CN206696233U - A kind of being imaged without lens miniflow based on surface acoustic wave driving and its detecting system - Google Patents
A kind of being imaged without lens miniflow based on surface acoustic wave driving and its detecting system Download PDFInfo
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- CN206696233U CN206696233U CN201720494232.6U CN201720494232U CN206696233U CN 206696233 U CN206696233 U CN 206696233U CN 201720494232 U CN201720494232 U CN 201720494232U CN 206696233 U CN206696233 U CN 206696233U
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- miniflow
- microfluidic channel
- acoustic wave
- surface acoustic
- storage tank
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Abstract
The utility model discloses it is a kind of based on surface acoustic wave driving without lens miniflow imaging and its detecting system, including surface acoustic wave miniflow drive module, the first miniflow flexible pipe, without lenticular image acquisition module, the second miniflow flexible pipe, waste liquid pool, light source module and image analysis module；First microfluidic channel is arranged on the exit of liquid storage tank, and the first miniflow flexible pipe connects the first microfluidic channel and the second microfluidic channel；The no lenticular image acquisition module includes nude film, the second microfluidic channel and the printed circuit board (PCB) of imaging sensor, the second miniflow flexible pipe connects the second microfluidic channel and waste liquid pool, the light source module is arranged on the top of no lenticular image acquisition module, and described image analysis module is electrically connected with printed circuit board (PCB)；The utility model provide a kind of sample introduction for realizing whole image-forming detecting system, be imaged, go out sample hardware integration, miniaturization without lens miniflow imaging and its detecting system.
Description
Technical field
Microfluidic analysis technical field is the utility model is related to, in particular, it is related to a kind of based on surface acoustic wave drive
It is dynamic without the imaging of lens miniflow and its detecting system.
Background technology
Face the future individualized biomedical diagnostics and field quick detection（Point-of-Care）Application demand just become
It is more and more extensive, this requires traditional complexity, expensive large-scale detection device to realize miniaturization, integrated, cost degradation.
Frequently with flow cytometer as goldstandard in being counted such as traditional cell detection, although it has very high detection flux, so
And equipment and expensive reagents, the shortcomings of needing special messenger's operation and maintenance, be bulky are still limited and widely used.At present on piece
Laboratory（Lab-on-a-Chip）Provide one to be combined micro-fluidic chip with CMOS/CCD imaging sensors, so as to realize
Without lens miniflow imaging system, for cell detection with counting（X. Huang, J. Guo, X. Wang, M. Yan are referred to,
Y. Kang, and H. Yu, A contact-imaging based microfluidic cytometer with
machine-learning for single-frame super-resolution processing, PLoS ONE,
2014, 9(8): e104539）.But in existing miniflow image-forming detecting system, although the part of detection passes via image
Sensor instead of traditional large-scale optical lens, however, system sample introduction part still needs external miniflow pump and syringe will
Sample push-in is detected, adds the complexity of system.Therefore, the sample introduction of whole image-forming detecting system how is realized, is imaged, goes out sample
Hardware integration, miniaturization, turn into the trend of development.
The content of the invention
The utility model overcomes huge, costly, complex operation of system present in existing Cell Measurement Technique etc.
The deficiency of technology, there is provided a kind of to be based on surface acoustic wave by being integrated on the printed circuit board (PCB) for be integrated with image sensor chip
Miniflow driving device, realize the sample introduction of whole image-forming detecting system, be imaged, go out sample hardware integration, miniaturization without lens
Miniflow is imaged and its detecting system.
