 | 深圳高性能医疗器械国家研究院有限公司 | Device and method for solidifying two polymer solutions into hollow tubular material |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20171222 Termination date: 20181102 |