The technical solution of the utility model is as follows：
It is a kind of to be driven based on surface acoustic wave driving without the imaging of lens miniflow and its detecting system, including surface acoustic wave miniflow
Module, the first miniflow flexible pipe, without lenticular image acquisition module, the second miniflow flexible pipe, waste liquid pool, light source module and graphical analysis mould
Block；The surface acoustic wave miniflow drive module includes Piezoelectric Substrates, interdigital transducer, liquid storage tank and the first microfluidic channel, institute
State interdigital transducer to be arranged in Piezoelectric Substrates, the liquid storage tank is arranged in Piezoelectric Substrates and positioned at the one of interdigital transducer
Side；First microfluidic channel is arranged on the exit of liquid storage tank, the first miniflow flexible pipe connection liquid storage tank exit
The second microfluidic channel of first microfluidic channel and access without lenticular image acquisition module, the liquid storage tank are shaped as justifying
Shape, the liquid storage tank are driven by surface acoustic wave miniflow drive module；The no lenticular image acquisition module includes imaging sensor
Nude film, the second microfluidic channel and printed circuit board (PCB), second microfluidic channel is bonded with die surfaces, the printing electricity
Running of the road plate control without lenticular image acquisition module；The second miniflow flexible pipe connects the second microfluidic channel and waste liquid pool,
The light source module is arranged on the top of no lenticular image acquisition module, and described image analysis module electrically connects with printed circuit board (PCB)
Connect.
Further, the Piezoelectric Substrates of the surface acoustic wave miniflow drive module are bonded on a printed circuit, the fork
Finger transducer, liquid storage tank and the first microfluidic channel are arranged in Piezoelectric Substrates.
Further, the liquid storage tank and the first microfluidic channel use same material integral production, and the material is poly-
Dimethyl siloxane.
Further, the solution in the liquid storage tank flows into the first microfluidic channel, the first miniflow flexible pipe, without lens successively
Second microfluidic channel of image capture module, the second miniflow flexible pipe and waste liquid pool.
Further, the light source module provides power supply by printed circuit board (PCB), and is connected with fixing structure for printed circuitboard,
The light source module is using white light or the lampet of specific frequency spectrum.
Advantage is the utility model compared with prior art：The utility model is added to the interdigital transducings of SAW by radiofrequency signal
Device（Inter-Digitated Transducer, IDT）When upper, the surface of piezoelectric will be produced perpendicular to electrode direction, and
The surface acoustic wave propagated forward.When sound wave runs into the liquid on surface, the kinetic energy of sound wave will be coupled in liquid and draw
Play sound and cause miniflow（Acoustic Streaming）.When the size of microchannel, which is less than sound, causes vortex radius, sound causes miniflow can be
Flow forward in micro-pipe, so as to apply the promotion of an entirety to the fluid in microchannel, effect is equivalent to porch liquid storage
Sample push-in detection interface in pond, the intensity of its flow velocity and RF signals（Voltage amplitude）Directly proportional, highest can reach per second
Tens centimetres, so as to realize high-throughout continuous fluid detection, so as to realize miniaturization, precision.
The utility model is micro- based on surface acoustic wave by being integrated on the printed circuit board (PCB) for be integrated with image sensor chip
Flow driving device, so as to realize the sample introduction of whole image-forming detecting system, be imaged, go out sample hardware integration, miniaturization.
Brief description of the drawings
Fig. 1 is being imaged without lens miniflow based on surface acoustic wave driving of the present utility model and detecting system schematic diagram；
Fig. 2 is surface acoustic wave miniflow drive module top view of the present utility model.
Identified in figure：Surface acoustic wave miniflow drive module 1, Piezoelectric Substrates 11, interdigital transducer 12, liquid storage tank 13, first
Microfluidic channel 14, the first miniflow flexible pipe 2, without lenticular image acquisition module 3, nude film 31, the second microfluidic channel 32, printing electricity
Road plate 33, the second miniflow flexible pipe 4 and waste liquid pool 5.
Embodiment
The utility model is further illustrated with reference to the accompanying drawings and detailed description.
As shown in figure 1, a kind of being imaged without lens miniflow based on surface acoustic wave driving and its detecting system, including sound surface
Ripple miniflow drive module 1, the first miniflow flexible pipe 2, without lenticular image acquisition module 3, the second miniflow flexible pipe 4, waste liquid pool 5, light source
Module and image analysis module.
It is micro- that the surface acoustic wave miniflow drive module 1 includes Piezoelectric Substrates 11, interdigital transducer 12, liquid storage tank 13 and first
Stream control passage 14, the interdigital transducer 12 are arranged in Piezoelectric Substrates 11, and what the liquid storage tank 13 was bonded is arranged on piezoelectricity lining
On bottom 11 and positioned at the side of interdigital transducer 12, the Piezoelectric Substrates 11 are fitted on printed circuit board (PCB) 33, described interdigital to change
Energy device 12, the microfluidic channel 14 of liquid storage tank 13 and first are arranged in Piezoelectric Substrates 11, are easy to space compression, and assurance function is just
Often.The microfluidic channel 14 of liquid storage tank 13 and first uses same material integral production, and the material is generally poly dimethyl
Siloxanes（PDMS）, the liquid storage tank 13 is shaped as circle, and the liquid storage tank 13 is driven by surface acoustic wave miniflow drive module 1
It is dynamic.First microfluidic channel 14 is arranged on the exit of liquid storage tank 13, and the first miniflow flexible pipe 2 connects liquid storage tank 13 and connect
The second microfluidic channel 32 of the first microfluidic channel 14 and access without lenticular image acquisition module 3 of outlet.
The no lenticular image acquisition module 3 includes the nude film 31, the second microfluidic channel 32 and printing of imaging sensor
Circuit board 33, second microfluidic channel 32 and the surface bond of nude film 31, the second microfluidic channel 32 after bonding（Or also cry
Micro-fluidic chip）Some spaces are also had between being encapsulated with sensor, so again by the PDMS material of liquid filling body shape this
Individual space is filled up, after its solidification after just and the second microfluidic channels of PDMS 32 form one.Wherein for being gathered without lenticular image
For module 3, nude film and the second microfluidic channel 32 pass through bonding line（bonding wire）Connect together.The printed circuit
Plate 33 controls the running of no lenticular image acquisition module 3, and corresponding component is provided with the printed circuit board (PCB) 33.Described
Two miniflow flexible pipes 4 connect the second microfluidic channel 32 and waste liquid pool 5, the light source module are arranged on no lenticular image acquisition module
3 top, the light source module provides power supply by printed circuit board (PCB) 33, and is connected with the fixed structure of printed circuit board (PCB) 33, described
Light source module is using white light or the lampet of specific frequency spectrum.Described image analysis module is electrically connected with printed circuit board (PCB) 33.
The light source module from without above lenticular image acquisition module 3 project, when sample to be tested is driven by surface acoustic wave miniflow drive module 1
It is dynamic, hence into the image sensor surface without lenticular image acquisition module 3 the second microfluidic channel 32 when, the no lens
Image capture module 3 is acquired the shadow image of sample, and is output to graphical analysis by the interface on printed circuit board (PCB) 33
Module is tested and analyzed, and the sample after detection flows out to the second miniflow flexible pipe 4 from the second microfluidic channel 32 and eventually entered into
Waste liquid pool 5, complete detection.Therefore, it is soft to flow into the first microfluidic channel 14, the first miniflow successively for the solution in the liquid storage tank 13
Pipe 2, the second microfluidic channel 32 without lenticular image acquisition module 3, the second miniflow flexible pipe 4 and waste liquid pool 5.
As shown in Fig. 2 be the top view of the utility model surface acoustic wave miniflow drive module 1, the interdigital transducer 12
In Piezoelectric Substrates 11, first microfluidic channel 14 passes through dimethyl silicone polymer with liquid storage tank 13 for processing（PDMS）Material
It is arranged on to realize in Piezoelectric Substrates 11.The material of Piezoelectric Substrates 11 is that 128 ° of Y cut lithium niobate.First microfluidic channel
14 input port connection liquid storage tank 13, sample solution bend the output for entering the first microfluidic channel 14 by one after flowing into
Mouthful, delivery outlet connects the first miniflow flexible pipe 2.The use of interdigital transducer 12 is multipair interdigital, general interdigital using 30 pairs, and it is produced
The direction of propagation of sound wave overlaps with the microfluidic channel center line direction after bending, therefore, when signal generator output signal just
When negative pole is connected with the two-stage of interdigital transducer 12 respectively, Regulate signal generator output sinusoidal signal can be by microchannel
Solution release.Specific first microfluidic channel 14 typically uses height as 50 microns, and width is 200 microns, bending angle
For 45 °.First miniflow flexible pipe 2, the second miniflow flexible pipe 4 use Teflon conduit.
Described above is only preferred embodiment of the present utility model, it is noted that for the common skill of the art
Art personnel, without departing from the concept of the premise utility, some improvements and modifications can also be made, these improvements and modifications
Also should be regarded as in scope of protection of the utility model.
Claims (5)
1. a kind of being imaged without lens miniflow based on surface acoustic wave driving and its detecting system, it is characterised in that including sound surface
Ripple miniflow drive module, the first miniflow flexible pipe, without lenticular image acquisition module, the second miniflow flexible pipe, waste liquid pool, light source module and
Image analysis module；The surface acoustic wave miniflow drive module includes Piezoelectric Substrates, interdigital transducer, liquid storage tank and the first miniflow
Passage is controlled, the interdigital transducer is arranged in Piezoelectric Substrates, and the liquid storage tank is arranged in Piezoelectric Substrates and changed positioned at interdigital
The side of energy device；First microfluidic channel is arranged on the exit of liquid storage tank, and the first miniflow flexible pipe connects liquid storage tank
The second microfluidic channel of the first microfluidic channel and access without lenticular image acquisition module of exit, the shape of the liquid storage tank
Shape is circle, and the liquid storage tank is driven by surface acoustic wave miniflow drive module；The no lenticular image acquisition module includes image
The nude film of sensor, the second microfluidic channel and printed circuit board (PCB), second microfluidic channel is bonded with die surfaces, described
Printed circuit board (PCB) controls the running without lenticular image acquisition module；The second miniflow flexible pipe connects the second microfluidic channel and given up
Liquid pool, the light source module are arranged on the top of no lenticular image acquisition module, described image analysis module and printed circuit board (PCB)
It is electrically connected with.
2. a kind of being imaged without lens miniflow based on surface acoustic wave driving according to claim 1 and its detecting system, its
It is characterised by：The Piezoelectric Substrates of the surface acoustic wave miniflow drive module are bonded on a printed circuit, the interdigital transducer,
Liquid storage tank and the first microfluidic channel are arranged in Piezoelectric Substrates.
3. a kind of being imaged without lens miniflow based on surface acoustic wave driving according to claim 1 and its detecting system, its
It is characterised by：The liquid storage tank and the first microfluidic channel use same material integral production, and the material is poly dimethyl silicon
Oxygen alkane.
4. a kind of being imaged without lens miniflow based on surface acoustic wave driving according to claim 1 and its detecting system, its
It is characterised by：Solution in the liquid storage tank flows into the first microfluidic channel, the first miniflow flexible pipe, gathered without lenticular image successively
Second microfluidic channel of module, the second miniflow flexible pipe and waste liquid pool.
5. a kind of being imaged without lens miniflow based on surface acoustic wave driving according to claim 1 and its detecting system, its
It is characterised by：The light source module provides power supply by printed circuit board (PCB), and is connected with fixing structure for printed circuitboard, the light source
Module is using white light or the lampet of specific frequency spectrum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720494232.6U CN206696233U (en) | 2017-05-05 | 2017-05-05 | A kind of being imaged without lens miniflow based on surface acoustic wave driving and its detecting system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720494232.6U CN206696233U (en) | 2017-05-05 | 2017-05-05 | A kind of being imaged without lens miniflow based on surface acoustic wave driving and its detecting system |
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| Publication Number | Publication Date |
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| CN206696233U true CN206696233U (en) | 2017-12-01 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107102058A (en) * | 2017-05-05 | 2017-08-29 | 杭州电子科技大学 | It is a kind of to be imaged based on what surface acoustic wave drove without lens miniflow and its detecting system |
-
2017
- 2017-05-05 CN CN201720494232.6U patent/CN206696233U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107102058A (en) * | 2017-05-05 | 2017-08-29 | 杭州电子科技大学 | It is a kind of to be imaged based on what surface acoustic wave drove without lens miniflow and its detecting system |
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